5TBK

Crystal structure of human importin a3 bound to RCC1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005643	cellular_component	nuclear pore
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006606	biological_process	protein import into nucleus
A	0006607	biological_process	NLS-bearing protein import into nucleus
A	0008139	molecular_function	nuclear localization sequence binding
A	0010467	biological_process	gene expression
A	0014046	biological_process	dopamine secretion
A	0015031	biological_process	protein transport
A	0031965	cellular_component	nuclear membrane
A	0042564	cellular_component	NLS-dependent protein nuclear import complex
A	0061608	molecular_function	nuclear import signal receptor activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005643	cellular_component	nuclear pore
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006606	biological_process	protein import into nucleus
B	0006607	biological_process	NLS-bearing protein import into nucleus
B	0008139	molecular_function	nuclear localization sequence binding
B	0010467	biological_process	gene expression
B	0014046	biological_process	dopamine secretion
B	0015031	biological_process	protein transport
B	0031965	cellular_component	nuclear membrane
B	0042564	cellular_component	NLS-dependent protein nuclear import complex
B	0061608	molecular_function	nuclear import signal receptor activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005643	cellular_component	nuclear pore
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006606	biological_process	protein import into nucleus
C	0006607	biological_process	NLS-bearing protein import into nucleus
C	0008139	molecular_function	nuclear localization sequence binding
C	0010467	biological_process	gene expression
C	0014046	biological_process	dopamine secretion
C	0015031	biological_process	protein transport
C	0031965	cellular_component	nuclear membrane
C	0042564	cellular_component	NLS-dependent protein nuclear import complex
C	0061608	molecular_function	nuclear import signal receptor activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005643	cellular_component	nuclear pore
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006606	biological_process	protein import into nucleus
D	0006607	biological_process	NLS-bearing protein import into nucleus
D	0008139	molecular_function	nuclear localization sequence binding
D	0010467	biological_process	gene expression
D	0014046	biological_process	dopamine secretion
D	0015031	biological_process	protein transport
D	0031965	cellular_component	nuclear membrane
D	0042564	cellular_component	NLS-dependent protein nuclear import complex
D	0061608	molecular_function	nuclear import signal receptor activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005643	cellular_component	nuclear pore
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006606	biological_process	protein import into nucleus
E	0006607	biological_process	NLS-bearing protein import into nucleus
E	0008139	molecular_function	nuclear localization sequence binding
E	0010467	biological_process	gene expression
E	0014046	biological_process	dopamine secretion
E	0015031	biological_process	protein transport
E	0031965	cellular_component	nuclear membrane
E	0042564	cellular_component	NLS-dependent protein nuclear import complex
E	0061608	molecular_function	nuclear import signal receptor activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005643	cellular_component	nuclear pore
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006606	biological_process	protein import into nucleus
F	0006607	biological_process	NLS-bearing protein import into nucleus
F	0008139	molecular_function	nuclear localization sequence binding
F	0010467	biological_process	gene expression
F	0014046	biological_process	dopamine secretion
F	0015031	biological_process	protein transport
F	0031965	cellular_component	nuclear membrane
F	0042564	cellular_component	NLS-dependent protein nuclear import complex
F	0061608	molecular_function	nuclear import signal receptor activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005643	cellular_component	nuclear pore
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006606	biological_process	protein import into nucleus
G	0006607	biological_process	NLS-bearing protein import into nucleus
G	0008139	molecular_function	nuclear localization sequence binding
G	0010467	biological_process	gene expression
G	0014046	biological_process	dopamine secretion
G	0015031	biological_process	protein transport
G	0031965	cellular_component	nuclear membrane
G	0042564	cellular_component	NLS-dependent protein nuclear import complex
G	0061608	molecular_function	nuclear import signal receptor activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005643	cellular_component	nuclear pore
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006606	biological_process	protein import into nucleus
H	0006607	biological_process	NLS-bearing protein import into nucleus
H	0008139	molecular_function	nuclear localization sequence binding
H	0010467	biological_process	gene expression
H	0014046	biological_process	dopamine secretion
H	0015031	biological_process	protein transport
H	0031965	cellular_component	nuclear membrane
H	0042564	cellular_component	NLS-dependent protein nuclear import complex
H	0061608	molecular_function	nuclear import signal receptor activity
I	0000082	biological_process	G1/S transition of mitotic cell cycle
I	0000785	cellular_component	chromatin
I	0000794	cellular_component	condensed nuclear chromosome
I	0003677	molecular_function	DNA binding
I	0003682	molecular_function	chromatin binding
I	0005085	molecular_function	guanyl-nucleotide exchange factor activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005694	cellular_component	chromosome
I	0005737	cellular_component	cytoplasm
I	0007052	biological_process	mitotic spindle organization
I	0007059	biological_process	chromosome segregation
I	0007084	biological_process	mitotic nuclear membrane reassembly
I	0007088	biological_process	regulation of mitotic nuclear division
I	0007346	biological_process	regulation of mitotic cell cycle
I	0016032	biological_process	viral process
I	0031267	molecular_function	small GTPase binding
I	0031491	molecular_function	nucleosome binding
I	0031492	molecular_function	nucleosomal DNA binding
I	0032991	cellular_component	protein-containing complex
I	0042393	molecular_function	histone binding
I	0043199	molecular_function	sulfate binding
I	0046982	molecular_function	protein heterodimerization activity
I	0051225	biological_process	spindle assembly
I	0051301	biological_process	cell division
I	1901673	biological_process	regulation of mitotic spindle assembly
J	0000082	biological_process	G1/S transition of mitotic cell cycle
J	0000785	cellular_component	chromatin
J	0000794	cellular_component	condensed nuclear chromosome
J	0003677	molecular_function	DNA binding
J	0003682	molecular_function	chromatin binding
J	0005085	molecular_function	guanyl-nucleotide exchange factor activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005694	cellular_component	chromosome
J	0005737	cellular_component	cytoplasm
J	0007052	biological_process	mitotic spindle organization
J	0007059	biological_process	chromosome segregation
J	0007084	biological_process	mitotic nuclear membrane reassembly
J	0007088	biological_process	regulation of mitotic nuclear division
J	0007346	biological_process	regulation of mitotic cell cycle
J	0016032	biological_process	viral process
J	0031267	molecular_function	small GTPase binding
J	0031491	molecular_function	nucleosome binding
J	0031492	molecular_function	nucleosomal DNA binding
J	0032991	cellular_component	protein-containing complex
J	0042393	molecular_function	histone binding
J	0043199	molecular_function	sulfate binding
J	0046982	molecular_function	protein heterodimerization activity
J	0051225	biological_process	spindle assembly
J	0051301	biological_process	cell division
J	1901673	biological_process	regulation of mitotic spindle assembly
K	0000082	biological_process	G1/S transition of mitotic cell cycle
K	0000785	cellular_component	chromatin
K	0000794	cellular_component	condensed nuclear chromosome
K	0003677	molecular_function	DNA binding
K	0003682	molecular_function	chromatin binding
K	0005085	molecular_function	guanyl-nucleotide exchange factor activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005694	cellular_component	chromosome
K	0005737	cellular_component	cytoplasm
K	0007052	biological_process	mitotic spindle organization
K	0007059	biological_process	chromosome segregation
K	0007084	biological_process	mitotic nuclear membrane reassembly
K	0007088	biological_process	regulation of mitotic nuclear division
K	0007346	biological_process	regulation of mitotic cell cycle
K	0016032	biological_process	viral process
K	0031267	molecular_function	small GTPase binding
K	0031491	molecular_function	nucleosome binding
K	0031492	molecular_function	nucleosomal DNA binding
K	0032991	cellular_component	protein-containing complex
K	0042393	molecular_function	histone binding
K	0043199	molecular_function	sulfate binding
K	0046982	molecular_function	protein heterodimerization activity
K	0051225	biological_process	spindle assembly
K	0051301	biological_process	cell division
K	1901673	biological_process	regulation of mitotic spindle assembly
L	0000082	biological_process	G1/S transition of mitotic cell cycle
L	0000785	cellular_component	chromatin
L	0000794	cellular_component	condensed nuclear chromosome
L	0003677	molecular_function	DNA binding
L	0003682	molecular_function	chromatin binding
L	0005085	molecular_function	guanyl-nucleotide exchange factor activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005694	cellular_component	chromosome
L	0005737	cellular_component	cytoplasm
L	0007052	biological_process	mitotic spindle organization
L	0007059	biological_process	chromosome segregation
L	0007084	biological_process	mitotic nuclear membrane reassembly
L	0007088	biological_process	regulation of mitotic nuclear division
L	0007346	biological_process	regulation of mitotic cell cycle
L	0016032	biological_process	viral process
L	0031267	molecular_function	small GTPase binding
L	0031491	molecular_function	nucleosome binding
L	0031492	molecular_function	nucleosomal DNA binding
L	0032991	cellular_component	protein-containing complex
L	0042393	molecular_function	histone binding
L	0043199	molecular_function	sulfate binding
L	0046982	molecular_function	protein heterodimerization activity
L	0051225	biological_process	spindle assembly
L	0051301	biological_process	cell division
L	1901673	biological_process	regulation of mitotic spindle assembly
M	0000082	biological_process	G1/S transition of mitotic cell cycle
M	0000785	cellular_component	chromatin
M	0000794	cellular_component	condensed nuclear chromosome
M	0003677	molecular_function	DNA binding
M	0003682	molecular_function	chromatin binding
M	0005085	molecular_function	guanyl-nucleotide exchange factor activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005694	cellular_component	chromosome
M	0005737	cellular_component	cytoplasm
M	0007052	biological_process	mitotic spindle organization
M	0007059	biological_process	chromosome segregation
M	0007084	biological_process	mitotic nuclear membrane reassembly
M	0007088	biological_process	regulation of mitotic nuclear division
M	0007346	biological_process	regulation of mitotic cell cycle
M	0016032	biological_process	viral process
M	0031267	molecular_function	small GTPase binding
M	0031491	molecular_function	nucleosome binding
M	0031492	molecular_function	nucleosomal DNA binding
M	0032991	cellular_component	protein-containing complex
M	0042393	molecular_function	histone binding
M	0043199	molecular_function	sulfate binding
M	0046982	molecular_function	protein heterodimerization activity
M	0051225	biological_process	spindle assembly
M	0051301	biological_process	cell division
M	1901673	biological_process	regulation of mitotic spindle assembly
N	0000082	biological_process	G1/S transition of mitotic cell cycle
N	0000785	cellular_component	chromatin
N	0000794	cellular_component	condensed nuclear chromosome
N	0003677	molecular_function	DNA binding
N	0003682	molecular_function	chromatin binding
N	0005085	molecular_function	guanyl-nucleotide exchange factor activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005694	cellular_component	chromosome
N	0005737	cellular_component	cytoplasm
N	0007052	biological_process	mitotic spindle organization
N	0007059	biological_process	chromosome segregation
N	0007084	biological_process	mitotic nuclear membrane reassembly
N	0007088	biological_process	regulation of mitotic nuclear division
N	0007346	biological_process	regulation of mitotic cell cycle
N	0016032	biological_process	viral process
N	0031267	molecular_function	small GTPase binding
N	0031491	molecular_function	nucleosome binding
N	0031492	molecular_function	nucleosomal DNA binding
N	0032991	cellular_component	protein-containing complex
N	0042393	molecular_function	histone binding
N	0043199	molecular_function	sulfate binding
N	0046982	molecular_function	protein heterodimerization activity
N	0051225	biological_process	spindle assembly
N	0051301	biological_process	cell division
N	1901673	biological_process	regulation of mitotic spindle assembly
O	0000082	biological_process	G1/S transition of mitotic cell cycle
O	0000785	cellular_component	chromatin
O	0000794	cellular_component	condensed nuclear chromosome
O	0003677	molecular_function	DNA binding
O	0003682	molecular_function	chromatin binding
O	0005085	molecular_function	guanyl-nucleotide exchange factor activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005694	cellular_component	chromosome
O	0005737	cellular_component	cytoplasm
O	0007052	biological_process	mitotic spindle organization
O	0007059	biological_process	chromosome segregation
O	0007084	biological_process	mitotic nuclear membrane reassembly
O	0007088	biological_process	regulation of mitotic nuclear division
O	0007346	biological_process	regulation of mitotic cell cycle
O	0016032	biological_process	viral process
O	0031267	molecular_function	small GTPase binding
O	0031491	molecular_function	nucleosome binding
O	0031492	molecular_function	nucleosomal DNA binding
O	0032991	cellular_component	protein-containing complex
O	0042393	molecular_function	histone binding
O	0043199	molecular_function	sulfate binding
O	0046982	molecular_function	protein heterodimerization activity
O	0051225	biological_process	spindle assembly
O	0051301	biological_process	cell division
O	1901673	biological_process	regulation of mitotic spindle assembly
P	0000082	biological_process	G1/S transition of mitotic cell cycle
P	0000785	cellular_component	chromatin
P	0000794	cellular_component	condensed nuclear chromosome
P	0003677	molecular_function	DNA binding
P	0003682	molecular_function	chromatin binding
P	0005085	molecular_function	guanyl-nucleotide exchange factor activity
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005694	cellular_component	chromosome
P	0005737	cellular_component	cytoplasm
P	0007052	biological_process	mitotic spindle organization
P	0007059	biological_process	chromosome segregation
P	0007084	biological_process	mitotic nuclear membrane reassembly
P	0007088	biological_process	regulation of mitotic nuclear division
P	0007346	biological_process	regulation of mitotic cell cycle
P	0016032	biological_process	viral process
P	0031267	molecular_function	small GTPase binding
P	0031491	molecular_function	nucleosome binding
P	0031492	molecular_function	nucleosomal DNA binding
P	0032991	cellular_component	protein-containing complex
P	0042393	molecular_function	histone binding
P	0043199	molecular_function	sulfate binding
P	0046982	molecular_function	protein heterodimerization activity
P	0051225	biological_process	spindle assembly
P	0051301	biological_process	cell division
P	1901673	biological_process	regulation of mitotic spindle assembly

Functional Information from PROSITE/UniProt

site_id	PS00625
Number of Residues	12
Details	RCC1_1 Regulator of chromosome condensation (RCC1) signature 1. GcNDegALGRdT

Chain	Residue	Details
I	GLY92-THR103

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site_id	PS00626
Number of Residues	11
Details	RCC1_2 Regulator of chromosome condensation (RCC1) signature 2. VSAGdSHTAAL

Chain	Residue	Details
I	VAL124-LEU134
I	VAL177-LEU187
I	PHE299-MET309
I	VAL404-LEU414

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:17435751

Chain	Residue	Details
I	SER2
K	SER2
L	SER2
M	SER2
N	SER2
O	SER2
P	SER2
J	SER2

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
I	SER11
K	SER11
L	SER11
M	SER11
N	SER11
O	SER11
P	SER11
J	SER11

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