5O9M

Crystal structure of human Histamine-Releasing Factor (HRF/TCTP)containing a disulphide-linked dimer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000922	cellular_component	spindle pole
A	0003723	molecular_function	RNA binding
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005771	cellular_component	multivesicular body
A	0005829	cellular_component	cytosol
A	0005881	cellular_component	cytoplasmic microtubule
A	0006816	biological_process	calcium ion transport
A	0006874	biological_process	intracellular calcium ion homeostasis
A	0009615	biological_process	response to virus
A	0019827	biological_process	stem cell population maintenance
A	0042981	biological_process	regulation of apoptotic process
A	0043066	biological_process	negative regulation of apoptotic process
A	0070062	cellular_component	extracellular exosome
A	0140297	molecular_function	DNA-binding transcription factor binding
A	1902230	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
A	2000384	biological_process	negative regulation of ectoderm development
B	0000922	cellular_component	spindle pole
B	0003723	molecular_function	RNA binding
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005771	cellular_component	multivesicular body
B	0005829	cellular_component	cytosol
B	0005881	cellular_component	cytoplasmic microtubule
B	0006816	biological_process	calcium ion transport
B	0006874	biological_process	intracellular calcium ion homeostasis
B	0009615	biological_process	response to virus
B	0019827	biological_process	stem cell population maintenance
B	0042981	biological_process	regulation of apoptotic process
B	0043066	biological_process	negative regulation of apoptotic process
B	0070062	cellular_component	extracellular exosome
B	0140297	molecular_function	DNA-binding transcription factor binding
B	1902230	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
B	2000384	biological_process	negative regulation of ectoderm development

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue PEG B 201

Chain	Residue
B	GLU120
B	LYS123
B	HIS124
B	PRO142

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Functional Information from PROSITE/UniProt

site_id	PS01002
Number of Residues	11
Details	TCTP_1 Translationally controlled tumor protein (TCTP) domain signature 1. IGGNASAEGPE

Chain	Residue	Details
A	ILE48-GLU58

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site_id	PS01003
Number of Residues	23
Details	TCTP_2 Translationally controlled tumor protein (TCTP) domain signature 2. FknyqFFIGEnmnp...DGmVAlldY

Chain	Residue	Details
A	PHE129-TYR151

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	204
Details	Region: {"description":"Required for reduction of TSC22D1 protein stability","evidences":[{"source":"PubMed","id":"18325344","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PLK1","evidences":[{"source":"PubMed","id":"12167714","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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