5UPV

Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis In the presence of G36

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0003938	molecular_function	IMP dehydrogenase activity
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	26
Details	binding site for residue IMP A 601

Chain	Residue
A	SER83
A	GLY376
A	MET395
A	GLY397
A	SER398
A	TYR421
A	GLY423
A	MET424
A	GLY425
A	GLU458
A	GLY459
A	MET85
A	8KV602
A	EDO607
A	HOH719
A	HOH749
A	HOH756
A	HOH775
A	HOH816
A	ASN313
A	GLY338
A	SER339
A	ILE340
A	CYS341
A	ASP374
A	GLY375

---

site_id	AC2
Number of Residues	9
Details	binding site for residue 8KV A 602

Chain	Residue
A	PRO61
A	MET424
A	GLY425
A	LEU455
A	VAL456
A	GLU458
A	TYR487
A	IMP601
A	FMT603

---

site_id	AC3
Number of Residues	4
Details	binding site for residue FMT A 603

Chain	Residue
A	THR284
A	ALA285
A	8KV602
A	HOH758

---

site_id	AC4
Number of Residues	8
Details	binding site for residue EDO A 604

Chain	Residue
A	LEU53
A	ALA315
A	ALA351
A	ALA356
A	GLU359
A	HOH710
A	HOH745
A	HOH807

---

site_id	AC5
Number of Residues	3
Details	binding site for residue FMT A 605

Chain	Residue
A	ASP36
A	GLN498
A	HOH798

---

site_id	AC6
Number of Residues	7
Details	binding site for residue EDO A 606

Chain	Residue
A	ALA56
A	SER57
A	ASP58
A	HIS288
A	ASN289
A	ARG290
A	LEU293

---

site_id	AC7
Number of Residues	9
Details	binding site for residue EDO A 607

Chain	Residue
A	ALA285
A	ASN313
A	GLY334
A	VAL335
A	GLY336
A	CYS341
A	IMP601
A	HOH714
A	HOH787

---

site_id	AC8
Number of Residues	5
Details	binding site for residue FMT A 608

Chain	Residue
A	ARG92
A	ALA404
A	GLU405
A	ALA406
A	HOH827

---

Functional Information from PROSITE/UniProt

site_id	PS00487
Number of Residues	13
Details	IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. VKVGVGpGSICtT

Chain	Residue	Details
A	VAL331-THR343

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Thioimidate intermediate => ECO:0000255|HAMAP-Rule:MF_01964, ECO:0000305|PubMed:26440283

Chain	Residue	Details
A	CYS341

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_01964, ECO:0000305|PubMed:26440283

Chain	Residue	Details
A	ARG443

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01964, ECO:0000269|PubMed:26440283

Chain	Residue	Details
A	ASP283
A	SER339
A	ASP374
A	GLY397
A	TYR421
A	GLU511
A	SER512
A	HIS513

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:26440283

Chain	Residue	Details
A	ASN289
A	THR343
A	GLU458

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01964

Chain	Residue	Details
A	GLY334

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_01964, ECO:0000269|PubMed:26440283

Chain	Residue	Details
A	GLY336
A	GLY338
A	CYS341

---