5VG9

Structure of the eukaryotic intramembrane Ras methyltransferase ICMT (isoprenylcysteine carboxyl methyltransferase) without a monobody

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004671	molecular_function	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006481	biological_process	C-terminal protein methylation
A	0008168	molecular_function	methyltransferase activity
A	0016020	cellular_component	membrane
A	0032259	biological_process	methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue SAH A 301

Chain	Residue
A	ASN185
A	PRO210
A	SER211
A	TYR212
A	GLU250
A	LEU254
A	PHE257
A	LEU187
A	VAL188
A	GLN189
A	HIS196
A	LEU198
A	VAL199
A	TYR204
A	HIS209

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:29342140

Chain	Residue	Details
A	MET1-LEU2
A	LYS54-ASN58
A	GLN114-VAL118
A	SER182-ARG208
A	LYS244-ILE281

---

site_id	SWS_FT_FI2
Number of Residues	178
Details	TRANSMEM: Helical => ECO:0000305|PubMed:29342140

Chain	Residue	Details
A	SER3-TYR29
A	VAL36-LEU53
A	GLU59-ALA85
A	ILE89-VAL113
A	SER119-PHE149
A	HIS156-GLY181
A	HIS209-LEU226
A	LEU230-PHE243

---

site_id	SWS_FT_FI3
Number of Residues	14
Details	TOPO_DOM: Lumenal => ECO:0000305|PubMed:29342140

Chain	Residue	Details
A	TYR30-LEU35
A	PRO86-ASN88
A	PRO150-ILE155
A	ILE227-PRO229

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:29342140, ECO:0007744|PDB:5V7P, ECO:0007744|PDB:5VG9

Chain	Residue	Details
A	GLN189
A	HIS196
A	TYR204
A	HIS209
A	GLU250

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305|PubMed:29342140

Chain	Residue	Details
A	ARG246

---