5T5N
Calcium-activated chloride channel bestrophin-1 (BEST1), triple mutant: I76A, F80A, F84A; in complex with an Fab antibody fragment, chloride, and calcium
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005254 | molecular_function | chloride channel activity |
| B | 0005254 | molecular_function | chloride channel activity |
| C | 0005254 | molecular_function | chloride channel activity |
| D | 0005254 | molecular_function | chloride channel activity |
| E | 0005254 | molecular_function | chloride channel activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 501 |
| Chain | Residue |
| A | PRO274 |
| A | PHE276 |
| A | THR277 |
| B | TYR68 |
| B | TYR72 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 502 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue K A 503 |
| Chain | Residue |
| B | GLU35 |
| B | TYR245 |
| B | GLU292 |
| A | LEU14 |
| A | SER18 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 504 |
| Chain | Residue |
| A | ALA146 |
| A | GLY299 |
| A | ASP301 |
| A | ASP304 |
| A | PHE305 |
| A | GLU306 |
| A | THR307 |
| A | ASN308 |
| E | ARG356 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 505 |
| Chain | Residue |
| A | GLN293 |
| A | ASN296 |
| A | ASP301 |
| A | ASP304 |
| A | HOH601 |
| E | ALA10 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 506 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue K A 507 |
| Chain | Residue |
| A | GLU35 |
| A | TYR245 |
| A | GLU292 |
| E | LEU14 |
| E | SER18 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 501 |
| Chain | Residue |
| A | ARG356 |
| B | ALA146 |
| B | GLY299 |
| B | ASP301 |
| B | ASP304 |
| B | PHE305 |
| B | GLU306 |
| B | THR307 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 502 |
| Chain | Residue |
| A | ALA10 |
| B | GLN293 |
| B | ASN296 |
| B | ASP301 |
| B | ASP304 |
| B | HOH601 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue CL B 504 |
| Chain | Residue |
| B | PRO274 |
| B | PHE276 |
| B | THR277 |
| C | TYR68 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 505 |
| Chain | Residue |
| B | GLU74 |
| B | LEU75 |
| B | ALA76 |
| site_id | AD3 |
| Number of Residues | 10 |
| Details | binding site for residue GOL C 501 |
| Chain | Residue |
| B | TYR354 |
| B | ARG356 |
| C | ALA146 |
| C | GLY299 |
| C | ASP301 |
| C | ASP304 |
| C | PHE305 |
| C | GLU306 |
| C | THR307 |
| C | ASN308 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 502 |
| Chain | Residue |
| B | ALA10 |
| C | GLN293 |
| C | ASN296 |
| C | ASP301 |
| C | ASP304 |
| C | HOH601 |
| site_id | AD5 |
| Number of Residues | 1 |
| Details | binding site for residue CL C 503 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue K C 504 |
| Chain | Residue |
| B | LEU14 |
| B | SER18 |
| C | GLU35 |
| C | TYR245 |
| C | GLU292 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue CL C 505 |
| Chain | Residue |
| C | PRO274 |
| C | PHE276 |
| C | THR277 |
| D | TYR68 |
| D | TYR72 |
| site_id | AD8 |
| Number of Residues | 2 |
| Details | binding site for residue CL C 506 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue K C 507 |
| Chain | Residue |
| C | LEU14 |
| C | SER18 |
| D | GLU35 |
| D | TYR245 |
| D | GLU292 |
| site_id | AE1 |
| Number of Residues | 8 |
| Details | binding site for residue GOL D 501 |
| Chain | Residue |
| C | ARG356 |
| D | ALA146 |
| D | GLY299 |
| D | ASP301 |
| D | PHE305 |
| D | GLU306 |
| D | THR307 |
| D | ASN308 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue CA D 502 |
| Chain | Residue |
| D | ASP301 |
| D | ASP304 |
| D | HOH601 |
| C | ALA10 |
| D | GLN293 |
| D | ASN296 |
| site_id | AE3 |
| Number of Residues | 1 |
| Details | binding site for residue CL D 503 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue CL D 504 |
| Chain | Residue |
| D | PRO274 |
| D | THR277 |
| E | TYR68 |
| E | TYR72 |
| site_id | AE5 |
| Number of Residues | 2 |
| Details | binding site for residue CL D 505 |
| site_id | AE6 |
| Number of Residues | 9 |
| Details | binding site for residue GOL E 501 |
| Chain | Residue |
| D | TYR354 |
| D | ARG356 |
| E | ALA146 |
| E | GLY299 |
| E | ASP301 |
| E | PHE305 |
| E | GLU306 |
| E | THR307 |
| E | ASN308 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for residue CA E 502 |
| Chain | Residue |
| D | ALA10 |
| E | GLN293 |
| E | ASN296 |
| E | ASP301 |
| E | ASP304 |
| E | HOH601 |
| site_id | AE8 |
| Number of Residues | 5 |
| Details | binding site for residue K E 504 |
| Chain | Residue |
| D | LEU14 |
| D | SER18 |
| E | GLU35 |
| E | TYR245 |
| E | GLU292 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue CL E 505 |
| Chain | Residue |
| A | TYR68 |
| A | TYR72 |
| E | PRO274 |
| E | THR277 |
| site_id | AF1 |
| Number of Residues | 2 |
| Details | binding site for residue CL E 506 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| F | TYR192-HIS198 | |
