5XA1
Crystal structure of inositol 1,4,5-trisphosphate receptor cytosolic domain with inositol 1,4,5-trisphosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005220 | molecular_function | inositol 1,4,5-trisphosphate-gated calcium channel activity |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0006816 | biological_process | calcium ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0070679 | molecular_function | inositol 1,4,5 trisphosphate binding |
| B | 0005220 | molecular_function | inositol 1,4,5-trisphosphate-gated calcium channel activity |
| B | 0005262 | molecular_function | calcium channel activity |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0006816 | biological_process | calcium ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0070588 | biological_process | calcium ion transmembrane transport |
| B | 0070679 | molecular_function | inositol 1,4,5 trisphosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue I3P A 3000 |
| Chain | Residue |
| A | ARG265 |
| A | THR267 |
| A | GLY268 |
| A | ARG269 |
| A | LYS508 |
| A | ARG511 |
| A | TYR567 |
| A | ARG568 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue I3P B 3000 |
| Chain | Residue |
| B | THR267 |
| B | GLY268 |
| B | ARG269 |
| B | LYS508 |
| B | ARG511 |
| B | TYR567 |
| B | ARG568 |
| B | LYS569 |
| B | ARG265 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 108 |
| Details | Domain: {"description":"MIR 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 112 |
| Details | Domain: {"description":"MIR 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12442173","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28416699","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1N4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5GUG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12442173","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1N4K","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q14573","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"25368151","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P29994","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
