5SVA

Mediator-RNA Polymerase II Pre-Initiation Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0001055	molecular_function	RNA polymerase II activity
A	0001172	biological_process	RNA-templated transcription
A	0003677	molecular_function	DNA binding
A	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
A	0003968	molecular_function	RNA-dependent RNA polymerase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005665	cellular_component	RNA polymerase II, core complex
A	0005739	cellular_component	mitochondrion
A	0006351	biological_process	DNA-templated transcription
A	0006366	biological_process	transcription by RNA polymerase II
A	0006367	biological_process	transcription initiation at RNA polymerase II promoter
A	0006368	biological_process	transcription elongation by RNA polymerase II
A	0008270	molecular_function	zinc ion binding
A	0010494	cellular_component	cytoplasmic stress granule
A	0016779	molecular_function	nucleotidyltransferase activity
A	0019985	biological_process	translesion synthesis
A	0034062	molecular_function	5'-3' RNA polymerase activity
A	0046872	molecular_function	metal ion binding
B	0000428	cellular_component	DNA-directed RNA polymerase complex
B	0001055	molecular_function	RNA polymerase II activity
B	0001172	biological_process	RNA-templated transcription
B	0003677	molecular_function	DNA binding
B	0003729	molecular_function	mRNA binding
B	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
B	0003968	molecular_function	RNA-dependent RNA polymerase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005665	cellular_component	RNA polymerase II, core complex
B	0005739	cellular_component	mitochondrion
B	0006351	biological_process	DNA-templated transcription
B	0006366	biological_process	transcription by RNA polymerase II
B	0006367	biological_process	transcription initiation at RNA polymerase II promoter
B	0006368	biological_process	transcription elongation by RNA polymerase II
B	0008270	molecular_function	zinc ion binding
B	0010494	cellular_component	cytoplasmic stress granule
B	0016779	molecular_function	nucleotidyltransferase activity
B	0032549	molecular_function	ribonucleoside binding
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0046872	molecular_function	metal ion binding
C	0000428	cellular_component	DNA-directed RNA polymerase complex
C	0001055	molecular_function	RNA polymerase II activity
C	0001172	biological_process	RNA-templated transcription
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
C	0003968	molecular_function	RNA-dependent RNA polymerase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005665	cellular_component	RNA polymerase II, core complex
C	0006351	biological_process	DNA-templated transcription
C	0006366	biological_process	transcription by RNA polymerase II
C	0006367	biological_process	transcription initiation at RNA polymerase II promoter
C	0006368	biological_process	transcription elongation by RNA polymerase II
C	0006369	biological_process	termination of RNA polymerase II transcription
C	0008270	molecular_function	zinc ion binding
C	0046872	molecular_function	metal ion binding
C	0046983	molecular_function	protein dimerization activity
C	0055029	cellular_component	nuclear DNA-directed RNA polymerase complex
D	0000166	molecular_function	nucleotide binding
D	0000288	biological_process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
D	0000428	cellular_component	DNA-directed RNA polymerase complex
D	0000932	cellular_component	P-body
D	0001172	biological_process	RNA-templated transcription
D	0003697	molecular_function	single-stranded DNA binding
D	0003727	molecular_function	single-stranded RNA binding
D	0003968	molecular_function	RNA-dependent RNA polymerase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005665	cellular_component	RNA polymerase II, core complex
D	0005737	cellular_component	cytoplasm
D	0006352	biological_process	DNA-templated transcription initiation
D	0006366	biological_process	transcription by RNA polymerase II
D	0006367	biological_process	transcription initiation at RNA polymerase II promoter
D	0006368	biological_process	transcription elongation by RNA polymerase II
D	0006397	biological_process	mRNA processing
D	0030880	cellular_component	RNA polymerase complex
D	0031369	molecular_function	translation initiation factor binding
D	0044237	biological_process	cellular metabolic process
D	0045948	biological_process	positive regulation of translational initiation
D	1990328	cellular_component	RPB4-RPB7 complex
E	0000428	cellular_component	DNA-directed RNA polymerase complex
E	0001054	molecular_function	RNA polymerase I activity
E	0001055	molecular_function	RNA polymerase II activity
E	0001056	molecular_function	RNA polymerase III activity
E	0001172	biological_process	RNA-templated transcription
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
E	0003968	molecular_function	RNA-dependent RNA polymerase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005665	cellular_component	RNA polymerase II, core complex
E	0005666	cellular_component	RNA polymerase III complex
E	0005736	cellular_component	RNA polymerase I complex
E	0006351	biological_process	DNA-templated transcription
E	0006360	biological_process	transcription by RNA polymerase I
E	0006361	biological_process	transcription initiation at RNA polymerase I promoter
E	0006362	biological_process	transcription elongation by RNA polymerase I
E	0006363	biological_process	termination of RNA polymerase I transcription
E	0006366	biological_process	transcription by RNA polymerase II
E	0006367	biological_process	transcription initiation at RNA polymerase II promoter
E	0006368	biological_process	transcription elongation by RNA polymerase II
E	0006383	biological_process	transcription by RNA polymerase III
E	0006384	biological_process	transcription initiation at RNA polymerase III promoter
E	0006386	biological_process	termination of RNA polymerase III transcription
E	0042254	biological_process	ribosome biogenesis
E	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
E	0042797	biological_process	tRNA transcription by RNA polymerase III
F	0000428	cellular_component	DNA-directed RNA polymerase complex
F	0001054	molecular_function	RNA polymerase I activity
F	0001055	molecular_function	RNA polymerase II activity
F	0001056	molecular_function	RNA polymerase III activity
F	0001172	biological_process	RNA-templated transcription
F	0003677	molecular_function	DNA binding
F	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
F	0003968	molecular_function	RNA-dependent RNA polymerase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005665	cellular_component	RNA polymerase II, core complex
F	0005666	cellular_component	RNA polymerase III complex
F	0005736	cellular_component	RNA polymerase I complex
F	0005737	cellular_component	cytoplasm
F	0006351	biological_process	DNA-templated transcription
F	0006360	biological_process	transcription by RNA polymerase I
F	0006361	biological_process	transcription initiation at RNA polymerase I promoter
F	0006362	biological_process	transcription elongation by RNA polymerase I
F	0006363	biological_process	termination of RNA polymerase I transcription
F	0006366	biological_process	transcription by RNA polymerase II
F	0006367	biological_process	transcription initiation at RNA polymerase II promoter
F	0006368	biological_process	transcription elongation by RNA polymerase II
F	0006383	biological_process	transcription by RNA polymerase III
F	0006384	biological_process	transcription initiation at RNA polymerase III promoter
F	0006386	biological_process	termination of RNA polymerase III transcription
F	0042254	biological_process	ribosome biogenesis
F	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
F	0042797	biological_process	tRNA transcription by RNA polymerase III
G	0000288	biological_process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
G	0000428	cellular_component	DNA-directed RNA polymerase complex
G	0000932	cellular_component	P-body
G	0000956	biological_process	nuclear-transcribed mRNA catabolic process
G	0001172	biological_process	RNA-templated transcription
G	0003676	molecular_function	nucleic acid binding
G	0003697	molecular_function	single-stranded DNA binding
G	0003727	molecular_function	single-stranded RNA binding
G	0003968	molecular_function	RNA-dependent RNA polymerase activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005665	cellular_component	RNA polymerase II, core complex
G	0005737	cellular_component	cytoplasm
G	0006351	biological_process	DNA-templated transcription
G	0006352	biological_process	DNA-templated transcription initiation
G	0006366	biological_process	transcription by RNA polymerase II
G	0006367	biological_process	transcription initiation at RNA polymerase II promoter
G	0006368	biological_process	transcription elongation by RNA polymerase II
G	0031369	molecular_function	translation initiation factor binding
G	0045948	biological_process	positive regulation of translational initiation
G	0055029	cellular_component	nuclear DNA-directed RNA polymerase complex
G	0060213	biological_process	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
G	1990328	cellular_component	RPB4-RPB7 complex
H	0000428	cellular_component	DNA-directed RNA polymerase complex
H	0001054	molecular_function	RNA polymerase I activity
H	0001055	molecular_function	RNA polymerase II activity
H	0001056	molecular_function	RNA polymerase III activity
H	0001172	biological_process	RNA-templated transcription
H	0003677	molecular_function	DNA binding
H	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
H	0003968	molecular_function	RNA-dependent RNA polymerase activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005665	cellular_component	RNA polymerase II, core complex
H	0005666	cellular_component	RNA polymerase III complex
H	0005736	cellular_component	RNA polymerase I complex
H	0006351	biological_process	DNA-templated transcription
H	0006360	biological_process	transcription by RNA polymerase I
H	0006361	biological_process	transcription initiation at RNA polymerase I promoter
H	0006362	biological_process	transcription elongation by RNA polymerase I
H	0006363	biological_process	termination of RNA polymerase I transcription
H	0006366	biological_process	transcription by RNA polymerase II
H	0006367	biological_process	transcription initiation at RNA polymerase II promoter
H	0006368	biological_process	transcription elongation by RNA polymerase II
H	0006383	biological_process	transcription by RNA polymerase III
H	0006384	biological_process	transcription initiation at RNA polymerase III promoter
H	0006386	biological_process	termination of RNA polymerase III transcription
H	0042254	biological_process	ribosome biogenesis
H	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
H	0042797	biological_process	tRNA transcription by RNA polymerase III
I	0000428	cellular_component	DNA-directed RNA polymerase complex
I	0001172	biological_process	RNA-templated transcription
I	0001193	biological_process	maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
I	0003676	molecular_function	nucleic acid binding
I	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
I	0003968	molecular_function	RNA-dependent RNA polymerase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005665	cellular_component	RNA polymerase II, core complex
I	0005730	cellular_component	nucleolus
I	0006281	biological_process	DNA repair
I	0006283	biological_process	transcription-coupled nucleotide-excision repair
I	0006351	biological_process	DNA-templated transcription
I	0006366	biological_process	transcription by RNA polymerase II
I	0006367	biological_process	transcription initiation at RNA polymerase II promoter
I	0006368	biological_process	transcription elongation by RNA polymerase II
I	0008270	molecular_function	zinc ion binding
I	0046872	molecular_function	metal ion binding
I	0055029	cellular_component	nuclear DNA-directed RNA polymerase complex
J	0000428	cellular_component	DNA-directed RNA polymerase complex
J	0001054	molecular_function	RNA polymerase I activity
J	0001055	molecular_function	RNA polymerase II activity
J	0001056	molecular_function	RNA polymerase III activity
J	0001172	biological_process	RNA-templated transcription
J	0003677	molecular_function	DNA binding
J	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
J	0003968	molecular_function	RNA-dependent RNA polymerase activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005665	cellular_component	RNA polymerase II, core complex
J	0005666	cellular_component	RNA polymerase III complex
J	0005730	cellular_component	nucleolus
J	0005736	cellular_component	RNA polymerase I complex
J	0006351	biological_process	DNA-templated transcription
J	0006360	biological_process	transcription by RNA polymerase I
J	0006361	biological_process	transcription initiation at RNA polymerase I promoter
J	0006362	biological_process	transcription elongation by RNA polymerase I
J	0006363	biological_process	termination of RNA polymerase I transcription
J	0006366	biological_process	transcription by RNA polymerase II
J	0006367	biological_process	transcription initiation at RNA polymerase II promoter
J	0006368	biological_process	transcription elongation by RNA polymerase II
J	0006383	biological_process	transcription by RNA polymerase III
J	0006384	biological_process	transcription initiation at RNA polymerase III promoter
J	0006386	biological_process	termination of RNA polymerase III transcription
J	0008270	molecular_function	zinc ion binding
J	0042254	biological_process	ribosome biogenesis
J	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
J	0042797	biological_process	tRNA transcription by RNA polymerase III
J	0046872	molecular_function	metal ion binding
K	0000428	cellular_component	DNA-directed RNA polymerase complex
K	0001055	molecular_function	RNA polymerase II activity
K	0001172	biological_process	RNA-templated transcription
K	0003677	molecular_function	DNA binding
K	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
K	0003968	molecular_function	RNA-dependent RNA polymerase activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005665	cellular_component	RNA polymerase II, core complex
K	0006351	biological_process	DNA-templated transcription
K	0006366	biological_process	transcription by RNA polymerase II
K	0006367	biological_process	transcription initiation at RNA polymerase II promoter
K	0006368	biological_process	transcription elongation by RNA polymerase II
K	0006369	biological_process	termination of RNA polymerase II transcription
K	0046983	molecular_function	protein dimerization activity
L	0000428	cellular_component	DNA-directed RNA polymerase complex
L	0001054	molecular_function	RNA polymerase I activity
L	0001055	molecular_function	RNA polymerase II activity
L	0001056	molecular_function	RNA polymerase III activity
L	0001172	biological_process	RNA-templated transcription
L	0003677	molecular_function	DNA binding
L	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
L	0003968	molecular_function	RNA-dependent RNA polymerase activity
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005665	cellular_component	RNA polymerase II, core complex
L	0005666	cellular_component	RNA polymerase III complex
L	0005730	cellular_component	nucleolus
L	0005736	cellular_component	RNA polymerase I complex
L	0005737	cellular_component	cytoplasm
L	0005777	cellular_component	peroxisome
L	0006351	biological_process	DNA-templated transcription
L	0006360	biological_process	transcription by RNA polymerase I
L	0006361	biological_process	transcription initiation at RNA polymerase I promoter
L	0006362	biological_process	transcription elongation by RNA polymerase I
L	0006363	biological_process	termination of RNA polymerase I transcription
L	0006366	biological_process	transcription by RNA polymerase II
L	0006367	biological_process	transcription initiation at RNA polymerase II promoter
L	0006368	biological_process	transcription elongation by RNA polymerase II
L	0006383	biological_process	transcription by RNA polymerase III
L	0006384	biological_process	transcription initiation at RNA polymerase III promoter
L	0006386	biological_process	termination of RNA polymerase III transcription
L	0008270	molecular_function	zinc ion binding
L	0042254	biological_process	ribosome biogenesis
L	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
L	0042797	biological_process	tRNA transcription by RNA polymerase III
L	0046872	molecular_function	metal ion binding
M	0003712	molecular_function	transcription coregulator activity
M	0003713	molecular_function	transcription coactivator activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0006357	biological_process	regulation of transcription by RNA polymerase II
M	0016592	cellular_component	mediator complex
M	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
M	0045944	biological_process	positive regulation of transcription by RNA polymerase II
M	0051123	biological_process	RNA polymerase II preinitiation complex assembly
M	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
M	0070847	cellular_component	core mediator complex
N	0000122	biological_process	negative regulation of transcription by RNA polymerase II
N	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
N	0003677	molecular_function	DNA binding
N	0003712	molecular_function	transcription coregulator activity
N	0003714	molecular_function	transcription corepressor activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0006357	biological_process	regulation of transcription by RNA polymerase II
N	0016592	cellular_component	mediator complex
N	0017025	molecular_function	TBP-class protein binding
N	0030674	molecular_function	protein-macromolecule adaptor activity
N	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
N	0045944	biological_process	positive regulation of transcription by RNA polymerase II
N	0051123	biological_process	RNA polymerase II preinitiation complex assembly
N	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
N	0070847	cellular_component	core mediator complex
O	0000122	biological_process	negative regulation of transcription by RNA polymerase II
O	0001097	molecular_function	TFIIH-class transcription factor complex binding
O	0003712	molecular_function	transcription coregulator activity
O	0003713	molecular_function	transcription coactivator activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0006357	biological_process	regulation of transcription by RNA polymerase II
O	0016592	cellular_component	mediator complex
O	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
O	0045944	biological_process	positive regulation of transcription by RNA polymerase II
O	0051123	biological_process	RNA polymerase II preinitiation complex assembly
O	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
O	0070847	cellular_component	core mediator complex
P	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
P	0001139	molecular_function	RNA polymerase II complex recruiting activity
P	0003712	molecular_function	transcription coregulator activity
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0006357	biological_process	regulation of transcription by RNA polymerase II
P	0006367	biological_process	transcription initiation at RNA polymerase II promoter
P	0016592	cellular_component	mediator complex
P	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
P	0034605	biological_process	cellular response to heat
P	0045944	biological_process	positive regulation of transcription by RNA polymerase II
P	0051123	biological_process	RNA polymerase II preinitiation complex assembly
P	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
P	0070847	cellular_component	core mediator complex
P	0140297	molecular_function	DNA-binding transcription factor binding
Q	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
Q	0001113	biological_process	transcription open complex formation at RNA polymerase II promoter
Q	0003712	molecular_function	transcription coregulator activity
Q	0003713	molecular_function	transcription coactivator activity
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0006357	biological_process	regulation of transcription by RNA polymerase II
Q	0006369	biological_process	termination of RNA polymerase II transcription
Q	0016592	cellular_component	mediator complex
Q	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
Q	0034605	biological_process	cellular response to heat
Q	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Q	0051123	biological_process	RNA polymerase II preinitiation complex assembly
Q	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
Q	0070847	cellular_component	core mediator complex
R	0001094	molecular_function	TFIID-class transcription factor complex binding
R	0003712	molecular_function	transcription coregulator activity
R	0003713	molecular_function	transcription coactivator activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0006357	biological_process	regulation of transcription by RNA polymerase II
R	0010688	biological_process	negative regulation of ribosomal protein gene transcription by RNA polymerase II
R	0016592	cellular_component	mediator complex
R	0019904	molecular_function	protein domain specific binding
R	0031669	biological_process	cellular response to nutrient levels
R	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
R	0032991	cellular_component	protein-containing complex
R	0045944	biological_process	positive regulation of transcription by RNA polymerase II
R	0051123	biological_process	RNA polymerase II preinitiation complex assembly
R	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
R	0070847	cellular_component	core mediator complex
S	0003674	molecular_function	molecular_function
S	0003712	molecular_function	transcription coregulator activity
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0006357	biological_process	regulation of transcription by RNA polymerase II
S	0016592	cellular_component	mediator complex
S	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
S	0045944	biological_process	positive regulation of transcription by RNA polymerase II
S	0051123	biological_process	RNA polymerase II preinitiation complex assembly
S	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
S	0070847	cellular_component	core mediator complex
T	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
T	0003712	molecular_function	transcription coregulator activity
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0006357	biological_process	regulation of transcription by RNA polymerase II
T	0006366	biological_process	transcription by RNA polymerase II
T	0016592	cellular_component	mediator complex
T	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
T	0034605	biological_process	cellular response to heat
T	0051123	biological_process	RNA polymerase II preinitiation complex assembly
T	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
T	0070847	cellular_component	core mediator complex
U	0000122	biological_process	negative regulation of transcription by RNA polymerase II
U	0003712	molecular_function	transcription coregulator activity
U	0003713	molecular_function	transcription coactivator activity
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0006357	biological_process	regulation of transcription by RNA polymerase II
U	0016592	cellular_component	mediator complex
U	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
U	0045944	biological_process	positive regulation of transcription by RNA polymerase II
U	0051123	biological_process	RNA polymerase II preinitiation complex assembly
U	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
U	0070847	cellular_component	core mediator complex
V	0000122	biological_process	negative regulation of transcription by RNA polymerase II
V	0003712	molecular_function	transcription coregulator activity
V	0003713	molecular_function	transcription coactivator activity
V	0005198	molecular_function	structural molecule activity
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005829	cellular_component	cytosol
V	0006357	biological_process	regulation of transcription by RNA polymerase II
V	0016592	cellular_component	mediator complex
V	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
V	0045944	biological_process	positive regulation of transcription by RNA polymerase II
V	0051123	biological_process	RNA polymerase II preinitiation complex assembly
V	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
V	0070847	cellular_component	core mediator complex
W	0000122	biological_process	negative regulation of transcription by RNA polymerase II
W	0003712	molecular_function	transcription coregulator activity
W	0003713	molecular_function	transcription coactivator activity
W	0003714	molecular_function	transcription corepressor activity
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0006357	biological_process	regulation of transcription by RNA polymerase II
W	0016592	cellular_component	mediator complex
W	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
W	0045944	biological_process	positive regulation of transcription by RNA polymerase II
W	0051123	biological_process	RNA polymerase II preinitiation complex assembly
W	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
W	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
W	0070847	cellular_component	core mediator complex
X	0003712	molecular_function	transcription coregulator activity
X	0003713	molecular_function	transcription coactivator activity
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0006281	biological_process	DNA repair
X	0006310	biological_process	DNA recombination
X	0006311	biological_process	meiotic gene conversion
X	0006355	biological_process	regulation of DNA-templated transcription
X	0006357	biological_process	regulation of transcription by RNA polymerase II
X	0006366	biological_process	transcription by RNA polymerase II
X	0016592	cellular_component	mediator complex
X	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
X	0051123	biological_process	RNA polymerase II preinitiation complex assembly
X	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
X	0070847	cellular_component	core mediator complex
Y	0000019	biological_process	regulation of mitotic recombination
Y	0000112	cellular_component	nucleotide-excision repair factor 3 complex
Y	0000439	cellular_component	transcription factor TFIIH core complex
Y	0003676	molecular_function	nucleic acid binding
Y	0003677	molecular_function	DNA binding
Y	0003678	molecular_function	DNA helicase activity
Y	0003684	molecular_function	damaged DNA binding
Y	0004386	molecular_function	helicase activity
Y	0005515	molecular_function	protein binding
Y	0005524	molecular_function	ATP binding
Y	0005634	cellular_component	nucleus
Y	0005675	cellular_component	transcription factor TFIIH holo complex
Y	0005829	cellular_component	cytosol
Y	0006139	biological_process	nucleobase-containing compound metabolic process
Y	0006281	biological_process	DNA repair
Y	0006289	biological_process	nucleotide-excision repair
Y	0006366	biological_process	transcription by RNA polymerase II
Y	0006367	biological_process	transcription initiation at RNA polymerase II promoter
Y	0006974	biological_process	DNA damage response
Y	0008094	molecular_function	ATP-dependent activity, acting on DNA
Y	0016787	molecular_function	hydrolase activity
Y	0016818	molecular_function	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Y	0016853	molecular_function	isomerase activity
Y	0016887	molecular_function	ATP hydrolysis activity
Y	0032508	biological_process	DNA duplex unwinding
Y	0032991	cellular_component	protein-containing complex
Y	0043139	molecular_function	5'-3' DNA helicase activity
Y	0045951	biological_process	positive regulation of mitotic recombination
Y	0046872	molecular_function	metal ion binding
Y	0051539	molecular_function	4 iron, 4 sulfur cluster binding
Z	0000019	biological_process	regulation of mitotic recombination
Z	0000112	cellular_component	nucleotide-excision repair factor 3 complex
Z	0000439	cellular_component	transcription factor TFIIH core complex
Z	0001111	biological_process	RNA polymerase II promoter clearance
Z	0001113	biological_process	transcription open complex formation at RNA polymerase II promoter
Z	0001174	biological_process	transcriptional start site selection at RNA polymerase II promoter
Z	0003677	molecular_function	DNA binding
Z	0003678	molecular_function	DNA helicase activity
Z	0004386	molecular_function	helicase activity
Z	0005524	molecular_function	ATP binding
Z	0005634	cellular_component	nucleus
Z	0005675	cellular_component	transcription factor TFIIH holo complex
Z	0005829	cellular_component	cytosol
Z	0006281	biological_process	DNA repair
Z	0006289	biological_process	nucleotide-excision repair
Z	0006366	biological_process	transcription by RNA polymerase II
Z	0006367	biological_process	transcription initiation at RNA polymerase II promoter
Z	0015616	molecular_function	DNA translocase activity
Z	0016787	molecular_function	hydrolase activity
Z	0016853	molecular_function	isomerase activity
Z	0016887	molecular_function	ATP hydrolysis activity
Z	0016973	biological_process	poly(A)+ mRNA export from nucleus
Z	0032508	biological_process	DNA duplex unwinding
Z	0043138	molecular_function	3'-5' DNA helicase activity
Z	0097550	cellular_component	transcription preinitiation complex
a	0000112	cellular_component	nucleotide-excision repair factor 3 complex
a	0000439	cellular_component	transcription factor TFIIH core complex
a	0001671	molecular_function	ATPase activator activity
a	0003690	molecular_function	double-stranded DNA binding
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005675	cellular_component	transcription factor TFIIH holo complex
a	0006281	biological_process	DNA repair
a	0006289	biological_process	nucleotide-excision repair
a	0006366	biological_process	transcription by RNA polymerase II
a	0006367	biological_process	transcription initiation at RNA polymerase II promoter
b	0000439	cellular_component	transcription factor TFIIH core complex
b	0000993	molecular_function	RNA polymerase II complex binding
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005675	cellular_component	transcription factor TFIIH holo complex
b	0005829	cellular_component	cytosol
b	0006281	biological_process	DNA repair
b	0006289	biological_process	nucleotide-excision repair
b	0006294	biological_process	nucleotide-excision repair, preincision complex assembly
b	0006366	biological_process	transcription by RNA polymerase II
b	0006367	biological_process	transcription initiation at RNA polymerase II promoter
c	0000993	molecular_function	RNA polymerase II complex binding
c	0001113	biological_process	transcription open complex formation at RNA polymerase II promoter
c	0001139	molecular_function	RNA polymerase II complex recruiting activity
c	0001174	biological_process	transcriptional start site selection at RNA polymerase II promoter
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0006352	biological_process	DNA-templated transcription initiation
c	0006367	biological_process	transcription initiation at RNA polymerase II promoter
c	0008270	molecular_function	zinc ion binding
c	0010467	biological_process	gene expression
c	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
c	0017025	molecular_function	TBP-class protein binding
c	0046872	molecular_function	metal ion binding
c	0051123	biological_process	RNA polymerase II preinitiation complex assembly
c	0070897	biological_process	transcription preinitiation complex assembly
c	0097550	cellular_component	transcription preinitiation complex
d	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
d	0003712	molecular_function	transcription coregulator activity
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005672	cellular_component	transcription factor TFIIA complex
d	0005737	cellular_component	cytoplasm
d	0006366	biological_process	transcription by RNA polymerase II
d	0006367	biological_process	transcription initiation at RNA polymerase II promoter
d	0017025	molecular_function	TBP-class protein binding
d	0045944	biological_process	positive regulation of transcription by RNA polymerase II
d	0051123	biological_process	RNA polymerase II preinitiation complex assembly
d	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
e	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005672	cellular_component	transcription factor TFIIA complex
e	0005737	cellular_component	cytoplasm
e	0006367	biological_process	transcription initiation at RNA polymerase II promoter
e	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
e	0017025	molecular_function	TBP-class protein binding
e	0045944	biological_process	positive regulation of transcription by RNA polymerase II
e	0051123	biological_process	RNA polymerase II preinitiation complex assembly
e	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
f	0001096	molecular_function	TFIIF-class transcription factor complex binding
f	0001174	biological_process	transcriptional start site selection at RNA polymerase II promoter
f	0003677	molecular_function	DNA binding
f	0005634	cellular_component	nucleus
f	0005674	cellular_component	transcription factor TFIIF complex
f	0006355	biological_process	regulation of DNA-templated transcription
f	0006367	biological_process	transcription initiation at RNA polymerase II promoter
f	0006368	biological_process	transcription elongation by RNA polymerase II
f	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
f	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
f	0051123	biological_process	RNA polymerase II preinitiation complex assembly
f	0072542	molecular_function	protein phosphatase activator activity
g	0000166	molecular_function	nucleotide binding
g	0000993	molecular_function	RNA polymerase II complex binding
g	0001174	biological_process	transcriptional start site selection at RNA polymerase II promoter
g	0003677	molecular_function	DNA binding
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005674	cellular_component	transcription factor TFIIF complex
g	0006355	biological_process	regulation of DNA-templated transcription
g	0006366	biological_process	transcription by RNA polymerase II
g	0006367	biological_process	transcription initiation at RNA polymerase II promoter
g	0006368	biological_process	transcription elongation by RNA polymerase II
g	0051123	biological_process	RNA polymerase II preinitiation complex assembly
h	0000993	molecular_function	RNA polymerase II complex binding
h	0001097	molecular_function	TFIIH-class transcription factor complex binding
h	0001113	biological_process	transcription open complex formation at RNA polymerase II promoter
h	0003697	molecular_function	single-stranded DNA binding
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005673	cellular_component	transcription factor TFIIE complex
h	0005739	cellular_component	mitochondrion
h	0006366	biological_process	transcription by RNA polymerase II
h	0006367	biological_process	transcription initiation at RNA polymerase II promoter
h	0008270	molecular_function	zinc ion binding
h	0046872	molecular_function	metal ion binding
h	0097550	cellular_component	transcription preinitiation complex
i	0000993	molecular_function	RNA polymerase II complex binding
i	0001097	molecular_function	TFIIH-class transcription factor complex binding
i	0003677	molecular_function	DNA binding
i	0003697	molecular_function	single-stranded DNA binding
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005673	cellular_component	transcription factor TFIIE complex
i	0006366	biological_process	transcription by RNA polymerase II
i	0006367	biological_process	transcription initiation at RNA polymerase II promoter
i	0097550	cellular_component	transcription preinitiation complex
j	0000126	cellular_component	transcription factor TFIIIB complex
j	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
j	0001016	molecular_function	RNA polymerase III transcription regulatory region sequence-specific DNA binding
j	0001092	molecular_function	TFIIA-class transcription factor complex binding
j	0001179	molecular_function	RNA polymerase I general transcription initiation factor binding
j	0001188	biological_process	RNA polymerase I preinitiation complex assembly
j	0003677	molecular_function	DNA binding
j	0003682	molecular_function	chromatin binding
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005654	cellular_component	nucleoplasm
j	0005667	cellular_component	transcription regulator complex
j	0005669	cellular_component	transcription factor TFIID complex
j	0005672	cellular_component	transcription factor TFIIA complex
j	0006352	biological_process	DNA-templated transcription initiation
j	0006359	biological_process	regulation of transcription by RNA polymerase III
j	0008301	molecular_function	DNA binding, bending
j	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
j	0032991	cellular_component	protein-containing complex
j	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
j	0045892	biological_process	negative regulation of DNA-templated transcription
j	0045944	biological_process	positive regulation of transcription by RNA polymerase II
j	0051123	biological_process	RNA polymerase II preinitiation complex assembly
j	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
j	0070898	biological_process	RNA polymerase III preinitiation complex assembly
j	0097718	molecular_function	disordered domain specific binding
j	0140297	molecular_function	DNA-binding transcription factor binding
k	0003677	molecular_function	DNA binding
k	0006366	biological_process	transcription by RNA polymerase II
n	0000785	cellular_component	chromatin
n	0003677	molecular_function	DNA binding
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0005669	cellular_component	transcription factor TFIID complex
n	0005674	cellular_component	transcription factor TFIIF complex
n	0006281	biological_process	DNA repair
n	0006338	biological_process	chromatin remodeling
n	0006351	biological_process	DNA-templated transcription
n	0006355	biological_process	regulation of DNA-templated transcription
n	0006357	biological_process	regulation of transcription by RNA polymerase II
n	0006366	biological_process	transcription by RNA polymerase II
n	0006367	biological_process	transcription initiation at RNA polymerase II promoter
n	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
n	0016514	cellular_component	SWI/SNF complex
n	0016592	cellular_component	mediator complex
n	0031011	cellular_component	Ino80 complex
n	0033100	cellular_component	NuA3 histone acetyltransferase complex
n	0042393	molecular_function	histone binding
n	0045944	biological_process	positive regulation of transcription by RNA polymerase II
n	0051123	biological_process	RNA polymerase II preinitiation complex assembly
n	1990467	cellular_component	NuA3a histone acetyltransferase complex
n	1990468	cellular_component	NuA3b histone acetyltransferase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1801

Chain	Residue
A	CYS107
A	CYS110
A	CYS148
A	CYS167

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1802

Chain	Residue
A	CYS67
A	CYS70
A	CYS77
A	HIS80

---

site_id	AC3
Number of Residues	3
Details	binding site for residue MG A 1803

Chain	Residue
A	ASP483
A	ASP485
A	ASP481

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN B 1301

Chain	Residue
B	CYS1163
B	CYS1166
B	CYS1182
B	CYS1185

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN C 401

Chain	Residue
C	CYS86
C	CYS88
C	CYS92
C	CYS95

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN I 201

Chain	Residue
I	CYS7
I	CYS10
I	CYS29
I	CYS32

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN I 202

Chain	Residue
I	CYS75
I	CYS78
I	CYS103
I	CYS106

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN J 101

Chain	Residue
J	CYS7
J	CYS10
J	CYS45
J	CYS46

---

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN L 101

Chain	Residue
L	CYS31
L	CYS34
L	CYS48
L	CYS51

---

Functional Information from PROSITE/UniProt

site_id	PS00115
Number of Residues	7
Details	RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPS

Chain	Residue	Details
k	TYR3-SER9
A	TYR1591-SER1597
A	TYR1598-SER1604
A	TYR1605-SER1611
A	TYR1612-SER1618
A	TYR1619-SER1625
A	TYR1626-SER1632
A	TYR1633-SER1639
A	TYR1640-SER1646
A	TYR1647-SER1653
A	TYR1654-ALA1660
k	TYR10-SER16
A	TYR1661-SER1667
A	TYR1668-SER1674
A	TYR1675-SER1681
A	TYR1682-SER1688
A	TYR1689-ASN1695
A	TYR1696-SER1702
k	TYR17-SER23
A	TYR1549-ALA1555
A	TYR1556-SER1562
A	TYR1563-SER1569
A	TYR1570-SER1576
A	TYR1577-SER1583
A	TYR1584-SER1590

---

site_id	PS00351
Number of Residues	50
Details	TFIID Transcription factor TFIID repeat signature. YnPkrFaaVImRirePKttaLIFaSGKMvvtGAKseddsklAsrkyariI

Chain	Residue	Details
j	TYR94-ILE143
j	TYR185-LEU234

---

site_id	PS00387
Number of Residues	7
Details	PPASE Inorganic pyrophosphatase signature. DDDEMDI

Chain	Residue	Details
h	ASP471-ILE477

---

site_id	PS00446
Number of Residues	41
Details	RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSLRRvmiaeiptlAidsVevetNtTvlaDEfIAhRLGLIP

Chain	Residue	Details
C	ASN31-PRO71

---

site_id	PS00466
Number of Residues	36
Details	ZF_TFIIS_1 Zinc finger TFIIS-type signature. CpkChsrenvffqSQQRRkDTSmvlffvCls...CshiF

Chain	Residue	Details
I	CYS75-PHE110

---

site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. SiVIFDEAHN

Chain	Residue	Details
Y	SER230-ASN239

---

site_id	PS00782
Number of Residues	16
Details	TFIIB Transcription factor TFIIB repeat signature. GKsmeSIMAASILIGC

Chain	Residue	Details
c	GLY165-CYS180

---

site_id	PS01030
Number of Residues	27
Details	RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCRDCNNMLypredkennrllfeCrtC

Chain	Residue	Details
I	PHE6-CYS32

---

site_id	PS01110
Number of Residues	14
Details	RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPKHirLssDE

Chain	Residue	Details
E	HIS147-GLU160

---

site_id	PS01111
Number of Residues	15
Details	RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARiLGtRAlQ

Chain	Residue	Details
F	THR86-GLN100

---

site_id	PS01112
Number of Residues	10
Details	RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IVPVrCFSCG

Chain	Residue	Details
J	ILE2-GLY11

---

site_id	PS01154
Number of Residues	32
Details	RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. FekEdHTLgNlIraeLlndrkVlfaaYkveHP

Chain	Residue	Details
K	PHE35-PRO66

---

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT

Chain	Residue	Details
B	GLY977-THR989

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Acylated histone binding => ECO:0000269|PubMed:26341557, ECO:0007744|PDB:5D7E

Chain	Residue	Details
n	ASP104
A	ASP483
A	ASP485
g	SER34
J	CYS45
J	CYS46
A	CYS107
A	CYS110
A	CYS148
A	CYS167
A	ASP481

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047

Chain	Residue	Details
n	LYS181
c	CYS27
c	CYS45
c	CYS48
B	CYS1185

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198

Chain	Residue	Details
i	SER97
I	CYS10
I	CYS29
I	CYS32

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956

Chain	Residue	Details
i	SER106
f	SER562
I	CYS103
I	CYS106

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358

Chain	Residue	Details
f	SER571

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956

Chain	Residue	Details
f	SER655

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	1
Details	M-CSA 788

Chain	Residue	Details
B	ASP837	metal ligand
A	ASP483	metal ligand
A	ASP485	metal ligand
A	HIS1085	proton acceptor, proton donor

---