5OGW
Cryo-EM structure of jasplakinolide-stabilized malaria parasite F-actin at near-atomic resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005200 | molecular_function | structural constituent of cytoskeleton |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005884 | cellular_component | actin filament |
| A | 0007010 | biological_process | cytoskeleton organization |
| A | 0009665 | biological_process | plastid inheritance |
| A | 0015629 | cellular_component | actin cytoskeleton |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0020014 | biological_process | schizogony |
| A | 0070360 | biological_process | symbiont-mediated actin polymerization-dependent cell-to-cell migration in host |
| A | 0085017 | biological_process | entry into host cell by a symbiont-containing vacuole |
| B | 0005200 | molecular_function | structural constituent of cytoskeleton |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005856 | cellular_component | cytoskeleton |
| B | 0005884 | cellular_component | actin filament |
| B | 0007010 | biological_process | cytoskeleton organization |
| B | 0009665 | biological_process | plastid inheritance |
| B | 0015629 | cellular_component | actin cytoskeleton |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0020014 | biological_process | schizogony |
| B | 0070360 | biological_process | symbiont-mediated actin polymerization-dependent cell-to-cell migration in host |
| B | 0085017 | biological_process | entry into host cell by a symbiont-containing vacuole |
| C | 0005200 | molecular_function | structural constituent of cytoskeleton |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005856 | cellular_component | cytoskeleton |
| C | 0005884 | cellular_component | actin filament |
| C | 0007010 | biological_process | cytoskeleton organization |
| C | 0009665 | biological_process | plastid inheritance |
| C | 0015629 | cellular_component | actin cytoskeleton |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016887 | molecular_function | ATP hydrolysis activity |
| C | 0020014 | biological_process | schizogony |
| C | 0070360 | biological_process | symbiont-mediated actin polymerization-dependent cell-to-cell migration in host |
| C | 0085017 | biological_process | entry into host cell by a symbiont-containing vacuole |
| D | 0005200 | molecular_function | structural constituent of cytoskeleton |
| D | 0005515 | molecular_function | protein binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005856 | cellular_component | cytoskeleton |
| D | 0005884 | cellular_component | actin filament |
| D | 0007010 | biological_process | cytoskeleton organization |
| D | 0009665 | biological_process | plastid inheritance |
| D | 0015629 | cellular_component | actin cytoskeleton |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016887 | molecular_function | ATP hydrolysis activity |
| D | 0020014 | biological_process | schizogony |
| D | 0070360 | biological_process | symbiont-mediated actin polymerization-dependent cell-to-cell migration in host |
| D | 0085017 | biological_process | entry into host cell by a symbiont-containing vacuole |
| E | 0005200 | molecular_function | structural constituent of cytoskeleton |
| E | 0005515 | molecular_function | protein binding |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005856 | cellular_component | cytoskeleton |
| E | 0005884 | cellular_component | actin filament |
| E | 0007010 | biological_process | cytoskeleton organization |
| E | 0009665 | biological_process | plastid inheritance |
| E | 0015629 | cellular_component | actin cytoskeleton |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0016887 | molecular_function | ATP hydrolysis activity |
| E | 0020014 | biological_process | schizogony |
| E | 0070360 | biological_process | symbiont-mediated actin polymerization-dependent cell-to-cell migration in host |
| E | 0085017 | biological_process | entry into host cell by a symbiont-containing vacuole |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue ADP A 401 |
| Chain | Residue |
| A | GLY16 |
| A | GLU217 |
| A | GLY305 |
| A | THR306 |
| A | TYR309 |
| A | MG402 |
| A | SER17 |
| A | ASN19 |
| A | LYS21 |
| A | GLY159 |
| A | ASP160 |
| A | GLY185 |
| A | ARG213 |
| A | LYS216 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue MG A 402 |
| Chain | Residue |
| A | GLN140 |
| A | ADP401 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | binding site for residue 9UE A 403 |
| Chain | Residue |
| A | HIS197 |
| A | GLY200 |
| A | TYR201 |
| A | GLY202 |
| A | PHE203 |
| A | GLU208 |
| A | LEU245 |
| A | ASN249 |
| B | VAL290 |
| D | HIS76 |
| D | ILE78 |
| D | PRO115 |
| D | GLY117 |
| D | ARG180 |
| D | ASP182 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | binding site for residue ADP B 401 |
| Chain | Residue |
| B | GLY16 |
| B | SER17 |
| B | ASN19 |
| B | LYS21 |
| B | GLY159 |
| B | ASP160 |
| B | ARG213 |
| B | LYS216 |
| B | GLU217 |
| B | GLY305 |
| B | THR306 |
| B | TYR309 |
| B | MG402 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue MG B 402 |
| Chain | Residue |
| B | GLN140 |
| B | ADP401 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | binding site for residue ADP C 401 |
| Chain | Residue |
| C | GLY16 |
| C | SER17 |
| C | ASN19 |
| C | LYS21 |
| C | GLY159 |
| C | ASP160 |
| C | ARG213 |
| C | LYS216 |
| C | GLU217 |
| C | GLY305 |
| C | THR306 |
| C | TYR309 |
| C | MG402 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue MG C 402 |
| Chain | Residue |
| C | GLN140 |
| C | ADP401 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | binding site for residue 9UE C 403 |
| Chain | Residue |
| A | VAL290 |
| C | HIS197 |
| C | GLY200 |
| C | TYR201 |
| C | GLY202 |
| C | PHE203 |
| C | GLU208 |
| C | LEU245 |
| C | ASN249 |
| C | ILE251 |
| E | HIS76 |
| E | ILE78 |
| E | PRO115 |
| E | GLY117 |
| E | ARG180 |
| site_id | AC9 |
| Number of Residues | 13 |
| Details | binding site for residue ADP D 401 |
| Chain | Residue |
| D | GLY16 |
| D | SER17 |
| D | ASN19 |
| D | LYS21 |
| D | GLY159 |
| D | ASP160 |
| D | ARG213 |
| D | LYS216 |
| D | GLU217 |
| D | GLY305 |
| D | THR306 |
| D | TYR309 |
| D | MG402 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue MG D 402 |
| Chain | Residue |
| D | GLN140 |
| D | ADP401 |
| site_id | AD2 |
| Number of Residues | 13 |
| Details | binding site for residue ADP E 401 |
| Chain | Residue |
| E | GLU217 |
| E | GLY305 |
| E | THR306 |
| E | TYR309 |
| E | MG402 |
| E | GLY16 |
| E | SER17 |
| E | ASN19 |
| E | LYS21 |
| E | GLY159 |
| E | ASP160 |
| E | ARG213 |
| E | LYS216 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue MG E 402 |
| Chain | Residue |
| E | GLN140 |
| E | ADP401 |
| site_id | AD4 |
| Number of Residues | 14 |
| Details | binding site for residue 9UE E 403 |
| Chain | Residue |
| A | HIS76 |
| A | ILE78 |
| A | PRO115 |
| A | ARG180 |
| A | ASP182 |
| D | VAL290 |
| E | HIS197 |
| E | GLY200 |
| E | TYR201 |
| E | GLY202 |
| E | PHE203 |
| E | GLU208 |
| E | LEU245 |
| E | ASN249 |
Functional Information from PROSITE/UniProt
| site_id | PS00406 |
| Number of Residues | 11 |
| Details | ACTINS_1 Actins signature 1. FVGDEAQt.KRG |
| Chain | Residue | Details |
| A | PHE56-GLY66 |
| site_id | PS00432 |
| Number of Residues | 9 |
| Details | ACTINS_2 Actins signature 2. WITKeEYDE |
| Chain | Residue | Details |
| A | TRP359-GLU367 |
| site_id | PS01132 |
| Number of Residues | 13 |
| Details | ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkgNR |
| Chain | Residue | Details |
| A | LEU107-ARG119 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 25 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24743229, ECO:0000269|PubMed:28695858, ECO:0000269|PubMed:31199804, ECO:0000269|PubMed:33767187, ECO:0000269|Ref.7, ECO:0007744|PDB:4CBU, ECO:0007744|PDB:5MVV, ECO:0007744|PDB:6I4D, ECO:0007744|PDB:6I4E, ECO:0007744|PDB:6TU4, ECO:0007744|PDB:7ALN |
| Chain | Residue | Details |
| A | SER17 | |
| B | GLY305 | |
| C | SER17 | |
| C | GLY18 | |
| C | ASP160 | |
| C | LYS216 | |
| C | GLY305 | |
| D | SER17 | |
| D | GLY18 | |
| D | ASP160 | |
| D | LYS216 | |
| A | GLY18 | |
| D | GLY305 | |
| E | SER17 | |
| E | GLY18 | |
| E | ASP160 | |
| E | LYS216 | |
| E | GLY305 | |
| A | ASP160 | |
| A | LYS216 | |
| A | GLY305 | |
| B | SER17 | |
| B | GLY18 | |
| B | ASP160 | |
| B | LYS216 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24743229, ECO:0000269|PubMed:28695858, ECO:0000269|PubMed:28923924, ECO:0000269|PubMed:31199804, ECO:0000269|Ref.7, ECO:0007744|PDB:4CBU, ECO:0007744|PDB:5MVV, ECO:0007744|PDB:5OGW, ECO:0007744|PDB:6I4D, ECO:0007744|PDB:6I4E, ECO:0007744|PDB:6TU4 |
| Chain | Residue | Details |
| A | ASN19 | |
| B | ASN19 | |
| C | ASN19 | |
| D | ASN19 | |
| E | ASN19 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24743229, ECO:0000269|PubMed:28695858, ECO:0000269|PubMed:28923924, ECO:0000269|PubMed:31199804, ECO:0000269|PubMed:33767187, ECO:0000269|Ref.7, ECO:0007744|PDB:4CBU, ECO:0007744|PDB:5MVV, ECO:0007744|PDB:5OGW, ECO:0007744|PDB:6I4D, ECO:0007744|PDB:6I4E, ECO:0007744|PDB:6TU4, ECO:0007744|PDB:7ALN |
| Chain | Residue | Details |
| A | LYS21 | |
| B | LYS21 | |
| C | LYS21 | |
| D | LYS21 | |
| E | LYS21 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24743229, ECO:0000269|PubMed:28695858, ECO:0000269|PubMed:31199804, ECO:0007744|PDB:4CBU, ECO:0007744|PDB:5MVV, ECO:0007744|PDB:6I4D |
| Chain | Residue | Details |
| A | GLY161 | |
| B | GLY161 | |
| C | GLY161 | |
| D | GLY161 | |
| E | GLY161 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24743229, ECO:0000269|PubMed:28695858, ECO:0000269|PubMed:28923924, ECO:0000269|PubMed:31199804, ECO:0007744|PDB:4CBU, ECO:0007744|PDB:5MVV, ECO:0007744|PDB:5OGW, ECO:0007744|PDB:6I4D |
| Chain | Residue | Details |
| A | VAL162 | |
| B | VAL162 | |
| C | VAL162 | |
| D | VAL162 | |
| E | VAL162 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24743229, ECO:0000269|PubMed:28695858, ECO:0000269|PubMed:31199804, ECO:0007744|PDB:4CBU, ECO:0007744|PDB:5MVV, ECO:0007744|PDB:6I4D, ECO:0007744|PDB:6I4E |
| Chain | Residue | Details |
| A | GLU217 | |
| B | GLU217 | |
| C | GLU217 | |
| D | GLU217 | |
| E | GLU217 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 5 |
| Details | SITE: Not methylated => ECO:0000269|PubMed:31199804 |
| Chain | Residue | Details |
| A | HIS76 | |
| B | HIS76 | |
| C | HIS76 | |
| D | HIS76 | |
| E | HIS76 |
