5UAU
Structure of human PYCR-1 complexed with proline
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004735 | molecular_function | pyrroline-5-carboxylate reductase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0051881 | biological_process | regulation of mitochondrial membrane potential |
| A | 0055129 | biological_process | L-proline biosynthetic process |
| A | 1902792 | cellular_component | pyrroline-5-carboxylate reductase complex |
| A | 1903377 | biological_process | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
| B | 0004735 | molecular_function | pyrroline-5-carboxylate reductase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0034599 | biological_process | cellular response to oxidative stress |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0051881 | biological_process | regulation of mitochondrial membrane potential |
| B | 0055129 | biological_process | L-proline biosynthetic process |
| B | 1902792 | cellular_component | pyrroline-5-carboxylate reductase complex |
| B | 1903377 | biological_process | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
| C | 0004735 | molecular_function | pyrroline-5-carboxylate reductase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005759 | cellular_component | mitochondrial matrix |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0034599 | biological_process | cellular response to oxidative stress |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0051881 | biological_process | regulation of mitochondrial membrane potential |
| C | 0055129 | biological_process | L-proline biosynthetic process |
| C | 1902792 | cellular_component | pyrroline-5-carboxylate reductase complex |
| C | 1903377 | biological_process | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
| D | 0004735 | molecular_function | pyrroline-5-carboxylate reductase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005759 | cellular_component | mitochondrial matrix |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0034599 | biological_process | cellular response to oxidative stress |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0051881 | biological_process | regulation of mitochondrial membrane potential |
| D | 0055129 | biological_process | L-proline biosynthetic process |
| D | 1902792 | cellular_component | pyrroline-5-carboxylate reductase complex |
| D | 1903377 | biological_process | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
| E | 0004735 | molecular_function | pyrroline-5-carboxylate reductase activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005739 | cellular_component | mitochondrion |
| E | 0005759 | cellular_component | mitochondrial matrix |
| E | 0008652 | biological_process | amino acid biosynthetic process |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0034599 | biological_process | cellular response to oxidative stress |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0051881 | biological_process | regulation of mitochondrial membrane potential |
| E | 0055129 | biological_process | L-proline biosynthetic process |
| E | 1902792 | cellular_component | pyrroline-5-carboxylate reductase complex |
| E | 1903377 | biological_process | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue PRO A 401 |
| Chain | Residue |
| A | VAL231 |
| A | SER233 |
| A | GLY236 |
| A | ALA237 |
| A | THR238 |
| A | HOH525 |
| B | THR171 |
| B | GLY175 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue PRO A 402 |
| Chain | Residue |
| A | THR137 |
| A | GLU163 |
| A | GLU164 |
| A | HOH502 |
| A | HOH541 |
| A | ALA136 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue PRO B 401 |
| Chain | Residue |
| A | THR171 |
| A | GLY175 |
| B | VAL231 |
| B | SER233 |
| B | GLY236 |
| B | ALA237 |
| B | THR238 |
| B | HOH517 |
| B | HOH541 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue PRO B 402 |
| Chain | Residue |
| B | THR137 |
| B | GLU163 |
| B | GLU164 |
| B | HOH513 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 403 |
| Chain | Residue |
| B | GLY9 |
| B | GLN10 |
| B | LEU11 |
| B | ALA69 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue PRO C 401 |
| Chain | Residue |
| C | VAL231 |
| C | SER233 |
| C | GLY236 |
| C | ALA237 |
| C | THR238 |
| C | HOH521 |
| D | THR171 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue PRO C 402 |
| Chain | Residue |
| C | THR137 |
| C | GLU163 |
| C | GLU164 |
| C | HOH501 |
| C | HOH505 |
| C | HOH548 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 403 |
| Chain | Residue |
| C | GLY9 |
| C | GLN10 |
| C | LEU11 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue PRO D 401 |
| Chain | Residue |
| C | THR171 |
| C | GLY175 |
| D | VAL231 |
| D | SER233 |
| D | GLY236 |
| D | ALA237 |
| D | THR238 |
| D | HOH523 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue PRO D 402 |
| Chain | Residue |
| D | THR137 |
| D | GLU163 |
| D | GLU164 |
| D | HOH507 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 D 403 |
| Chain | Residue |
| D | GLY9 |
| D | GLN10 |
| D | LEU11 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue PRO E 401 |
| Chain | Residue |
| E | THR171 |
| E | GLY175 |
| E | VAL231 |
| E | SER233 |
| E | GLY236 |
| E | ALA237 |
| E | THR238 |
| E | HOH526 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue PRO E 402 |
| Chain | Residue |
| E | THR137 |
| E | GLU163 |
| E | GLU164 |
| E | HOH502 |
| E | HOH538 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 E 403 |
| Chain | Residue |
| E | GLY9 |
| E | GLN10 |
| E | LEU11 |
Functional Information from PROSITE/UniProt
| site_id | PS00521 |
| Number of Residues | 23 |
| Details | P5CR Delta 1-pyrroline-5-carboxylate reductase signature. Pgq.LkdnVSSpGGaTihALhvLE |
| Chain | Residue | Details |
| A | PRO224-GLU246 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 50 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human pyrroline-5-carboxylate reductase.","authoringGroup":["Structural genomics consortium (SGC)"]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 30 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28258219","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UAT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UAV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28258219","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UAT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28258219","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UAV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 15 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28258219","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UAU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 5 |
| Details | Modified residue: {"description":"N-acetylserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Zebisch A.","Kolch W."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
