Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5U6P

Structure of the human HCN1 hyperpolarization-activated cyclic nucleotide-gated ion channel in complex with cAMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005249	molecular_function	voltage-gated potassium channel activity
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0005249	molecular_function	voltage-gated potassium channel activity
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0005249	molecular_function	voltage-gated potassium channel activity
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0005249	molecular_function	voltage-gated potassium channel activity
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue CMP A 901

Chain	Residue
A	MET530
A	ARG590
A	PHE538
A	GLY539
A	GLU540
A	ILE541
A	CYS542
A	ARG549
A	THR550
A	ALA551

site_id	AC2
Number of Residues	10
Details	binding site for residue CMP B 901

Chain	Residue
B	MET530
B	PHE538
B	GLY539
B	GLU540
B	ILE541
B	CYS542
B	ARG549
B	THR550
B	ALA551
B	ARG590

site_id	AC3
Number of Residues	10
Details	binding site for residue CMP C 901

Chain	Residue
C	MET530
C	PHE538
C	GLY539
C	GLU540
C	ILE541
C	CYS542
C	ARG549
C	THR550
C	ALA551
C	ARG590

site_id	AC4
Number of Residues	10
Details	binding site for residue CMP D 901

Chain	Residue
D	MET530
D	PHE538
D	GLY539
D	GLU540
D	ILE541
D	CYS542
D	ARG549
D	THR550
D	ALA551
D	ARG590

Functional Information from PROSITE/UniProt

site_id	PS00888
Number of Residues	17
Details	CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. IIrEGAvGKkMYFIqhG

Chain	Residue	Details
A	ILE502-GLY518

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	84
Details	Transmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31787376","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5U6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	148
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31787376","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5U6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31787376","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5U6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31787376","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5U6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	52
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	88
Details	Transmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"PDB","id":"5U6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	84
Details	Intramembrane: {"description":"Pore-forming; Name=Segment H5","evidences":[{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31787376","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5U6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31787376","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5U6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	16
Details	Motif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31787376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28086084","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5U6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UQF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31787376","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6UQF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O88704","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)