5ULH

Structure of RNF165 in complex with a UbcH5b~Ub conjugate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000209	biological_process	protein polyubiquitination
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005829	cellular_component	cytosol
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0016567	biological_process	protein ubiquitination
A	0016740	molecular_function	transferase activity
A	0032991	cellular_component	protein-containing complex
A	0036211	biological_process	protein modification process
A	0051865	biological_process	protein autoubiquitination
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0061631	molecular_function	ubiquitin conjugating enzyme activity
A	0070062	cellular_component	extracellular exosome
A	0070936	biological_process	protein K48-linked ubiquitination
C	0008270	molecular_function	zinc ion binding
C	0061630	molecular_function	ubiquitin protein ligase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue GOL A 201

Chain	Residue
A	ALA14
A	PRO17
A	SER22
A	HOH303
A	HOH336
B	PHE45
B	ALA46
B	THR66
B	HIS68

---

site_id	AC2
Number of Residues	7
Details	binding site for residue GOL A 202

Chain	Residue
A	PRO65
A	LYS66
A	VAL67
A	SER83
A	ILE84
A	LEU89
A	HOH316

---

site_id	AC3
Number of Residues	8
Details	binding site for residue SCN A 203

Chain	Residue
A	PHE69
A	THR70
A	THR71
A	ARG72
A	SER80
A	ASN81
A	GLY82
A	HOH339

---

site_id	AC4
Number of Residues	5
Details	binding site for residue SCN B 101

Chain	Residue
A	ARG125
B	THR7
B	LEU8
B	VAL70
B	LEU71

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN C 401

Chain	Residue
C	CYS312
C	HIS314
C	CYS331
C	CYS334

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN C 402

Chain	Residue
C	CYS294
C	CYS297
C	HIS317
C	CYS320

---

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
B	LYS27-ASP52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	146
Details	Domain: {"description":"UBC core","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10133","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	41
Details	Zinc finger: {"description":"RING-type; atypical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Region: {"description":"Ubiquitin binding","evidences":[{"source":"PubMed","id":"26656854","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5D0K","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26656854","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5D0I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D0K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---