5U0P

Cryo-EM structure of the transcriptional Mediator

Functional Information from GO Data

Chain	GOid	namespace	contents
2	0003713	molecular_function	transcription coactivator activity
2	0005515	molecular_function	protein binding
2	0005634	cellular_component	nucleus
2	0006351	biological_process	DNA-templated transcription
2	0016592	cellular_component	mediator complex
2	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
3	0003712	molecular_function	transcription coregulator activity
3	0003713	molecular_function	transcription coactivator activity
3	0005634	cellular_component	nucleus
3	0006351	biological_process	DNA-templated transcription
3	0006355	biological_process	regulation of DNA-templated transcription
3	0006357	biological_process	regulation of transcription by RNA polymerase II
3	0016592	cellular_component	mediator complex
3	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
3	0070847	cellular_component	core mediator complex
F	0003712	molecular_function	transcription coregulator activity
F	0003713	molecular_function	transcription coactivator activity
F	0005634	cellular_component	nucleus
F	0006351	biological_process	DNA-templated transcription
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0016592	cellular_component	mediator complex
F	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
F	0070847	cellular_component	core mediator complex
G	0000791	cellular_component	euchromatin
G	0003712	molecular_function	transcription coregulator activity
G	0003713	molecular_function	transcription coactivator activity
G	0005634	cellular_component	nucleus
G	0006351	biological_process	DNA-templated transcription
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0016592	cellular_component	mediator complex
G	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
G	0070847	cellular_component	core mediator complex
H	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
H	0003712	molecular_function	transcription coregulator activity
H	0003713	molecular_function	transcription coactivator activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0006351	biological_process	DNA-templated transcription
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0006367	biological_process	transcription initiation at RNA polymerase II promoter
H	0016592	cellular_component	mediator complex
H	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
H	0070847	cellular_component	core mediator complex
I	0003713	molecular_function	transcription coactivator activity
I	0005634	cellular_component	nucleus
I	0016592	cellular_component	mediator complex
I	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
K	0003712	molecular_function	transcription coregulator activity
K	0003713	molecular_function	transcription coactivator activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0006357	biological_process	regulation of transcription by RNA polymerase II
K	0016592	cellular_component	mediator complex
K	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
N	0003712	molecular_function	transcription coregulator activity
N	0003713	molecular_function	transcription coactivator activity
N	0005634	cellular_component	nucleus
N	0006351	biological_process	DNA-templated transcription
N	0006357	biological_process	regulation of transcription by RNA polymerase II
N	0006367	biological_process	transcription initiation at RNA polymerase II promoter
N	0016592	cellular_component	mediator complex
N	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
N	0070847	cellular_component	core mediator complex
Q	0003712	molecular_function	transcription coregulator activity
Q	0003713	molecular_function	transcription coactivator activity
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0006351	biological_process	DNA-templated transcription
Q	0006357	biological_process	regulation of transcription by RNA polymerase II
Q	0006367	biological_process	transcription initiation at RNA polymerase II promoter
Q	0016592	cellular_component	mediator complex
Q	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
Q	0070847	cellular_component	core mediator complex
R	0003712	molecular_function	transcription coregulator activity
R	0003713	molecular_function	transcription coactivator activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0006351	biological_process	DNA-templated transcription
R	0006357	biological_process	regulation of transcription by RNA polymerase II
R	0016592	cellular_component	mediator complex
R	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
R	0070847	cellular_component	core mediator complex
T	0003712	molecular_function	transcription coregulator activity
T	0003713	molecular_function	transcription coactivator activity
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0006357	biological_process	regulation of transcription by RNA polymerase II
T	0016592	cellular_component	mediator complex
T	0032991	cellular_component	protein-containing complex
T	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
U	0003712	molecular_function	transcription coregulator activity
U	0003713	molecular_function	transcription coactivator activity
U	0005634	cellular_component	nucleus
U	0006351	biological_process	DNA-templated transcription
U	0006357	biological_process	regulation of transcription by RNA polymerase II
U	0016592	cellular_component	mediator complex
U	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
V	0003712	molecular_function	transcription coregulator activity
V	0003713	molecular_function	transcription coactivator activity
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0006351	biological_process	DNA-templated transcription
V	0006357	biological_process	regulation of transcription by RNA polymerase II
V	0006367	biological_process	transcription initiation at RNA polymerase II promoter
V	0016592	cellular_component	mediator complex
V	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DENKNQSIEnaDY

Chain	Residue	Details
F	ASP177-TYR189

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	13
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	41
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	10
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

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