5U6P
Structure of the human HCN1 hyperpolarization-activated cyclic nucleotide-gated ion channel in complex with cAMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005249 | molecular_function | voltage-gated potassium channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005249 | molecular_function | voltage-gated potassium channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0055085 | biological_process | transmembrane transport |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005249 | molecular_function | voltage-gated potassium channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006813 | biological_process | potassium ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0055085 | biological_process | transmembrane transport |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005249 | molecular_function | voltage-gated potassium channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0006813 | biological_process | potassium ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0055085 | biological_process | transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue CMP A 901 |
| Chain | Residue |
| A | MET530 |
| A | ARG590 |
| A | PHE538 |
| A | GLY539 |
| A | GLU540 |
| A | ILE541 |
| A | CYS542 |
| A | ARG549 |
| A | THR550 |
| A | ALA551 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue CMP B 901 |
| Chain | Residue |
| B | MET530 |
| B | PHE538 |
| B | GLY539 |
| B | GLU540 |
| B | ILE541 |
| B | CYS542 |
| B | ARG549 |
| B | THR550 |
| B | ALA551 |
| B | ARG590 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue CMP C 901 |
| Chain | Residue |
| C | MET530 |
| C | PHE538 |
| C | GLY539 |
| C | GLU540 |
| C | ILE541 |
| C | CYS542 |
| C | ARG549 |
| C | THR550 |
| C | ALA551 |
| C | ARG590 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue CMP D 901 |
| Chain | Residue |
| D | MET530 |
| D | PHE538 |
| D | GLY539 |
| D | GLU540 |
| D | ILE541 |
| D | CYS542 |
| D | ARG549 |
| D | THR550 |
| D | ALA551 |
| D | ARG590 |
Functional Information from PROSITE/UniProt
| site_id | PS00888 |
| Number of Residues | 17 |
| Details | CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. IIrEGAvGKkMYFIqhG |
| Chain | Residue | Details |
| A | ILE502-GLY518 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2684 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:28086084 |
| Chain | Residue | Details |
| A | MET1-ARG142 | |
| C | ARG195-MET215 | |
| C | GLU282-VAL295 | |
| D | MET1-ARG142 | |
| D | ARG195-MET215 | |
| D | GLU282-VAL295 | |
| A | ARG195-MET215 | |
| A | GLU282-VAL295 | |
| B | MET1-ARG142 | |
| B | ARG195-MET215 | |
| B | GLU282-VAL295 | |
| C | MET1-ARG142 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 84 |
| Details | TRANSMEM: Helical; Name=Segment S1 => ECO:0000269|PubMed:28086084, ECO:0000269|PubMed:31787376, ECO:0007744|PDB:5U6O, ECO:0007744|PDB:5U6P, ECO:0007744|PDB:6UQF, ECO:0007744|PDB:6UQG |
| Chain | Residue | Details |
| A | PHE143-ILE164 | |
| B | PHE143-ILE164 | |
| C | PHE143-ILE164 | |
| D | PHE143-ILE164 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 240 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:28086084 |
| Chain | Residue | Details |
| A | THR165-THR173 | |
| C | LEU237-THR260 | |
| C | VAL319-GLN344 | |
| C | VAL367-ASP371 | |
| D | THR165-THR173 | |
| D | LEU237-THR260 | |
| D | VAL319-GLN344 | |
| D | VAL367-ASP371 | |
| A | LEU237-THR260 | |
| A | VAL319-GLN344 | |
| A | VAL367-ASP371 | |
| B | THR165-THR173 | |
| B | LEU237-THR260 | |
| B | VAL319-GLN344 | |
| B | VAL367-ASP371 | |
| C | THR165-THR173 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=Segment S2 => ECO:0000269|PubMed:28086084, ECO:0000269|PubMed:31787376, ECO:0007744|PDB:5U6O, ECO:0007744|PDB:5U6P, ECO:0007744|PDB:6UQF, ECO:0007744|PDB:6UQG |
| Chain | Residue | Details |
| A | PRO174-PHE194 | |
| B | PRO174-PHE194 | |
| C | PRO174-PHE194 | |
| D | PRO174-PHE194 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=Segment S3 => ECO:0000269|PubMed:28086084, ECO:0000269|PubMed:31787376, ECO:0007744|PDB:5U6O, ECO:0007744|PDB:5U6P, ECO:0007744|PDB:6UQF, ECO:0007744|PDB:6UQG |
| Chain | Residue | Details |
| A | ASN216-PHE236 | |
| B | ASN216-PHE236 | |
| C | ASN216-PHE236 | |
| D | ASN216-PHE236 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000269|PubMed:28086084, ECO:0000269|PubMed:31787376, ECO:0007744|PDB:5U6O, ECO:0007744|PDB:5U6P, ECO:0007744|PDB:6UQF, ECO:0007744|PDB:6UQG |
| Chain | Residue | Details |
| A | LYS261-TRP281 | |
| B | LYS261-TRP281 | |
| C | LYS261-TRP281 | |
| D | LYS261-TRP281 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 88 |
| Details | TRANSMEM: Helical; Name=Segment S5 => ECO:0007744|PDB:5U6O, ECO:0007744|PDB:5U6P, ECO:0007744|PDB:6UQF, ECO:0007744|PDB:6UQG |
| Chain | Residue | Details |
| A | VAL296-LEU318 | |
| B | VAL296-LEU318 | |
| C | VAL296-LEU318 | |
| D | VAL296-LEU318 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 84 |
| Details | INTRAMEM: Pore-forming; Name=Segment H5 => ECO:0000269|PubMed:28086084, ECO:0000269|PubMed:31787376, ECO:0007744|PDB:5U6O, ECO:0007744|PDB:5U6P, ECO:0007744|PDB:6UQF, ECO:0007744|PDB:6UQG |
| Chain | Residue | Details |
| A | TYR345-PRO366 | |
| B | TYR345-PRO366 | |
| C | TYR345-PRO366 | |
| D | TYR345-PRO366 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=Segment S6 => ECO:0000269|PubMed:28086084, ECO:0000269|PubMed:31787376, ECO:0007744|PDB:5U6O, ECO:0007744|PDB:5U6P, ECO:0007744|PDB:6UQF, ECO:0007744|PDB:6UQG |
| Chain | Residue | Details |
| A | LEU372-HIS392 | |
| B | LEU372-HIS392 | |
| C | LEU372-HIS392 | |
| D | LEU372-HIS392 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31787376, ECO:0000305|PubMed:28086084, ECO:0007744|PDB:5U6P, ECO:0007744|PDB:6UQF |
| Chain | Residue | Details |
| A | GLY539 | |
| C | CYS542 | |
| C | ARG549 | |
| C | THR550 | |
| D | GLY539 | |
| D | CYS542 | |
| D | ARG549 | |
| D | THR550 | |
| A | CYS542 | |
| A | ARG549 | |
| A | THR550 | |
| B | GLY539 | |
| B | CYS542 | |
| B | ARG549 | |
| B | THR550 | |
| C | GLY539 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31787376, ECO:0007744|PDB:6UQF |
| Chain | Residue | Details |
| A | GLU540 | |
| A | ARG593 | |
| B | GLU540 | |
| B | ARG593 | |
| C | GLU540 | |
| C | ARG593 | |
| D | GLU540 | |
| D | ARG593 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:O88704 |
| Chain | Residue | Details |
| A | ARG590 | |
| B | ARG590 | |
| C | ARG590 | |
| D | ARG590 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN338 | |
| B | ASN338 | |
| C | ASN338 | |
| D | ASN338 |
