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5T0C

Structural basis for dynamic regulation of the human 26S proteasome

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
Aa0000502cellular_componentproteasome complex
Aa0005198molecular_functionstructural molecule activity
Aa0005515molecular_functionprotein binding
Aa0005576cellular_componentextracellular region
Aa0005634cellular_componentnucleus
Aa0005654cellular_componentnucleoplasm
Aa0005829cellular_componentcytosol
Aa0005838cellular_componentproteasome regulatory particle
Aa0006511biological_processubiquitin-dependent protein catabolic process
Aa0006979biological_processresponse to oxidative stress
Aa0008021cellular_componentsynaptic vesicle
Aa0008541cellular_componentproteasome regulatory particle, lid subcomplex
Aa0010498biological_processproteasomal protein catabolic process
Aa0016020cellular_componentmembrane
Aa0022624cellular_componentproteasome accessory complex
Aa0034774cellular_componentsecretory granule lumen
Aa0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Aa0061136biological_processregulation of proteasomal protein catabolic process
Aa0071357biological_processcellular response to type I interferon
Aa1904813cellular_componentficolin-1-rich granule lumen
AA0000166molecular_functionnucleotide binding
AA0000502cellular_componentproteasome complex
AA0000932cellular_componentP-body
AA0001649biological_processosteoblast differentiation
AA0005515molecular_functionprotein binding
AA0005524molecular_functionATP binding
AA0005576cellular_componentextracellular region
AA0005634cellular_componentnucleus
AA0005654cellular_componentnucleoplasm
AA0005737cellular_componentcytoplasm
AA0005829cellular_componentcytosol
AA0006511biological_processubiquitin-dependent protein catabolic process
AA0006979biological_processresponse to oxidative stress
AA0008021cellular_componentsynaptic vesicle
AA0008540cellular_componentproteasome regulatory particle, base subcomplex
AA0010498biological_processproteasomal protein catabolic process
AA0016020cellular_componentmembrane
AA0016887molecular_functionATP hydrolysis activity
AA0022624cellular_componentproteasome accessory complex
AA0034774cellular_componentsecretory granule lumen
AA0036402molecular_functionproteasome-activating activity
AA0036464cellular_componentcytoplasmic ribonucleoprotein granule
AA0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
AA0061136biological_processregulation of proteasomal protein catabolic process
AA0071357biological_processcellular response to type I interferon
AA1901800biological_processpositive regulation of proteasomal protein catabolic process
AA1904813cellular_componentficolin-1-rich granule lumen
Ab0000502cellular_componentproteasome complex
Ab0003723molecular_functionRNA binding
Ab0005515molecular_functionprotein binding
Ab0005634cellular_componentnucleus
Ab0005829cellular_componentcytosol
Ab0006979biological_processresponse to oxidative stress
Ab0008021cellular_componentsynaptic vesicle
Ab0008540cellular_componentproteasome regulatory particle, base subcomplex
Ab0010498biological_processproteasomal protein catabolic process
Ab0022624cellular_componentproteasome accessory complex
Ab0031593molecular_functionpolyubiquitin modification-dependent protein binding
Ab0042802molecular_functionidentical protein binding
Ab0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Ab0060090molecular_functionmolecular adaptor activity
Ab0061136biological_processregulation of proteasomal protein catabolic process
Ab0071357biological_processcellular response to type I interferon
AB0000166molecular_functionnucleotide binding
AB0000502cellular_componentproteasome complex
AB0003723molecular_functionRNA binding
AB0005515molecular_functionprotein binding
AB0005524molecular_functionATP binding
AB0005634cellular_componentnucleus
AB0005654cellular_componentnucleoplasm
AB0005737cellular_componentcytoplasm
AB0005829cellular_componentcytosol
AB0005838cellular_componentproteasome regulatory particle
AB0006979biological_processresponse to oxidative stress
AB0008021cellular_componentsynaptic vesicle
AB0008540cellular_componentproteasome regulatory particle, base subcomplex
AB0010498biological_processproteasomal protein catabolic process
AB0016020cellular_componentmembrane
AB0016887molecular_functionATP hydrolysis activity
AB0022624cellular_componentproteasome accessory complex
AB0036402molecular_functionproteasome-activating activity
AB0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
AB0061136biological_processregulation of proteasomal protein catabolic process
AB0071357biological_processcellular response to type I interferon
Ac0000502cellular_componentproteasome complex
Ac0000724biological_processdouble-strand break repair via homologous recombination
Ac0004843molecular_functioncysteine-type deubiquitinase activity
Ac0005515molecular_functionprotein binding
Ac0005576cellular_componentextracellular region
Ac0005634cellular_componentnucleus
Ac0005654cellular_componentnucleoplasm
Ac0005829cellular_componentcytosol
Ac0006281biological_processDNA repair
Ac0006303biological_processdouble-strand break repair via nonhomologous end joining
Ac0006508biological_processproteolysis
Ac0006511biological_processubiquitin-dependent protein catabolic process
Ac0006890biological_processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
Ac0006914biological_processautophagy
Ac0006974biological_processDNA damage response
Ac0006979biological_processresponse to oxidative stress
Ac0008021cellular_componentsynaptic vesicle
Ac0008233molecular_functionpeptidase activity
Ac0008234molecular_functioncysteine-type peptidase activity
Ac0008237molecular_functionmetallopeptidase activity
Ac0008541cellular_componentproteasome regulatory particle, lid subcomplex
Ac0010498biological_processproteasomal protein catabolic process
Ac0016192biological_processvesicle-mediated transport
Ac0016241biological_processregulation of macroautophagy
Ac0016579biological_processprotein deubiquitination
Ac0016787molecular_functionhydrolase activity
Ac0022624cellular_componentproteasome accessory complex
Ac0031597cellular_componentcytosolic proteasome complex
Ac0034774cellular_componentsecretory granule lumen
Ac0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Ac0045471biological_processresponse to ethanol
Ac0046872molecular_functionmetal ion binding
Ac0061133molecular_functionendopeptidase activator activity
Ac0061136biological_processregulation of proteasomal protein catabolic process
Ac0061578molecular_functionK63-linked deubiquitinase activity
Ac0070536biological_processprotein K63-linked deubiquitination
Ac0070628molecular_functionproteasome binding
Ac0071357biological_processcellular response to type I interferon
Ac0140492molecular_functionmetal-dependent deubiquitinase activity
Ac1904813cellular_componentficolin-1-rich granule lumen
AC0000166molecular_functionnucleotide binding
AC0000502cellular_componentproteasome complex
AC0005102molecular_functionsignaling receptor binding
AC0005515molecular_functionprotein binding
AC0005524molecular_functionATP binding
AC0005634cellular_componentnucleus
AC0005654cellular_componentnucleoplasm
AC0005737cellular_componentcytoplasm
AC0005829cellular_componentcytosol
AC0005838cellular_componentproteasome regulatory particle
AC0005886cellular_componentplasma membrane
AC0006357biological_processregulation of transcription by RNA polymerase II
AC0006979biological_processresponse to oxidative stress
AC0008021cellular_componentsynaptic vesicle
AC0008134molecular_functiontranscription factor binding
AC0008540cellular_componentproteasome regulatory particle, base subcomplex
AC0010498biological_processproteasomal protein catabolic process
AC0016020cellular_componentmembrane
AC0016234cellular_componentinclusion body
AC0016887molecular_functionATP hydrolysis activity
AC0017025molecular_functionTBP-class protein binding
AC0022624cellular_componentproteasome accessory complex
AC0031410cellular_componentcytoplasmic vesicle
AC0031531molecular_functionthyrotropin-releasing hormone receptor binding
AC0031595cellular_componentnuclear proteasome complex
AC0031597cellular_componentcytosolic proteasome complex
AC0036402molecular_functionproteasome-activating activity
AC0043069biological_processnegative regulation of programmed cell death
AC0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
AC0045893biological_processpositive regulation of DNA-templated transcription
AC0061136biological_processregulation of proteasomal protein catabolic process
AC0070062cellular_componentextracellular exosome
AC0071357biological_processcellular response to type I interferon
AC0072562cellular_componentblood microparticle
AC0090261biological_processpositive regulation of inclusion body assembly
AC0140296molecular_functiongeneral transcription initiation factor binding
AC0140297molecular_functionDNA-binding transcription factor binding
AC1901800biological_processpositive regulation of proteasomal protein catabolic process
Ad0005838cellular_componentproteasome regulatory particle
Ad0006508biological_processproteolysis
AD0000166molecular_functionnucleotide binding
AD0000502cellular_componentproteasome complex
AD0005515molecular_functionprotein binding
AD0005524molecular_functionATP binding
AD0005634cellular_componentnucleus
AD0005654cellular_componentnucleoplasm
AD0005737cellular_componentcytoplasm
AD0005829cellular_componentcytosol
AD0006508biological_processproteolysis
AD0006979biological_processresponse to oxidative stress
AD0008021cellular_componentsynaptic vesicle
AD0008540cellular_componentproteasome regulatory particle, base subcomplex
AD0010498biological_processproteasomal protein catabolic process
AD0016020cellular_componentmembrane
AD0016887molecular_functionATP hydrolysis activity
AD0022624cellular_componentproteasome accessory complex
AD0036402molecular_functionproteasome-activating activity
AD0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
AD0061136biological_processregulation of proteasomal protein catabolic process
AD0071357biological_processcellular response to type I interferon
Ae0000502cellular_componentproteasome complex
Ae0005515molecular_functionprotein binding
Ae0005634cellular_componentnucleus
Ae0005654cellular_componentnucleoplasm
Ae0005829cellular_componentcytosol
Ae0006406biological_processmRNA export from nucleus
Ae0006979biological_processresponse to oxidative stress
Ae0008021cellular_componentsynaptic vesicle
Ae0008541cellular_componentproteasome regulatory particle, lid subcomplex
Ae0010498biological_processproteasomal protein catabolic process
Ae0032039cellular_componentintegrator complex
Ae0032991cellular_componentprotein-containing complex
Ae0043130molecular_functionubiquitin binding
Ae0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Ae0043248biological_processproteasome assembly
Ae0045944biological_processpositive regulation of transcription by RNA polymerase II
Ae0061136biological_processregulation of proteasomal protein catabolic process
Ae0071357biological_processcellular response to type I interferon
AE0000166molecular_functionnucleotide binding
AE0000502cellular_componentproteasome complex
AE0005515molecular_functionprotein binding
AE0005524molecular_functionATP binding
AE0005634cellular_componentnucleus
AE0005654cellular_componentnucleoplasm
AE0005737cellular_componentcytoplasm
AE0005829cellular_componentcytosol
AE0006979biological_processresponse to oxidative stress
AE0008021cellular_componentsynaptic vesicle
AE0008540cellular_componentproteasome regulatory particle, base subcomplex
AE0010498biological_processproteasomal protein catabolic process
AE0016020cellular_componentmembrane
AE0016234cellular_componentinclusion body
AE0016887molecular_functionATP hydrolysis activity
AE0022624cellular_componentproteasome accessory complex
AE0030674molecular_functionprotein-macromolecule adaptor activity
AE0031597cellular_componentcytosolic proteasome complex
AE0036402molecular_functionproteasome-activating activity
AE0036503biological_processERAD pathway
AE0042802molecular_functionidentical protein binding
AE0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
AE0045899biological_processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
AE0061136biological_processregulation of proteasomal protein catabolic process
AE0070062cellular_componentextracellular exosome
AE0071357biological_processcellular response to type I interferon
AE0090261biological_processpositive regulation of inclusion body assembly
AE1901800biological_processpositive regulation of proteasomal protein catabolic process
Af0000502cellular_componentproteasome complex
Af0005515molecular_functionprotein binding
Af0005576cellular_componentextracellular region
Af0005634cellular_componentnucleus
Af0005654cellular_componentnucleoplasm
Af0005829cellular_componentcytosol
Af0005838cellular_componentproteasome regulatory particle
Af0006979biological_processresponse to oxidative stress
Af0008021cellular_componentsynaptic vesicle
Af0008540cellular_componentproteasome regulatory particle, base subcomplex
Af0010498biological_processproteasomal protein catabolic process
Af0016020cellular_componentmembrane
Af0022624cellular_componentproteasome accessory complex
Af0030234molecular_functionenzyme regulator activity
Af0034515cellular_componentproteasome storage granule
Af0034774cellular_componentsecretory granule lumen
Af0042176biological_processregulation of protein catabolic process
Af0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Af0061136biological_processregulation of proteasomal protein catabolic process
Af0070062cellular_componentextracellular exosome
Af0071357biological_processcellular response to type I interferon
Af1904813cellular_componentficolin-1-rich granule lumen
AF0000166molecular_functionnucleotide binding
AF0000502cellular_componentproteasome complex
AF0000932cellular_componentP-body
AF0005515molecular_functionprotein binding
AF0005524molecular_functionATP binding
AF0005576cellular_componentextracellular region
AF0005634cellular_componentnucleus
AF0005654cellular_componentnucleoplasm
AF0005737cellular_componentcytoplasm
AF0005829cellular_componentcytosol
AF0006979biological_processresponse to oxidative stress
AF0008021cellular_componentsynaptic vesicle
AF0008540cellular_componentproteasome regulatory particle, base subcomplex
AF0010498biological_processproteasomal protein catabolic process
AF0016020cellular_componentmembrane
AF0016887molecular_functionATP hydrolysis activity
AF0022624cellular_componentproteasome accessory complex
AF0034774cellular_componentsecretory granule lumen
AF0036402molecular_functionproteasome-activating activity
AF0042802molecular_functionidentical protein binding
AF0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
AF0043921biological_processhost-mediated perturbation of viral transcription
AF0045944biological_processpositive regulation of transcription by RNA polymerase II
AF0061136biological_processregulation of proteasomal protein catabolic process
AF0071357biological_processcellular response to type I interferon
AF1901800biological_processpositive regulation of proteasomal protein catabolic process
AF1904813cellular_componentficolin-1-rich granule lumen
AG0000502cellular_componentproteasome complex
AG0000932cellular_componentP-body
AG0002376biological_processimmune system process
AG0003723molecular_functionRNA binding
AG0004175molecular_functionendopeptidase activity
AG0005515molecular_functionprotein binding
AG0005634cellular_componentnucleus
AG0005654cellular_componentnucleoplasm
AG0005737cellular_componentcytoplasm
AG0005829cellular_componentcytosol
AG0005839cellular_componentproteasome core complex
AG0005840cellular_componentribosome
AG0006281biological_processDNA repair
AG0006511biological_processubiquitin-dependent protein catabolic process
AG0006915biological_processapoptotic process
AG0006974biological_processDNA damage response
AG0006979biological_processresponse to oxidative stress
AG0007283biological_processspermatogenesis
AG0008021cellular_componentsynaptic vesicle
AG0010498biological_processproteasomal protein catabolic process
AG0010499biological_processproteasomal ubiquitin-independent protein catabolic process
AG0016363cellular_componentnuclear matrix
AG0019773cellular_componentproteasome core complex, alpha-subunit complex
AG0030016cellular_componentmyofibril
AG0030017cellular_componentsarcomere
AG0030317biological_processflagellated sperm motility
AG0032729biological_processpositive regulation of type II interferon production
AG0032743biological_processpositive regulation of interleukin-2 production
AG0032760biological_processpositive regulation of tumor necrosis factor production
AG0034341biological_processresponse to type II interferon
AG0034515cellular_componentproteasome storage granule
AG0035639molecular_functionpurine ribonucleoside triphosphate binding
AG0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
AG0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
AG0043374biological_processCD8-positive, alpha-beta T cell differentiation
AG0045061biological_processthymic T cell selection
AG0045063biological_processT-helper 1 cell differentiation
AG0045590biological_processnegative regulation of regulatory T cell differentiation
AG0050727biological_processregulation of inflammatory response
AG0051059molecular_functionNF-kappaB binding
AG0051321biological_processmeiotic cell cycle
AG0051603biological_processproteolysis involved in protein catabolic process
AG0061136biological_processregulation of proteasomal protein catabolic process
AG0070062cellular_componentextracellular exosome
AG0071357biological_processcellular response to type I interferon
AG0072539biological_processT-helper 17 cell differentiation
AG0097229cellular_componentsperm end piece
AG0097542cellular_componentciliary tip
AG0160165biological_processCD8-positive, alpha-beta T cell homeostasis
AG2000045biological_processregulation of G1/S transition of mitotic cell cycle
AH0000502cellular_componentproteasome complex
AH0000932cellular_componentP-body
AH0002376biological_processimmune system process
AH0005515molecular_functionprotein binding
AH0005576cellular_componentextracellular region
AH0005634cellular_componentnucleus
AH0005654cellular_componentnucleoplasm
AH0005737cellular_componentcytoplasm
AH0005829cellular_componentcytosol
AH0005839cellular_componentproteasome core complex
AH0006281biological_processDNA repair
AH0006511biological_processubiquitin-dependent protein catabolic process
AH0006915biological_processapoptotic process
AH0006974biological_processDNA damage response
AH0006979biological_processresponse to oxidative stress
AH0007283biological_processspermatogenesis
AH0008021cellular_componentsynaptic vesicle
AH0009615biological_processresponse to virus
AH0010498biological_processproteasomal protein catabolic process
AH0010499biological_processproteasomal ubiquitin-independent protein catabolic process
AH0019773cellular_componentproteasome core complex, alpha-subunit complex
AH0030317biological_processflagellated sperm motility
AH0032729biological_processpositive regulation of type II interferon production
AH0032743biological_processpositive regulation of interleukin-2 production
AH0032760biological_processpositive regulation of tumor necrosis factor production
AH0034341biological_processresponse to type II interferon
AH0034515cellular_componentproteasome storage granule
AH0034774cellular_componentsecretory granule lumen
AH0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
AH0043374biological_processCD8-positive, alpha-beta T cell differentiation
AH0045061biological_processthymic T cell selection
AH0045063biological_processT-helper 1 cell differentiation
AH0045590biological_processnegative regulation of regulatory T cell differentiation
AH0051321biological_processmeiotic cell cycle
AH0051603biological_processproteolysis involved in protein catabolic process
AH0061136biological_processregulation of proteasomal protein catabolic process
AH0070062cellular_componentextracellular exosome
AH0071357biological_processcellular response to type I interferon
AH0072539biological_processT-helper 17 cell differentiation
AH0160165biological_processCD8-positive, alpha-beta T cell homeostasis
AH1904813cellular_componentficolin-1-rich granule lumen
AH2000045biological_processregulation of G1/S transition of mitotic cell cycle
AI0000502cellular_componentproteasome complex
AI0000932cellular_componentP-body
AI0002376biological_processimmune system process
AI0005515molecular_functionprotein binding
AI0005634cellular_componentnucleus
AI0005654cellular_componentnucleoplasm
AI0005737cellular_componentcytoplasm
AI0005829cellular_componentcytosol
AI0005839cellular_componentproteasome core complex
AI0006281biological_processDNA repair
AI0006511biological_processubiquitin-dependent protein catabolic process
AI0006915biological_processapoptotic process
AI0006974biological_processDNA damage response
AI0006979biological_processresponse to oxidative stress
AI0007283biological_processspermatogenesis
AI0008021cellular_componentsynaptic vesicle
AI0010498biological_processproteasomal protein catabolic process
AI0010499biological_processproteasomal ubiquitin-independent protein catabolic process
AI0019773cellular_componentproteasome core complex, alpha-subunit complex
AI0030317biological_processflagellated sperm motility
AI0032729biological_processpositive regulation of type II interferon production
AI0032743biological_processpositive regulation of interleukin-2 production
AI0032760biological_processpositive regulation of tumor necrosis factor production
AI0034341biological_processresponse to type II interferon
AI0034515cellular_componentproteasome storage granule
AI0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
AI0043374biological_processCD8-positive, alpha-beta T cell differentiation
AI0045061biological_processthymic T cell selection
AI0045063biological_processT-helper 1 cell differentiation
AI0045590biological_processnegative regulation of regulatory T cell differentiation
AI0051321biological_processmeiotic cell cycle
AI0051603biological_processproteolysis involved in protein catabolic process
AI0061136biological_processregulation of proteasomal protein catabolic process
AI0070062cellular_componentextracellular exosome
AI0071357biological_processcellular response to type I interferon
AI0072539biological_processT-helper 17 cell differentiation
AI0160165biological_processCD8-positive, alpha-beta T cell homeostasis
AI2000045biological_processregulation of G1/S transition of mitotic cell cycle
AJ0000502cellular_componentproteasome complex
AJ0002376biological_processimmune system process
AJ0005515molecular_functionprotein binding
AJ0005634cellular_componentnucleus
AJ0005654cellular_componentnucleoplasm
AJ0005737cellular_componentcytoplasm
AJ0005829cellular_componentcytosol
AJ0005839cellular_componentproteasome core complex
AJ0006281biological_processDNA repair
AJ0006511biological_processubiquitin-dependent protein catabolic process
AJ0006915biological_processapoptotic process
AJ0006974biological_processDNA damage response
AJ0006979biological_processresponse to oxidative stress
AJ0008021cellular_componentsynaptic vesicle
AJ0010498biological_processproteasomal protein catabolic process
AJ0010499biological_processproteasomal ubiquitin-independent protein catabolic process
AJ0019773cellular_componentproteasome core complex, alpha-subunit complex
AJ0030317biological_processflagellated sperm motility
AJ0032729biological_processpositive regulation of type II interferon production
AJ0032743biological_processpositive regulation of interleukin-2 production
AJ0032760biological_processpositive regulation of tumor necrosis factor production
AJ0034341biological_processresponse to type II interferon
AJ0034515cellular_componentproteasome storage granule
AJ0042802molecular_functionidentical protein binding
AJ0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
AJ0043374biological_processCD8-positive, alpha-beta T cell differentiation
AJ0045061biological_processthymic T cell selection
AJ0045063biological_processT-helper 1 cell differentiation
AJ0045590biological_processnegative regulation of regulatory T cell differentiation
AJ0051603biological_processproteolysis involved in protein catabolic process
AJ0061136biological_processregulation of proteasomal protein catabolic process
AJ0070062cellular_componentextracellular exosome
AJ0071357biological_processcellular response to type I interferon
AJ0072539biological_processT-helper 17 cell differentiation
AJ0160165biological_processCD8-positive, alpha-beta T cell homeostasis
AJ2000045biological_processregulation of G1/S transition of mitotic cell cycle
AK0000502cellular_componentproteasome complex
AK0002376biological_processimmune system process
AK0005515molecular_functionprotein binding
AK0005576cellular_componentextracellular region
AK0005634cellular_componentnucleus
AK0005654cellular_componentnucleoplasm
AK0005737cellular_componentcytoplasm
AK0005829cellular_componentcytosol
AK0005839cellular_componentproteasome core complex
AK0006281biological_processDNA repair
AK0006511biological_processubiquitin-dependent protein catabolic process
AK0006915biological_processapoptotic process
AK0006974biological_processDNA damage response
AK0006979biological_processresponse to oxidative stress
AK0007283biological_processspermatogenesis
AK0008021cellular_componentsynaptic vesicle
AK0010498biological_processproteasomal protein catabolic process
AK0010499biological_processproteasomal ubiquitin-independent protein catabolic process
AK0019773cellular_componentproteasome core complex, alpha-subunit complex
AK0030317biological_processflagellated sperm motility
AK0032729biological_processpositive regulation of type II interferon production
AK0032743biological_processpositive regulation of interleukin-2 production
AK0032760biological_processpositive regulation of tumor necrosis factor production
AK0034341biological_processresponse to type II interferon
AK0034515cellular_componentproteasome storage granule
AK0034774cellular_componentsecretory granule lumen
AK0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
AK0043374biological_processCD8-positive, alpha-beta T cell differentiation
AK0045061biological_processthymic T cell selection
AK0045063biological_processT-helper 1 cell differentiation
AK0045590biological_processnegative regulation of regulatory T cell differentiation
AK0051321biological_processmeiotic cell cycle
AK0051603biological_processproteolysis involved in protein catabolic process
AK0061136biological_processregulation of proteasomal protein catabolic process
AK0070062cellular_componentextracellular exosome
AK0071357biological_processcellular response to type I interferon
AK0072539biological_processT-helper 17 cell differentiation
AK0160165biological_processCD8-positive, alpha-beta T cell homeostasis
AK1904813cellular_componentficolin-1-rich granule lumen
AK2000045biological_processregulation of G1/S transition of mitotic cell cycle
AL0000502cellular_componentproteasome complex
AL0001530molecular_functionlipopolysaccharide binding
AL0002376biological_processimmune system process
AL0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
AL0005515molecular_functionprotein binding
AL0005634cellular_componentnucleus
AL0005654cellular_componentnucleoplasm
AL0005737cellular_componentcytoplasm
AL0005829cellular_componentcytosol
AL0005839cellular_componentproteasome core complex
AL0006281biological_processDNA repair
AL0006511biological_processubiquitin-dependent protein catabolic process
AL0006915biological_processapoptotic process
AL0006974biological_processDNA damage response
AL0006979biological_processresponse to oxidative stress
AL0007283biological_processspermatogenesis
AL0008021cellular_componentsynaptic vesicle
AL0010498biological_processproteasomal protein catabolic process
AL0010499biological_processproteasomal ubiquitin-independent protein catabolic process
AL0016604cellular_componentnuclear body
AL0019773cellular_componentproteasome core complex, alpha-subunit complex
AL0030317biological_processflagellated sperm motility
AL0032729biological_processpositive regulation of type II interferon production
AL0032743biological_processpositive regulation of interleukin-2 production
AL0032760biological_processpositive regulation of tumor necrosis factor production
AL0034341biological_processresponse to type II interferon
AL0034515cellular_componentproteasome storage granule
AL0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
AL0043374biological_processCD8-positive, alpha-beta T cell differentiation
AL0045061biological_processthymic T cell selection
AL0045063biological_processT-helper 1 cell differentiation
AL0045590biological_processnegative regulation of regulatory T cell differentiation
AL0051321biological_processmeiotic cell cycle
AL0051603biological_processproteolysis involved in protein catabolic process
AL0061136biological_processregulation of proteasomal protein catabolic process
AL0070062cellular_componentextracellular exosome
AL0071357biological_processcellular response to type I interferon
AL0072539biological_processT-helper 17 cell differentiation
AL0160165biological_processCD8-positive, alpha-beta T cell homeostasis
AL2000045biological_processregulation of G1/S transition of mitotic cell cycle
AM0000502cellular_componentproteasome complex
AM0002376biological_processimmune system process
AM0005515molecular_functionprotein binding
AM0005634cellular_componentnucleus
AM0005654cellular_componentnucleoplasm
AM0005737cellular_componentcytoplasm
AM0005829cellular_componentcytosol
AM0005839cellular_componentproteasome core complex
AM0006281biological_processDNA repair
AM0006511biological_processubiquitin-dependent protein catabolic process
AM0006915biological_processapoptotic process
AM0006974biological_processDNA damage response
AM0006979biological_processresponse to oxidative stress
AM0007283biological_processspermatogenesis
AM0008021cellular_componentsynaptic vesicle
AM0010498biological_processproteasomal protein catabolic process
AM0010499biological_processproteasomal ubiquitin-independent protein catabolic process
AM0019773cellular_componentproteasome core complex, alpha-subunit complex
AM0030317biological_processflagellated sperm motility
AM0031625molecular_functionubiquitin protein ligase binding
AM0032729biological_processpositive regulation of type II interferon production
AM0032743biological_processpositive regulation of interleukin-2 production
AM0032760biological_processpositive regulation of tumor necrosis factor production
AM0034341biological_processresponse to type II interferon
AM0034515cellular_componentproteasome storage granule
AM0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
AM0043374biological_processCD8-positive, alpha-beta T cell differentiation
AM0045061biological_processthymic T cell selection
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AM0051321biological_processmeiotic cell cycle
AM0051603biological_processproteolysis involved in protein catabolic process
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AO0005829cellular_componentcytosol
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AO0006508biological_processproteolysis
AO0006915biological_processapoptotic process
AO0006974biological_processDNA damage response
AO0006979biological_processresponse to oxidative stress
AO0007283biological_processspermatogenesis
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AP0000502cellular_componentproteasome complex
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AP0005737cellular_componentcytoplasm
AP0005829cellular_componentcytosol
AP0005839cellular_componentproteasome core complex
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AP0006915biological_processapoptotic process
AP0006974biological_processDNA damage response
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AP0007283biological_processspermatogenesis
AP0008021cellular_componentsynaptic vesicle
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AP0019774cellular_componentproteasome core complex, beta-subunit complex
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AP0032743biological_processpositive regulation of interleukin-2 production
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AP0034341biological_processresponse to type II interferon
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AP0045061biological_processthymic T cell selection
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AP0070062cellular_componentextracellular exosome
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AW0008021cellular_componentsynaptic vesicle
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AX0008021cellular_componentsynaptic vesicle
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AX0048863biological_processstem cell differentiation
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AY0005829cellular_componentcytosol
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Ba0008021cellular_componentsynaptic vesicle
Ba0008541cellular_componentproteasome regulatory particle, lid subcomplex
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Ba1904813cellular_componentficolin-1-rich granule lumen
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BA0000502cellular_componentproteasome complex
BA0000932cellular_componentP-body
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BA0005524molecular_functionATP binding
BA0005576cellular_componentextracellular region
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BA0005654cellular_componentnucleoplasm
BA0005737cellular_componentcytoplasm
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BA0008021cellular_componentsynaptic vesicle
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BA0016020cellular_componentmembrane
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BA0022624cellular_componentproteasome accessory complex
BA0034774cellular_componentsecretory granule lumen
BA0036402molecular_functionproteasome-activating activity
BA0036464cellular_componentcytoplasmic ribonucleoprotein granule
BA0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
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BA0071357biological_processcellular response to type I interferon
BA1901800biological_processpositive regulation of proteasomal protein catabolic process
BA1904813cellular_componentficolin-1-rich granule lumen
Bb0000502cellular_componentproteasome complex
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Bb0005515molecular_functionprotein binding
Bb0005634cellular_componentnucleus
Bb0005829cellular_componentcytosol
Bb0006979biological_processresponse to oxidative stress
Bb0008021cellular_componentsynaptic vesicle
Bb0008540cellular_componentproteasome regulatory particle, base subcomplex
Bb0010498biological_processproteasomal protein catabolic process
Bb0022624cellular_componentproteasome accessory complex
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Bb0071357biological_processcellular response to type I interferon
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BB0000502cellular_componentproteasome complex
BB0003723molecular_functionRNA binding
BB0005515molecular_functionprotein binding
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BB0005634cellular_componentnucleus
BB0005654cellular_componentnucleoplasm
BB0005737cellular_componentcytoplasm
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BB0008021cellular_componentsynaptic vesicle
BB0008540cellular_componentproteasome regulatory particle, base subcomplex
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BB0016020cellular_componentmembrane
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BB0061136biological_processregulation of proteasomal protein catabolic process
BB0071357biological_processcellular response to type I interferon
Bc0000502cellular_componentproteasome complex
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Bc0005634cellular_componentnucleus
Bc0005654cellular_componentnucleoplasm
Bc0005829cellular_componentcytosol
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Bc0006303biological_processdouble-strand break repair via nonhomologous end joining
Bc0006508biological_processproteolysis
Bc0006511biological_processubiquitin-dependent protein catabolic process
Bc0006890biological_processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
Bc0006914biological_processautophagy
Bc0006974biological_processDNA damage response
Bc0006979biological_processresponse to oxidative stress
Bc0008021cellular_componentsynaptic vesicle
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Bc0008237molecular_functionmetallopeptidase activity
Bc0008541cellular_componentproteasome regulatory particle, lid subcomplex
Bc0010498biological_processproteasomal protein catabolic process
Bc0016192biological_processvesicle-mediated transport
Bc0016241biological_processregulation of macroautophagy
Bc0016579biological_processprotein deubiquitination
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Bc0022624cellular_componentproteasome accessory complex
Bc0031597cellular_componentcytosolic proteasome complex
Bc0034774cellular_componentsecretory granule lumen
Bc0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Bc0045471biological_processresponse to ethanol
Bc0046872molecular_functionmetal ion binding
Bc0061133molecular_functionendopeptidase activator activity
Bc0061136biological_processregulation of proteasomal protein catabolic process
Bc0061578molecular_functionK63-linked deubiquitinase activity
Bc0070536biological_processprotein K63-linked deubiquitination
Bc0070628molecular_functionproteasome binding
Bc0071357biological_processcellular response to type I interferon
Bc0140492molecular_functionmetal-dependent deubiquitinase activity
Bc1904813cellular_componentficolin-1-rich granule lumen
BC0000166molecular_functionnucleotide binding
BC0000502cellular_componentproteasome complex
BC0005102molecular_functionsignaling receptor binding
BC0005515molecular_functionprotein binding
BC0005524molecular_functionATP binding
BC0005634cellular_componentnucleus
BC0005654cellular_componentnucleoplasm
BC0005737cellular_componentcytoplasm
BC0005829cellular_componentcytosol
BC0005838cellular_componentproteasome regulatory particle
BC0005886cellular_componentplasma membrane
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BC0006979biological_processresponse to oxidative stress
BC0008021cellular_componentsynaptic vesicle
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BC0008540cellular_componentproteasome regulatory particle, base subcomplex
BC0010498biological_processproteasomal protein catabolic process
BC0016020cellular_componentmembrane
BC0016234cellular_componentinclusion body
BC0016887molecular_functionATP hydrolysis activity
BC0017025molecular_functionTBP-class protein binding
BC0022624cellular_componentproteasome accessory complex
BC0031410cellular_componentcytoplasmic vesicle
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BC0031595cellular_componentnuclear proteasome complex
BC0031597cellular_componentcytosolic proteasome complex
BC0036402molecular_functionproteasome-activating activity
BC0043069biological_processnegative regulation of programmed cell death
BC0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
BC0045893biological_processpositive regulation of DNA-templated transcription
BC0061136biological_processregulation of proteasomal protein catabolic process
BC0070062cellular_componentextracellular exosome
BC0071357biological_processcellular response to type I interferon
BC0072562cellular_componentblood microparticle
BC0090261biological_processpositive regulation of inclusion body assembly
BC0140296molecular_functiongeneral transcription initiation factor binding
BC0140297molecular_functionDNA-binding transcription factor binding
BC1901800biological_processpositive regulation of proteasomal protein catabolic process
Bd0005838cellular_componentproteasome regulatory particle
Bd0006508biological_processproteolysis
BD0000166molecular_functionnucleotide binding
BD0000502cellular_componentproteasome complex
BD0005515molecular_functionprotein binding
BD0005524molecular_functionATP binding
BD0005634cellular_componentnucleus
BD0005654cellular_componentnucleoplasm
BD0005737cellular_componentcytoplasm
BD0005829cellular_componentcytosol
BD0006508biological_processproteolysis
BD0006979biological_processresponse to oxidative stress
BD0008021cellular_componentsynaptic vesicle
BD0008540cellular_componentproteasome regulatory particle, base subcomplex
BD0010498biological_processproteasomal protein catabolic process
BD0016020cellular_componentmembrane
BD0016887molecular_functionATP hydrolysis activity
BD0022624cellular_componentproteasome accessory complex
BD0036402molecular_functionproteasome-activating activity
BD0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
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BR0061136biological_processregulation of proteasomal protein catabolic process
BR0070062cellular_componentextracellular exosome
BR0071357biological_processcellular response to type I interferon
BR2000045biological_processregulation of G1/S transition of mitotic cell cycle
BS0000502cellular_componentproteasome complex
BS0002376biological_processimmune system process
BS0005515molecular_functionprotein binding
BS0005576cellular_componentextracellular region
BS0005634cellular_componentnucleus
BS0005654cellular_componentnucleoplasm
BS0005737cellular_componentcytoplasm
BS0005829cellular_componentcytosol
BS0005839cellular_componentproteasome core complex
BS0006281biological_processDNA repair
BS0006915biological_processapoptotic process
BS0006974biological_processDNA damage response
BS0006979biological_processresponse to oxidative stress
BS0007283biological_processspermatogenesis
BS0008021cellular_componentsynaptic vesicle
BS0010498biological_processproteasomal protein catabolic process
BS0010499biological_processproteasomal ubiquitin-independent protein catabolic process
BS0019774cellular_componentproteasome core complex, beta-subunit complex
BS0030317biological_processflagellated sperm motility
BS0032729biological_processpositive regulation of type II interferon production
BS0032743biological_processpositive regulation of interleukin-2 production
BS0032760biological_processpositive regulation of tumor necrosis factor production
BS0034341biological_processresponse to type II interferon
BS0034515cellular_componentproteasome storage granule
BS0034774cellular_componentsecretory granule lumen
BS0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
BS0043374biological_processCD8-positive, alpha-beta T cell differentiation
BS0045061biological_processthymic T cell selection
BS0045063biological_processT-helper 1 cell differentiation
BS0045590biological_processnegative regulation of regulatory T cell differentiation
BS0051321biological_processmeiotic cell cycle
BS0051603biological_processproteolysis involved in protein catabolic process
BS0061136biological_processregulation of proteasomal protein catabolic process
BS0070062cellular_componentextracellular exosome
BS0071357biological_processcellular response to type I interferon
BS0072539biological_processT-helper 17 cell differentiation
BS0160165biological_processCD8-positive, alpha-beta T cell homeostasis
BS1904813cellular_componentficolin-1-rich granule lumen
BS2000045biological_processregulation of G1/S transition of mitotic cell cycle
BT0000502cellular_componentproteasome complex
BT0001530molecular_functionlipopolysaccharide binding
BT0002376biological_processimmune system process
BT0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
BT0005515molecular_functionprotein binding
BT0005634cellular_componentnucleus
BT0005654cellular_componentnucleoplasm
BT0005737cellular_componentcytoplasm
BT0005829cellular_componentcytosol
BT0005839cellular_componentproteasome core complex
BT0006281biological_processDNA repair
BT0006915biological_processapoptotic process
BT0006974biological_processDNA damage response
BT0006979biological_processresponse to oxidative stress
BT0007283biological_processspermatogenesis
BT0008021cellular_componentsynaptic vesicle
BT0010498biological_processproteasomal protein catabolic process
BT0010499biological_processproteasomal ubiquitin-independent protein catabolic process
BT0019774cellular_componentproteasome core complex, beta-subunit complex
BT0030317biological_processflagellated sperm motility
BT0032729biological_processpositive regulation of type II interferon production
BT0032743biological_processpositive regulation of interleukin-2 production
BT0032760biological_processpositive regulation of tumor necrosis factor production
BT0034341biological_processresponse to type II interferon
BT0034515cellular_componentproteasome storage granule
BT0036064cellular_componentciliary basal body
BT0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
BT0043374biological_processCD8-positive, alpha-beta T cell differentiation
BT0045061biological_processthymic T cell selection
BT0045063biological_processT-helper 1 cell differentiation
BT0045590biological_processnegative regulation of regulatory T cell differentiation
BT0051321biological_processmeiotic cell cycle
BT0051603biological_processproteolysis involved in protein catabolic process
BT0061136biological_processregulation of proteasomal protein catabolic process
BT0070062cellular_componentextracellular exosome
BT0071357biological_processcellular response to type I interferon
BT0072539biological_processT-helper 17 cell differentiation
BT0160165biological_processCD8-positive, alpha-beta T cell homeostasis
BT2000045biological_processregulation of G1/S transition of mitotic cell cycle
BU0000502cellular_componentproteasome complex
BU0005515molecular_functionprotein binding
BU0005576cellular_componentextracellular region
BU0005634cellular_componentnucleus
BU0005654cellular_componentnucleoplasm
BU0005829cellular_componentcytosol
BU0005838cellular_componentproteasome regulatory particle
BU0006979biological_processresponse to oxidative stress
BU0008021cellular_componentsynaptic vesicle
BU0008540cellular_componentproteasome regulatory particle, base subcomplex
BU0010498biological_processproteasomal protein catabolic process
BU0016020cellular_componentmembrane
BU0022624cellular_componentproteasome accessory complex
BU0030234molecular_functionenzyme regulator activity
BU0031625molecular_functionubiquitin protein ligase binding
BU0034515cellular_componentproteasome storage granule
BU0035578cellular_componentazurophil granule lumen
BU0042176biological_processregulation of protein catabolic process
BU0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
BU0061136biological_processregulation of proteasomal protein catabolic process
BU0071357biological_processcellular response to type I interferon
BV0000502cellular_componentproteasome complex
BV0005515molecular_functionprotein binding
BV0005576cellular_componentextracellular region
BV0005634cellular_componentnucleus
BV0005654cellular_componentnucleoplasm
BV0005829cellular_componentcytosol
BV0005838cellular_componentproteasome regulatory particle
BV0006511biological_processubiquitin-dependent protein catabolic process
BV0006979biological_processresponse to oxidative stress
BV0008021cellular_componentsynaptic vesicle
BV0008541cellular_componentproteasome regulatory particle, lid subcomplex
BV0010498biological_processproteasomal protein catabolic process
BV0016020cellular_componentmembrane
BV0022624cellular_componentproteasome accessory complex
BV0030234molecular_functionenzyme regulator activity
BV0034774cellular_componentsecretory granule lumen
BV0042176biological_processregulation of protein catabolic process
BV0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
BV0061136biological_processregulation of proteasomal protein catabolic process
BV0070062cellular_componentextracellular exosome
BV0071357biological_processcellular response to type I interferon
BV1904813cellular_componentficolin-1-rich granule lumen
BW0000502cellular_componentproteasome complex
BW0005515molecular_functionprotein binding
BW0005576cellular_componentextracellular region
BW0005654cellular_componentnucleoplasm
BW0005737cellular_componentcytoplasm
BW0005829cellular_componentcytosol
BW0005838cellular_componentproteasome regulatory particle
BW0006979biological_processresponse to oxidative stress
BW0008021cellular_componentsynaptic vesicle
BW0008541cellular_componentproteasome regulatory particle, lid subcomplex
BW0010498biological_processproteasomal protein catabolic process
BW0016020cellular_componentmembrane
BW0022624cellular_componentproteasome accessory complex
BW0034774cellular_componentsecretory granule lumen
BW0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
BW0061136biological_processregulation of proteasomal protein catabolic process
BW0070062cellular_componentextracellular exosome
BW0071357biological_processcellular response to type I interferon
BW1904813cellular_componentficolin-1-rich granule lumen
BX0000502cellular_componentproteasome complex
BX0005198molecular_functionstructural molecule activity
BX0005515molecular_functionprotein binding
BX0005576cellular_componentextracellular region
BX0005634cellular_componentnucleus
BX0005654cellular_componentnucleoplasm
BX0005829cellular_componentcytosol
BX0005838cellular_componentproteasome regulatory particle
BX0006511biological_processubiquitin-dependent protein catabolic process
BX0006979biological_processresponse to oxidative stress
BX0008021cellular_componentsynaptic vesicle
BX0008541cellular_componentproteasome regulatory particle, lid subcomplex
BX0010498biological_processproteasomal protein catabolic process
BX0016020cellular_componentmembrane
BX0022624cellular_componentproteasome accessory complex
BX0032991cellular_componentprotein-containing complex
BX0034774cellular_componentsecretory granule lumen
BX0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
BX0043248biological_processproteasome assembly
BX0048863biological_processstem cell differentiation
BX0061136biological_processregulation of proteasomal protein catabolic process
BX0071357biological_processcellular response to type I interferon
BX1904813cellular_componentficolin-1-rich granule lumen
BY0000502cellular_componentproteasome complex
BY0005515molecular_functionprotein binding
BY0005576cellular_componentextracellular region
BY0005654cellular_componentnucleoplasm
BY0005829cellular_componentcytosol
BY0005838cellular_componentproteasome regulatory particle
BY0006979biological_processresponse to oxidative stress
BY0008021cellular_componentsynaptic vesicle
BY0010498biological_processproteasomal protein catabolic process
BY0022624cellular_componentproteasome accessory complex
BY0032991cellular_componentprotein-containing complex
BY0034774cellular_componentsecretory granule lumen
BY0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
BY0061136biological_processregulation of proteasomal protein catabolic process
BY0071357biological_processcellular response to type I interferon
BY1904813cellular_componentficolin-1-rich granule lumen
BZ0000502cellular_componentproteasome complex
BZ0005515molecular_functionprotein binding
BZ0005576cellular_componentextracellular region
BZ0005634cellular_componentnucleus
BZ0005654cellular_componentnucleoplasm
BZ0005829cellular_componentcytosol
BZ0005838cellular_componentproteasome regulatory particle
BZ0006979biological_processresponse to oxidative stress
BZ0008021cellular_componentsynaptic vesicle
BZ0008233molecular_functionpeptidase activity
BZ0008237molecular_functionmetallopeptidase activity
BZ0010498biological_processproteasomal protein catabolic process
BZ0016020cellular_componentmembrane
BZ0034774cellular_componentsecretory granule lumen
BZ0042803molecular_functionprotein homodimerization activity
BZ0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
BZ0061136biological_processregulation of proteasomal protein catabolic process
BZ0070062cellular_componentextracellular exosome
BZ0071357biological_processcellular response to type I interferon
BZ0140492molecular_functionmetal-dependent deubiquitinase activity
BZ1904813cellular_componentficolin-1-rich granule lumen
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN Ac 401
ChainResidue
AcHIS113
AcHIS115
AcSER123
AcASP126

site_idAC2
Number of Residues11
Detailsbinding site for residue ATP AA 501
ChainResidue
AALYS222
AATHR223
AAGLY382
AAALA383
ABASP317
ABPRO344
AAASP176
AAGLY178
AAPRO218
AATHR220
AAGLY221

site_idAC3
Number of Residues13
Detailsbinding site for residue ADP AB 501
ChainResidue
ABILE187
ABGLY229
ABTHR230
ABGLY231
ABLYS232
ABTHR233
ABASP285
ABILE364
ABSER391
ABGLY392
ABALA393
ACASP281
ACARG310

site_idAC4
Number of Residues14
Detailsbinding site for residue ATP AD 501
ChainResidue
ADILE167
ADPRO207
ADCYS210
ADGLY211
ADLYS212
ADTHR213
ADMET214
ADILE344
ADASN376
ADSER377
AEASP265
AEARG291
AEGLY293
AEARG294

site_idAC5
Number of Residues15
Detailsbinding site for residue ATP AE 401
ChainResidue
AEILE135
AEPRO175
AETHR178
AEGLY179
AELYS180
AETHR181
AELEU182
AEILE312
AEALA341
AEARG344
AFLEU314
AFASP318
AFALA341
AFARG344
AFARG347

site_idAC6
Number of Residues16
Detailsbinding site for residue ATP AF 501
ChainResidue
AAASP307
AAMET332
AFILE188
AFPRO229
AFGLY230
AFTHR231
AFGLY232
AFLYS233
AFTHR234
AFLEU235
AFASP286
AFASN333
AFILE365
AFGLY393
AFALA394
AFLYS397

site_idAC7
Number of Residues13
Detailsbinding site for residue ADP AC 501
ChainResidue
ACILE151
ACGLY152
ACGLY193
ACTHR194
ACGLY195
ACLYS196
ACTHR197
ACLEU198
ACGLU250
ACILE328
ACHIS332
ACGLY356
ACLYS360

site_idAC8
Number of Residues4
Detailsbinding site for residue ZN Bc 401
ChainResidue
BcHIS113
BcHIS115
BcSER123
BcASP126

site_idAC9
Number of Residues11
Detailsbinding site for residue ATP BA 501
ChainResidue
BBASP317
BBPRO344
BAASP176
BAGLY178
BAPRO218
BATHR220
BAGLY221
BALYS222
BATHR223
BAGLY382
BAALA383

site_idAD1
Number of Residues13
Detailsbinding site for residue ADP BB 501
ChainResidue
BBILE187
BBGLY229
BBTHR230
BBGLY231
BBLYS232
BBTHR233
BBASP285
BBILE364
BBSER391
BBGLY392
BBALA393
BCASP281
BCARG310

site_idAD2
Number of Residues14
Detailsbinding site for residue ATP BD 501
ChainResidue
BDILE167
BDPRO207
BDCYS210
BDGLY211
BDLYS212
BDTHR213
BDMET214
BDILE344
BDASN376
BDSER377
BEASP265
BEARG291
BEGLY293
BEARG294

site_idAD3
Number of Residues15
Detailsbinding site for residue ATP BE 401
ChainResidue
BEILE135
BEPRO175
BETHR178
BEGLY179
BELYS180
BETHR181
BELEU182
BEILE312
BEALA341
BEARG344
BFLEU314
BFASP318
BFALA341
BFARG344
BFARG347

site_idAD4
Number of Residues16
Detailsbinding site for residue ATP BF 501
ChainResidue
BAASP307
BAMET332
BFILE188
BFPRO229
BFGLY230
BFTHR231
BFGLY232
BFLYS233
BFTHR234
BFLEU235
BFASP286
BFASN333
BFILE365
BFGLY393
BFALA394
BFLYS397

site_idAD5
Number of Residues13
Detailsbinding site for residue ADP BC 501
ChainResidue
BCILE151
BCGLY152
BCGLY193
BCTHR194
BCGLY195
BCLYS196
BCTHR197
BCLEU198
BCGLU250
BCILE328
BCHIS332
BCGLY356
BCLYS360

Functional Information from PROSITE/UniProt
site_idPS00388
Number of Residues23
DetailsPROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdrgvNtFSPeGRlfQVEYAieA
ChainResidueDetails
BKTYR8-ALA30
BJTYR3-ALA25
AGPHE9-ALA31
BMTYR7-ALA29
AHTYR6-ALA28
BITYR5-ALA27
BLTYR6-ALA28

site_idPS00674
Number of Residues19
DetailsAAA AAA-protein family signature. VkVImATNrietLDpALi.R
ChainResidueDetails
ABVAL325-ARG343
ADVAL305-ARG323
AFVAL326-ARG344
AEVAL273-ARG291
AAILE315-ARG333
ACILE289-ARG307

site_idPS00854
Number of Residues48
DetailsPROTEASOME_BETA_1 Proteasome beta-type subunits signature. LAIaGedFAIVASDtrlsegfsihtrdsp.KcykltdktvigcsGfhGD
ChainResidueDetails
ASLEU13-ASP60
AOALA4-ASP51
ATLEU12-ASP59
AQILE5-ASP52
APMET12-ASP59
BILEU35-ASP82
ARLEU4-ASP51
BNMET4-ASP51

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues132
DetailsRepeat: {"description":"PC 1"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues138
DetailsRepeat: {"description":"PC 2"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues136
DetailsRepeat: {"description":"PC 3"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues136
DetailsRepeat: {"description":"PC 4"}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues124
DetailsRepeat: {"description":"PC 5"}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues132
DetailsRepeat: {"description":"PC 6"}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues94
DetailsRepeat: {"description":"PC 7"}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues68
DetailsRepeat: {"description":"PC 8"}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues80
DetailsRepeat: {"description":"PC 9"}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues64
DetailsRepeat: {"description":"PC 10"}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q3TXS7","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues2058
DetailsDomain: {"description":"PCI","evidences":[{"source":"PROSITE-ProRule","id":"PRU01185","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues34
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI15
Number of Residues2
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"12665801","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI16
Number of Residues50
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI17
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI18
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI19
Number of Residues540
DetailsDomain: {"description":"MPN","evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI20
Number of Residues10
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"}
ChainResidueDetails

site_idSWS_FT_FI21
Number of Residues366
DetailsDomain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI22
Number of Residues8
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI23
Number of Residues26
DetailsMotif: {"description":"JAMM motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI24
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI25
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17693683","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI26
Number of Residues6
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI27
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI28
Number of Residues44
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails

site_idSWS_FT_FI29
Number of Residues40
DetailsCompositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails

site_idSWS_FT_FI30
Number of Residues2
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"UniProtKB","id":"Q8VDM4","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI31
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI32
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI33
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI34
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q8VDM4","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI35
Number of Residues84
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI36
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"17370265","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI37
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9QUM9","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI38
Number of Residues10
DetailsGlycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI39
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P49722","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI40
Number of Residues4
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI41
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI42
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P17220","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI43
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI44
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine; by ABL1 and ABL2","evidences":[{"source":"PubMed","id":"16678104","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI45
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI46
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI47
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI48
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; alternate","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI49
Number of Residues2
DetailsGlycosylation: {"description":"O-linked (GlcNAc) serine; alternate","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI50
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI51
Number of Residues6
DetailsActive site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"25599644","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27493187","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI52
Number of Residues2
DetailsModified residue: {"description":"N-acetylserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","von Kriegsheim A.F.","Kolch W."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI53
Number of Residues2
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI54
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"18502982","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18565852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19426847","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI55
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"O09061","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

247947

PDB entries from 2026-01-21

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