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5U8C

CRYSTAL STRUCTURE OF GLUN1/GLUN2A LIGAND-BINDING DOMAIN IN COMPLEX WITH GLYCINE AND NVP-AAM077

Functional Information from GO Data
ChainGOidnamespacecontents
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0016020cellular_componentmembrane
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues9
Detailsbinding site for residue GLY A 901
ChainResidue
APHE92
APRO124
ALEU125
ATHR126
AARG131
ASER179
ASER180
AASP224
APHE250

site_idAC2
Number of Residues5
Detailsbinding site for residue GOL A 902
ChainResidue
ASER168
AASP169
AHIS197
ALYS200
AHOH1151

site_idAC3
Number of Residues15
Detailsbinding site for residue 84J B 301
ChainResidue
AGLU273
BGLU16
BHIS88
BSER114
BTHR116
BARG121
BGLY172
BSER173
BTHR174
BTYR214
BASP215
BHOH411
BHOH422
BHOH474
BHOH523

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues39
DetailsTRANSMEM: Helical => ECO:0000250|UniProtKB:B7ZSK1
ChainResidueDetails
BASP159-ARG179
BCYS229-ALA248

site_idSWS_FT_FI2
Number of Residues27
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305
ChainResidueDetails
BASN180-SER203
BGLY224-GLY228
AASP224

site_idSWS_FT_FI3
Number of Residues19
DetailsINTRAMEM: Discontinuously helical => ECO:0000250|UniProtKB:B7ZSK1
ChainResidueDetails
BLEU204-ALA223

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:16281028, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8, ECO:0007744|PDB:5I56, ECO:0007744|PDB:5I57, ECO:0007744|PDB:5I58, ECO:0007744|PDB:5I59, ECO:0007744|PDB:5JTY
ChainResidueDetails
BSER114
AASN99
AASN166

site_idSWS_FT_FI5
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:16281028, ECO:0000269|PubMed:24462099, ECO:0000269|PubMed:27618671, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8, ECO:0007744|PDB:5I56, ECO:0007744|PDB:5I57, ECO:0007744|PDB:5I58, ECO:0007744|PDB:5I59, ECO:0007744|PDB:5JTY
ChainResidueDetails
BARG121

site_idSWS_FT_FI6
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:16281028, ECO:0000269|PubMed:24462099, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues1
DetailsSITE: Functional determinant of NMDA receptors => ECO:0000250
ChainResidueDetails
BALA217

site_idSWS_FT_FI8
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN46
BASN47
BTHR144

222415

PDB entries from 2024-07-10

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