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5OOB

COMPLEX OF HUMAN NUCLEAR CAP-BINDING COMPLEX WITH M7GTP AND NELF-E C-TERMINAL PEPTIDE

Functional Information from GO Data
ChainGOidnamespacecontents
A0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
A0000245biological_processspliceosomal complex assembly
A0000339molecular_functionRNA cap binding
A0000340molecular_functionRNA 7-methylguanosine cap binding
A0000380biological_processalternative mRNA splicing, via spliceosome
A0000398biological_processmRNA splicing, via spliceosome
A0002191biological_processcap-dependent translational initiation
A0003723molecular_functionRNA binding
A0003729molecular_functionmRNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005846cellular_componentnuclear cap binding complex
A0006370biological_process7-methylguanosine mRNA capping
A0006401biological_processRNA catabolic process
A0006406biological_processmRNA export from nucleus
A0006408biological_processsnRNA export from nucleus
A0006417biological_processregulation of translation
A0006446biological_processregulation of translational initiation
A0008334biological_processhistone mRNA metabolic process
A0008380biological_processRNA splicing
A0016070biological_processRNA metabolic process
A0016071biological_processmRNA metabolic process
A0030307biological_processpositive regulation of cell growth
A0031047biological_processregulatory ncRNA-mediated gene silencing
A0031053biological_processprimary miRNA processing
A0031124biological_processmRNA 3'-end processing
A0031442biological_processpositive regulation of mRNA 3'-end processing
A0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
A0034518cellular_componentRNA cap binding complex
A0035194biological_processregulatory ncRNA-mediated post-transcriptional gene silencing
A0035195biological_processmiRNA-mediated post-transcriptional gene silencing
A0042789biological_processmRNA transcription by RNA polymerase II
A0048026biological_processpositive regulation of mRNA splicing, via spliceosome
A0050684biological_processregulation of mRNA processing
A0051028biological_processmRNA transport
A0051607biological_processdefense response to virus
A0060090molecular_functionmolecular adaptor activity
A1905216biological_processpositive regulation of RNA binding
A1990904cellular_componentribonucleoprotein complex
B0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
B0000339molecular_functionRNA cap binding
B0000340molecular_functionRNA 7-methylguanosine cap binding
B0000380biological_processalternative mRNA splicing, via spliceosome
B0000398biological_processmRNA splicing, via spliceosome
B0002191biological_processcap-dependent translational initiation
B0003676molecular_functionnucleic acid binding
B0003677molecular_functionDNA binding
B0003723molecular_functionRNA binding
B0003729molecular_functionmRNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005846cellular_componentnuclear cap binding complex
B0006397biological_processmRNA processing
B0006406biological_processmRNA export from nucleus
B0006408biological_processsnRNA export from nucleus
B0006417biological_processregulation of translation
B0006446biological_processregulation of translational initiation
B0008334biological_processhistone mRNA metabolic process
B0008380biological_processRNA splicing
B0016071biological_processmRNA metabolic process
B0017069molecular_functionsnRNA binding
B0031047biological_processregulatory ncRNA-mediated gene silencing
B0031053biological_processprimary miRNA processing
B0031124biological_processmRNA 3'-end processing
B0031442biological_processpositive regulation of mRNA 3'-end processing
B0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
B0034518cellular_componentRNA cap binding complex
B0035194biological_processregulatory ncRNA-mediated post-transcriptional gene silencing
B0035195biological_processmiRNA-mediated post-transcriptional gene silencing
B0042789biological_processmRNA transcription by RNA polymerase II
B0045292biological_processmRNA cis splicing, via spliceosome
B0046833biological_processpositive regulation of RNA export from nucleus
B0051028biological_processmRNA transport
C0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
C0000245biological_processspliceosomal complex assembly
C0000339molecular_functionRNA cap binding
C0000340molecular_functionRNA 7-methylguanosine cap binding
C0000380biological_processalternative mRNA splicing, via spliceosome
C0000398biological_processmRNA splicing, via spliceosome
C0002191biological_processcap-dependent translational initiation
C0003723molecular_functionRNA binding
C0003729molecular_functionmRNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0005846cellular_componentnuclear cap binding complex
C0006370biological_process7-methylguanosine mRNA capping
C0006401biological_processRNA catabolic process
C0006406biological_processmRNA export from nucleus
C0006408biological_processsnRNA export from nucleus
C0006417biological_processregulation of translation
C0006446biological_processregulation of translational initiation
C0008334biological_processhistone mRNA metabolic process
C0008380biological_processRNA splicing
C0016070biological_processRNA metabolic process
C0016071biological_processmRNA metabolic process
C0030307biological_processpositive regulation of cell growth
C0031047biological_processregulatory ncRNA-mediated gene silencing
C0031053biological_processprimary miRNA processing
C0031124biological_processmRNA 3'-end processing
C0031442biological_processpositive regulation of mRNA 3'-end processing
C0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
C0034518cellular_componentRNA cap binding complex
C0035194biological_processregulatory ncRNA-mediated post-transcriptional gene silencing
C0035195biological_processmiRNA-mediated post-transcriptional gene silencing
C0042789biological_processmRNA transcription by RNA polymerase II
C0048026biological_processpositive regulation of mRNA splicing, via spliceosome
C0050684biological_processregulation of mRNA processing
C0051028biological_processmRNA transport
C0051607biological_processdefense response to virus
C0060090molecular_functionmolecular adaptor activity
C1905216biological_processpositive regulation of RNA binding
C1990904cellular_componentribonucleoprotein complex
D0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
D0000339molecular_functionRNA cap binding
D0000340molecular_functionRNA 7-methylguanosine cap binding
D0000380biological_processalternative mRNA splicing, via spliceosome
D0000398biological_processmRNA splicing, via spliceosome
D0002191biological_processcap-dependent translational initiation
D0003676molecular_functionnucleic acid binding
D0003677molecular_functionDNA binding
D0003723molecular_functionRNA binding
D0003729molecular_functionmRNA binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005846cellular_componentnuclear cap binding complex
D0006397biological_processmRNA processing
D0006406biological_processmRNA export from nucleus
D0006408biological_processsnRNA export from nucleus
D0006417biological_processregulation of translation
D0006446biological_processregulation of translational initiation
D0008334biological_processhistone mRNA metabolic process
D0008380biological_processRNA splicing
D0016071biological_processmRNA metabolic process
D0017069molecular_functionsnRNA binding
D0031047biological_processregulatory ncRNA-mediated gene silencing
D0031053biological_processprimary miRNA processing
D0031124biological_processmRNA 3'-end processing
D0031442biological_processpositive regulation of mRNA 3'-end processing
D0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
D0034518cellular_componentRNA cap binding complex
D0035194biological_processregulatory ncRNA-mediated post-transcriptional gene silencing
D0035195biological_processmiRNA-mediated post-transcriptional gene silencing
D0042789biological_processmRNA transcription by RNA polymerase II
D0045292biological_processmRNA cis splicing, via spliceosome
D0046833biological_processpositive regulation of RNA export from nucleus
D0051028biological_processmRNA transport
F0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
F0000245biological_processspliceosomal complex assembly
F0000339molecular_functionRNA cap binding
F0000340molecular_functionRNA 7-methylguanosine cap binding
F0000380biological_processalternative mRNA splicing, via spliceosome
F0000398biological_processmRNA splicing, via spliceosome
F0002191biological_processcap-dependent translational initiation
F0003723molecular_functionRNA binding
F0003729molecular_functionmRNA binding
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005829cellular_componentcytosol
F0005846cellular_componentnuclear cap binding complex
F0006370biological_process7-methylguanosine mRNA capping
F0006401biological_processRNA catabolic process
F0006406biological_processmRNA export from nucleus
F0006408biological_processsnRNA export from nucleus
F0006417biological_processregulation of translation
F0006446biological_processregulation of translational initiation
F0008334biological_processhistone mRNA metabolic process
F0008380biological_processRNA splicing
F0016070biological_processRNA metabolic process
F0016071biological_processmRNA metabolic process
F0030307biological_processpositive regulation of cell growth
F0031047biological_processregulatory ncRNA-mediated gene silencing
F0031053biological_processprimary miRNA processing
F0031124biological_processmRNA 3'-end processing
F0031442biological_processpositive regulation of mRNA 3'-end processing
F0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
F0034518cellular_componentRNA cap binding complex
F0035194biological_processregulatory ncRNA-mediated post-transcriptional gene silencing
F0035195biological_processmiRNA-mediated post-transcriptional gene silencing
F0042789biological_processmRNA transcription by RNA polymerase II
F0048026biological_processpositive regulation of mRNA splicing, via spliceosome
F0050684biological_processregulation of mRNA processing
F0051028biological_processmRNA transport
F0051607biological_processdefense response to virus
F0060090molecular_functionmolecular adaptor activity
F1905216biological_processpositive regulation of RNA binding
F1990904cellular_componentribonucleoprotein complex
G0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
G0000339molecular_functionRNA cap binding
G0000340molecular_functionRNA 7-methylguanosine cap binding
G0000380biological_processalternative mRNA splicing, via spliceosome
G0000398biological_processmRNA splicing, via spliceosome
G0002191biological_processcap-dependent translational initiation
G0003676molecular_functionnucleic acid binding
G0003677molecular_functionDNA binding
G0003723molecular_functionRNA binding
G0003729molecular_functionmRNA binding
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005846cellular_componentnuclear cap binding complex
G0006397biological_processmRNA processing
G0006406biological_processmRNA export from nucleus
G0006408biological_processsnRNA export from nucleus
G0006417biological_processregulation of translation
G0006446biological_processregulation of translational initiation
G0008334biological_processhistone mRNA metabolic process
G0008380biological_processRNA splicing
G0016071biological_processmRNA metabolic process
G0017069molecular_functionsnRNA binding
G0031047biological_processregulatory ncRNA-mediated gene silencing
G0031053biological_processprimary miRNA processing
G0031124biological_processmRNA 3'-end processing
G0031442biological_processpositive regulation of mRNA 3'-end processing
G0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
G0034518cellular_componentRNA cap binding complex
G0035194biological_processregulatory ncRNA-mediated post-transcriptional gene silencing
G0035195biological_processmiRNA-mediated post-transcriptional gene silencing
G0042789biological_processmRNA transcription by RNA polymerase II
G0045292biological_processmRNA cis splicing, via spliceosome
G0046833biological_processpositive regulation of RNA export from nucleus
G0051028biological_processmRNA transport
I0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
I0000245biological_processspliceosomal complex assembly
I0000339molecular_functionRNA cap binding
I0000340molecular_functionRNA 7-methylguanosine cap binding
I0000380biological_processalternative mRNA splicing, via spliceosome
I0000398biological_processmRNA splicing, via spliceosome
I0002191biological_processcap-dependent translational initiation
I0003723molecular_functionRNA binding
I0003729molecular_functionmRNA binding
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005737cellular_componentcytoplasm
I0005739cellular_componentmitochondrion
I0005829cellular_componentcytosol
I0005846cellular_componentnuclear cap binding complex
I0006370biological_process7-methylguanosine mRNA capping
I0006401biological_processRNA catabolic process
I0006406biological_processmRNA export from nucleus
I0006408biological_processsnRNA export from nucleus
I0006417biological_processregulation of translation
I0006446biological_processregulation of translational initiation
I0008334biological_processhistone mRNA metabolic process
I0008380biological_processRNA splicing
I0016070biological_processRNA metabolic process
I0016071biological_processmRNA metabolic process
I0030307biological_processpositive regulation of cell growth
I0031047biological_processregulatory ncRNA-mediated gene silencing
I0031053biological_processprimary miRNA processing
I0031124biological_processmRNA 3'-end processing
I0031442biological_processpositive regulation of mRNA 3'-end processing
I0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
I0034518cellular_componentRNA cap binding complex
I0035194biological_processregulatory ncRNA-mediated post-transcriptional gene silencing
I0035195biological_processmiRNA-mediated post-transcriptional gene silencing
I0042789biological_processmRNA transcription by RNA polymerase II
I0048026biological_processpositive regulation of mRNA splicing, via spliceosome
I0050684biological_processregulation of mRNA processing
I0051028biological_processmRNA transport
I0051607biological_processdefense response to virus
I0060090molecular_functionmolecular adaptor activity
I1905216biological_processpositive regulation of RNA binding
I1990904cellular_componentribonucleoprotein complex
J0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
J0000339molecular_functionRNA cap binding
J0000340molecular_functionRNA 7-methylguanosine cap binding
J0000380biological_processalternative mRNA splicing, via spliceosome
J0000398biological_processmRNA splicing, via spliceosome
J0002191biological_processcap-dependent translational initiation
J0003676molecular_functionnucleic acid binding
J0003677molecular_functionDNA binding
J0003723molecular_functionRNA binding
J0003729molecular_functionmRNA binding
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0005846cellular_componentnuclear cap binding complex
J0006397biological_processmRNA processing
J0006406biological_processmRNA export from nucleus
J0006408biological_processsnRNA export from nucleus
J0006417biological_processregulation of translation
J0006446biological_processregulation of translational initiation
J0008334biological_processhistone mRNA metabolic process
J0008380biological_processRNA splicing
J0016071biological_processmRNA metabolic process
J0017069molecular_functionsnRNA binding
J0031047biological_processregulatory ncRNA-mediated gene silencing
J0031053biological_processprimary miRNA processing
J0031124biological_processmRNA 3'-end processing
J0031442biological_processpositive regulation of mRNA 3'-end processing
J0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
J0034518cellular_componentRNA cap binding complex
J0035194biological_processregulatory ncRNA-mediated post-transcriptional gene silencing
J0035195biological_processmiRNA-mediated post-transcriptional gene silencing
J0042789biological_processmRNA transcription by RNA polymerase II
J0045292biological_processmRNA cis splicing, via spliceosome
J0046833biological_processpositive regulation of RNA export from nucleus
J0051028biological_processmRNA transport
Functional Information from PDB Data
site_idAC1
Number of Residues12
Detailsbinding site for residue MGT B 201
ChainResidue
BTYR20
BGLN133
BVAL134
BARG135
BASP22
BTYR43
BPHE83
BASP114
BTRP115
BASP116
BARG123
BARG127

site_idAC2
Number of Residues13
Detailsbinding site for residue MGT D 201
ChainResidue
DTYR20
DASP22
DTYR43
DPHE83
DPHE85
DARG112
DASP114
DTRP115
DASP116
DARG123
DARG127
DGLN133
DVAL134

site_idAC3
Number of Residues14
Detailsbinding site for residue MGT G 201
ChainResidue
GTYR20
GASP22
GTYR43
GPHE83
GPHE85
GARG112
GASP114
GTRP115
GASP116
GARG123
GARG127
GGLN133
GVAL134
GARG135

site_idAC4
Number of Residues14
Detailsbinding site for residue MGT J 201
ChainResidue
JTYR20
JASP22
JTYR43
JPHE83
JARG112
JASP114
JTRP115
JASP116
JARG123
JGLY126
JARG127
JGLN133
JVAL134
JARG135

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsMOD_RES: PolyADP-ribosyl glutamic acid => ECO:0000269|PubMed:27256882
ChainResidueDetails
EGLU374
KGLU374
ZGLU374
DTYR43
GTYR20
GTYR43
JTYR20
JTYR43

site_idSWS_FT_FI2
Number of Residues12
DetailsBINDING:
ChainResidueDetails
BARG112
JARG112
JARG123
JGLN133
BARG123
BGLN133
DARG112
DARG123
DGLN133
GARG112
GARG123
GGLN133

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: N-acetylserine => ECO:0007744|PubMed:22814378
ChainResidueDetails
BSER2
DSER2
GSER2
JSER2

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER13
DSER13
GSER13
JSER13
FLYS204
FLYS698
ILYS204
ILYS698

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17525332
ChainResidueDetails
BSER18
DSER18
GSER18
JSER18
FLYS684
ILYS684

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Omega-N-methylarginine => ECO:0007744|PubMed:24129315
ChainResidueDetails
BARG146
DARG146
GARG146
JARG146

227344

PDB entries from 2024-11-13

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