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5WBV

Crystal Structure of the SET Domain of Human SUV420H1 In Complex With Inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0042799molecular_functionhistone H4K20 methyltransferase activity
B0042799molecular_functionhistone H4K20 methyltransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 401
ChainResidue
ACYS275
ACYS319
ACYS321
ACYS324

site_idAC2
Number of Residues18
Detailsbinding site for residue SAM A 402
ChainResidue
AALA210
APHE250
AALA269
APHE270
AILE271
AASN272
AHIS273
ATYR307
APHE312
ACYS319
AGLU320
ACYS321
BARG257
AHIS98
ATYR203
ASER205
AGLU206
AGLY209

site_idAC3
Number of Residues13
Detailsbinding site for residue 9ZY A 403
ChainResidue
AGLY229
AVAL252
AMET253
ATRP264
AALA268
AALA269
APHE281
AALA289
ATYR307
APHE311
AHOH512
BARG244
BHIS245

site_idAC4
Number of Residues4
Detailsbinding site for residue ZN B 401
ChainResidue
BCYS275
BCYS319
BCYS321
BCYS324

site_idAC5
Number of Residues20
Detailsbinding site for residue SAM B 402
ChainResidue
AARG257
AHOH510
BHIS98
BTYR203
BSER205
BGLU206
BGLY209
BALA210
BPHE250
BALA269
BPHE270
BILE271
BASN272
BHIS273
BTYR307
BPHE312
BCYS319
BGLU320
BCYS321
BHOH508

site_idAC6
Number of Residues12
Detailsbinding site for residue 9ZY B 403
ChainResidue
AARG244
AHIS245
BGLY229
BVAL252
BMET253
BTRP264
BALA268
BALA269
BPHE281
BALA289
BTYR307
BPHE311

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues18
DetailsBINDING: BINDING => ECO:0000269|PubMed:24396869, ECO:0000269|PubMed:28114273, ECO:0000269|Ref.14, ECO:0007744|PDB:3S8P, ECO:0007744|PDB:5CPR, ECO:0007744|PDB:5WBV
ChainResidueDetails
AHIS98
BHIS98
BTYR203
BALA210
BASN272
BCYS275
BCYS319
BGLU320
BCYS321
BCYS324
ATYR203
AALA210
AASN272
ACYS275
ACYS319
AGLU320
ACYS321
ACYS324

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:24396869, ECO:0000269|PubMed:28114273, ECO:0007744|PDB:3S8P, ECO:0007744|PDB:5CPR
ChainResidueDetails
AARG257
BARG257

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PDB entries from 2024-10-30

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