5ULH
Structure of RNF165 in complex with a UbcH5b~Ub conjugate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000151 | cellular_component | ubiquitin ligase complex |
A | 0000209 | biological_process | protein polyubiquitination |
A | 0004842 | molecular_function | ubiquitin-protein transferase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
A | 0016567 | biological_process | protein ubiquitination |
A | 0016740 | molecular_function | transferase activity |
A | 0019787 | molecular_function | ubiquitin-like protein transferase activity |
A | 0031371 | cellular_component | ubiquitin conjugating enzyme complex |
A | 0031625 | molecular_function | ubiquitin protein ligase binding |
A | 0032991 | cellular_component | protein-containing complex |
A | 0036211 | biological_process | protein modification process |
A | 0051865 | biological_process | protein autoubiquitination |
A | 0061630 | molecular_function | ubiquitin protein ligase activity |
A | 0061631 | molecular_function | ubiquitin conjugating enzyme activity |
A | 0070062 | cellular_component | extracellular exosome |
A | 0070936 | biological_process | protein K48-linked ubiquitination |
C | 0008270 | molecular_function | zinc ion binding |
C | 0061630 | molecular_function | ubiquitin protein ligase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 9 |
Details | binding site for residue GOL A 201 |
Chain | Residue |
A | ALA14 |
A | PRO17 |
A | SER22 |
A | HOH303 |
A | HOH336 |
B | PHE45 |
B | ALA46 |
B | THR66 |
B | HIS68 |
site_id | AC2 |
Number of Residues | 7 |
Details | binding site for residue GOL A 202 |
Chain | Residue |
A | PRO65 |
A | LYS66 |
A | VAL67 |
A | SER83 |
A | ILE84 |
A | LEU89 |
A | HOH316 |
site_id | AC3 |
Number of Residues | 8 |
Details | binding site for residue SCN A 203 |
Chain | Residue |
A | PHE69 |
A | THR70 |
A | THR71 |
A | ARG72 |
A | SER80 |
A | ASN81 |
A | GLY82 |
A | HOH339 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue SCN B 101 |
Chain | Residue |
A | ARG125 |
B | THR7 |
B | LEU8 |
B | VAL70 |
B | LEU71 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue ZN C 401 |
Chain | Residue |
C | CYS312 |
C | HIS314 |
C | CYS331 |
C | CYS334 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue ZN C 402 |
Chain | Residue |
C | CYS294 |
C | CYS297 |
C | HIS317 |
C | CYS320 |
Functional Information from PROSITE/UniProt
site_id | PS00299 |
Number of Residues | 26 |
Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
Chain | Residue | Details |
B | LYS27-ASP52 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 41 |
Details | ZN_FING: RING-type; atypical => ECO:0000255|PROSITE-ProRule:PRU00175 |
Chain | Residue | Details |
C | SER299-THR340 | |
B | ARG72 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:26656854, ECO:0007744|PDB:5D0I, ECO:0007744|PDB:5D0K, ECO:0007744|PDB:5D0M |
Chain | Residue | Details |
C | SER299 | |
C | GLU302 | |
C | ASP322 | |
C | LEU325 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 |
Chain | Residue | Details |
B | SER65 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 |
Chain | Residue | Details |
B | THR66 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | MOD_RES: ADP-ribosylglycine => ECO:0000269|PubMed:28525742 |
Chain | Residue | Details |
B | GLY76 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 |
Chain | Residue | Details |
B | LYS6 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) |
Chain | Residue | Details |
B | GLY76 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 |
Chain | Residue | Details |
B | LYS11 | |
B | LYS48 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 |
Chain | Residue | Details |
B | LYS27 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 |
Chain | Residue | Details |
B | LYS29 |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 |
Chain | Residue | Details |
B | LYS33 |
site_id | SWS_FT_FI12 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 |
Chain | Residue | Details |
B | LYS63 |