5U8C
CRYSTAL STRUCTURE OF GLUN1/GLUN2A LIGAND-BINDING DOMAIN IN COMPLEX WITH GLYCINE AND NVP-AAM077
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue GLY A 901 |
| Chain | Residue |
| A | PHE92 |
| A | PRO124 |
| A | LEU125 |
| A | THR126 |
| A | ARG131 |
| A | SER179 |
| A | SER180 |
| A | ASP224 |
| A | PHE250 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 902 |
| Chain | Residue |
| A | SER168 |
| A | ASP169 |
| A | HIS197 |
| A | LYS200 |
| A | HOH1151 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | binding site for residue 84J B 301 |
| Chain | Residue |
| A | GLU273 |
| B | GLU16 |
| B | HIS88 |
| B | SER114 |
| B | THR116 |
| B | ARG121 |
| B | GLY172 |
| B | SER173 |
| B | THR174 |
| B | TYR214 |
| B | ASP215 |
| B | HOH411 |
| B | HOH422 |
| B | HOH474 |
| B | HOH523 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 41 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:30500536, ECO:0007744|PDB:6MM9, ECO:0007744|PDB:6MMA, ECO:0007744|PDB:6MMB, ECO:0007744|PDB:6MMG, ECO:0007744|PDB:6MMH, ECO:0007744|PDB:6MMI, ECO:0007744|PDB:6MMJ, ECO:0007744|PDB:6MMK, ECO:0007744|PDB:6MML, ECO:0007744|PDB:6MMM, ECO:0007744|PDB:6MMN, ECO:0007744|PDB:6MMP, ECO:0007744|PDB:6MMR, ECO:0007744|PDB:6MMS, ECO:0007744|PDB:6MMT, ECO:0007744|PDB:6MMU, ECO:0007744|PDB:6MMV, ECO:0007744|PDB:6MMW, ECO:0007744|PDB:6MMX |
| Chain | Residue | Details |
| B | HIS158-ILE178 | |
| B | GLY228-LEU249 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:30500536 |
| Chain | Residue | Details |
| B | ARG179-SER203 | |
| B | LEU219-GLU227 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | INTRAMEM: Discontinuously helical => ECO:0000250|UniProtKB:Q12879 |
| Chain | Residue | Details |
| B | LEU204-VAL218 | |
| A | SER180 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16281028, ECO:0000269|PubMed:24462099, ECO:0000269|PubMed:27618671, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8, ECO:0007744|PDB:5I56, ECO:0007744|PDB:5I57, ECO:0007744|PDB:5I58, ECO:0007744|PDB:5I59, ECO:0007744|PDB:5JTY |
| Chain | Residue | Details |
| B | SER114 | |
| B | THR116 | |
| B | ARG121 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16281028, ECO:0000269|PubMed:24462099, ECO:0000269|PubMed:27618671, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8, ECO:0007744|PDB:5I56, ECO:0007744|PDB:5I57, ECO:0007744|PDB:5I58, ECO:0007744|PDB:5JTY |
| Chain | Residue | Details |
| A | ASN79 | |
| A | ASN99 | |
| A | ASN166 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | SITE: Functional determinant of NMDA receptors => ECO:0000250 |
| Chain | Residue | Details |
| B | ALA217 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN46 | |
| B | ASN47 | |
| B | THR144 |
