Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004737 | molecular_function | pyruvate decarboxylase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0030976 | molecular_function | thiamine pyrophosphate binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004737 | molecular_function | pyruvate decarboxylase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0030976 | molecular_function | thiamine pyrophosphate binding |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | binding site for residue TPP A 601 |
| Chain | Residue |
| A | ALA25 |
| A | ILE415 |
| A | GLY439 |
| A | ASP440 |
| A | GLY441 |
| A | SER442 |
| A | ASN467 |
| A | GLY469 |
| A | TYR470 |
| A | THR471 |
| A | ILE472 |
| A | GLY26 |
| A | GLU473 |
| A | MG602 |
| A | HOH719 |
| A | HOH815 |
| A | HOH961 |
| A | GLU50 |
| A | VAL75 |
| A | HIS114 |
| A | GLY389 |
| A | ASP390 |
| A | GLY413 |
| A | HIS414 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 602 |
| Chain | Residue |
| A | ASP440 |
| A | ASN467 |
| A | GLY469 |
| A | TPP601 |
| A | HOH961 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 603 |
| Chain | Residue |
| A | ILE484 |
| A | LYS485 |
| A | ASN486 |
| A | SER504 |
| A | EDO616 |
| A | HOH714 |
| A | HOH814 |
| A | HOH992 |
| A | HOH1078 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 604 |
| Chain | Residue |
| A | ASP234 |
| A | GLY237 |
| A | HIS256 |
| A | LYS337 |
| A | HOH747 |
| A | HOH819 |
| A | HOH939 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 605 |
| Chain | Residue |
| A | GLU308 |
| A | PRO309 |
| A | ARG310 |
| A | SER311 |
| A | HOH721 |
| A | HOH763 |
| A | HOH921 |
| A | HOH987 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | binding site for residue SO4 A 606 |
| Chain | Residue |
| A | HIS106 |
| A | ALA107 |
| A | ASP120 |
| A | TYR121 |
| A | HIS122 |
| A | HOH710 |
| A | HOH723 |
| A | HOH739 |
| B | HIS122 |
| B | SO4606 |
| B | HOH709 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | binding site for residue SO4 A 607 |
| Chain | Residue |
| A | HIS150 |
| A | LYS153 |
| A | ARG157 |
| A | HOH701 |
| A | HOH702 |
| A | HOH709 |
| A | HOH715 |
| A | HOH760 |
| A | HOH822 |
| A | HOH911 |
| B | ARG157 |
| B | ARG310 |
| B | HOH722 |
| B | HOH748 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 608 |
| Chain | Residue |
| A | THR379 |
| A | ASN381 |
| A | ARG433 |
| A | HOH704 |
| A | HOH761 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 609 |
| Chain | Residue |
| A | GLU192 |
| A | LEU195 |
| A | ASN196 |
| A | ARG330 |
| A | HOH716 |
| A | HOH1031 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 610 |
| Chain | Residue |
| A | ILE16 |
| A | LYS64 |
| A | GLY65 |
| A | ALA66 |
| A | HOH750 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 611 |
| Chain | Residue |
| A | TYR257 |
| A | LYS399 |
| A | HOH703 |
| A | HOH802 |
| A | HOH847 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 612 |
| Chain | Residue |
| A | ALA222 |
| A | PRO309 |
| A | ARG310 |
| A | HOH712 |
| A | HOH773 |
| A | HOH921 |
| A | HOH1015 |
| site_id | AD4 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 613 |
| Chain | Residue |
| A | LYS153 |
| A | LEU156 |
| A | ARG157 |
| A | LEU184 |
| A | PHE185 |
| A | ASN186 |
| A | HOH733 |
| A | HOH753 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 614 |
| Chain | Residue |
| A | SER190 |
| A | ASP191 |
| A | GLU192 |
| A | HOH832 |
| site_id | AD6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 615 |
| Chain | Residue |
| A | ARG157 |
| A | ASP187 |
| A | GLU188 |
| A | HOH706 |
| B | ARG157 |
| B | ASP187 |
| B | GLU188 |
| site_id | AD7 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 616 |
| Chain | Residue |
| A | ARG455 |
| A | ILE484 |
| A | SO4603 |
| A | HOH714 |
| A | HOH741 |
| A | HOH752 |
| A | HOH897 |
| A | HOH994 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 617 |
| Chain | Residue |
| A | PHE205 |
| A | LEU304 |
| A | VAL305 |
| A | VAL314 |
| A | ASN315 |
| A | HOH823 |
| A | HOH1012 |
| site_id | AD9 |
| Number of Residues | 25 |
| Details | binding site for residue TPP B 601 |
| Chain | Residue |
| B | ALA25 |
| B | GLY26 |
| B | GLU50 |
| B | VAL75 |
| B | HIS114 |
| B | GLY389 |
| B | ASP390 |
| B | GLY413 |
| B | HIS414 |
| B | ILE415 |
| B | GLY439 |
| B | ASP440 |
| B | GLY441 |
| B | SER442 |
| B | ASN467 |
| B | GLY469 |
| B | TYR470 |
| B | THR471 |
| B | ILE472 |
| B | GLU473 |
| B | MG602 |
| B | HOH777 |
| B | HOH792 |
| B | HOH927 |
| B | HOH962 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 602 |
| Chain | Residue |
| B | ASP440 |
| B | ASN467 |
| B | GLY469 |
| B | TPP601 |
| B | HOH962 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 603 |
| Chain | Residue |
| B | GLN15 |
| B | PRO180 |
| B | ALA181 |
| B | HOH765 |
| B | HOH959 |
| B | HOH964 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 604 |
| Chain | Residue |
| B | ILE484 |
| B | LYS485 |
| B | ASN486 |
| B | EDO620 |
| B | HOH914 |
| site_id | AE4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 605 |
| Chain | Residue |
| B | GLY237 |
| B | HIS256 |
| B | LYS337 |
| B | HOH833 |
| B | HOH937 |
| site_id | AE5 |
| Number of Residues | 13 |
| Details | binding site for residue SO4 B 606 |
| Chain | Residue |
| A | SO4606 |
| A | HOH739 |
| A | HOH804 |
| B | HIS106 |
| B | ALA107 |
| B | THR119 |
| B | ASP120 |
| B | TYR121 |
| B | HIS122 |
| B | TYR139 |
| B | HOH709 |
| B | HOH710 |
| B | HOH758 |
| site_id | AE6 |
| Number of Residues | 12 |
| Details | binding site for residue SO4 B 607 |
| Chain | Residue |
| A | ARG157 |
| A | ARG310 |
| A | HOH737 |
| A | HOH769 |
| B | HIS150 |
| B | LYS153 |
| B | THR154 |
| B | ARG157 |
| B | HOH727 |
| B | HOH889 |
| B | HOH919 |
| B | HOH1007 |
| site_id | AE7 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 B 608 |
| Chain | Residue |
| A | HOH822 |
| B | GLU308 |
| B | PRO309 |
| B | ARG310 |
| B | SER311 |
| B | HOH721 |
| B | HOH791 |
| B | HOH798 |
| B | HOH974 |
| site_id | AE8 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 609 |
| Chain | Residue |
| B | THR379 |
| B | ASN381 |
| B | ARG433 |
| B | HOH829 |
| B | HOH947 |
| site_id | AE9 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 610 |
| Chain | Residue |
| A | HOH876 |
| B | HIS150 |
| B | HOH719 |
| B | HOH736 |
| B | HOH789 |
| B | HOH844 |
| site_id | AF1 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 611 |
| Chain | Residue |
| B | THR260 |
| B | VAL265 |
| B | TYR267 |
| B | GLN396 |
| B | ARG397 |
| B | GLU547 |
| B | HOH702 |
| B | HOH708 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 612 |
| Chain | Residue |
| B | PRO268 |
| B | GLY269 |
| B | LYS272 |
| B | HOH772 |
| site_id | AF3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 613 |
| Chain | Residue |
| B | TYR257 |
| B | LYS399 |
| B | HOH818 |
| B | HOH822 |
| site_id | AF4 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 614 |
| Chain | Residue |
| B | SER248 |
| B | PRO251 |
| B | PRO401 |
| B | GLY403 |
| B | ALA404 |
| B | HOH780 |
| B | HOH863 |
| B | HOH946 |
| site_id | AF5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 615 |
| Chain | Residue |
| B | PHE205 |
| B | LEU304 |
| B | VAL305 |
| B | VAL314 |
| B | ASN315 |
| B | HOH977 |
| site_id | AF6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 616 |
| Chain | Residue |
| B | GLU158 |
| B | PRO309 |
| B | ARG310 |
| B | HOH760 |
| B | HOH798 |
| B | HOH819 |
| site_id | AF7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 617 |
| Chain | Residue |
| B | GLU142 |
| B | PRO174 |
| B | CYS175 |
| B | ALA176 |
| B | HOH701 |
| B | HOH704 |
| B | HOH941 |
| site_id | AF8 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 618 |
| Chain | Residue |
| B | ASN402 |
| B | HOH902 |
| site_id | AF9 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 619 |
| Chain | Residue |
| B | TYR88 |
| B | LEU116 |
| B | GLY117 |
| B | LYS160 |
| B | LYS219 |
| B | HOH755 |
| B | HOH1016 |
| site_id | AG1 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 620 |
| Chain | Residue |
| B | ARG455 |
| B | LYS457 |
| B | LYS485 |
| B | SER504 |
| B | SO4604 |
| B | HOH707 |
| B | HOH712 |
| site_id | AG2 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 621 |
| Chain | Residue |
| A | PRO480 |
| B | MET1 |
| B | ASP38 |
| B | ASN39 |
| B | LYS40 |
| B | HOH703 |
| B | HOH886 |
| B | HOH1119 |
Functional Information from PROSITE/UniProt
| site_id | PS00187 |
| Number of Residues | 20 |
| Details | TPP_ENZYMES Thiamine pyrophosphate enzymes signature. FGyavgaPerrnIlMvGDGS |
| Chain | Residue | Details |
| A | PHE423-SER442 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 164 |
| Details | Region: {"description":"Thiamine pyrophosphate binding"} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {} |
5TMA
