5WY0

Crystal structure of the methyltranferase domain of human HEN1 in complex with AdoMet

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001510	biological_process	RNA methylation
A	0008171	molecular_function	O-methyltransferase activity
A	0008173	molecular_function	RNA methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue SAM A 800

Chain	Residue
A	TYR6
A	VAL85
A	ILE101
A	GLU102
A	LEU103
A	HIS106
A	HOH912
A	HOH921
A	HOH938
A	HOH966
A	GLY25
A	GLY27
A	ASP48
A	ILE49
A	ASN50
A	LYS53
A	GLY83
A	SER84

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2014","submissionDatabase":"PDB data bank","title":"Crystal structure of human C1ORF59 in complex with SAH.","authors":["Walker J.R.","Zeng H.","Dong A.","Li Y.","Wernimont A.","Bountra C.","Arrowsmith C.H.","Edwards A.M.","Brown P.J.","Wu H."]}},{"source":"PDB","id":"4XCX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PDB","id":"4XCX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9C5Q8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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