5OFA
Crystal structure of human MORC2 (residues 1-603) with spinal muscular atrophy mutation T424R
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 701 |
| Chain | Residue |
| B | CYS499 |
| B | CYS502 |
| B | CYS525 |
| B | CYS536 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | binding site for residue ANP B 702 |
| Chain | Residue |
| B | VAL81 |
| B | SER87 |
| B | LYS89 |
| B | GLY98 |
| B | GLN99 |
| B | TYR100 |
| B | GLY101 |
| B | ASN102 |
| B | GLY103 |
| B | LEU104 |
| B | LYS105 |
| B | THR197 |
| B | LYS427 |
| B | MG703 |
| B | HOH805 |
| B | HOH806 |
| B | HOH814 |
| B | GLU35 |
| B | ASN39 |
| B | ALA43 |
| B | ASP68 |
| B | MET73 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue MG B 703 |
| Chain | Residue |
| B | ASN39 |
| B | ANP702 |
| B | HOH806 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 701 |
| Chain | Residue |
| A | CYS499 |
| A | CYS502 |
| A | CYS525 |
| A | CYS536 |
| site_id | AC5 |
| Number of Residues | 22 |
| Details | binding site for residue ANP A 702 |
| Chain | Residue |
| A | GLU35 |
| A | ASN39 |
| A | ALA43 |
| A | ASP68 |
| A | MET73 |
| A | VAL81 |
| A | SER87 |
| A | LYS89 |
| A | GLY98 |
| A | GLN99 |
| A | TYR100 |
| A | GLY101 |
| A | ASN102 |
| A | GLY103 |
| A | LEU104 |
| A | LYS105 |
| A | THR197 |
| A | LYS427 |
| A | MG703 |
| A | HOH808 |
| A | HOH810 |
| A | HOH811 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 703 |
| Chain | Residue |
| A | ASN39 |
| A | ANP702 |
| A | HOH808 |
| A | HOH810 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 54 |
| Details | Zinc finger: {"description":"CW-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00454","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"29440755","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 22 |
| Details | Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29440755","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00454","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 80 |
| Details | Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
