Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5T0C

Structural basis for dynamic regulation of the human 26S proteasome

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AA	0000502	cellular_component	proteasome complex
AA	0000932	cellular_component	P-body
AA	0001649	biological_process	osteoblast differentiation
AA	0005515	molecular_function	protein binding
AA	0005524	molecular_function	ATP binding
AA	0005576	cellular_component	extracellular region
AA	0005634	cellular_component	nucleus
AA	0005654	cellular_component	nucleoplasm
AA	0005737	cellular_component	cytoplasm
AA	0005829	cellular_component	cytosol
AA	0006511	biological_process	ubiquitin-dependent protein catabolic process
AA	0008540	cellular_component	proteasome regulatory particle, base subcomplex
AA	0016020	cellular_component	membrane
AA	0016887	molecular_function	ATP hydrolysis activity
AA	0022624	cellular_component	proteasome accessory complex
AA	0034774	cellular_component	secretory granule lumen
AA	0036402	molecular_function	proteasome-activating activity
AA	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
AA	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AA	1901800	biological_process	positive regulation of proteasomal protein catabolic process
AA	1904813	cellular_component	ficolin-1-rich granule lumen
AB	0000502	cellular_component	proteasome complex
AB	0003723	molecular_function	RNA binding
AB	0005515	molecular_function	protein binding
AB	0005524	molecular_function	ATP binding
AB	0005634	cellular_component	nucleus
AB	0005654	cellular_component	nucleoplasm
AB	0005737	cellular_component	cytoplasm
AB	0005829	cellular_component	cytosol
AB	0005838	cellular_component	proteasome regulatory particle
AB	0008540	cellular_component	proteasome regulatory particle, base subcomplex
AB	0016020	cellular_component	membrane
AB	0016887	molecular_function	ATP hydrolysis activity
AB	0022624	cellular_component	proteasome accessory complex
AB	0036402	molecular_function	proteasome-activating activity
AB	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AB	1901800	biological_process	positive regulation of proteasomal protein catabolic process
AC	0000502	cellular_component	proteasome complex
AC	0005102	molecular_function	signaling receptor binding
AC	0005515	molecular_function	protein binding
AC	0005524	molecular_function	ATP binding
AC	0005634	cellular_component	nucleus
AC	0005654	cellular_component	nucleoplasm
AC	0005737	cellular_component	cytoplasm
AC	0005829	cellular_component	cytosol
AC	0005838	cellular_component	proteasome regulatory particle
AC	0006357	biological_process	regulation of transcription by RNA polymerase II
AC	0008134	molecular_function	transcription factor binding
AC	0008540	cellular_component	proteasome regulatory particle, base subcomplex
AC	0016020	cellular_component	membrane
AC	0016887	molecular_function	ATP hydrolysis activity
AC	0022624	cellular_component	proteasome accessory complex
AC	0031410	cellular_component	cytoplasmic vesicle
AC	0031531	molecular_function	thyrotropin-releasing hormone receptor binding
AC	0036402	molecular_function	proteasome-activating activity
AC	0043069	biological_process	negative regulation of programmed cell death
AC	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AC	0045892	biological_process	negative regulation of DNA-templated transcription
AC	0045893	biological_process	positive regulation of DNA-templated transcription
AC	0070062	cellular_component	extracellular exosome
AC	0072562	cellular_component	blood microparticle
AC	0140296	molecular_function	general transcription initiation factor binding
AC	0140297	molecular_function	DNA-binding transcription factor binding
AC	1901800	biological_process	positive regulation of proteasomal protein catabolic process
AD	0000502	cellular_component	proteasome complex
AD	0001824	biological_process	blastocyst development
AD	0005515	molecular_function	protein binding
AD	0005524	molecular_function	ATP binding
AD	0005634	cellular_component	nucleus
AD	0005654	cellular_component	nucleoplasm
AD	0005737	cellular_component	cytoplasm
AD	0005829	cellular_component	cytosol
AD	0006508	biological_process	proteolysis
AD	0008540	cellular_component	proteasome regulatory particle, base subcomplex
AD	0016020	cellular_component	membrane
AD	0016234	cellular_component	inclusion body
AD	0016887	molecular_function	ATP hydrolysis activity
AD	0022624	cellular_component	proteasome accessory complex
AD	0031597	cellular_component	cytosolic proteasome complex
AD	0036402	molecular_function	proteasome-activating activity
AD	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AD	1901800	biological_process	positive regulation of proteasomal protein catabolic process
AE	0000502	cellular_component	proteasome complex
AE	0005515	molecular_function	protein binding
AE	0005524	molecular_function	ATP binding
AE	0005634	cellular_component	nucleus
AE	0005654	cellular_component	nucleoplasm
AE	0005737	cellular_component	cytoplasm
AE	0005829	cellular_component	cytosol
AE	0008540	cellular_component	proteasome regulatory particle, base subcomplex
AE	0016020	cellular_component	membrane
AE	0016234	cellular_component	inclusion body
AE	0016887	molecular_function	ATP hydrolysis activity
AE	0022624	cellular_component	proteasome accessory complex
AE	0030674	molecular_function	protein-macromolecule adaptor activity
AE	0031597	cellular_component	cytosolic proteasome complex
AE	0036402	molecular_function	proteasome-activating activity
AE	0036503	biological_process	ERAD pathway
AE	0042802	molecular_function	identical protein binding
AE	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AE	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
AE	0070062	cellular_component	extracellular exosome
AE	0090261	biological_process	positive regulation of inclusion body assembly
AE	1901800	biological_process	positive regulation of proteasomal protein catabolic process
AF	0000502	cellular_component	proteasome complex
AF	0000932	cellular_component	P-body
AF	0005515	molecular_function	protein binding
AF	0005524	molecular_function	ATP binding
AF	0005576	cellular_component	extracellular region
AF	0005634	cellular_component	nucleus
AF	0005654	cellular_component	nucleoplasm
AF	0005737	cellular_component	cytoplasm
AF	0005829	cellular_component	cytosol
AF	0008540	cellular_component	proteasome regulatory particle, base subcomplex
AF	0016020	cellular_component	membrane
AF	0016887	molecular_function	ATP hydrolysis activity
AF	0022624	cellular_component	proteasome accessory complex
AF	0034774	cellular_component	secretory granule lumen
AF	0036402	molecular_function	proteasome-activating activity
AF	0042802	molecular_function	identical protein binding
AF	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AF	0043921	biological_process	modulation by host of viral transcription
AF	0045944	biological_process	positive regulation of transcription by RNA polymerase II
AF	1901800	biological_process	positive regulation of proteasomal protein catabolic process
AF	1904813	cellular_component	ficolin-1-rich granule lumen
AG	0000502	cellular_component	proteasome complex
AG	0000932	cellular_component	P-body
AG	0003723	molecular_function	RNA binding
AG	0004175	molecular_function	endopeptidase activity
AG	0005515	molecular_function	protein binding
AG	0005634	cellular_component	nucleus
AG	0005654	cellular_component	nucleoplasm
AG	0005737	cellular_component	cytoplasm
AG	0005829	cellular_component	cytosol
AG	0005839	cellular_component	proteasome core complex
AG	0005840	cellular_component	ribosome
AG	0006511	biological_process	ubiquitin-dependent protein catabolic process
AG	0016363	cellular_component	nuclear matrix
AG	0019773	cellular_component	proteasome core complex, alpha-subunit complex
AG	0030016	cellular_component	myofibril
AG	0030017	cellular_component	sarcomere
AG	0035639	molecular_function	purine ribonucleoside triphosphate binding
AG	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AG	0050727	biological_process	regulation of inflammatory response
AG	0051059	molecular_function	NF-kappaB binding
AG	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
AG	0051603	biological_process	proteolysis involved in protein catabolic process
AG	0070062	cellular_component	extracellular exosome
AH	0000502	cellular_component	proteasome complex
AH	0000932	cellular_component	P-body
AH	0005515	molecular_function	protein binding
AH	0005576	cellular_component	extracellular region
AH	0005634	cellular_component	nucleus
AH	0005654	cellular_component	nucleoplasm
AH	0005737	cellular_component	cytoplasm
AH	0005829	cellular_component	cytosol
AH	0005839	cellular_component	proteasome core complex
AH	0006511	biological_process	ubiquitin-dependent protein catabolic process
AH	0009615	biological_process	response to virus
AH	0019773	cellular_component	proteasome core complex, alpha-subunit complex
AH	0034774	cellular_component	secretory granule lumen
AH	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AH	0051603	biological_process	proteolysis involved in protein catabolic process
AH	0070062	cellular_component	extracellular exosome
AH	1904813	cellular_component	ficolin-1-rich granule lumen
AI	0000502	cellular_component	proteasome complex
AI	0000932	cellular_component	P-body
AI	0005515	molecular_function	protein binding
AI	0005634	cellular_component	nucleus
AI	0005654	cellular_component	nucleoplasm
AI	0005737	cellular_component	cytoplasm
AI	0005829	cellular_component	cytosol
AI	0005839	cellular_component	proteasome core complex
AI	0006511	biological_process	ubiquitin-dependent protein catabolic process
AI	0019773	cellular_component	proteasome core complex, alpha-subunit complex
AI	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AI	0043231	cellular_component	intracellular membrane-bounded organelle
AI	0051603	biological_process	proteolysis involved in protein catabolic process
AI	0070062	cellular_component	extracellular exosome
AJ	0000502	cellular_component	proteasome complex
AJ	0005515	molecular_function	protein binding
AJ	0005634	cellular_component	nucleus
AJ	0005654	cellular_component	nucleoplasm
AJ	0005737	cellular_component	cytoplasm
AJ	0005829	cellular_component	cytosol
AJ	0005839	cellular_component	proteasome core complex
AJ	0006511	biological_process	ubiquitin-dependent protein catabolic process
AJ	0019773	cellular_component	proteasome core complex, alpha-subunit complex
AJ	0042802	molecular_function	identical protein binding
AJ	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AJ	0051603	biological_process	proteolysis involved in protein catabolic process
AJ	0070062	cellular_component	extracellular exosome
AK	0000502	cellular_component	proteasome complex
AK	0005515	molecular_function	protein binding
AK	0005576	cellular_component	extracellular region
AK	0005634	cellular_component	nucleus
AK	0005654	cellular_component	nucleoplasm
AK	0005737	cellular_component	cytoplasm
AK	0005829	cellular_component	cytosol
AK	0005839	cellular_component	proteasome core complex
AK	0006511	biological_process	ubiquitin-dependent protein catabolic process
AK	0019773	cellular_component	proteasome core complex, alpha-subunit complex
AK	0034774	cellular_component	secretory granule lumen
AK	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AK	0051603	biological_process	proteolysis involved in protein catabolic process
AK	0070062	cellular_component	extracellular exosome
AK	1904813	cellular_component	ficolin-1-rich granule lumen
AL	0000502	cellular_component	proteasome complex
AL	0001530	molecular_function	lipopolysaccharide binding
AL	0002376	biological_process	immune system process
AL	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
AL	0005515	molecular_function	protein binding
AL	0005634	cellular_component	nucleus
AL	0005654	cellular_component	nucleoplasm
AL	0005737	cellular_component	cytoplasm
AL	0005813	cellular_component	centrosome
AL	0005829	cellular_component	cytosol
AL	0005839	cellular_component	proteasome core complex
AL	0006511	biological_process	ubiquitin-dependent protein catabolic process
AL	0019773	cellular_component	proteasome core complex, alpha-subunit complex
AL	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AL	0051603	biological_process	proteolysis involved in protein catabolic process
AL	0070062	cellular_component	extracellular exosome
AM	0000502	cellular_component	proteasome complex
AM	0005515	molecular_function	protein binding
AM	0005634	cellular_component	nucleus
AM	0005654	cellular_component	nucleoplasm
AM	0005737	cellular_component	cytoplasm
AM	0005829	cellular_component	cytosol
AM	0005839	cellular_component	proteasome core complex
AM	0006511	biological_process	ubiquitin-dependent protein catabolic process
AM	0019773	cellular_component	proteasome core complex, alpha-subunit complex
AM	0031625	molecular_function	ubiquitin protein ligase binding
AM	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AM	0045202	cellular_component	synapse
AM	0051603	biological_process	proteolysis involved in protein catabolic process
AM	0052548	biological_process	regulation of endopeptidase activity
AM	0070062	cellular_component	extracellular exosome
AN	0000502	cellular_component	proteasome complex
AN	0004175	molecular_function	endopeptidase activity
AN	0004298	molecular_function	threonine-type endopeptidase activity
AN	0005515	molecular_function	protein binding
AN	0005634	cellular_component	nucleus
AN	0005654	cellular_component	nucleoplasm
AN	0005737	cellular_component	cytoplasm
AN	0005739	cellular_component	mitochondrion
AN	0005829	cellular_component	cytosol
AN	0005839	cellular_component	proteasome core complex
AN	0006508	biological_process	proteolysis
AN	0019774	cellular_component	proteasome core complex, beta-subunit complex
AN	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AN	0045296	molecular_function	cadherin binding
AN	0051603	biological_process	proteolysis involved in protein catabolic process
AN	0070062	cellular_component	extracellular exosome
AO	0000502	cellular_component	proteasome complex
AO	0004175	molecular_function	endopeptidase activity
AO	0004298	molecular_function	threonine-type endopeptidase activity
AO	0005515	molecular_function	protein binding
AO	0005576	cellular_component	extracellular region
AO	0005634	cellular_component	nucleus
AO	0005654	cellular_component	nucleoplasm
AO	0005737	cellular_component	cytoplasm
AO	0005829	cellular_component	cytosol
AO	0005839	cellular_component	proteasome core complex
AO	0006508	biological_process	proteolysis
AO	0016604	cellular_component	nuclear body
AO	0019774	cellular_component	proteasome core complex, beta-subunit complex
AO	0034774	cellular_component	secretory granule lumen
AO	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AO	0051603	biological_process	proteolysis involved in protein catabolic process
AO	1904813	cellular_component	ficolin-1-rich granule lumen
AP	0000502	cellular_component	proteasome complex
AP	0005515	molecular_function	protein binding
AP	0005634	cellular_component	nucleus
AP	0005654	cellular_component	nucleoplasm
AP	0005737	cellular_component	cytoplasm
AP	0005829	cellular_component	cytosol
AP	0005839	cellular_component	proteasome core complex
AP	0019774	cellular_component	proteasome core complex, beta-subunit complex
AP	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AP	0051603	biological_process	proteolysis involved in protein catabolic process
AP	0070062	cellular_component	extracellular exosome
AQ	0000502	cellular_component	proteasome complex
AQ	0005515	molecular_function	protein binding
AQ	0005634	cellular_component	nucleus
AQ	0005654	cellular_component	nucleoplasm
AQ	0005737	cellular_component	cytoplasm
AQ	0005829	cellular_component	cytosol
AQ	0005839	cellular_component	proteasome core complex
AQ	0010498	biological_process	proteasomal protein catabolic process
AQ	0014070	biological_process	response to organic cyclic compound
AQ	0016020	cellular_component	membrane
AQ	0019774	cellular_component	proteasome core complex, beta-subunit complex
AQ	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AQ	0051603	biological_process	proteolysis involved in protein catabolic process
AQ	0070062	cellular_component	extracellular exosome
AR	0000502	cellular_component	proteasome complex
AR	0004175	molecular_function	endopeptidase activity
AR	0004298	molecular_function	threonine-type endopeptidase activity
AR	0005515	molecular_function	protein binding
AR	0005634	cellular_component	nucleus
AR	0005654	cellular_component	nucleoplasm
AR	0005737	cellular_component	cytoplasm
AR	0005813	cellular_component	centrosome
AR	0005829	cellular_component	cytosol
AR	0005839	cellular_component	proteasome core complex
AR	0006508	biological_process	proteolysis
AR	0006979	biological_process	response to oxidative stress
AR	0008233	molecular_function	peptidase activity
AR	0019774	cellular_component	proteasome core complex, beta-subunit complex
AR	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AR	0051603	biological_process	proteolysis involved in protein catabolic process
AR	0070062	cellular_component	extracellular exosome
AS	0000502	cellular_component	proteasome complex
AS	0005515	molecular_function	protein binding
AS	0005576	cellular_component	extracellular region
AS	0005634	cellular_component	nucleus
AS	0005654	cellular_component	nucleoplasm
AS	0005737	cellular_component	cytoplasm
AS	0005829	cellular_component	cytosol
AS	0005839	cellular_component	proteasome core complex
AS	0019774	cellular_component	proteasome core complex, beta-subunit complex
AS	0034774	cellular_component	secretory granule lumen
AS	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AS	0051603	biological_process	proteolysis involved in protein catabolic process
AS	0070062	cellular_component	extracellular exosome
AS	1904813	cellular_component	ficolin-1-rich granule lumen
AT	0000502	cellular_component	proteasome complex
AT	0001530	molecular_function	lipopolysaccharide binding
AT	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
AT	0005515	molecular_function	protein binding
AT	0005634	cellular_component	nucleus
AT	0005654	cellular_component	nucleoplasm
AT	0005737	cellular_component	cytoplasm
AT	0005739	cellular_component	mitochondrion
AT	0005829	cellular_component	cytosol
AT	0005839	cellular_component	proteasome core complex
AT	0019774	cellular_component	proteasome core complex, beta-subunit complex
AT	0036064	cellular_component	ciliary basal body
AT	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AT	0051603	biological_process	proteolysis involved in protein catabolic process
AT	0070062	cellular_component	extracellular exosome
AU	0000502	cellular_component	proteasome complex
AU	0005515	molecular_function	protein binding
AU	0005576	cellular_component	extracellular region
AU	0005634	cellular_component	nucleus
AU	0005654	cellular_component	nucleoplasm
AU	0005829	cellular_component	cytosol
AU	0005838	cellular_component	proteasome regulatory particle
AU	0008540	cellular_component	proteasome regulatory particle, base subcomplex
AU	0016020	cellular_component	membrane
AU	0022624	cellular_component	proteasome accessory complex
AU	0030234	molecular_function	enzyme regulator activity
AU	0031625	molecular_function	ubiquitin protein ligase binding
AU	0034515	cellular_component	proteasome storage granule
AU	0035578	cellular_component	azurophil granule lumen
AU	0042176	biological_process	regulation of protein catabolic process
AU	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AV	0000502	cellular_component	proteasome complex
AV	0005515	molecular_function	protein binding
AV	0005576	cellular_component	extracellular region
AV	0005634	cellular_component	nucleus
AV	0005654	cellular_component	nucleoplasm
AV	0005829	cellular_component	cytosol
AV	0005838	cellular_component	proteasome regulatory particle
AV	0006511	biological_process	ubiquitin-dependent protein catabolic process
AV	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
AV	0016020	cellular_component	membrane
AV	0022624	cellular_component	proteasome accessory complex
AV	0030234	molecular_function	enzyme regulator activity
AV	0032991	cellular_component	protein-containing complex
AV	0034774	cellular_component	secretory granule lumen
AV	0042176	biological_process	regulation of protein catabolic process
AV	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AV	0070062	cellular_component	extracellular exosome
AV	1904813	cellular_component	ficolin-1-rich granule lumen
AW	0000502	cellular_component	proteasome complex
AW	0005515	molecular_function	protein binding
AW	0005576	cellular_component	extracellular region
AW	0005654	cellular_component	nucleoplasm
AW	0005737	cellular_component	cytoplasm
AW	0005829	cellular_component	cytosol
AW	0005838	cellular_component	proteasome regulatory particle
AW	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
AW	0016020	cellular_component	membrane
AW	0022624	cellular_component	proteasome accessory complex
AW	0034774	cellular_component	secretory granule lumen
AW	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AW	0070062	cellular_component	extracellular exosome
AW	1904813	cellular_component	ficolin-1-rich granule lumen
AX	0000502	cellular_component	proteasome complex
AX	0005198	molecular_function	structural molecule activity
AX	0005515	molecular_function	protein binding
AX	0005576	cellular_component	extracellular region
AX	0005634	cellular_component	nucleus
AX	0005654	cellular_component	nucleoplasm
AX	0005737	cellular_component	cytoplasm
AX	0005829	cellular_component	cytosol
AX	0005838	cellular_component	proteasome regulatory particle
AX	0006511	biological_process	ubiquitin-dependent protein catabolic process
AX	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
AX	0016020	cellular_component	membrane
AX	0022624	cellular_component	proteasome accessory complex
AX	0032991	cellular_component	protein-containing complex
AX	0034774	cellular_component	secretory granule lumen
AX	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AX	0043248	biological_process	proteasome assembly
AX	0048863	biological_process	stem cell differentiation
AX	1904813	cellular_component	ficolin-1-rich granule lumen
AY	0000502	cellular_component	proteasome complex
AY	0005515	molecular_function	protein binding
AY	0005576	cellular_component	extracellular region
AY	0005654	cellular_component	nucleoplasm
AY	0005829	cellular_component	cytosol
AY	0005838	cellular_component	proteasome regulatory particle
AY	0022624	cellular_component	proteasome accessory complex
AY	0034774	cellular_component	secretory granule lumen
AY	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AY	1904813	cellular_component	ficolin-1-rich granule lumen
AZ	0000502	cellular_component	proteasome complex
AZ	0005515	molecular_function	protein binding
AZ	0005576	cellular_component	extracellular region
AZ	0005634	cellular_component	nucleus
AZ	0005654	cellular_component	nucleoplasm
AZ	0005829	cellular_component	cytosol
AZ	0005838	cellular_component	proteasome regulatory particle
AZ	0008233	molecular_function	peptidase activity
AZ	0008237	molecular_function	metallopeptidase activity
AZ	0016020	cellular_component	membrane
AZ	0034774	cellular_component	secretory granule lumen
AZ	0042803	molecular_function	protein homodimerization activity
AZ	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AZ	0070062	cellular_component	extracellular exosome
AZ	0140492	molecular_function	metal-dependent deubiquitinase activity
AZ	1904813	cellular_component	ficolin-1-rich granule lumen
Aa	0000502	cellular_component	proteasome complex
Aa	0005198	molecular_function	structural molecule activity
Aa	0005515	molecular_function	protein binding
Aa	0005576	cellular_component	extracellular region
Aa	0005634	cellular_component	nucleus
Aa	0005654	cellular_component	nucleoplasm
Aa	0005829	cellular_component	cytosol
Aa	0005838	cellular_component	proteasome regulatory particle
Aa	0006511	biological_process	ubiquitin-dependent protein catabolic process
Aa	0007127	biological_process	meiosis I
Aa	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
Aa	0016020	cellular_component	membrane
Aa	0022624	cellular_component	proteasome accessory complex
Aa	0034774	cellular_component	secretory granule lumen
Aa	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Aa	1904813	cellular_component	ficolin-1-rich granule lumen
Ab	0000502	cellular_component	proteasome complex
Ab	0003723	molecular_function	RNA binding
Ab	0005515	molecular_function	protein binding
Ab	0005634	cellular_component	nucleus
Ab	0005654	cellular_component	nucleoplasm
Ab	0005829	cellular_component	cytosol
Ab	0008540	cellular_component	proteasome regulatory particle, base subcomplex
Ab	0022624	cellular_component	proteasome accessory complex
Ab	0031593	molecular_function	polyubiquitin modification-dependent protein binding
Ab	0042802	molecular_function	identical protein binding
Ab	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Ab	0060090	molecular_function	molecular adaptor activity
Ac	0000502	cellular_component	proteasome complex
Ac	0000724	biological_process	double-strand break repair via homologous recombination
Ac	0005515	molecular_function	protein binding
Ac	0005576	cellular_component	extracellular region
Ac	0005634	cellular_component	nucleus
Ac	0005654	cellular_component	nucleoplasm
Ac	0005829	cellular_component	cytosol
Ac	0006281	biological_process	DNA repair
Ac	0006303	biological_process	double-strand break repair via nonhomologous end joining
Ac	0006508	biological_process	proteolysis
Ac	0006511	biological_process	ubiquitin-dependent protein catabolic process
Ac	0008233	molecular_function	peptidase activity
Ac	0008237	molecular_function	metallopeptidase activity
Ac	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
Ac	0016579	biological_process	protein deubiquitination
Ac	0022624	cellular_component	proteasome accessory complex
Ac	0031597	cellular_component	cytosolic proteasome complex
Ac	0034774	cellular_component	secretory granule lumen
Ac	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Ac	0045471	biological_process	response to ethanol
Ac	0046872	molecular_function	metal ion binding
Ac	0061133	molecular_function	endopeptidase activator activity
Ac	0061136	biological_process	regulation of proteasomal protein catabolic process
Ac	0061578	molecular_function	K63-linked deubiquitinase activity
Ac	0070536	biological_process	protein K63-linked deubiquitination
Ac	0070628	molecular_function	proteasome binding
Ac	0140492	molecular_function	metal-dependent deubiquitinase activity
Ac	1904813	cellular_component	ficolin-1-rich granule lumen
Ad	0005838	cellular_component	proteasome regulatory particle
Ad	0006508	biological_process	proteolysis
Ae	0000502	cellular_component	proteasome complex
Ae	0000724	biological_process	double-strand break repair via homologous recombination
Ae	0005515	molecular_function	protein binding
Ae	0005634	cellular_component	nucleus
Ae	0005654	cellular_component	nucleoplasm
Ae	0005829	cellular_component	cytosol
Ae	0006406	biological_process	mRNA export from nucleus
Ae	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
Ae	0032039	cellular_component	integrator complex
Ae	0032991	cellular_component	protein-containing complex
Ae	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Ae	0043248	biological_process	proteasome assembly
Af	0000502	cellular_component	proteasome complex
Af	0005515	molecular_function	protein binding
Af	0005576	cellular_component	extracellular region
Af	0005634	cellular_component	nucleus
Af	0005654	cellular_component	nucleoplasm
Af	0005829	cellular_component	cytosol
Af	0005838	cellular_component	proteasome regulatory particle
Af	0008540	cellular_component	proteasome regulatory particle, base subcomplex
Af	0016020	cellular_component	membrane
Af	0022624	cellular_component	proteasome accessory complex
Af	0030234	molecular_function	enzyme regulator activity
Af	0034515	cellular_component	proteasome storage granule
Af	0034774	cellular_component	secretory granule lumen
Af	0042176	biological_process	regulation of protein catabolic process
Af	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Af	0070062	cellular_component	extracellular exosome
Af	1904813	cellular_component	ficolin-1-rich granule lumen
BA	0000502	cellular_component	proteasome complex
BA	0000932	cellular_component	P-body
BA	0001649	biological_process	osteoblast differentiation
BA	0005515	molecular_function	protein binding
BA	0005524	molecular_function	ATP binding
BA	0005576	cellular_component	extracellular region
BA	0005634	cellular_component	nucleus
BA	0005654	cellular_component	nucleoplasm
BA	0005737	cellular_component	cytoplasm
BA	0005829	cellular_component	cytosol
BA	0006511	biological_process	ubiquitin-dependent protein catabolic process
BA	0008540	cellular_component	proteasome regulatory particle, base subcomplex
BA	0016020	cellular_component	membrane
BA	0016887	molecular_function	ATP hydrolysis activity
BA	0022624	cellular_component	proteasome accessory complex
BA	0034774	cellular_component	secretory granule lumen
BA	0036402	molecular_function	proteasome-activating activity
BA	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
BA	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
BA	1901800	biological_process	positive regulation of proteasomal protein catabolic process
BA	1904813	cellular_component	ficolin-1-rich granule lumen
BB	0000502	cellular_component	proteasome complex
BB	0003723	molecular_function	RNA binding
BB	0005515	molecular_function	protein binding
BB	0005524	molecular_function	ATP binding
BB	0005634	cellular_component	nucleus
BB	0005654	cellular_component	nucleoplasm
BB	0005737	cellular_component	cytoplasm
BB	0005829	cellular_component	cytosol
BB	0005838	cellular_component	proteasome regulatory particle
BB	0008540	cellular_component	proteasome regulatory particle, base subcomplex
BB	0016020	cellular_component	membrane
BB	0016887	molecular_function	ATP hydrolysis activity
BB	0022624	cellular_component	proteasome accessory complex
BB	0036402	molecular_function	proteasome-activating activity
BB	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
BB	1901800	biological_process	positive regulation of proteasomal protein catabolic process
BC	0000502	cellular_component	proteasome complex
BC	0005102	molecular_function	signaling receptor binding
BC	0005515	molecular_function	protein binding
BC	0005524	molecular_function	ATP binding
BC	0005634	cellular_component	nucleus
BC	0005654	cellular_component	nucleoplasm
BC	0005737	cellular_component	cytoplasm
BC	0005829	cellular_component	cytosol
BC	0005838	cellular_component	proteasome regulatory particle
BC	0006357	biological_process	regulation of transcription by RNA polymerase II
BC	0008134	molecular_function	transcription factor binding
BC	0008540	cellular_component	proteasome regulatory particle, base subcomplex
BC	0016020	cellular_component	membrane
BC	0016887	molecular_function	ATP hydrolysis activity
BC	0022624	cellular_component	proteasome accessory complex
BC	0031410	cellular_component	cytoplasmic vesicle
BC	0031531	molecular_function	thyrotropin-releasing hormone receptor binding
BC	0036402	molecular_function	proteasome-activating activity
BC	0043069	biological_process	negative regulation of programmed cell death
BC	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
BC	0045892	biological_process	negative regulation of DNA-templated transcription
BC	0045893	biological_process	positive regulation of DNA-templated transcription
BC	0070062	cellular_component	extracellular exosome
BC	0072562	cellular_component	blood microparticle
BC	0140296	molecular_function	general transcription initiation factor binding
BC	0140297	molecular_function	DNA-binding transcription factor binding
BC	1901800	biological_process	positive regulation of proteasomal protein catabolic process
BD	0000502	cellular_component	proteasome complex
BD	0001824	biological_process	blastocyst development
BD	0005515	molecular_function	protein binding
BD	0005524	molecular_function	ATP binding
BD	0005634	cellular_component	nucleus
BD	0005654	cellular_component	nucleoplasm
BD	0005737	cellular_component	cytoplasm
BD	0005829	cellular_component	cytosol
BD	0006508	biological_process	proteolysis
BD	0008540	cellular_component	proteasome regulatory particle, base subcomplex
BD	0016020	cellular_component	membrane
BD	0016234	cellular_component	inclusion body
BD	0016887	molecular_function	ATP hydrolysis activity
BD	0022624	cellular_component	proteasome accessory complex
BD	0031597	cellular_component	cytosolic proteasome complex
BD	0036402	molecular_function	proteasome-activating activity
BD	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
BD	1901800	biological_process	positive regulation of proteasomal protein catabolic process
BE	0000502	cellular_component	proteasome complex
BE	0005515	molecular_function	protein binding
BE	0005524	molecular_function	ATP binding
BE	0005634	cellular_component	nucleus
BE	0005654	cellular_component	nucleoplasm
BE	0005737	cellular_component	cytoplasm
BE	0005829	cellular_component	cytosol
BE	0008540	cellular_component	proteasome regulatory particle, base subcomplex
BE	0016020	cellular_component	membrane
BE	0016234	cellular_component	inclusion body
BE	0016887	molecular_function	ATP hydrolysis activity
BE	0022624	cellular_component	proteasome accessory complex
BE	0030674	molecular_function	protein-macromolecule adaptor activity
BE	0031597	cellular_component	cytosolic proteasome complex
BE	0036402	molecular_function	proteasome-activating activity
BE	0036503	biological_process	ERAD pathway
BE	0042802	molecular_function	identical protein binding
BE	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
BE	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
BE	0070062	cellular_component	extracellular exosome
BE	0090261	biological_process	positive regulation of inclusion body assembly
BE	1901800	biological_process	positive regulation of proteasomal protein catabolic process
BF	0000502	cellular_component	proteasome complex
BF	0000932	cellular_component	P-body
BF	0005515	molecular_function	protein binding
BF	0005524	molecular_function	ATP binding
BF	0005576	cellular_component	extracellular region
BF	0005634	cellular_component	nucleus
BF	0005654	cellular_component	nucleoplasm
BF	0005737	cellular_component	cytoplasm
BF	0005829	cellular_component	cytosol
BF	0008540	cellular_component	proteasome regulatory particle, base subcomplex
BF	0016020	cellular_component	membrane
BF	0016887	molecular_function	ATP hydrolysis activity
BF	0022624	cellular_component	proteasome accessory complex
BF	0034774	cellular_component	secretory granule lumen
BF	0036402	molecular_function	proteasome-activating activity
BF	0042802	molecular_function	identical protein binding
BF	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
BF	0043921	biological_process	modulation by host of viral transcription
BF	0045944	biological_process	positive regulation of transcription by RNA polymerase II
BF	1901800	biological_process	positive regulation of proteasomal protein catabolic process
BF	1904813	cellular_component	ficolin-1-rich granule lumen
BG	0000502	cellular_component	proteasome complex
BG	0000932	cellular_component	P-body
BG	0003723	molecular_function	RNA binding
BG	0004175	molecular_function	endopeptidase activity
BG	0005515	molecular_function	protein binding
BG	0005634	cellular_component	nucleus
BG	0005654	cellular_component	nucleoplasm
BG	0005737	cellular_component	cytoplasm
BG	0005829	cellular_component	cytosol
BG	0005839	cellular_component	proteasome core complex
BG	0005840	cellular_component	ribosome
BG	0006511	biological_process	ubiquitin-dependent protein catabolic process
BG	0016363	cellular_component	nuclear matrix
BG	0019773	cellular_component	proteasome core complex, alpha-subunit complex
BG	0030016	cellular_component	myofibril
BG	0030017	cellular_component	sarcomere
BG	0035639	molecular_function	purine ribonucleoside triphosphate binding
BG	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
BG	0050727	biological_process	regulation of inflammatory response
BG	0051059	molecular_function	NF-kappaB binding
BG	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
BG	0051603	biological_process	proteolysis involved in protein catabolic process
BG	0070062	cellular_component	extracellular exosome
BH	0000502	cellular_component	proteasome complex
BH	0000932	cellular_component	P-body
BH	0005515	molecular_function	protein binding
BH	0005576	cellular_component	extracellular region
BH	0005634	cellular_component	nucleus
BH	0005654	cellular_component	nucleoplasm
BH	0005737	cellular_component	cytoplasm
BH	0005829	cellular_component	cytosol
BH	0005839	cellular_component	proteasome core complex
BH	0006511	biological_process	ubiquitin-dependent protein catabolic process
BH	0009615	biological_process	response to virus
BH	0019773	cellular_component	proteasome core complex, alpha-subunit complex
BH	0034774	cellular_component	secretory granule lumen
BH	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
BH	0051603	biological_process	proteolysis involved in protein catabolic process
BH	0070062	cellular_component	extracellular exosome
BH	1904813	cellular_component	ficolin-1-rich granule lumen
BI	0000502	cellular_component	proteasome complex
BI	0000932	cellular_component	P-body
BI	0005515	molecular_function	protein binding
BI	0005634	cellular_component	nucleus
BI	0005654	cellular_component	nucleoplasm
BI	0005737	cellular_component	cytoplasm
BI	0005829	cellular_component	cytosol
BI	0005839	cellular_component	proteasome core complex
BI	0006511	biological_process	ubiquitin-dependent protein catabolic process
BI	0019773	cellular_component	proteasome core complex, alpha-subunit complex
BI	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
BI	0043231	cellular_component	intracellular membrane-bounded organelle
BI	0051603	biological_process	proteolysis involved in protein catabolic process
BI	0070062	cellular_component	extracellular exosome
BJ	0000502	cellular_component	proteasome complex
BJ	0005515	molecular_function	protein binding
BJ	0005634	cellular_component	nucleus
BJ	0005654	cellular_component	nucleoplasm
BJ	0005737	cellular_component	cytoplasm
BJ	0005829	cellular_component	cytosol
BJ	0005839	cellular_component	proteasome core complex
BJ	0006511	biological_process	ubiquitin-dependent protein catabolic process
BJ	0019773	cellular_component	proteasome core complex, alpha-subunit complex
BJ	0042802	molecular_function	identical protein binding
BJ	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
BJ	0051603	biological_process	proteolysis involved in protein catabolic process
BJ	0070062	cellular_component	extracellular exosome
BK	0000502	cellular_component	proteasome complex
BK	0005515	molecular_function	protein binding
BK	0005576	cellular_component	extracellular region
BK	0005634	cellular_component	nucleus
BK	0005654	cellular_component	nucleoplasm
BK	0005737	cellular_component	cytoplasm
BK	0005829	cellular_component	cytosol
BK	0005839	cellular_component	proteasome core complex
BK	0006511	biological_process	ubiquitin-dependent protein catabolic process
BK	0019773	cellular_component	proteasome core complex, alpha-subunit complex
BK	0034774	cellular_component	secretory granule lumen
BK	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
BK	0051603	biological_process	proteolysis involved in protein catabolic process
BK	0070062	cellular_component	extracellular exosome
BK	1904813	cellular_component	ficolin-1-rich granule lumen
BL	0000502	cellular_component	proteasome complex
BL	0001530	molecular_function	lipopolysaccharide binding
BL	0002376	biological_process	immune system process
BL	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
BL	0005515	molecular_function	protein binding
BL	0005634	cellular_component	nucleus
BL	0005654	cellular_component	nucleoplasm
BL	0005737	cellular_component	cytoplasm
BL	0005813	cellular_component	centrosome
BL	0005829	cellular_component	cytosol
BL	0005839	cellular_component	proteasome core complex
BL	0006511	biological_process	ubiquitin-dependent protein catabolic process
BL	0019773	cellular_component	proteasome core complex, alpha-subunit complex
BL	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
BL	0051603	biological_process	proteolysis involved in protein catabolic process
BL	0070062	cellular_component	extracellular exosome
BM	0000502	cellular_component	proteasome complex
BM	0005515	molecular_function	protein binding
BM	0005634	cellular_component	nucleus
BM	0005654	cellular_component	nucleoplasm
BM	0005737	cellular_component	cytoplasm
BM	0005829	cellular_component	cytosol
BM	0005839	cellular_component	proteasome core complex
BM	0006511	biological_process	ubiquitin-dependent protein catabolic process
BM	0019773	cellular_component	proteasome core complex, alpha-subunit complex
BM	0031625	molecular_function	ubiquitin protein ligase binding
BM	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
BM	0045202	cellular_component	synapse
BM	0051603	biological_process	proteolysis involved in protein catabolic process
BM	0052548	biological_process	regulation of endopeptidase activity
BM	0070062	cellular_component	extracellular exosome
BN	0000502	cellular_component	proteasome complex
BN	0004175	molecular_function	endopeptidase activity
BN	0004298	molecular_function	threonine-type endopeptidase activity
BN	0005515	molecular_function	protein binding
BN	0005634	cellular_component	nucleus
BN	0005654	cellular_component	nucleoplasm
BN	0005737	cellular_component	cytoplasm
BN	0005739	cellular_component	mitochondrion
BN	0005829	cellular_component	cytosol
BN	0005839	cellular_component	proteasome core complex
BN	0006508	biological_process	proteolysis
BN	0019774	cellular_component	proteasome core complex, beta-subunit complex
BN	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
BN	0045296	molecular_function	cadherin binding
BN	0051603	biological_process	proteolysis involved in protein catabolic process
BN	0070062	cellular_component	extracellular exosome
BO	0000502	cellular_component	proteasome complex
BO	0004175	molecular_function	endopeptidase activity
BO	0004298	molecular_function	threonine-type endopeptidase activity
BO	0005515	molecular_function	protein binding
BO	0005576	cellular_component	extracellular region
BO	0005634	cellular_component	nucleus
BO	0005654	cellular_component	nucleoplasm
BO	0005737	cellular_component	cytoplasm
BO	0005829	cellular_component	cytosol
BO	0005839	cellular_component	proteasome core complex
BO	0006508	biological_process	proteolysis
BO	0016604	cellular_component	nuclear body
BO	0019774	cellular_component	proteasome core complex, beta-subunit complex
BO	0034774	cellular_component	secretory granule lumen
BO	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
BO	0051603	biological_process	proteolysis involved in protein catabolic process
BO	1904813	cellular_component	ficolin-1-rich granule lumen
BP	0000502	cellular_component	proteasome complex
BP	0005515	molecular_function	protein binding
BP	0005634	cellular_component	nucleus
BP	0005654	cellular_component	nucleoplasm
BP	0005737	cellular_component	cytoplasm
BP	0005829	cellular_component	cytosol
BP	0005839	cellular_component	proteasome core complex
BP	0019774	cellular_component	proteasome core complex, beta-subunit complex
BP	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
BP	0051603	biological_process	proteolysis involved in protein catabolic process
BP	0070062	cellular_component	extracellular exosome
BQ	0000502	cellular_component	proteasome complex
BQ	0005515	molecular_function	protein binding
BQ	0005634	cellular_component	nucleus
BQ	0005654	cellular_component	nucleoplasm
BQ	0005737	cellular_component	cytoplasm
BQ	0005829	cellular_component	cytosol
BQ	0005839	cellular_component	proteasome core complex
BQ	0010498	biological_process	proteasomal protein catabolic process
BQ	0014070	biological_process	response to organic cyclic compound
BQ	0016020	cellular_component	membrane
BQ	0019774	cellular_component	proteasome core complex, beta-subunit complex
BQ	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
BQ	0051603	biological_process	proteolysis involved in protein catabolic process
BQ	0070062	cellular_component	extracellular exosome
BR	0000502	cellular_component	proteasome complex
BR	0004175	molecular_function	endopeptidase activity
BR	0004298	molecular_function	threonine-type endopeptidase activity
BR	0005515	molecular_function	protein binding
BR	0005634	cellular_component	nucleus
BR	0005654	cellular_component	nucleoplasm
BR	0005737	cellular_component	cytoplasm
BR	0005813	cellular_component	centrosome
BR	0005829	cellular_component	cytosol
BR	0005839	cellular_component	proteasome core complex
BR	0006508	biological_process	proteolysis
BR	0006979	biological_process	response to oxidative stress
BR	0008233	molecular_function	peptidase activity
BR	0019774	cellular_component	proteasome core complex, beta-subunit complex
BR	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
BR	0051603	biological_process	proteolysis involved in protein catabolic process
BR	0070062	cellular_component	extracellular exosome
BS	0000502	cellular_component	proteasome complex
BS	0005515	molecular_function	protein binding
BS	0005576	cellular_component	extracellular region
BS	0005634	cellular_component	nucleus
BS	0005654	cellular_component	nucleoplasm
BS	0005737	cellular_component	cytoplasm
BS	0005829	cellular_component	cytosol
BS	0005839	cellular_component	proteasome core complex
BS	0019774	cellular_component	proteasome core complex, beta-subunit complex
BS	0034774	cellular_component	secretory granule lumen
BS	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
BS	0051603	biological_process	proteolysis involved in protein catabolic process
BS	0070062	cellular_component	extracellular exosome
BS	1904813	cellular_component	ficolin-1-rich granule lumen
BT	0000502	cellular_component	proteasome complex
BT	0001530	molecular_function	lipopolysaccharide binding
BT	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
BT	0005515	molecular_function	protein binding
BT	0005634	cellular_component	nucleus
BT	0005654	cellular_component	nucleoplasm
BT	0005737	cellular_component	cytoplasm
BT	0005739	cellular_component	mitochondrion
BT	0005829	cellular_component	cytosol
BT	0005839	cellular_component	proteasome core complex
BT	0019774	cellular_component	proteasome core complex, beta-subunit complex
BT	0036064	cellular_component	ciliary basal body
BT	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
BT	0051603	biological_process	proteolysis involved in protein catabolic process
BT	0070062	cellular_component	extracellular exosome
BU	0000502	cellular_component	proteasome complex
BU	0005515	molecular_function	protein binding
BU	0005576	cellular_component	extracellular region
BU	0005634	cellular_component	nucleus
BU	0005654	cellular_component	nucleoplasm
BU	0005829	cellular_component	cytosol
BU	0005838	cellular_component	proteasome regulatory particle
BU	0008540	cellular_component	proteasome regulatory particle, base subcomplex
BU	0016020	cellular_component	membrane
BU	0022624	cellular_component	proteasome accessory complex
BU	0030234	molecular_function	enzyme regulator activity
BU	0031625	molecular_function	ubiquitin protein ligase binding
BU	0034515	cellular_component	proteasome storage granule
BU	0035578	cellular_component	azurophil granule lumen
BU	0042176	biological_process	regulation of protein catabolic process
BU	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
BV	0000502	cellular_component	proteasome complex
BV	0005515	molecular_function	protein binding
BV	0005576	cellular_component	extracellular region
BV	0005634	cellular_component	nucleus
BV	0005654	cellular_component	nucleoplasm
BV	0005829	cellular_component	cytosol
BV	0005838	cellular_component	proteasome regulatory particle
BV	0006511	biological_process	ubiquitin-dependent protein catabolic process
BV	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
BV	0016020	cellular_component	membrane
BV	0022624	cellular_component	proteasome accessory complex
BV	0030234	molecular_function	enzyme regulator activity
BV	0032991	cellular_component	protein-containing complex
BV	0034774	cellular_component	secretory granule lumen
BV	0042176	biological_process	regulation of protein catabolic process
BV	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
BV	0070062	cellular_component	extracellular exosome
BV	1904813	cellular_component	ficolin-1-rich granule lumen
BW	0000502	cellular_component	proteasome complex
BW	0005515	molecular_function	protein binding
BW	0005576	cellular_component	extracellular region
BW	0005654	cellular_component	nucleoplasm
BW	0005737	cellular_component	cytoplasm
BW	0005829	cellular_component	cytosol
BW	0005838	cellular_component	proteasome regulatory particle
BW	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
BW	0016020	cellular_component	membrane
BW	0022624	cellular_component	proteasome accessory complex
BW	0034774	cellular_component	secretory granule lumen
BW	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
BW	0070062	cellular_component	extracellular exosome
BW	1904813	cellular_component	ficolin-1-rich granule lumen
BX	0000502	cellular_component	proteasome complex
BX	0005198	molecular_function	structural molecule activity
BX	0005515	molecular_function	protein binding
BX	0005576	cellular_component	extracellular region
BX	0005634	cellular_component	nucleus
BX	0005654	cellular_component	nucleoplasm
BX	0005737	cellular_component	cytoplasm
BX	0005829	cellular_component	cytosol
BX	0005838	cellular_component	proteasome regulatory particle
BX	0006511	biological_process	ubiquitin-dependent protein catabolic process
BX	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
BX	0016020	cellular_component	membrane
BX	0022624	cellular_component	proteasome accessory complex
BX	0032991	cellular_component	protein-containing complex
BX	0034774	cellular_component	secretory granule lumen
BX	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
BX	0043248	biological_process	proteasome assembly
BX	0048863	biological_process	stem cell differentiation
BX	1904813	cellular_component	ficolin-1-rich granule lumen
BY	0000502	cellular_component	proteasome complex
BY	0005515	molecular_function	protein binding
BY	0005576	cellular_component	extracellular region
BY	0005654	cellular_component	nucleoplasm
BY	0005829	cellular_component	cytosol
BY	0005838	cellular_component	proteasome regulatory particle
BY	0022624	cellular_component	proteasome accessory complex
BY	0034774	cellular_component	secretory granule lumen
BY	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
BY	1904813	cellular_component	ficolin-1-rich granule lumen
BZ	0000502	cellular_component	proteasome complex
BZ	0005515	molecular_function	protein binding
BZ	0005576	cellular_component	extracellular region
BZ	0005634	cellular_component	nucleus
BZ	0005654	cellular_component	nucleoplasm
BZ	0005829	cellular_component	cytosol
BZ	0005838	cellular_component	proteasome regulatory particle
BZ	0008233	molecular_function	peptidase activity
BZ	0008237	molecular_function	metallopeptidase activity
BZ	0016020	cellular_component	membrane
BZ	0034774	cellular_component	secretory granule lumen
BZ	0042803	molecular_function	protein homodimerization activity
BZ	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
BZ	0070062	cellular_component	extracellular exosome
BZ	0140492	molecular_function	metal-dependent deubiquitinase activity
BZ	1904813	cellular_component	ficolin-1-rich granule lumen
Ba	0000502	cellular_component	proteasome complex
Ba	0005198	molecular_function	structural molecule activity
Ba	0005515	molecular_function	protein binding
Ba	0005576	cellular_component	extracellular region
Ba	0005634	cellular_component	nucleus
Ba	0005654	cellular_component	nucleoplasm
Ba	0005829	cellular_component	cytosol
Ba	0005838	cellular_component	proteasome regulatory particle
Ba	0006511	biological_process	ubiquitin-dependent protein catabolic process
Ba	0007127	biological_process	meiosis I
Ba	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
Ba	0016020	cellular_component	membrane
Ba	0022624	cellular_component	proteasome accessory complex
Ba	0034774	cellular_component	secretory granule lumen
Ba	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Ba	1904813	cellular_component	ficolin-1-rich granule lumen
Bb	0000502	cellular_component	proteasome complex
Bb	0003723	molecular_function	RNA binding
Bb	0005515	molecular_function	protein binding
Bb	0005634	cellular_component	nucleus
Bb	0005654	cellular_component	nucleoplasm
Bb	0005829	cellular_component	cytosol
Bb	0008540	cellular_component	proteasome regulatory particle, base subcomplex
Bb	0022624	cellular_component	proteasome accessory complex
Bb	0031593	molecular_function	polyubiquitin modification-dependent protein binding
Bb	0042802	molecular_function	identical protein binding
Bb	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Bb	0060090	molecular_function	molecular adaptor activity
Bc	0000502	cellular_component	proteasome complex
Bc	0000724	biological_process	double-strand break repair via homologous recombination
Bc	0005515	molecular_function	protein binding
Bc	0005576	cellular_component	extracellular region
Bc	0005634	cellular_component	nucleus
Bc	0005654	cellular_component	nucleoplasm
Bc	0005829	cellular_component	cytosol
Bc	0006281	biological_process	DNA repair
Bc	0006303	biological_process	double-strand break repair via nonhomologous end joining
Bc	0006508	biological_process	proteolysis
Bc	0006511	biological_process	ubiquitin-dependent protein catabolic process
Bc	0008233	molecular_function	peptidase activity
Bc	0008237	molecular_function	metallopeptidase activity
Bc	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
Bc	0016579	biological_process	protein deubiquitination
Bc	0022624	cellular_component	proteasome accessory complex
Bc	0031597	cellular_component	cytosolic proteasome complex
Bc	0034774	cellular_component	secretory granule lumen
Bc	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Bc	0045471	biological_process	response to ethanol
Bc	0046872	molecular_function	metal ion binding
Bc	0061133	molecular_function	endopeptidase activator activity
Bc	0061136	biological_process	regulation of proteasomal protein catabolic process
Bc	0061578	molecular_function	K63-linked deubiquitinase activity
Bc	0070536	biological_process	protein K63-linked deubiquitination
Bc	0070628	molecular_function	proteasome binding
Bc	0140492	molecular_function	metal-dependent deubiquitinase activity
Bc	1904813	cellular_component	ficolin-1-rich granule lumen
Bd	0005838	cellular_component	proteasome regulatory particle
Bd	0006508	biological_process	proteolysis
Be	0000502	cellular_component	proteasome complex
Be	0000724	biological_process	double-strand break repair via homologous recombination
Be	0005515	molecular_function	protein binding
Be	0005634	cellular_component	nucleus
Be	0005654	cellular_component	nucleoplasm
Be	0005829	cellular_component	cytosol
Be	0006406	biological_process	mRNA export from nucleus
Be	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
Be	0032039	cellular_component	integrator complex
Be	0032991	cellular_component	protein-containing complex
Be	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Be	0043248	biological_process	proteasome assembly
Bf	0000502	cellular_component	proteasome complex
Bf	0005515	molecular_function	protein binding
Bf	0005576	cellular_component	extracellular region
Bf	0005634	cellular_component	nucleus
Bf	0005654	cellular_component	nucleoplasm
Bf	0005829	cellular_component	cytosol
Bf	0005838	cellular_component	proteasome regulatory particle
Bf	0008540	cellular_component	proteasome regulatory particle, base subcomplex
Bf	0016020	cellular_component	membrane
Bf	0022624	cellular_component	proteasome accessory complex
Bf	0030234	molecular_function	enzyme regulator activity
Bf	0034515	cellular_component	proteasome storage granule
Bf	0034774	cellular_component	secretory granule lumen
Bf	0042176	biological_process	regulation of protein catabolic process
Bf	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Bf	0070062	cellular_component	extracellular exosome
Bf	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN Ac 401

Chain	Residue
Ac	HIS113
Ac	HIS115
Ac	SER123
Ac	ASP126

site_id	AC2
Number of Residues	11
Details	binding site for residue ATP AA 501

Chain	Residue
AA	LYS222
AA	THR223
AA	GLY382
AA	ALA383
AB	ASP317
AB	PRO344
AA	ASP176
AA	GLY178
AA	PRO218
AA	THR220
AA	GLY221

site_id	AC3
Number of Residues	13
Details	binding site for residue ADP AB 501

Chain	Residue
AB	ILE187
AB	GLY229
AB	THR230
AB	GLY231
AB	LYS232
AB	THR233
AB	ASP285
AB	ILE364
AB	SER391
AB	GLY392
AB	ALA393
AC	ASP281
AC	ARG310

site_id	AC4
Number of Residues	14
Details	binding site for residue ATP AD 501

Chain	Residue
AD	ILE167
AD	PRO207
AD	CYS210
AD	GLY211
AD	LYS212
AD	THR213
AD	MET214
AD	ILE344
AD	ASN376
AD	SER377
AE	ASP265
AE	ARG291
AE	GLY293
AE	ARG294

site_id	AC5
Number of Residues	15
Details	binding site for residue ATP AE 401

Chain	Residue
AE	ILE135
AE	PRO175
AE	THR178
AE	GLY179
AE	LYS180
AE	THR181
AE	LEU182
AE	ILE312
AE	ALA341
AE	ARG344
AF	LEU314
AF	ASP318
AF	ALA341
AF	ARG344
AF	ARG347

site_id	AC6
Number of Residues	16
Details	binding site for residue ATP AF 501

Chain	Residue
AA	ASP307
AA	MET332
AF	ILE188
AF	PRO229
AF	GLY230
AF	THR231
AF	GLY232
AF	LYS233
AF	THR234
AF	LEU235
AF	ASP286
AF	ASN333
AF	ILE365
AF	GLY393
AF	ALA394
AF	LYS397

site_id	AC7
Number of Residues	13
Details	binding site for residue ADP AC 501

Chain	Residue
AC	ILE151
AC	GLY152
AC	GLY193
AC	THR194
AC	GLY195
AC	LYS196
AC	THR197
AC	LEU198
AC	GLU250
AC	ILE328
AC	HIS332
AC	GLY356
AC	LYS360

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN Bc 401

Chain	Residue
Bc	HIS113
Bc	HIS115
Bc	SER123
Bc	ASP126

site_id	AC9
Number of Residues	11
Details	binding site for residue ATP BA 501

Chain	Residue
BB	ASP317
BB	PRO344
BA	ASP176
BA	GLY178
BA	PRO218
BA	THR220
BA	GLY221
BA	LYS222
BA	THR223
BA	GLY382
BA	ALA383

site_id	AD1
Number of Residues	13
Details	binding site for residue ADP BB 501

Chain	Residue
BB	ILE187
BB	GLY229
BB	THR230
BB	GLY231
BB	LYS232
BB	THR233
BB	ASP285
BB	ILE364
BB	SER391
BB	GLY392
BB	ALA393
BC	ASP281
BC	ARG310

site_id	AD2
Number of Residues	14
Details	binding site for residue ATP BD 501

Chain	Residue
BD	ILE167
BD	PRO207
BD	CYS210
BD	GLY211
BD	LYS212
BD	THR213
BD	MET214
BD	ILE344
BD	ASN376
BD	SER377
BE	ASP265
BE	ARG291
BE	GLY293
BE	ARG294

site_id	AD3
Number of Residues	15
Details	binding site for residue ATP BE 401

Chain	Residue
BE	ILE135
BE	PRO175
BE	THR178
BE	GLY179
BE	LYS180
BE	THR181
BE	LEU182
BE	ILE312
BE	ALA341
BE	ARG344
BF	LEU314
BF	ASP318
BF	ALA341
BF	ARG344
BF	ARG347

site_id	AD4
Number of Residues	16
Details	binding site for residue ATP BF 501

Chain	Residue
BA	ASP307
BA	MET332
BF	ILE188
BF	PRO229
BF	GLY230
BF	THR231
BF	GLY232
BF	LYS233
BF	THR234
BF	LEU235
BF	ASP286
BF	ASN333
BF	ILE365
BF	GLY393
BF	ALA394
BF	LYS397

site_id	AD5
Number of Residues	13
Details	binding site for residue ADP BC 501

Chain	Residue
BC	ILE151
BC	GLY152
BC	GLY193
BC	THR194
BC	GLY195
BC	LYS196
BC	THR197
BC	LEU198
BC	GLU250
BC	ILE328
BC	HIS332
BC	GLY356
BC	LYS360

Functional Information from PROSITE/UniProt

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdraiTvFSPdGHlfQVEYAqeA

Chain	Residue	Details
BJ	TYR3-ALA25
AH	TYR6-ALA28
BI	TYR5-ALA27
AG	PHE9-ALA31
BL	TYR6-ALA28
BK	TYR8-ALA30
BM	TYR7-ALA29

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. VkVImATNradtLDpALl.R

Chain	Residue	Details
AD	VAL305-ARG323
AB	VAL325-ARG343
AC	ILE289-ARG307
AA	ILE315-ARG333
AE	VAL273-ARG291
AF	VAL326-ARG344

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. AGVvYkdGIVLGADtrategmvvadkncs.KihfispniyccgaGtaAD

Chain	Residue	Details
AO	ALA4-ASP51
AP	MET12-ASP59
AS	LEU13-ASP60
AQ	ILE5-ASP52
AR	LEU4-ASP51
BI	LEU35-ASP82
BN	MET4-ASP51
AT	LEU12-ASP59

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
AT	SER-19
BT	SER-19
AS	SER134
BS	SER34
BS	SER40
BS	SER134

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:15592455

Chain	Residue	Details
AT	TYR57
BT	TYR57
AM	LYS229
BM	LYS56
BM	LYS205
BM	LYS229

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
AS	LYS176
BS	LYS176
BI	LYS127
BI	LYS176
BH	SER14
BH	SER16

site_id	SWS_FT_FI4
Number of Residues	4
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250

Chain	Residue	Details
AS	SER30
AS	SER181
BS	SER30
BS	SER181
BL	LYS208

site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250

Chain	Residue	Details
AK	SER198
BK	SER198
BH	LYS70
BH	LYS171

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
AH	TYR76
BH	TYR76
BD	LYS397
BD	LYS401

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:P17220

Chain	Residue	Details
AH	TYR121
BH	TYR121

site_id	SWS_FT_FI8
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:17370265

Chain	Residue	Details
AB	LYS237
Bf	SER363
BB	LYS237

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:Q8VDM4

Chain	Residue	Details
Af	LYS551
Bf	LYS551

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)