Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5TEF

Crystal structure of Gemin5 WD40 repeats in complex with m7GpppG

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue GTG A 801

Chain	Residue
A	TYR474
A	HOH1003
A	THR540
A	GLU541
A	ASN582
A	LYS641
A	THR643
A	TYR660
A	ARG684
A	HOH996

site_id	AC2
Number of Residues	5
Details	binding site for residue GOL A 802

Chain	Residue
A	PRO12
A	ASN13
A	TRP14
A	ARG359
A	HOH935

site_id	AC3
Number of Residues	6
Details	binding site for residue GOL A 803

Chain	Residue
A	TYR15
A	SER113
A	PHE155
A	HOH967
A	HOH976
A	HOH978

site_id	AC4
Number of Residues	4
Details	binding site for residue GOL A 804

Chain	Residue
A	SER293
A	ASN294
A	PRO342
A	GLN350

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. CATSsdDgTVKIWDV

Chain	Residue	Details
A	CYS82-VAL96
A	LEU395-THR409
A	LEU655-ALA669

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	41
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	39
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	41
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	40
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	40
Details	Repeat: {"description":"WD 8"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	40
Details	Repeat: {"description":"WD 10"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	46
Details	Repeat: {"description":"WD 11"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	40
Details	Repeat: {"description":"WD 12"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	40
Details	Repeat: {"description":"WD 13"}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	2
Details	Region: {"description":"Interaction with U4 snRNA","evidences":[{"source":"PubMed","id":"27834343","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881600","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5GXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5GXI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H1K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H1L","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	2
Details	Site: {"description":"Interaction with U4 snRNA","evidences":[{"source":"PubMed","id":"27834343","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881600","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5GXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5GXI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H1K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H1L","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	3
Details	Site: {"description":"Interaction with U4 snRNA","evidences":[{"source":"PubMed","id":"27834343","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5H1K","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	1
Details	Site: {"description":"Interaction with U4 snRNA","evidences":[{"source":"PubMed","id":"27834343","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881600","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5GXI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H1K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H1L","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	4
Details	Site: {"description":"Interaction with U4 snRNA","evidences":[{"source":"PubMed","id":"27881601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5H1K","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	1
Details	Site: {"description":"Interaction with U4 snRNA and with the 7-methylguanosine cap of RNA molecules","evidences":[{"source":"PubMed","id":"27834343","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881601","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2016","submissionDatabase":"PDB data bank","title":"Crystal structure of Gemin5 WD40 repeats in complex with m7GpppG.","authors":["Chao X.","Tempel W.","Bian C.","He H.","Cerovina T.","Bountra C.","Arrowsmith C.H.","Edwards A.M.","Min J."]}},{"source":"PDB","id":"5H1M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TEF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	1
Details	Site: {"description":"Interaction with U4 snRNA and with the 7-methylguanosine cap of RNA molecules","evidences":[{"source":"PubMed","id":"27834343","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881601","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2016","submissionDatabase":"PDB data bank","title":"Crystal structure of Gemin5 WD40 repeats in complex with m7GpppG.","authors":["Chao X.","Tempel W.","Bian C.","He H.","Cerovina T.","Bountra C.","Arrowsmith C.H.","Edwards A.M.","Min J."]}},{"source":"PDB","id":"5H1K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TEF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	1
Details	Site: {"description":"Interaction with U4 snRNA and with the 7-methylguanosine cap of RNA molecules","evidences":[{"source":"PubMed","id":"27834343","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881601","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2016","submissionDatabase":"PDB data bank","title":"Crystal structure of Gemin5 WD40 repeats in complex with m7GpppG.","authors":["Chao X.","Tempel W.","Bian C.","He H.","Cerovina T.","Bountra C.","Arrowsmith C.H.","Edwards A.M.","Min J."]}},{"source":"PDB","id":"5H1K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H1M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TEF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	1
Details	Site: {"description":"Interaction with U4 snRNA and with the 7-methylguanosine cap of RNA molecules","evidences":[{"source":"PubMed","id":"27834343","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881600","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5GXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H1K","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)