5TCX

Crystal structure of human tetraspanin CD81

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001618	molecular_function	virus receptor activity
A	0001771	biological_process	immunological synapse formation
A	0001772	cellular_component	immunological synapse
A	0002250	biological_process	adaptive immune response
A	0002376	biological_process	immune system process
A	0002455	biological_process	humoral immune response mediated by circulating immunoglobulin
A	0002863	biological_process	positive regulation of inflammatory response to antigenic stimulus
A	0005178	molecular_function	integrin binding
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0005925	cellular_component	focal adhesion
A	0008289	molecular_function	lipid binding
A	0009925	cellular_component	basal plasma membrane
A	0014905	biological_process	myoblast fusion involved in skeletal muscle regeneration
A	0015485	molecular_function	cholesterol binding
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0023026	molecular_function	MHC class II protein complex binding
A	0030890	biological_process	positive regulation of B cell proliferation
A	0031623	biological_process	receptor internalization
A	0031647	biological_process	regulation of protein stability
A	0031982	cellular_component	vesicle
A	0034238	biological_process	macrophage fusion
A	0035783	biological_process	CD4-positive, alpha-beta T cell costimulation
A	0042127	biological_process	regulation of cell population proliferation
A	0042289	molecular_function	MHC class II protein binding
A	0043410	biological_process	positive regulation of MAPK cascade
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046718	biological_process	symbiont entry into host cell
A	0050861	biological_process	positive regulation of B cell receptor signaling pathway
A	0050862	biological_process	positive regulation of T cell receptor signaling pathway
A	0050871	biological_process	positive regulation of B cell activation
A	0061462	biological_process	protein localization to lysosome
A	0070062	cellular_component	extracellular exosome
A	0070863	biological_process	positive regulation of protein exit from endoplasmic reticulum
A	0071404	biological_process	cellular response to low-density lipoprotein particle stimulus
A	0072659	biological_process	protein localization to plasma membrane
A	0072675	biological_process	osteoclast fusion
A	0097197	cellular_component	tetraspanin-enriched microdomain
A	1903911	biological_process	positive regulation of receptor clustering
A	1904352	biological_process	positive regulation of protein catabolic process in the vacuole
A	1905521	biological_process	regulation of macrophage migration
A	1905676	biological_process	positive regulation of adaptive immune memory response
A	1990459	molecular_function	transferrin receptor binding
A	2000553	biological_process	positive regulation of T-helper 2 cell cytokine production
A	2000563	biological_process	positive regulation of CD4-positive, alpha-beta T cell proliferation
A	2001190	biological_process	positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue CLR A 301

Chain	Residue
A	ASN18
A	GLU219
A	PHE21
A	VAL68
A	VAL71
A	MET72
A	VAL75
A	YCM89
A	LEU101
A	MET216

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Functional Information from PROSITE/UniProt

site_id	PS00421
Number of Residues	23
Details	TM4_1 Transmembrane 4 family signature. GavmMfvGFLGCyGAiqEsqCLL

Chain	Residue	Details
A	GLY69-LEU91

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	64
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"27881302","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	88
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"27881302","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27881302","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TCX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	3
Details	Site: {"description":"Important for interaction with integrin","evidences":[{"source":"PubMed","id":"27993971","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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