5OKZ

Crystal Strucrure of the Mpp6 Exosome complex

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000176	cellular_component	nuclear exosome (RNase complex)
a	0000177	cellular_component	cytoplasmic exosome (RNase complex)
a	0000178	cellular_component	exosome (RNase complex)
a	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
a	0000956	biological_process	nuclear-transcribed mRNA catabolic process
a	0003723	molecular_function	RNA binding
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005730	cellular_component	nucleolus
a	0005737	cellular_component	cytoplasm
a	0006364	biological_process	rRNA processing
a	0006396	biological_process	RNA processing
a	0006401	biological_process	RNA catabolic process
a	0030145	molecular_function	manganese ion binding
a	0034475	biological_process	U4 snRNA 3'-end processing
a	0071034	biological_process	CUT catabolic process
a	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
a	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
a	0071051	biological_process	poly(A)-dependent snoRNA 3'-end processing
A	0000176	cellular_component	nuclear exosome (RNase complex)
A	0000177	cellular_component	cytoplasmic exosome (RNase complex)
A	0000178	cellular_component	exosome (RNase complex)
A	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A	0003674	molecular_function	molecular_function
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0006364	biological_process	rRNA processing
A	0006396	biological_process	RNA processing
A	0006401	biological_process	RNA catabolic process
A	0016075	biological_process	rRNA catabolic process
A	0034473	biological_process	U1 snRNA 3'-end processing
A	0034475	biological_process	U4 snRNA 3'-end processing
A	0034476	biological_process	U5 snRNA 3'-end processing
A	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
A	0071028	biological_process	nuclear mRNA surveillance
A	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
A	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
b	0000178	cellular_component	exosome (RNase complex)
b	0003723	molecular_function	RNA binding
B	0000176	cellular_component	nuclear exosome (RNase complex)
B	0000177	cellular_component	cytoplasmic exosome (RNase complex)
B	0000178	cellular_component	exosome (RNase complex)
B	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B	0000956	biological_process	nuclear-transcribed mRNA catabolic process
B	0003674	molecular_function	molecular_function
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0006364	biological_process	rRNA processing
B	0006396	biological_process	RNA processing
B	0006401	biological_process	RNA catabolic process
B	0016075	biological_process	rRNA catabolic process
B	0034473	biological_process	U1 snRNA 3'-end processing
B	0034475	biological_process	U4 snRNA 3'-end processing
B	0034476	biological_process	U5 snRNA 3'-end processing
B	0070478	biological_process	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
B	0071028	biological_process	nuclear mRNA surveillance
B	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
B	0071039	biological_process	nuclear polyadenylation-dependent CUT catabolic process
B	0071051	biological_process	poly(A)-dependent snoRNA 3'-end processing
c	0000176	cellular_component	nuclear exosome (RNase complex)
c	0000177	cellular_component	cytoplasmic exosome (RNase complex)
c	0000178	cellular_component	exosome (RNase complex)
c	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
c	0000956	biological_process	nuclear-transcribed mRNA catabolic process
c	0003674	molecular_function	molecular_function
c	0003723	molecular_function	RNA binding
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005730	cellular_component	nucleolus
c	0005737	cellular_component	cytoplasm
c	0006364	biological_process	rRNA processing
c	0006396	biological_process	RNA processing
c	0006397	biological_process	mRNA processing
c	0006401	biological_process	RNA catabolic process
c	0070481	biological_process	nuclear-transcribed mRNA catabolic process, non-stop decay
c	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
c	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
C	0000176	cellular_component	nuclear exosome (RNase complex)
C	0000177	cellular_component	cytoplasmic exosome (RNase complex)
C	0000178	cellular_component	exosome (RNase complex)
C	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C	0000956	biological_process	nuclear-transcribed mRNA catabolic process
C	0003674	molecular_function	molecular_function
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0006364	biological_process	rRNA processing
C	0006396	biological_process	RNA processing
C	0006397	biological_process	mRNA processing
C	0006401	biological_process	RNA catabolic process
C	0006402	biological_process	mRNA catabolic process
C	0016072	biological_process	rRNA metabolic process
C	0016075	biological_process	rRNA catabolic process
C	0034473	biological_process	U1 snRNA 3'-end processing
C	0034475	biological_process	U4 snRNA 3'-end processing
C	0034476	biological_process	U5 snRNA 3'-end processing
C	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
C	0071028	biological_process	nuclear mRNA surveillance
C	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
C	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
C	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process
d	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
d	0003723	molecular_function	RNA binding
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005829	cellular_component	cytosol
d	0006364	biological_process	rRNA processing
d	0008266	molecular_function	poly(U) RNA binding
d	0044877	molecular_function	protein-containing complex binding
d	0071030	biological_process	nuclear mRNA surveillance of spliceosomal pre-mRNA splicing
d	0071031	biological_process	nuclear mRNA surveillance of mRNA 3'-end processing
d	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
d	0071039	biological_process	nuclear polyadenylation-dependent CUT catabolic process
D	0000176	cellular_component	nuclear exosome (RNase complex)
D	0000177	cellular_component	cytoplasmic exosome (RNase complex)
D	0000178	cellular_component	exosome (RNase complex)
D	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D	0003674	molecular_function	molecular_function
D	0003723	molecular_function	RNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005730	cellular_component	nucleolus
D	0005737	cellular_component	cytoplasm
D	0006364	biological_process	rRNA processing
D	0006396	biological_process	RNA processing
D	0006401	biological_process	RNA catabolic process
D	0016075	biological_process	rRNA catabolic process
D	0034475	biological_process	U4 snRNA 3'-end processing
D	0071028	biological_process	nuclear mRNA surveillance
D	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
D	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
D	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process
D	0071051	biological_process	poly(A)-dependent snoRNA 3'-end processing
e	0000176	cellular_component	nuclear exosome (RNase complex)
e	0000177	cellular_component	cytoplasmic exosome (RNase complex)
e	0000178	cellular_component	exosome (RNase complex)
e	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
e	0003674	molecular_function	molecular_function
e	0003723	molecular_function	RNA binding
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005730	cellular_component	nucleolus
e	0005737	cellular_component	cytoplasm
e	0006364	biological_process	rRNA processing
e	0006396	biological_process	RNA processing
e	0006401	biological_process	RNA catabolic process
e	0016075	biological_process	rRNA catabolic process
e	0034473	biological_process	U1 snRNA 3'-end processing
e	0034475	biological_process	U4 snRNA 3'-end processing
e	0034476	biological_process	U5 snRNA 3'-end processing
e	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
e	0071028	biological_process	nuclear mRNA surveillance
e	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
e	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
E	0000176	cellular_component	nuclear exosome (RNase complex)
E	0000177	cellular_component	cytoplasmic exosome (RNase complex)
E	0000178	cellular_component	exosome (RNase complex)
E	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E	0003674	molecular_function	molecular_function
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005730	cellular_component	nucleolus
E	0005737	cellular_component	cytoplasm
E	0006364	biological_process	rRNA processing
E	0006396	biological_process	RNA processing
E	0006401	biological_process	RNA catabolic process
E	0016075	biological_process	rRNA catabolic process
E	0034473	biological_process	U1 snRNA 3'-end processing
E	0034475	biological_process	U4 snRNA 3'-end processing
E	0034476	biological_process	U5 snRNA 3'-end processing
E	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
E	0071028	biological_process	nuclear mRNA surveillance
E	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
E	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
f	0000176	cellular_component	nuclear exosome (RNase complex)
f	0000177	cellular_component	cytoplasmic exosome (RNase complex)
f	0000178	cellular_component	exosome (RNase complex)
f	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
f	0000956	biological_process	nuclear-transcribed mRNA catabolic process
f	0003674	molecular_function	molecular_function
f	0003723	molecular_function	RNA binding
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005730	cellular_component	nucleolus
f	0005737	cellular_component	cytoplasm
f	0006364	biological_process	rRNA processing
f	0006396	biological_process	RNA processing
f	0006401	biological_process	RNA catabolic process
f	0016075	biological_process	rRNA catabolic process
f	0034473	biological_process	U1 snRNA 3'-end processing
f	0034475	biological_process	U4 snRNA 3'-end processing
f	0034476	biological_process	U5 snRNA 3'-end processing
f	0070478	biological_process	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
f	0071028	biological_process	nuclear mRNA surveillance
f	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
f	0071039	biological_process	nuclear polyadenylation-dependent CUT catabolic process
f	0071051	biological_process	poly(A)-dependent snoRNA 3'-end processing
F	0000176	cellular_component	nuclear exosome (RNase complex)
F	0000177	cellular_component	cytoplasmic exosome (RNase complex)
F	0000178	cellular_component	exosome (RNase complex)
F	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F	0003674	molecular_function	molecular_function
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005730	cellular_component	nucleolus
F	0005737	cellular_component	cytoplasm
F	0006364	biological_process	rRNA processing
F	0006396	biological_process	RNA processing
F	0006401	biological_process	RNA catabolic process
F	0016075	biological_process	rRNA catabolic process
F	0034475	biological_process	U4 snRNA 3'-end processing
F	0071028	biological_process	nuclear mRNA surveillance
F	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
F	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
F	0071039	biological_process	nuclear polyadenylation-dependent CUT catabolic process
F	0071051	biological_process	poly(A)-dependent snoRNA 3'-end processing
g	0000176	cellular_component	nuclear exosome (RNase complex)
g	0000177	cellular_component	cytoplasmic exosome (RNase complex)
g	0000178	cellular_component	exosome (RNase complex)
g	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
g	0000956	biological_process	nuclear-transcribed mRNA catabolic process
g	0003674	molecular_function	molecular_function
g	0003723	molecular_function	RNA binding
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005654	cellular_component	nucleoplasm
g	0005730	cellular_component	nucleolus
g	0005737	cellular_component	cytoplasm
g	0006364	biological_process	rRNA processing
g	0006396	biological_process	RNA processing
g	0006397	biological_process	mRNA processing
g	0006401	biological_process	RNA catabolic process
g	0006402	biological_process	mRNA catabolic process
g	0016072	biological_process	rRNA metabolic process
g	0016075	biological_process	rRNA catabolic process
g	0034473	biological_process	U1 snRNA 3'-end processing
g	0034475	biological_process	U4 snRNA 3'-end processing
g	0034476	biological_process	U5 snRNA 3'-end processing
g	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
g	0071028	biological_process	nuclear mRNA surveillance
g	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
g	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
g	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process
G	0000176	cellular_component	nuclear exosome (RNase complex)
G	0000177	cellular_component	cytoplasmic exosome (RNase complex)
G	0000178	cellular_component	exosome (RNase complex)
G	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G	0000956	biological_process	nuclear-transcribed mRNA catabolic process
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005730	cellular_component	nucleolus
G	0005737	cellular_component	cytoplasm
G	0006364	biological_process	rRNA processing
G	0006396	biological_process	RNA processing
G	0006401	biological_process	RNA catabolic process
G	0030145	molecular_function	manganese ion binding
G	0034475	biological_process	U4 snRNA 3'-end processing
G	0071034	biological_process	CUT catabolic process
G	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
G	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
G	0071051	biological_process	poly(A)-dependent snoRNA 3'-end processing
h	0000176	cellular_component	nuclear exosome (RNase complex)
h	0000177	cellular_component	cytoplasmic exosome (RNase complex)
h	0000178	cellular_component	exosome (RNase complex)
h	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
h	0003674	molecular_function	molecular_function
h	0003723	molecular_function	RNA binding
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005730	cellular_component	nucleolus
h	0005737	cellular_component	cytoplasm
h	0006364	biological_process	rRNA processing
h	0006396	biological_process	RNA processing
h	0006401	biological_process	RNA catabolic process
h	0016075	biological_process	rRNA catabolic process
h	0034475	biological_process	U4 snRNA 3'-end processing
h	0071028	biological_process	nuclear mRNA surveillance
h	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
h	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
h	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process
h	0071051	biological_process	poly(A)-dependent snoRNA 3'-end processing
H	0000178	cellular_component	exosome (RNase complex)
H	0003723	molecular_function	RNA binding
i	0000176	cellular_component	nuclear exosome (RNase complex)
i	0000177	cellular_component	cytoplasmic exosome (RNase complex)
i	0000178	cellular_component	exosome (RNase complex)
i	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
i	0003674	molecular_function	molecular_function
i	0003723	molecular_function	RNA binding
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005730	cellular_component	nucleolus
i	0005737	cellular_component	cytoplasm
i	0006364	biological_process	rRNA processing
i	0006396	biological_process	RNA processing
i	0006401	biological_process	RNA catabolic process
i	0016075	biological_process	rRNA catabolic process
i	0034473	biological_process	U1 snRNA 3'-end processing
i	0034475	biological_process	U4 snRNA 3'-end processing
i	0034476	biological_process	U5 snRNA 3'-end processing
i	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
i	0071028	biological_process	nuclear mRNA surveillance
i	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
i	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
I	0000176	cellular_component	nuclear exosome (RNase complex)
I	0000177	cellular_component	cytoplasmic exosome (RNase complex)
I	0000178	cellular_component	exosome (RNase complex)
I	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I	0000956	biological_process	nuclear-transcribed mRNA catabolic process
I	0003674	molecular_function	molecular_function
I	0003723	molecular_function	RNA binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005730	cellular_component	nucleolus
I	0005737	cellular_component	cytoplasm
I	0006364	biological_process	rRNA processing
I	0006396	biological_process	RNA processing
I	0006397	biological_process	mRNA processing
I	0006401	biological_process	RNA catabolic process
I	0070481	biological_process	nuclear-transcribed mRNA catabolic process, non-stop decay
I	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
I	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
j	0000176	cellular_component	nuclear exosome (RNase complex)
j	0000177	cellular_component	cytoplasmic exosome (RNase complex)
j	0000178	cellular_component	exosome (RNase complex)
j	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
j	0003674	molecular_function	molecular_function
j	0003723	molecular_function	RNA binding
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005730	cellular_component	nucleolus
j	0005737	cellular_component	cytoplasm
j	0006364	biological_process	rRNA processing
j	0006396	biological_process	RNA processing
j	0006401	biological_process	RNA catabolic process
j	0016075	biological_process	rRNA catabolic process
j	0034475	biological_process	U4 snRNA 3'-end processing
j	0071028	biological_process	nuclear mRNA surveillance
j	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
j	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
j	0071039	biological_process	nuclear polyadenylation-dependent CUT catabolic process
j	0071051	biological_process	poly(A)-dependent snoRNA 3'-end processing
J	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J	0003723	molecular_function	RNA binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005829	cellular_component	cytosol
J	0006364	biological_process	rRNA processing
J	0008266	molecular_function	poly(U) RNA binding
J	0044877	molecular_function	protein-containing complex binding
J	0071030	biological_process	nuclear mRNA surveillance of spliceosomal pre-mRNA splicing
J	0071031	biological_process	nuclear mRNA surveillance of mRNA 3'-end processing
J	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
J	0071039	biological_process	nuclear polyadenylation-dependent CUT catabolic process
k	0000176	cellular_component	nuclear exosome (RNase complex)
k	0000177	cellular_component	cytoplasmic exosome (RNase complex)
k	0000178	cellular_component	exosome (RNase complex)
k	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
k	0000956	biological_process	nuclear-transcribed mRNA catabolic process
k	0003723	molecular_function	RNA binding
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005730	cellular_component	nucleolus
k	0005737	cellular_component	cytoplasm
k	0006364	biological_process	rRNA processing
k	0006396	biological_process	RNA processing
k	0006401	biological_process	RNA catabolic process
k	0030145	molecular_function	manganese ion binding
k	0034475	biological_process	U4 snRNA 3'-end processing
k	0071034	biological_process	CUT catabolic process
k	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
k	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
k	0071051	biological_process	poly(A)-dependent snoRNA 3'-end processing
K	0000176	cellular_component	nuclear exosome (RNase complex)
K	0000177	cellular_component	cytoplasmic exosome (RNase complex)
K	0000178	cellular_component	exosome (RNase complex)
K	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K	0003674	molecular_function	molecular_function
K	0003723	molecular_function	RNA binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005730	cellular_component	nucleolus
K	0005737	cellular_component	cytoplasm
K	0006364	biological_process	rRNA processing
K	0006396	biological_process	RNA processing
K	0006401	biological_process	RNA catabolic process
K	0016075	biological_process	rRNA catabolic process
K	0034473	biological_process	U1 snRNA 3'-end processing
K	0034475	biological_process	U4 snRNA 3'-end processing
K	0034476	biological_process	U5 snRNA 3'-end processing
K	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
K	0071028	biological_process	nuclear mRNA surveillance
K	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
K	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
l	0000178	cellular_component	exosome (RNase complex)
l	0003723	molecular_function	RNA binding
L	0000176	cellular_component	nuclear exosome (RNase complex)
L	0000177	cellular_component	cytoplasmic exosome (RNase complex)
L	0000178	cellular_component	exosome (RNase complex)
L	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L	0000956	biological_process	nuclear-transcribed mRNA catabolic process
L	0003674	molecular_function	molecular_function
L	0003723	molecular_function	RNA binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005730	cellular_component	nucleolus
L	0005737	cellular_component	cytoplasm
L	0006364	biological_process	rRNA processing
L	0006396	biological_process	RNA processing
L	0006401	biological_process	RNA catabolic process
L	0016075	biological_process	rRNA catabolic process
L	0034473	biological_process	U1 snRNA 3'-end processing
L	0034475	biological_process	U4 snRNA 3'-end processing
L	0034476	biological_process	U5 snRNA 3'-end processing
L	0070478	biological_process	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
L	0071028	biological_process	nuclear mRNA surveillance
L	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
L	0071039	biological_process	nuclear polyadenylation-dependent CUT catabolic process
L	0071051	biological_process	poly(A)-dependent snoRNA 3'-end processing
m	0000176	cellular_component	nuclear exosome (RNase complex)
m	0000177	cellular_component	cytoplasmic exosome (RNase complex)
m	0000178	cellular_component	exosome (RNase complex)
m	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
m	0000956	biological_process	nuclear-transcribed mRNA catabolic process
m	0003674	molecular_function	molecular_function
m	0003723	molecular_function	RNA binding
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005730	cellular_component	nucleolus
m	0005737	cellular_component	cytoplasm
m	0006364	biological_process	rRNA processing
m	0006396	biological_process	RNA processing
m	0006397	biological_process	mRNA processing
m	0006401	biological_process	RNA catabolic process
m	0070481	biological_process	nuclear-transcribed mRNA catabolic process, non-stop decay
m	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
m	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
M	0000176	cellular_component	nuclear exosome (RNase complex)
M	0000177	cellular_component	cytoplasmic exosome (RNase complex)
M	0000178	cellular_component	exosome (RNase complex)
M	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M	0000956	biological_process	nuclear-transcribed mRNA catabolic process
M	0003674	molecular_function	molecular_function
M	0003723	molecular_function	RNA binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005730	cellular_component	nucleolus
M	0005737	cellular_component	cytoplasm
M	0006364	biological_process	rRNA processing
M	0006396	biological_process	RNA processing
M	0006397	biological_process	mRNA processing
M	0006401	biological_process	RNA catabolic process
M	0006402	biological_process	mRNA catabolic process
M	0016072	biological_process	rRNA metabolic process
M	0016075	biological_process	rRNA catabolic process
M	0034473	biological_process	U1 snRNA 3'-end processing
M	0034475	biological_process	U4 snRNA 3'-end processing
M	0034476	biological_process	U5 snRNA 3'-end processing
M	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
M	0071028	biological_process	nuclear mRNA surveillance
M	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
M	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
M	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process
n	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
n	0003723	molecular_function	RNA binding
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0005829	cellular_component	cytosol
n	0006364	biological_process	rRNA processing
n	0008266	molecular_function	poly(U) RNA binding
n	0044877	molecular_function	protein-containing complex binding
n	0071030	biological_process	nuclear mRNA surveillance of spliceosomal pre-mRNA splicing
n	0071031	biological_process	nuclear mRNA surveillance of mRNA 3'-end processing
n	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
n	0071039	biological_process	nuclear polyadenylation-dependent CUT catabolic process
N	0000176	cellular_component	nuclear exosome (RNase complex)
N	0000177	cellular_component	cytoplasmic exosome (RNase complex)
N	0000178	cellular_component	exosome (RNase complex)
N	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N	0003674	molecular_function	molecular_function
N	0003723	molecular_function	RNA binding
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005730	cellular_component	nucleolus
N	0005737	cellular_component	cytoplasm
N	0006364	biological_process	rRNA processing
N	0006396	biological_process	RNA processing
N	0006401	biological_process	RNA catabolic process
N	0016075	biological_process	rRNA catabolic process
N	0034475	biological_process	U4 snRNA 3'-end processing
N	0071028	biological_process	nuclear mRNA surveillance
N	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
N	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
N	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process
N	0071051	biological_process	poly(A)-dependent snoRNA 3'-end processing
O	0000176	cellular_component	nuclear exosome (RNase complex)
O	0000177	cellular_component	cytoplasmic exosome (RNase complex)
O	0000178	cellular_component	exosome (RNase complex)
O	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
O	0003674	molecular_function	molecular_function
O	0003723	molecular_function	RNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005730	cellular_component	nucleolus
O	0005737	cellular_component	cytoplasm
O	0006364	biological_process	rRNA processing
O	0006396	biological_process	RNA processing
O	0006401	biological_process	RNA catabolic process
O	0016075	biological_process	rRNA catabolic process
O	0034473	biological_process	U1 snRNA 3'-end processing
O	0034475	biological_process	U4 snRNA 3'-end processing
O	0034476	biological_process	U5 snRNA 3'-end processing
O	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
O	0071028	biological_process	nuclear mRNA surveillance
O	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
O	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
P	0000176	cellular_component	nuclear exosome (RNase complex)
P	0000177	cellular_component	cytoplasmic exosome (RNase complex)
P	0000178	cellular_component	exosome (RNase complex)
P	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
P	0003674	molecular_function	molecular_function
P	0003723	molecular_function	RNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005730	cellular_component	nucleolus
P	0005737	cellular_component	cytoplasm
P	0006364	biological_process	rRNA processing
P	0006396	biological_process	RNA processing
P	0006401	biological_process	RNA catabolic process
P	0016075	biological_process	rRNA catabolic process
P	0034475	biological_process	U4 snRNA 3'-end processing
P	0071028	biological_process	nuclear mRNA surveillance
P	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
P	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
P	0071039	biological_process	nuclear polyadenylation-dependent CUT catabolic process
P	0071051	biological_process	poly(A)-dependent snoRNA 3'-end processing
Q	0000176	cellular_component	nuclear exosome (RNase complex)
Q	0000177	cellular_component	cytoplasmic exosome (RNase complex)
Q	0000178	cellular_component	exosome (RNase complex)
Q	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Q	0000956	biological_process	nuclear-transcribed mRNA catabolic process
Q	0003723	molecular_function	RNA binding
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005730	cellular_component	nucleolus
Q	0005737	cellular_component	cytoplasm
Q	0006364	biological_process	rRNA processing
Q	0006396	biological_process	RNA processing
Q	0006401	biological_process	RNA catabolic process
Q	0030145	molecular_function	manganese ion binding
Q	0034475	biological_process	U4 snRNA 3'-end processing
Q	0071034	biological_process	CUT catabolic process
Q	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
Q	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
Q	0071051	biological_process	poly(A)-dependent snoRNA 3'-end processing
R	0000178	cellular_component	exosome (RNase complex)
R	0003723	molecular_function	RNA binding
S	0000176	cellular_component	nuclear exosome (RNase complex)
S	0000177	cellular_component	cytoplasmic exosome (RNase complex)
S	0000178	cellular_component	exosome (RNase complex)
S	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
S	0000956	biological_process	nuclear-transcribed mRNA catabolic process
S	0003674	molecular_function	molecular_function
S	0003723	molecular_function	RNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005730	cellular_component	nucleolus
S	0005737	cellular_component	cytoplasm
S	0006364	biological_process	rRNA processing
S	0006396	biological_process	RNA processing
S	0006397	biological_process	mRNA processing
S	0006401	biological_process	RNA catabolic process
S	0070481	biological_process	nuclear-transcribed mRNA catabolic process, non-stop decay
S	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
S	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
T	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
T	0003723	molecular_function	RNA binding
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005829	cellular_component	cytosol
T	0006364	biological_process	rRNA processing
T	0008266	molecular_function	poly(U) RNA binding
T	0044877	molecular_function	protein-containing complex binding
T	0071030	biological_process	nuclear mRNA surveillance of spliceosomal pre-mRNA splicing
T	0071031	biological_process	nuclear mRNA surveillance of mRNA 3'-end processing
T	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
T	0071039	biological_process	nuclear polyadenylation-dependent CUT catabolic process
U	0000176	cellular_component	nuclear exosome (RNase complex)
U	0000177	cellular_component	cytoplasmic exosome (RNase complex)
U	0000178	cellular_component	exosome (RNase complex)
U	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
U	0003674	molecular_function	molecular_function
U	0003723	molecular_function	RNA binding
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005730	cellular_component	nucleolus
U	0005737	cellular_component	cytoplasm
U	0006364	biological_process	rRNA processing
U	0006396	biological_process	RNA processing
U	0006401	biological_process	RNA catabolic process
U	0016075	biological_process	rRNA catabolic process
U	0034473	biological_process	U1 snRNA 3'-end processing
U	0034475	biological_process	U4 snRNA 3'-end processing
U	0034476	biological_process	U5 snRNA 3'-end processing
U	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
U	0071028	biological_process	nuclear mRNA surveillance
U	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
U	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
V	0000176	cellular_component	nuclear exosome (RNase complex)
V	0000177	cellular_component	cytoplasmic exosome (RNase complex)
V	0000178	cellular_component	exosome (RNase complex)
V	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
V	0000956	biological_process	nuclear-transcribed mRNA catabolic process
V	0003674	molecular_function	molecular_function
V	0003723	molecular_function	RNA binding
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005730	cellular_component	nucleolus
V	0005737	cellular_component	cytoplasm
V	0006364	biological_process	rRNA processing
V	0006396	biological_process	RNA processing
V	0006401	biological_process	RNA catabolic process
V	0016075	biological_process	rRNA catabolic process
V	0034473	biological_process	U1 snRNA 3'-end processing
V	0034475	biological_process	U4 snRNA 3'-end processing
V	0034476	biological_process	U5 snRNA 3'-end processing
V	0070478	biological_process	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
V	0071028	biological_process	nuclear mRNA surveillance
V	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
V	0071039	biological_process	nuclear polyadenylation-dependent CUT catabolic process
V	0071051	biological_process	poly(A)-dependent snoRNA 3'-end processing
W	0000176	cellular_component	nuclear exosome (RNase complex)
W	0000177	cellular_component	cytoplasmic exosome (RNase complex)
W	0000178	cellular_component	exosome (RNase complex)
W	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
W	0000956	biological_process	nuclear-transcribed mRNA catabolic process
W	0003674	molecular_function	molecular_function
W	0003723	molecular_function	RNA binding
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005730	cellular_component	nucleolus
W	0005737	cellular_component	cytoplasm
W	0006364	biological_process	rRNA processing
W	0006396	biological_process	RNA processing
W	0006397	biological_process	mRNA processing
W	0006401	biological_process	RNA catabolic process
W	0006402	biological_process	mRNA catabolic process
W	0016072	biological_process	rRNA metabolic process
W	0016075	biological_process	rRNA catabolic process
W	0034473	biological_process	U1 snRNA 3'-end processing
W	0034475	biological_process	U4 snRNA 3'-end processing
W	0034476	biological_process	U5 snRNA 3'-end processing
W	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
W	0071028	biological_process	nuclear mRNA surveillance
W	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
W	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
W	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process
X	0000176	cellular_component	nuclear exosome (RNase complex)
X	0000177	cellular_component	cytoplasmic exosome (RNase complex)
X	0000178	cellular_component	exosome (RNase complex)
X	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
X	0003674	molecular_function	molecular_function
X	0003723	molecular_function	RNA binding
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005730	cellular_component	nucleolus
X	0005737	cellular_component	cytoplasm
X	0006364	biological_process	rRNA processing
X	0006396	biological_process	RNA processing
X	0006401	biological_process	RNA catabolic process
X	0016075	biological_process	rRNA catabolic process
X	0034475	biological_process	U4 snRNA 3'-end processing
X	0071028	biological_process	nuclear mRNA surveillance
X	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
X	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
X	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process
X	0071051	biological_process	poly(A)-dependent snoRNA 3'-end processing
Y	0000176	cellular_component	nuclear exosome (RNase complex)
Y	0000177	cellular_component	cytoplasmic exosome (RNase complex)
Y	0000178	cellular_component	exosome (RNase complex)
Y	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Y	0003674	molecular_function	molecular_function
Y	0003723	molecular_function	RNA binding
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005730	cellular_component	nucleolus
Y	0005737	cellular_component	cytoplasm
Y	0006364	biological_process	rRNA processing
Y	0006396	biological_process	RNA processing
Y	0006401	biological_process	RNA catabolic process
Y	0016075	biological_process	rRNA catabolic process
Y	0034473	biological_process	U1 snRNA 3'-end processing
Y	0034475	biological_process	U4 snRNA 3'-end processing
Y	0034476	biological_process	U5 snRNA 3'-end processing
Y	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
Y	0071028	biological_process	nuclear mRNA surveillance
Y	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
Y	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
Z	0000176	cellular_component	nuclear exosome (RNase complex)
Z	0000177	cellular_component	cytoplasmic exosome (RNase complex)
Z	0000178	cellular_component	exosome (RNase complex)
Z	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Z	0003674	molecular_function	molecular_function
Z	0003723	molecular_function	RNA binding
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005730	cellular_component	nucleolus
Z	0005737	cellular_component	cytoplasm
Z	0006364	biological_process	rRNA processing
Z	0006396	biological_process	RNA processing
Z	0006401	biological_process	RNA catabolic process
Z	0016075	biological_process	rRNA catabolic process
Z	0034475	biological_process	U4 snRNA 3'-end processing
Z	0071028	biological_process	nuclear mRNA surveillance
Z	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
Z	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
Z	0071039	biological_process	nuclear polyadenylation-dependent CUT catabolic process
Z	0071051	biological_process	poly(A)-dependent snoRNA 3'-end processing

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue TAM A 401

Chain	Residue
A	GLU121
A	CYS124

---

site_id	AC2
Number of Residues	1
Details	binding site for residue CL G 301

Chain	Residue
G	TYR59

---

site_id	AC3
Number of Residues	1
Details	binding site for residue CL H 401

Chain	Residue
H	ARG115

---

site_id	AC4
Number of Residues	1
Details	binding site for residue TAM K 401

Chain	Residue
K	GLU121

---

site_id	AC5
Number of Residues	1
Details	binding site for residue MG O 301

Chain	Residue
R	GLU337

---

site_id	AC6
Number of Residues	2
Details	binding site for residue CL R 401

Chain	Residue
R	GLN201
R	TYR230

---

site_id	AC7
Number of Residues	1
Details	binding site for residue CL R 402

Chain	Residue
R	ARG115

---

site_id	AC8
Number of Residues	2
Details	binding site for residue TAM U 401

Chain	Residue
U	GLU121
U	GLY122

---

site_id	AC9
Number of Residues	1
Details	binding site for residue CL b 401

Chain	Residue
b	ARG115

---

site_id	AD1
Number of Residues	2
Details	binding site for residue TAM e 401

Chain	Residue
B	ASP208
e	GLU121

---

site_id	AD2
Number of Residues	1
Details	binding site for residue CL f 301

Chain	Residue
f	GLN131

---

site_id	AD3
Number of Residues	2
Details	binding site for residue MG g 401

Chain	Residue
g	GLY142
g	GLU148

---

site_id	AD4
Number of Residues	1
Details	binding site for residue CL l 401

Chain	Residue
l	ARG115

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	140
Details	Domain: {"description":"S1 motif"}

Chain

Residue

Details

---