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5VHE

DHX36 in complex with the c-Myc G-quadruplex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0000781cellular_componentchromosome, telomeric region
A0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
A0002151molecular_functionG-quadruplex RNA binding
A0003676molecular_functionnucleic acid binding
A0003677molecular_functionDNA binding
A0003678molecular_functionDNA helicase activity
A0003723molecular_functionRNA binding
A0003724molecular_functionRNA helicase activity
A0003730molecular_functionmRNA 3'-UTR binding
A0004386molecular_functionhelicase activity
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005694cellular_componentchromosome
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0006359biological_processregulation of transcription by RNA polymerase III
A0006417biological_processregulation of translation
A0007283biological_processspermatogenesis
A0010494cellular_componentcytoplasmic stress granule
A0010501biological_processRNA secondary structure unwinding
A0010628biological_processpositive regulation of gene expression
A0016607cellular_componentnuclear speck
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0017148biological_processnegative regulation of translation
A0030154biological_processcell differentiation
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0031442biological_processpositive regulation of mRNA 3'-end processing
A0032508biological_processDNA duplex unwinding
A0034605biological_processcellular response to heat
A0034644biological_processcellular response to UV
A0035925molecular_functionmRNA 3'-UTR AU-rich region binding
A0042995cellular_componentcell projection
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043204cellular_componentperikaryon
A0043488biological_processregulation of mRNA stability
A0044806biological_processG-quadruplex DNA unwinding
A0045087biological_processinnate immune response
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0045995biological_processregulation of embryonic development
A0046872molecular_functionmetal ion binding
A0048027molecular_functionmRNA 5'-UTR binding
A0051607biological_processdefense response to virus
A0051880molecular_functionG-quadruplex DNA binding
A0051891biological_processpositive regulation of cardioblast differentiation
A0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
A0061003biological_processpositive regulation of dendritic spine morphogenesis
A0061158biological_process3'-UTR-mediated mRNA destabilization
A0070034molecular_functiontelomerase RNA binding
A0070883molecular_functionpre-miRNA binding
A1900153biological_processpositive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
A1901534biological_processpositive regulation of hematopoietic progenitor cell differentiation
A1903843biological_processcellular response to arsenite ion
A1904358biological_processpositive regulation of telomere maintenance via telomere lengthening
A1904582biological_processpositive regulation of intracellular mRNA localization
A2000767biological_processpositive regulation of cytoplasmic translation
Functional Information from PDB Data
site_idAC1
Number of Residues9
Detailsbinding site for residue K B 101
ChainResidue
BDG2
BDG3
BDG6
BDG7
BDA10
BDG11
BDT14
BDG15
BK102

site_idAC2
Number of Residues9
Detailsbinding site for residue K B 102
ChainResidue
BDG3
BDG4
BDG7
BDG8
BDG11
BDG12
BDG15
BDG16
BK101

Functional Information from PROSITE/UniProt
site_idPS00690
Number of Residues10
DetailsDEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. ShIVLDEIHE
ChainResidueDetails
ASER331-GLU340

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:29899445, ECO:0007744|PDB:5VHC, ECO:0007744|PDB:5VHD
ChainResidueDetails
AARG267
ATHR636

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:29899445, ECO:0007744|PDB:5VHC
ChainResidueDetails
AALA369
ALEU371

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:29899445, ECO:0007744|PDB:5VHD
ChainResidueDetails
AGLU591

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9H2U1
ChainResidueDetails
AVAL981

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9H2U1
ChainResidueDetails
APRO997

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PDB entries from 2024-07-17

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