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5TUF

Crystal structure of tetracycline destructase Tet(50) in complex with anhydrotetracycline

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0016491molecular_functionoxidoreductase activity
A0046677biological_processresponse to antibiotic
A0071949molecular_functionFAD binding
B0000166molecular_functionnucleotide binding
B0016491molecular_functionoxidoreductase activity
B0046677biological_processresponse to antibiotic
B0071949molecular_functionFAD binding
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue SO4 A 401
ChainResidue
ATHR280
ALYS281
AGLY282
AHOH509
AHOH553
AHOH602

site_idAC2
Number of Residues7
Detailsbinding site for residue SO4 A 402
ChainResidue
AILE61
ATYR62
AASP63
AHOH550
AALA56
ALYS57
AGLY60

site_idAC3
Number of Residues5
Detailsbinding site for residue SO4 A 403
ChainResidue
APRO296
ALEU297
ASER298
AGLY299
AHOH561

site_idAC4
Number of Residues4
Detailsbinding site for residue SO4 A 404
ChainResidue
ASER201
AASN202
AHIS203
ALYS204

site_idAC5
Number of Residues31
Detailsbinding site for residue FAD A 405
ChainResidue
AILE10
AGLY11
AVAL12
AGLY13
AVAL14
AALA15
AGLU34
ALYS35
ASER36
AGLN44
AALA45
ALEU46
AASP47
AARG105
AALA155
AASP156
AGLY157
AALA161
ATYR267
AGLY288
AASP289
APRO296
AGLY299
AGLY301
AASN302
AHOH515
AHOH574
AHOH578
AHOH587
AHOH613
AHOH673

site_idAC6
Number of Residues2
Detailsbinding site for residue SO4 B 401
ChainResidue
BLYS281
BGLY282

site_idAC7
Number of Residues3
Detailsbinding site for residue SO4 B 402
ChainResidue
BHIS54
BLYS57
BASN248

site_idAC8
Number of Residues4
Detailsbinding site for residue SO4 B 403
ChainResidue
AHIS240
BPRO187
BTYR189
BARG259

site_idAC9
Number of Residues25
Detailsbinding site for residue FAD B 404
ChainResidue
BILE10
BGLY11
BVAL12
BGLY13
BVAL14
BALA15
BGLU34
BLYS35
BARG40
BGLY42
BGLY43
BGLN44
BARG105
BALA155
BASP156
BGLY157
BTYR267
BGLY288
BASP289
BASN302
BTDC405
BHOH516
BHOH529
BHOH550
BHOH589

site_idAD1
Number of Residues10
Detailsbinding site for residue TDC B 405
ChainResidue
BGLN44
BLEU198
BLEU205
BTHR207
BMET222
BPRO296
BLEU297
BVAL348
BILE371
BFAD404

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING: BINDING => ECO:0007744|PDB:5TUE, ECO:0007744|PDB:5TUF, ECO:0007744|PDB:5TUI
ChainResidueDetails
AVAL12
BARG105
BASP289
BPRO296
AGLU34
AGLN44
AARG105
AASP289
APRO296
BVAL12
BGLU34
BGLN44

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0007744|PDB:5TUE, ECO:0007744|PDB:5TUF
ChainResidueDetails
ATYR267
BTYR267

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PDB entries from 2024-11-13

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