5VG9
Structure of the eukaryotic intramembrane Ras methyltransferase ICMT (isoprenylcysteine carboxyl methyltransferase) without a monobody
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004671 | molecular_function | protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0006481 | biological_process | C-terminal protein methylation |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016740 | molecular_function | transferase activity |
| A | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue SAH A 301 |
| Chain | Residue |
| A | ASN185 |
| A | PRO210 |
| A | SER211 |
| A | TYR212 |
| A | GLU250 |
| A | LEU254 |
| A | PHE257 |
| A | LEU187 |
| A | VAL188 |
| A | GLN189 |
| A | HIS196 |
| A | LEU198 |
| A | VAL199 |
| A | TYR204 |
| A | HIS209 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 178 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"29342140","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"29342140","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 34 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"29342140","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29342140","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5V7P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VG9","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29342140","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
