5UM3

Crystal structure of the V122L mutant of human UBR-box domain from UBR2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008270	molecular_function	zinc ion binding
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0071596	biological_process	ubiquitin-dependent protein catabolic process via the N-end rule pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 201

Chain	Residue
A	CYS99
A	CYS124
A	CYS127
A	CYS149

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 202

Chain	Residue
A	CYS127
A	CYS151
A	CYS163
A	HIS166

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 203

Chain	Residue
A	CYS115
A	HIS133
A	HIS136
A	CYS112

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20835242","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28392261","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NY2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NY3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TDA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TDB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TDD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UM3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20835242","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28392261","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NY3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TDA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20835242","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28392261","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NY3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"38225265","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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