5PAB

Crystal Structure of Factor VIIa in complex with 1-[[3-[2-hydroxy-3-(1H-pyrrolo[3,2-c]pyridin-2-yl)phenyl]phenyl]methyl]-3-phenylurea

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0004252	molecular_function	serine-type endopeptidase activity
H	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue 7XD H 301

Chain	Residue
H	LEU25
H	SER192
H	SER211
H	TRP212
H	GLY213
H	GLY215
H	GOL304
H	HOH415
H	HOH519
H	HIS41
H	CYS42
H	ASP44
H	LYS45
H	GLY85
H	SER187
H	CYS188
H	LYS189

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site_id	AC2
Number of Residues	2
Details	binding site for residue CL H 302

Chain	Residue
H	ARG72
H	HIS97

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site_id	AC3
Number of Residues	5
Details	binding site for residue GOL H 303

Chain	Residue
H	PHE43
H	ASP44
H	ARG138
H	HOH451
H	HOH475

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site_id	AC4
Number of Residues	8
Details	binding site for residue GOL H 304

Chain	Residue
H	GLN24
H	LEU25
H	LYS189
H	GLY190
H	7XD301
H	HOH407
H	HOH413
H	HOH415

---

site_id	AC5
Number of Residues	1
Details	binding site for residue GOL H 305

Chain	Residue
H	HOH547

---

site_id	AC6
Number of Residues	6
Details	binding site for residue CA H 306

Chain	Residue
H	GLU58
H	ASP60
H	GLU63
H	GLU68
H	HOH432
H	HOH564

---

site_id	AC7
Number of Residues	1
Details	binding site for residue CL H 307

Chain	Residue
H	ARG240

---

site_id	AC8
Number of Residues	2
Details	binding site for residue CL H 308

Chain	Residue
H	GLU242
L	GOL201

---

site_id	AC9
Number of Residues	5
Details	binding site for residue SO4 H 309

Chain	Residue
H	MET154
H	THR155
H	ARG227
H	HOH409
H	HOH481

---

site_id	AD1
Number of Residues	6
Details	binding site for residue GOL L 201

Chain	Residue
H	GLU242
H	CL308
L	CYS114
L	SER119
L	LEU120
L	HOH308

---

site_id	AD2
Number of Residues	5
Details	binding site for residue SO4 L 202

Chain	Residue
H	ARG119
L	CYS102
L	SER103
L	ASP104
L	HOH314

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Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
H	VAL37-CYS42

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPHA

Chain	Residue	Details
H	ASP186-ALA197

---

site_id	PS01186
Number of Residues	16
Details	EGF_2 EGF-like domain signature 2. CrCheGYslladgvsC

Chain	Residue	Details
L	CYS112-CYS127

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Cleavage; by factor Xa, factor XIIa, factor IXa, or thrombin

Chain	Residue	Details
L	ARG152
H	ASP90
H	SER192

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19167329, ECO:0000269|PubMed:3264725

Chain	Residue	Details
L	ASN145

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site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19167329, ECO:0000269|PubMed:3264725

Chain	Residue	Details
H	ASN170

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