5WY0

Crystal structure of the methyltranferase domain of human HEN1 in complex with AdoMet

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001510	biological_process	RNA methylation
A	0008171	molecular_function	O-methyltransferase activity
A	0008173	molecular_function	RNA methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue SAM A 800

Chain	Residue
A	TYR6
A	VAL85
A	ILE101
A	GLU102
A	LEU103
A	HIS106
A	HOH912
A	HOH921
A	HOH938
A	HOH966
A	GLY25
A	GLY27
A	ASP48
A	ILE49
A	ASN50
A	LYS53
A	GLY83
A	SER84

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|Ref.5, ECO:0007744|PDB:4XCX

Chain	Residue	Details
A	TYR6
A	GLY25
A	ASP48
A	LYS53

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0007744|PDB:4XCX

Chain	Residue	Details
A	VAL85
A	ILE101

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q9C5Q8

Chain	Residue	Details
A	GLU102
A	GLU105
A	HIS106
A	HIS151

---