5TWK

Crystal Structure of RlmH in Complex with Sinefungin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0006364	biological_process	rRNA processing
A	0008168	molecular_function	methyltransferase activity
A	0031167	biological_process	rRNA methylation
A	0032259	biological_process	methylation
A	0042803	molecular_function	protein homodimerization activity
A	0043022	molecular_function	ribosome binding
A	0070038	molecular_function	rRNA (pseudouridine-N3-)-methyltransferase activity
A	0070475	biological_process	rRNA base methylation
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0006364	biological_process	rRNA processing
B	0008168	molecular_function	methyltransferase activity
B	0031167	biological_process	rRNA methylation
B	0032259	biological_process	methylation
B	0042803	molecular_function	protein homodimerization activity
B	0043022	molecular_function	ribosome binding
B	0070038	molecular_function	rRNA (pseudouridine-N3-)-methyltransferase activity
B	0070475	biological_process	rRNA base methylation
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0006364	biological_process	rRNA processing
C	0008168	molecular_function	methyltransferase activity
C	0031167	biological_process	rRNA methylation
C	0032259	biological_process	methylation
C	0042803	molecular_function	protein homodimerization activity
C	0043022	molecular_function	ribosome binding
C	0070038	molecular_function	rRNA (pseudouridine-N3-)-methyltransferase activity
C	0070475	biological_process	rRNA base methylation
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0006364	biological_process	rRNA processing
D	0008168	molecular_function	methyltransferase activity
D	0031167	biological_process	rRNA methylation
D	0032259	biological_process	methylation
D	0042803	molecular_function	protein homodimerization activity
D	0043022	molecular_function	ribosome binding
D	0070038	molecular_function	rRNA (pseudouridine-N3-)-methyltransferase activity
D	0070475	biological_process	rRNA base methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue SFG C 201

Chain	Residue
C	LEU72
C	SER123
C	LEU125
C	THR126
C	LEU127
C	VAL132
C	HOH307
D	GLU155
C	ASP73
C	ILE74
C	GLY103
C	GLY104
C	GLY107
C	LEU108
C	TRP120
C	LEU122

---

site_id	AC2
Number of Residues	16
Details	binding site for residue SFG D 201

Chain	Residue
C	ARG142
C	GLU155
D	LEU72
D	ASP73
D	ILE74
D	GLY103
D	GLY104
D	PRO105
D	GLY107
D	LEU122
D	SER123
D	LEU125
D	THR126
D	LEU127
D	HIS129
D	HOH337

---

site_id	AC3
Number of Residues	18
Details	binding site for residue SFG A 201

Chain	Residue
A	LEU72
A	ASP73
A	ILE74
A	GLY103
A	GLY104
A	PRO105
A	GLU106
A	GLY107
A	LEU108
A	TRP120
A	LEU122
A	SER123
A	LEU125
A	THR126
A	LEU127
A	HOH313
B	GLU155
B	HOH317

---

site_id	AC4
Number of Residues	17
Details	binding site for residue SFG B 201

Chain	Residue
A	HOH301
B	LEU72
B	ASP73
B	ILE74
B	ILE102
B	GLY103
B	GLY104
B	PRO105
B	GLY107
B	LEU108
B	TRP120
B	LEU122
B	SER123
B	LEU125
B	LEU127
B	VAL132
B	HOH306

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00658, ECO:0000269|PubMed:28428565, ECO:0007744|PDB:5TWJ

Chain	Residue	Details
C	LEU72
B	LEU72
B	GLY103
B	LEU122
C	GLY103
C	LEU122
D	LEU72
D	GLY103
D	LEU122
A	LEU72
A	GLY103
A	LEU122

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