5WHE

KRas G12V/D38P, bound to GppNHp and miniprotein 225-11

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0007165	biological_process	signal transduction
A	0016020	cellular_component	membrane
D	0003924	molecular_function	GTPase activity
D	0005525	molecular_function	GTP binding
D	0007165	biological_process	signal transduction
D	0016020	cellular_component	membrane
G	0003924	molecular_function	GTPase activity
G	0005525	molecular_function	GTP binding
G	0007165	biological_process	signal transduction
G	0016020	cellular_component	membrane
J	0003924	molecular_function	GTPase activity
J	0005525	molecular_function	GTP binding
J	0007165	biological_process	signal transduction
J	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue GNP A 801

Chain	Residue
A	VAL12
A	ASN116
A	LYS117
A	ASP119
A	LEU120
A	SER145
A	ALA146
A	LYS147
A	MG806
A	HOH915
A	HOH924
A	GLY13
A	HOH938
A	HOH952
A	HOH966
A	VAL14
A	GLY15
A	LYS16
A	SER17
A	ALA18
A	PHE28
A	GLY60

---

site_id	AC2
Number of Residues	7
Details	binding site for residue CA A 802

Chain	Residue
A	GLN25
A	HOH906
A	HOH939
A	HOH956
A	HOH982
A	HOH984
A	HOH991

---

site_id	AC3
Number of Residues	4
Details	binding site for residue CA A 803

Chain	Residue
A	GLU63
A	HOH968
B	ALA32
I	ASP16

---

site_id	AC4
Number of Residues	6
Details	binding site for residue CA A 804

Chain	Residue
A	GLU63
A	TYR64
A	HOH970
B	HOH104
I	ASP16
I	GLU19

---

site_id	AC5
Number of Residues	5
Details	binding site for residue MG A 806

Chain	Residue
A	SER17
A	GNP801
A	HOH924
A	HOH938
A	HOH966

---

site_id	AC6
Number of Residues	20
Details	binding site for residue GNP D 801

Chain	Residue
D	VAL12
D	GLY13
D	VAL14
D	GLY15
D	LYS16
D	SER17
D	ALA18
D	PHE28
D	GLY60
D	ASN116
D	LYS117
D	ASP119
D	LEU120
D	SER145
D	ALA146
D	LYS147
D	MG804
D	HOH908
D	HOH918
D	HOH930

---

site_id	AC7
Number of Residues	6
Details	binding site for residue CA D 802

Chain	Residue
D	GLU63
D	TYR64
D	HOH948
E	HOH107
L	ASP16
L	GLU19

---

site_id	AC8
Number of Residues	3
Details	binding site for residue CA D 803

Chain	Residue
D	GLU63
E	ALA32
L	ASP16

---

site_id	AC9
Number of Residues	5
Details	binding site for residue MG D 804

Chain	Residue
D	SER17
D	GNP801
D	HOH908
D	HOH918
D	HOH946

---

site_id	AD1
Number of Residues	17
Details	binding site for residue GNP G 801

Chain	Residue
G	VAL12
G	GLY13
G	VAL14
G	GLY15
G	LYS16
G	SER17
G	ALA18
G	ASN116
G	LYS117
G	ASP119
G	LEU120
G	SER145
G	ALA146
G	LYS147
G	MG804
G	HOH920
G	HOH922

---

site_id	AD2
Number of Residues	6
Details	binding site for residue CA G 802

Chain	Residue
G	HOH941
H	HOH108
C	ASP16
C	GLU19
G	GLU63
G	TYR64

---

site_id	AD3
Number of Residues	4
Details	binding site for residue CA G 803

Chain	Residue
C	ASP16
G	GLU63
G	HOH942
H	ALA32

---

site_id	AD4
Number of Residues	5
Details	binding site for residue MG G 804

Chain	Residue
G	SER17
G	GNP801
G	HOH920
G	HOH922
G	HOH940

---

site_id	AD5
Number of Residues	19
Details	binding site for residue GNP J 801

Chain	Residue
J	VAL12
J	GLY13
J	VAL14
J	GLY15
J	LYS16
J	SER17
J	ALA18
J	PHE28
J	ASN116
J	LYS117
J	ASP119
J	LEU120
J	SER145
J	ALA146
J	LYS147
J	MG802
J	HOH915
J	HOH922
J	HOH924

---

site_id	AD6
Number of Residues	5
Details	binding site for residue MG J 802

Chain	Residue
J	SER17
J	GNP801
J	HOH915
J	HOH922
J	HOH954

---

site_id	AD7
Number of Residues	6
Details	binding site for residue CA F 101

Chain	Residue
F	ASP16
F	GLU19
F	HOH203
F	HOH214
J	GLU63
J	TYR64

---

site_id	AD8
Number of Residues	5
Details	binding site for residue CA F 102

Chain	Residue
F	ASP16
F	HOH209
J	GLU63
K	ALA32
K	HOH115

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22431598","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22566140","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34380736","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"N-acetylthreonine; in GTPase KRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"22711838","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine; in GTPase KRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}

Chain

Residue

Details

---