5VK3
Apo ctPRC2 with E840A and K852D mutations in Ezh2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0005634 | cellular_component | nucleus |
| A | 0006325 | biological_process | chromatin organization |
| A | 0031491 | molecular_function | nucleosome binding |
| B | 0006338 | biological_process | chromatin remodeling |
| B | 0042054 | molecular_function | histone methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 8001 |
| Chain | Residue |
| B | CYS727 |
| B | CYS748 |
| B | CYS755 |
| B | CYS760 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 8002 |
| Chain | Residue |
| B | CYS736 |
| B | CYS755 |
| B | CYS763 |
| B | CYS784 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 8003 |
| Chain | Residue |
| B | CYS729 |
| B | CYS736 |
| B | CYS746 |
| B | CYS727 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 8004 |
| Chain | Residue |
| B | CYS685 |
| B | HIS687 |
| B | CYS691 |
| B | CYS697 |
| B | ZN8006 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 8005 |
| Chain | Residue |
| B | CYS691 |
| B | CYS709 |
| B | CYS715 |
| B | CYS720 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 8006 |
| Chain | Residue |
| B | CYS685 |
| B | CYS699 |
| B | CYS709 |
| B | CYS713 |
| B | ZN8004 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 8007 |
| Chain | Residue |
| B | CYS508 |
| B | CYS511 |
| B | CYS516 |
| B | HIS518 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 8008 |
| Chain | Residue |
| B | CYS570 |
| B | CYS574 |
| B | CYS615 |
| B | CYS625 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 23 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26472914, ECO:0000269|PubMed:28607149, ECO:0000269|PubMed:29904056, ECO:0007744|PDB:5BJS, ECO:0007744|PDB:5KJH, ECO:0007744|PDB:5KJI, ECO:0007744|PDB:5KKL, ECO:0007744|PDB:5M5G, ECO:0007744|PDB:5TQR, ECO:0007744|PDB:5VK3, ECO:0007744|PDB:5WF7, ECO:0007744|PDB:5WFC, ECO:0007744|PDB:5WFD |
| Chain | Residue | Details |
| B | CYS508 | |
| B | CYS691 | |
| B | CYS697 | |
| B | CYS699 | |
| B | CYS709 | |
| B | CYS713 | |
| B | CYS715 | |
| B | CYS720 | |
| B | CYS727 | |
| B | CYS729 | |
| B | CYS736 | |
| B | CYS511 | |
| B | CYS746 | |
| B | CYS748 | |
| B | CYS755 | |
| B | CYS760 | |
| B | CYS516 | |
| B | HIS518 | |
| B | CYS574 | |
| B | CYS615 | |
| B | CYS625 | |
| B | CYS685 | |
| B | HIS687 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26472914, ECO:0000269|PubMed:28607149, ECO:0000269|PubMed:29904056, ECO:0007744|PDB:5BJS, ECO:0007744|PDB:5KJH, ECO:0007744|PDB:5KJI, ECO:0007744|PDB:5M5G, ECO:0007744|PDB:5TQR, ECO:0007744|PDB:5VK3, ECO:0007744|PDB:5WF7, ECO:0007744|PDB:5WFC, ECO:0007744|PDB:5WFD |
| Chain | Residue | Details |
| B | CYS570 | |
| B | CYS763 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26472914, ECO:0000269|PubMed:28607149, ECO:0000269|PubMed:29904056, ECO:0007744|PDB:5BJS, ECO:0007744|PDB:5KJH, ECO:0007744|PDB:5KJI, ECO:0007744|PDB:5KKL, ECO:0007744|PDB:5M5G, ECO:0007744|PDB:5TQR, ECO:0007744|PDB:5VK3, ECO:0007744|PDB:5WF7, ECO:0007744|PDB:5WFC |
| Chain | Residue | Details |
| B | CYS784 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26472914, ECO:0000269|PubMed:28607149, ECO:0007744|PDB:5KKL, ECO:0007744|PDB:5TQR |
| Chain | Residue | Details |
| B | TYR809 | |
| B | SER854 | |
| B | TYR855 | |
| B | HIS881 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26472914, ECO:0000269|PubMed:28607149, ECO:0007744|PDB:5TQR |
| Chain | Residue | Details |
| B | ASP852 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26472914, ECO:0007744|PDB:5KKL |
| Chain | Residue | Details |
| B | ASN880 | |
| B | THR926 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26472914, ECO:0007744|PDB:5KJH, ECO:0007744|PDB:5KJI, ECO:0007744|PDB:5M5G |
| Chain | Residue | Details |
| B | LYS927 |
