5OSB

GLIC-GABAAR alpha1 chimera crystallized in complex with THDOC at pH4.5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue A8Z A 501

Chain	Residue
A	ALA304
A	THR305
A	TYR308
A	PHE309
E	GLN241
E	VAL242
E	PRO400

---

site_id	AC2
Number of Residues	7
Details	binding site for residue A8Z A 502

Chain	Residue
A	PRO400
B	ALA304
B	THR305
B	TYR308
B	PHE309
A	GLN241
A	VAL242

---

site_id	AC3
Number of Residues	5
Details	binding site for residue ACT A 503

Chain	Residue
A	ARG76
A	ILE130
A	GLU180
E	PHE41
E	ARG104

---

site_id	AC4
Number of Residues	2
Details	binding site for residue CL A 504

Chain	Residue
A	PHE77
A	ARG84

---

site_id	AC5
Number of Residues	7
Details	binding site for residue A8Z B 501

Chain	Residue
B	GLN241
B	VAL242
B	TRP245
B	PRO400
C	ALA304
C	THR305
C	TYR308

---

site_id	AC6
Number of Residues	5
Details	binding site for residue ACT B 502

Chain	Residue
A	PHE41
A	ARG104
B	ARG76
B	ILE130
B	GLU180

---

site_id	AC7
Number of Residues	7
Details	binding site for residue A8Z C 501

Chain	Residue
C	GLN241
C	VAL242
C	PRO400
D	ALA304
D	THR305
D	TYR308
D	PHE309

---

site_id	AC8
Number of Residues	6
Details	binding site for residue ACT C 502

Chain	Residue
B	PHE41
B	ARG104
C	ARG76
C	ILE130
C	LEU175
C	GLU180

---

site_id	AC9
Number of Residues	5
Details	binding site for residue ACT D 501

Chain	Residue
C	PHE41
C	ARG104
D	ARG76
D	ILE130
D	GLU180

---

site_id	AD1
Number of Residues	2
Details	binding site for residue CL D 502

Chain	Residue
D	PHE77
D	ARG84

---

site_id	AD2
Number of Residues	6
Details	binding site for residue A8Z E 501

Chain	Residue
D	GLN241
D	VAL242
E	ALA304
E	THR305
E	TYR308
E	PHE309

---

site_id	AD3
Number of Residues	5
Details	binding site for residue ACT E 502

Chain	Residue
D	PHE41
D	ARG104
E	ARG76
E	ILE130
E	GLU180

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	405
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"UniProtKB","id":"P14867","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	45
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P14867","evidenceCode":"ECO:0000250"},{"source":"UniProtKB","id":"P62813","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P62813","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	5
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	230
Details	Transmembrane: {"description":"Helical"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	20
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	35
Details	Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---