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5TCX

Crystal structure of human tetraspanin CD81

Functional Information from GO Data
ChainGOidnamespacecontents
A0001618molecular_functionvirus receptor activity
A0001771biological_processimmunological synapse formation
A0001772cellular_componentimmunological synapse
A0002250biological_processadaptive immune response
A0002455biological_processhumoral immune response mediated by circulating immunoglobulin
A0002863biological_processpositive regulation of inflammatory response to antigenic stimulus
A0005178molecular_functionintegrin binding
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0008289molecular_functionlipid binding
A0009925cellular_componentbasal plasma membrane
A0014905biological_processmyoblast fusion involved in skeletal muscle regeneration
A0015485molecular_functioncholesterol binding
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0023026molecular_functionMHC class II protein complex binding
A0030890biological_processpositive regulation of B cell proliferation
A0031623biological_processreceptor internalization
A0031647biological_processregulation of protein stability
A0031982cellular_componentvesicle
A0034238biological_processmacrophage fusion
A0035783biological_processCD4-positive, alpha-beta T cell costimulation
A0042289molecular_functionMHC class II protein binding
A0043410biological_processpositive regulation of MAPK cascade
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046718biological_processsymbiont entry into host cell
A0050861biological_processpositive regulation of B cell receptor signaling pathway
A0050862biological_processpositive regulation of T cell receptor signaling pathway
A0050871biological_processpositive regulation of B cell activation
A0061462biological_processprotein localization to lysosome
A0070062cellular_componentextracellular exosome
A0070863biological_processpositive regulation of protein exit from endoplasmic reticulum
A0071404biological_processcellular response to low-density lipoprotein particle stimulus
A0072659biological_processprotein localization to plasma membrane
A0072675biological_processosteoclast fusion
A0097197cellular_componenttetraspanin-enriched microdomain
A1903911biological_processpositive regulation of receptor clustering
A1904352biological_processpositive regulation of protein catabolic process in the vacuole
A1905521biological_processregulation of macrophage migration
A1905676biological_processpositive regulation of adaptive immune memory response
A1990459molecular_functiontransferrin receptor binding
A2000145biological_processregulation of cell motility
A2000553biological_processpositive regulation of T-helper 2 cell cytokine production
A2000563biological_processpositive regulation of CD4-positive, alpha-beta T cell proliferation
A2001190biological_processpositive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue CLR A 301
ChainResidue
AASN18
AGLU219
APHE21
AVAL68
AVAL71
AMET72
AVAL75
AYCM89
ALEU101
AMET216

Functional Information from PROSITE/UniProt
site_idPS00421
Number of Residues23
DetailsTM4_1 Transmembrane 4 family signature. GavmMfvGFLGCyGAiqEsqCLL
ChainResidueDetails
AGLY69-LEU91

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues84
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:27881302
ChainResidueDetails
ALEU13-LEU33
AILE64-ILE84
ALEU90-GLY112
ALEU202-MET224

site_idSWS_FT_FI2
Number of Residues117
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:27881302
ChainResidueDetails
ATRP34-TYR63
APHE113-LYS201

site_idSWS_FT_FI3
Number of Residues4
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:27881302
ChainResidueDetails
AGLN85-YCM89

site_idSWS_FT_FI4
Number of Residues11
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:27881302, ECO:0000305|PubMed:1860863
ChainResidueDetails
AVAL225-TYR236

site_idSWS_FT_FI5
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:27881302, ECO:0007744|PDB:5TCX
ChainResidueDetails
AGLU219

site_idSWS_FT_FI6
Number of Residues3
DetailsSITE: Important for interaction with integrin => ECO:0000269|PubMed:27993971
ChainResidueDetails
ALYS116
ALYS144
ALYS148

224201

PDB entries from 2024-08-28

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