Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5SWZ

Crystal Structure of NP1-B17 TCR-H2Db-NP complex

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0001913	biological_process	T cell mediated cytotoxicity
B	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
B	0002237	biological_process	response to molecule of bacterial origin
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005765	cellular_component	lysosomal membrane
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0006968	biological_process	cellular defense response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0010977	biological_process	negative regulation of neuron projection development
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0023026	molecular_function	MHC class II protein complex binding
B	0030670	cellular_component	phagocytic vesicle membrane
B	0031902	cellular_component	late endosome membrane
B	0033077	biological_process	T cell differentiation in thymus
B	0034756	biological_process	regulation of iron ion transport
B	0042026	biological_process	protein refolding
B	0042605	molecular_function	peptide antigen binding
B	0042612	cellular_component	MHC class I protein complex
B	0042613	cellular_component	MHC class II protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0045646	biological_process	regulation of erythrocyte differentiation
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0050778	biological_process	positive regulation of immune response
B	0050870	biological_process	positive regulation of T cell activation
B	0051289	biological_process	protein homotetramerization
B	0060586	biological_process	multicellular organismal-level iron ion homeostasis
B	0071281	biological_process	cellular response to iron ion
B	0071283	biological_process	cellular response to iron(III) ion
B	0071316	biological_process	cellular response to nicotine
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
G	0001913	biological_process	T cell mediated cytotoxicity
G	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
G	0002237	biological_process	response to molecule of bacterial origin
G	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
G	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
G	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
G	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
G	0002726	biological_process	positive regulation of T cell cytokine production
G	0005198	molecular_function	structural molecule activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005765	cellular_component	lysosomal membrane
G	0005794	cellular_component	Golgi apparatus
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006826	biological_process	iron ion transport
G	0006879	biological_process	intracellular iron ion homeostasis
G	0006955	biological_process	immune response
G	0006968	biological_process	cellular defense response
G	0007608	biological_process	sensory perception of smell
G	0007611	biological_process	learning or memory
G	0009897	cellular_component	external side of plasma membrane
G	0010977	biological_process	negative regulation of neuron projection development
G	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
G	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
G	0023026	molecular_function	MHC class II protein complex binding
G	0030670	cellular_component	phagocytic vesicle membrane
G	0031902	cellular_component	late endosome membrane
G	0033077	biological_process	T cell differentiation in thymus
G	0034756	biological_process	regulation of iron ion transport
G	0042026	biological_process	protein refolding
G	0042605	molecular_function	peptide antigen binding
G	0042612	cellular_component	MHC class I protein complex
G	0042613	cellular_component	MHC class II protein complex
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0042824	cellular_component	MHC class I peptide loading complex
G	0045646	biological_process	regulation of erythrocyte differentiation
G	0048260	biological_process	positive regulation of receptor-mediated endocytosis
G	0050680	biological_process	negative regulation of epithelial cell proliferation
G	0050768	biological_process	negative regulation of neurogenesis
G	0050778	biological_process	positive regulation of immune response
G	0050870	biological_process	positive regulation of T cell activation
G	0051289	biological_process	protein homotetramerization
G	0060586	biological_process	multicellular organismal-level iron ion homeostasis
G	0071281	biological_process	cellular response to iron ion
G	0071283	biological_process	cellular response to iron(III) ion
G	0071316	biological_process	cellular response to nicotine
G	1990000	biological_process	amyloid fibril formation
G	1990712	cellular_component	HFE-transferrin receptor complex
G	2000774	biological_process	positive regulation of cellular senescence
G	2000978	biological_process	negative regulation of forebrain neuron differentiation
L	0001913	biological_process	T cell mediated cytotoxicity
L	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
L	0002237	biological_process	response to molecule of bacterial origin
L	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
L	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
L	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
L	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
L	0002726	biological_process	positive regulation of T cell cytokine production
L	0005198	molecular_function	structural molecule activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005765	cellular_component	lysosomal membrane
L	0005794	cellular_component	Golgi apparatus
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0006826	biological_process	iron ion transport
L	0006879	biological_process	intracellular iron ion homeostasis
L	0006955	biological_process	immune response
L	0006968	biological_process	cellular defense response
L	0007608	biological_process	sensory perception of smell
L	0007611	biological_process	learning or memory
L	0009897	cellular_component	external side of plasma membrane
L	0010977	biological_process	negative regulation of neuron projection development
L	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
L	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
L	0023026	molecular_function	MHC class II protein complex binding
L	0030670	cellular_component	phagocytic vesicle membrane
L	0031902	cellular_component	late endosome membrane
L	0033077	biological_process	T cell differentiation in thymus
L	0034756	biological_process	regulation of iron ion transport
L	0042026	biological_process	protein refolding
L	0042605	molecular_function	peptide antigen binding
L	0042612	cellular_component	MHC class I protein complex
L	0042613	cellular_component	MHC class II protein complex
L	0042802	molecular_function	identical protein binding
L	0042803	molecular_function	protein homodimerization activity
L	0042824	cellular_component	MHC class I peptide loading complex
L	0045646	biological_process	regulation of erythrocyte differentiation
L	0048260	biological_process	positive regulation of receptor-mediated endocytosis
L	0050680	biological_process	negative regulation of epithelial cell proliferation
L	0050768	biological_process	negative regulation of neurogenesis
L	0050778	biological_process	positive regulation of immune response
L	0050870	biological_process	positive regulation of T cell activation
L	0051289	biological_process	protein homotetramerization
L	0060586	biological_process	multicellular organismal-level iron ion homeostasis
L	0071281	biological_process	cellular response to iron ion
L	0071283	biological_process	cellular response to iron(III) ion
L	0071316	biological_process	cellular response to nicotine
L	1990000	biological_process	amyloid fibril formation
L	1990712	cellular_component	HFE-transferrin receptor complex
L	2000774	biological_process	positive regulation of cellular senescence
L	2000978	biological_process	negative regulation of forebrain neuron differentiation
Q	0001913	biological_process	T cell mediated cytotoxicity
Q	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
Q	0002237	biological_process	response to molecule of bacterial origin
Q	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
Q	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
Q	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
Q	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
Q	0002726	biological_process	positive regulation of T cell cytokine production
Q	0005198	molecular_function	structural molecule activity
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005615	cellular_component	extracellular space
Q	0005765	cellular_component	lysosomal membrane
Q	0005794	cellular_component	Golgi apparatus
Q	0005829	cellular_component	cytosol
Q	0005886	cellular_component	plasma membrane
Q	0006826	biological_process	iron ion transport
Q	0006879	biological_process	intracellular iron ion homeostasis
Q	0006955	biological_process	immune response
Q	0006968	biological_process	cellular defense response
Q	0007608	biological_process	sensory perception of smell
Q	0007611	biological_process	learning or memory
Q	0009897	cellular_component	external side of plasma membrane
Q	0010977	biological_process	negative regulation of neuron projection development
Q	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
Q	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
Q	0023026	molecular_function	MHC class II protein complex binding
Q	0030670	cellular_component	phagocytic vesicle membrane
Q	0031902	cellular_component	late endosome membrane
Q	0033077	biological_process	T cell differentiation in thymus
Q	0034756	biological_process	regulation of iron ion transport
Q	0042026	biological_process	protein refolding
Q	0042605	molecular_function	peptide antigen binding
Q	0042612	cellular_component	MHC class I protein complex
Q	0042613	cellular_component	MHC class II protein complex
Q	0042802	molecular_function	identical protein binding
Q	0042803	molecular_function	protein homodimerization activity
Q	0042824	cellular_component	MHC class I peptide loading complex
Q	0045646	biological_process	regulation of erythrocyte differentiation
Q	0048260	biological_process	positive regulation of receptor-mediated endocytosis
Q	0050680	biological_process	negative regulation of epithelial cell proliferation
Q	0050768	biological_process	negative regulation of neurogenesis
Q	0050778	biological_process	positive regulation of immune response
Q	0050870	biological_process	positive regulation of T cell activation
Q	0051289	biological_process	protein homotetramerization
Q	0060586	biological_process	multicellular organismal-level iron ion homeostasis
Q	0071281	biological_process	cellular response to iron ion
Q	0071283	biological_process	cellular response to iron(III) ion
Q	0071316	biological_process	cellular response to nicotine
Q	1990000	biological_process	amyloid fibril formation
Q	1990712	cellular_component	HFE-transferrin receptor complex
Q	2000774	biological_process	positive regulation of cellular senescence
Q	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue SO4 D 301

Chain	Residue
A	GLU58
D	GLN43
D	PHE76
D	ASP98

site_id	AC2
Number of Residues	2
Details	binding site for residue SO4 E 301

Chain	Residue
E	ASP109
E	LEU110

site_id	AC3
Number of Residues	5
Details	binding site for residue NA E 302

Chain	Residue
E	GLY111
E	ASP113
E	TYR40
E	SER107
E	ASP109

site_id	AC4
Number of Residues	4
Details	binding site for residue NA I 301

Chain	Residue
I	GLN1
L	HIS34
L	GLU36
L	LYS83

site_id	AC5
Number of Residues	5
Details	binding site for residue NA J 301

Chain	Residue
J	TYR40
J	SER107
J	ASP109
J	LEU110
J	GLY111

site_id	AC6
Number of Residues	2
Details	binding site for residue SO4 K 301

Chain	Residue
K	GLU19
K	GLU71

site_id	AC7
Number of Residues	4
Details	binding site for residue NA K 302

Chain	Residue
K	LYS253
K	GLU254
K	ASN256
K	TYR257

site_id	AC8
Number of Residues	4
Details	binding site for residue SO4 O 301

Chain	Residue
K	GLN72
O	TYR57
O	ASP109
O	LEU110

site_id	AC9
Number of Residues	4
Details	binding site for residue SO4 T 301

Chain	Residue
J	HIS219
J	ALA251
T	GLN223
T	HOH421

site_id	AD1
Number of Residues	5
Details	binding site for residue NA T 302

Chain	Residue
T	TYR40
T	SER107
T	ASP109
T	GLY111
T	ASP113

site_id	AD2
Number of Residues	2
Details	binding site for residue NA T 303

Chain	Residue
P	HOH338
T	LEU110

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVKH

Chain	Residue	Details
B	TYR78-HIS84
A	TYR257-HIS263

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:3980466, ECO:0000269\|PubMed:7118212

Chain	Residue	Details
A	ASN86
F	ASN86
K	ASN86
P	ASN86

site_id	SWS_FT_FI2
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305

Chain	Residue	Details
A	ASN176
F	ASN176
K	ASN176
P	ASN176

site_id	SWS_FT_FI3
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:3980466

Chain	Residue	Details
A	ASN256
F	ASN256
K	ASN256
P	ASN256

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)