5V59

Crystal structure of catalytic fragment of human AlaRS in complex with Aze-SA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003676	molecular_function	nucleic acid binding
A	0004813	molecular_function	alanine-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006419	biological_process	alanyl-tRNA aminoacylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	binding site for residue 8X1 A 501

Chain	Residue
A	ARG77
A	ASN216
A	VAL218
A	ASP239
A	THR240
A	GLY241
A	GLY243
A	ARG246
A	HOH601
A	HOH665
A	HOH732
A	TYR93
A	HOH772
A	HOH789
A	HIS94
A	HIS95
A	PHE98
A	MET100
A	TRP176
A	GLU213
A	ILE214

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27622773","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2014","submissionDatabase":"PDB data bank","title":"Crystal structure of wild type human AlaRS catalytic domain.","authors":["Zhou H.","Yang X.L."]}},{"source":"PDB","id":"4XEM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XEO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KNN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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