5O58

Structure of the inactive T.maritima PDE (TM1595) D80N D154N mutant with substrate 5'-pApG

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003676	molecular_function	nucleic acid binding
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue EDO A 401

Chain	Residue
A	GLU195
A	LYS198
A	HIS228

---

site_id	AC2
Number of Residues	4
Details	binding site for residue EDO A 402

Chain	Residue
A	PHE272
A	ASN273
A	GLU276
A	LYS313

---

site_id	AC3
Number of Residues	5
Details	binding site for residue EDO A 403

Chain	Residue
A	TYR61
A	ASP140
A	ASN142
A	LEU35
A	LYS39

---

site_id	AC4
Number of Residues	4
Details	binding site for residue EDO A 404

Chain	Residue
A	ARG193
A	PHE194
A	ARG246
A	HOH659

---

site_id	AC5
Number of Residues	4
Details	binding site for residue EDO A 405

Chain	Residue
A	GLY247
A	GLU249
A	ASP270
A	HOH591

---

site_id	AC6
Number of Residues	6
Details	binding site for residue EDO A 406

Chain	Residue
A	SER161
A	ALA163
A	ALA179
A	ASP180
A	ALA181
A	HIS182

---

site_id	AC7
Number of Residues	5
Details	binding site for residue EDO A 407

Chain	Residue
A	LYS133
A	VAL137
A	GLU138
A	TYR139
A	MET177

---

site_id	AC8
Number of Residues	7
Details	binding site for residue EDO A 408

Chain	Residue
A	PHE129
A	ARG130
A	LYS133
A	ASP170
A	LYS173
A	HOH538
A	HOH685

---

site_id	AC9
Number of Residues	5
Details	binding site for residue EDO A 409

Chain	Residue
A	LEU35
A	GLU38
A	LYS39
A	GLN208
A	HOH508

---

site_id	AD1
Number of Residues	4
Details	binding site for residue EDO A 410

Chain	Residue
A	TYR50
A	THR231
A	ASP232
A	PHE257

---

site_id	AD2
Number of Residues	3
Details	binding site for residue EDO A 411

Chain	Residue
A	PRO60
A	TYR61
A	EDO413

---

site_id	AD3
Number of Residues	5
Details	binding site for residue EDO A 412

Chain	Residue
A	PHE294
A	LYS297
A	GLU301
A	ARG305
A	IPA422

---

site_id	AD4
Number of Residues	5
Details	binding site for residue EDO A 413

Chain	Residue
A	TYR61
A	ASP63
A	LYS64
A	EDO411
A	HOH670

---

site_id	AD5
Number of Residues	4
Details	binding site for residue EDO A 414

Chain	Residue
A	ASP12
A	ARG13
A	GLU43
A	GLU300

---

site_id	AD6
Number of Residues	6
Details	binding site for residue EDO A 415

Chain	Residue
A	PRO119
A	GLY285
A	HIS286
A	PRO287
A	HOH517
A	HOH543

---

site_id	AD7
Number of Residues	4
Details	binding site for residue EDO A 416

Chain	Residue
A	ASP118
A	SER120
A	PHE121
A	ARG166

---

site_id	AD8
Number of Residues	4
Details	binding site for residue EDO A 417

Chain	Residue
A	ASN113
A	TRP114
A	HOH594
A	HOH683

---

site_id	AD9
Number of Residues	3
Details	binding site for residue EDO A 418

Chain	Residue
A	GLU169
A	TYR172
A	TYR172

---

site_id	AE1
Number of Residues	7
Details	binding site for residue IPA A 419

Chain	Residue
A	SER120
A	PHE121
A	ALA122
A	GLN126
A	ASN162
A	ASP164
A	ARG166

---

site_id	AE2
Number of Residues	5
Details	binding site for residue IPA A 420

Chain	Residue
A	GLY237
A	ARG267
A	CL424
B	A1
B	G2

---

site_id	AE3
Number of Residues	5
Details	binding site for residue IPA A 421

Chain	Residue
A	LYS192
A	GLN196
A	PHE197
A	HOH546
A	HOH687

---

site_id	AE4
Number of Residues	4
Details	binding site for residue IPA A 422

Chain	Residue
A	GLY282
A	PHE294
A	EDO412
A	LEU281

---

site_id	AE5
Number of Residues	4
Details	binding site for residue IPA A 423

Chain	Residue
A	LYS89
A	PHE90
A	ASP92
A	LEU93

---

site_id	AE6
Number of Residues	3
Details	binding site for residue CL A 424

Chain	Residue
A	GLY240
A	ARG267
A	IPA420

---

site_id	AE7
Number of Residues	4
Details	binding site for residue CL A 425

Chain	Residue
A	SER161
A	ASN162
B	G2
B	HOH110

---