5T04

STRUCTURE OF CONSTITUTIVELY ACTIVE NEUROTENSIN RECEPTOR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0004930	molecular_function	G protein-coupled receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0009253	biological_process	peptidoglycan catabolic process
A	0016020	cellular_component	membrane
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016998	biological_process	cell wall macromolecule catabolic process
A	0030430	cellular_component	host cell cytoplasm
A	0031640	biological_process	killing of cells of another organism
A	0042742	biological_process	defense response to bacterium
A	0044659	biological_process	viral release from host cell by cytolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue TCE A 1201

Chain	Residue
A	MET1106
A	GLY1113
A	PHE1114
A	LYS1135
A	SER1136
A	ARG1137
A	TRP1138

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site_id	AC2
Number of Residues	2
Details	binding site for residue GOL A 1202

Chain	Residue
A	ARG143
A	PHE206

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site_id	AC3
Number of Residues	2
Details	binding site for residue PEG A 1203

Chain	Residue
A	PHE342
A	PHE346

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site_id	AC4
Number of Residues	2
Details	binding site for residue PEG A 1204

Chain	Residue
A	ASP60
A	TYR349

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Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ATAlNVASLSVERYLaI

Chain	Residue	Details
A	ALA155-ILE171

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Cleavage; by MME => ECO:0000250|UniProtKB:P30990

Chain	Residue	Details
B	PRO10

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Cleavage; by ACE and MME => ECO:0000250|UniProtKB:P30990

Chain	Residue	Details
B	TYR11
A	GLU166-ARG185

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site_id	SWS_FT_FI3
Number of Residues	19
Details	TRANSMEM: Helical; Name=2

Chain	Residue	Details
A	TYR104-VAL123

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site_id	SWS_FT_FI4
Number of Residues	64
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:24453215

Chain	Residue	Details
A	GLU124-ARG143
A	THR207-LYS235
A	PHE331-HIS348

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site_id	SWS_FT_FI5
Number of Residues	21
Details	TRANSMEM: Helical; Name=3

Chain	Residue	Details
A	GLY144-VAL165

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site_id	SWS_FT_FI6
Number of Residues	20
Details	TRANSMEM: Helical; Name=4

Chain	Residue	Details
A	THR186-PHE206

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site_id	SWS_FT_FI7
Number of Residues	24
Details	TRANSMEM: Helical; Name=5

Chain	Residue	Details
A	VAL236-ILE260

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site_id	SWS_FT_FI8
Number of Residues	21
Details	TRANSMEM: Helical; Name=6

Chain	Residue	Details
A	VAL309-MET330

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site_id	SWS_FT_FI9
Number of Residues	20
Details	TRANSMEM: Helical; Name=7

Chain	Residue	Details
A	TYR349-TYR369

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site_id	SWS_FT_FI10
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:P30989

Chain	Residue	Details
A	CYS386
A	CYS388

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site_id	SWS_FT_FI11
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098

Chain	Residue	Details
A	GLU1011

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site_id	SWS_FT_FI12
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098

Chain	Residue	Details
A	ASP1020

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site_id	SWS_FT_FI13
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:8266098

Chain	Residue	Details
A	LEU1032
A	PHE1104

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	BINDING: BINDING => ECO:0000303|PubMed:7831309

Chain	Residue	Details
A	SER1117
A	ASN1132

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 921

Chain	Residue	Details
A	GLU1011	proton shuttle (general acid/base)
A	ASP1020	covalent catalysis

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