5WGK

Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with HPB

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000118	cellular_component	histone deacetylase complex
A	0004407	molecular_function	histone deacetylase activity
A	0006325	biological_process	chromatin organization
A	0016575	biological_process	histone deacetylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue IOD A 801

Chain	Residue
A	TRP459
A	TRP459

---

site_id	AC2
Number of Residues	1
Details	binding site for residue IOD A 802

Chain	Residue
A	HIS463

---

site_id	AC3
Number of Residues	1
Details	binding site for residue IOD A 803

Chain	Residue
A	ALA733

---

site_id	AC4
Number of Residues	2
Details	binding site for residue IOD A 804

Chain	Residue
A	PRO519
A	HOH1192

---

site_id	AC5
Number of Residues	1
Details	binding site for residue IOD A 808

Chain	Residue
A	LYS506

---

site_id	AC6
Number of Residues	1
Details	binding site for residue IOD A 809

Chain	Residue
A	HOH1043

---

site_id	AC7
Number of Residues	1
Details	binding site for residue IOD A 810

Chain	Residue
A	GLY657

---

site_id	AC8
Number of Residues	1
Details	binding site for residue IOD A 811

Chain	Residue
A	PHE643

---

site_id	AC9
Number of Residues	5
Details	binding site for residue ZN A 812

Chain	Residue
A	ASP612
A	HIS614
A	ASP705
A	AGJ816
A	HOH915

---

site_id	AD1
Number of Residues	5
Details	binding site for residue K A 813

Chain	Residue
A	ASP610
A	ASP612
A	HIS614
A	SER633
A	LEU634

---

site_id	AD2
Number of Residues	6
Details	binding site for residue K A 814

Chain	Residue
A	PHE623
A	ASP626
A	VAL629
A	TYR662
A	HOH960
A	HOH1066

---

site_id	AD3
Number of Residues	2
Details	binding site for residue K A 815

Chain	Residue
A	GLU624
A	GLY655

---

site_id	AD4
Number of Residues	14
Details	binding site for residue AGJ A 816

Chain	Residue
A	SER531
A	HIS574
A	GLY582
A	PHE583
A	ARG601
A	ASP612
A	HIS614
A	PHE643
A	ASP705
A	GLY743
A	TYR745
A	ZN812
A	HOH915
A	HOH1002

---

site_id	AD5
Number of Residues	4
Details	binding site for residue EDO A 817

Chain	Residue
A	ARG472
A	HOH912
A	HOH972
A	HOH978

---

site_id	AD6
Number of Residues	3
Details	binding site for residue EDO A 818

Chain	Residue
A	ARG488
A	PRO490
A	HOH1072

---

site_id	AD7
Number of Residues	4
Details	binding site for residue EDO A 819

Chain	Residue
A	ARG451
A	ALA491
A	LEU493
A	HOH1128

---

site_id	AD8
Number of Residues	6
Details	binding site for residue EDO A 820

Chain	Residue
A	PRO442
A	ARG485
A	LEU762
A	HOH939
A	HOH977
A	HOH1138

---

site_id	AD9
Number of Residues	4
Details	binding site for residue EDO A 821

Chain	Residue
A	GLN554
A	THR558
A	ASP639
A	HOH906

---

site_id	AE1
Number of Residues	5
Details	binding site for residue EDO A 822

Chain	Residue
A	SER475
A	GLU478
A	ARG660
A	HOH914
A	HOH1224

---

site_id	AE2
Number of Residues	6
Details	binding site for residue EDO A 823

Chain	Residue
A	ARG708
A	GLU752
A	HOH909
A	HOH1041
A	HOH1102
A	HOH1180

---

site_id	AE3
Number of Residues	5
Details	binding site for residue EDO A 824

Chain	Residue
A	HIS487
A	ARG488
A	PRO490
A	GLN560
A	HOH906

---

site_id	AE4
Number of Residues	1
Details	binding site for residue EDO A 825

Chain	Residue
A	THR773

---

site_id	AE5
Number of Residues	6
Details	binding site for residue EDO A 826

Chain	Residue
A	HIS684
A	LEU775
A	THR780
A	ASN784
A	HOH905
A	HOH1100

---

site_id	AE6
Number of Residues	8
Details	binding site for residue EDO A 827

Chain	Residue
A	ASN523
A	ASN523
A	ARG524
A	ARG524
A	ASP527
A	ASP527
A	HOH964
A	HOH964

---

site_id	AE7
Number of Residues	4
Details	binding site for residue EDO A 828

Chain	Residue
A	LYS506
A	HIS727
A	MET730
A	SER731

---

site_id	AE8
Number of Residues	6
Details	binding site for residue EDO A 829

Chain	Residue
A	LYS658
A	ARG660
A	TYR662
A	HOH981
A	HOH1001
A	ASP627

---

site_id	AE9
Number of Residues	3
Details	binding site for residue EDO A 830

Chain	Residue
A	LEU482
A	MET756
A	SER759

---

site_id	AF1
Number of Residues	8
Details	binding site for residue PEG A 831

Chain	Residue
A	ASP449
A	GLN450
A	PHE474
A	ARG488
A	HOH902
A	HOH903
A	HOH1106
A	HOH1168

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