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5O33

A structure of the GEF Kalirin DH1 domain in complex with the small GTPase Rac1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000242cellular_componentpericentriolar material
A0001764biological_processneuron migration
A0001891cellular_componentphagocytic cup
A0001934biological_processpositive regulation of protein phosphorylation
A0002093biological_processauditory receptor cell morphogenesis
A0003376biological_processsphingosine-1-phosphate receptor signaling pathway
A0003382biological_processepithelial cell morphogenesis
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005789cellular_componentendoplasmic reticulum membrane
A0005802cellular_componenttrans-Golgi network
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005884cellular_componentactin filament
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0005938cellular_componentcell cortex
A0006897biological_processendocytosis
A0006911biological_processphagocytosis, engulfment
A0006954biological_processinflammatory response
A0006972biological_processhyperosmotic response
A0007010biological_processcytoskeleton organization
A0007015biological_processactin filament organization
A0007155biological_processcell adhesion
A0007160biological_processcell-matrix adhesion
A0007163biological_processestablishment or maintenance of cell polarity
A0007167biological_processenzyme-linked receptor protein signaling pathway
A0007186biological_processG protein-coupled receptor signaling pathway
A0007264biological_processsmall GTPase-mediated signal transduction
A0007411biological_processaxon guidance
A0008045biological_processmotor neuron axon guidance
A0008360biological_processregulation of cell shape
A0009611biological_processresponse to wounding
A0009653biological_processanatomical structure morphogenesis
A0010310biological_processregulation of hydrogen peroxide metabolic process
A0010591biological_processregulation of lamellipodium assembly
A0010592biological_processpositive regulation of lamellipodium assembly
A0010595biological_processpositive regulation of endothelial cell migration
A0010762biological_processregulation of fibroblast migration
A0010764biological_processnegative regulation of fibroblast migration
A0010810biological_processregulation of cell-substrate adhesion
A0010811biological_processpositive regulation of cell-substrate adhesion
A0014041biological_processregulation of neuron maturation
A0016020cellular_componentmembrane
A0016358biological_processdendrite development
A0016477biological_processcell migration
A0016601biological_processRac protein signal transduction
A0016787molecular_functionhydrolase activity
A0019899molecular_functionenzyme binding
A0019901molecular_functionprotein kinase binding
A0021799biological_processcerebral cortex radially oriented cell migration
A0021831biological_processembryonic olfactory bulb interneuron precursor migration
A0021894biological_processcerebral cortex GABAergic interneuron development
A0022604biological_processregulation of cell morphogenesis
A0030027cellular_componentlamellipodium
A0030031biological_processcell projection assembly
A0030032biological_processlamellipodium assembly
A0030036biological_processactin cytoskeleton organization
A0030041biological_processactin filament polymerization
A0030334biological_processregulation of cell migration
A0030425cellular_componentdendrite
A0030667cellular_componentsecretory granule membrane
A0030672cellular_componentsynaptic vesicle membrane
A0030742molecular_functionGTP-dependent protein binding
A0030838biological_processpositive regulation of actin filament polymerization
A0030865biological_processcortical cytoskeleton organization
A0030900biological_processforebrain development
A0031116biological_processpositive regulation of microtubule polymerization
A0031410cellular_componentcytoplasmic vesicle
A0031529biological_processruffle organization
A0031901cellular_componentearly endosome membrane
A0031996molecular_functionthioesterase binding
A0032496biological_processresponse to lipopolysaccharide
A0032587cellular_componentruffle membrane
A0032707biological_processnegative regulation of interleukin-23 production
A0032956biological_processregulation of actin cytoskeleton organization
A0034446biological_processsubstrate adhesion-dependent cell spreading
A0035025biological_processpositive regulation of Rho protein signal transduction
A0035556biological_processintracellular signal transduction
A0035567biological_processnon-canonical Wnt signaling pathway
A0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
A0036464cellular_componentcytoplasmic ribonucleoprotein granule
A0042470cellular_componentmelanosome
A0042554biological_processsuperoxide anion generation
A0042734cellular_componentpresynaptic membrane
A0042995cellular_componentcell projection
A0043020cellular_componentNADPH oxidase complex
A0043131biological_processerythrocyte enucleation
A0043652biological_processengulfment of apoptotic cell
A0044877molecular_functionprotein-containing complex binding
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0045216biological_processcell-cell junction organization
A0045428biological_processregulation of nitric oxide biosynthetic process
A0045730biological_processrespiratory burst
A0046425biological_processregulation of receptor signaling pathway via JAK-STAT
A0048012biological_processhepatocyte growth factor receptor signaling pathway
A0048168biological_processregulation of neuronal synaptic plasticity
A0048261biological_processnegative regulation of receptor-mediated endocytosis
A0048532biological_processanatomical structure arrangement
A0048812biological_processneuron projection morphogenesis
A0048813biological_processdendrite morphogenesis
A0048870biological_processcell motility
A0048873biological_processhomeostasis of number of cells within a tissue
A0051022molecular_functionRho GDP-dissociation inhibitor binding
A0051492biological_processregulation of stress fiber assembly
A0051496biological_processpositive regulation of stress fiber assembly
A0051668biological_processlocalization within membrane
A0051894biological_processpositive regulation of focal adhesion assembly
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051932biological_processsynaptic transmission, GABAergic
A0055038cellular_componentrecycling endosome membrane
A0060071biological_processWnt signaling pathway, planar cell polarity pathway
A0060091cellular_componentkinocilium
A0060263biological_processregulation of respiratory burst
A0060326biological_processcell chemotaxis
A0060999biological_processpositive regulation of dendritic spine development
A0061344biological_processregulation of cell adhesion involved in heart morphogenesis
A0070062cellular_componentextracellular exosome
A0070376biological_processregulation of ERK5 cascade
A0071526biological_processsemaphorin-plexin signaling pathway
A0071542biological_processdopaminergic neuron differentiation
A0072659biological_processprotein localization to plasma membrane
A0086098biological_processangiotensin-activated signaling pathway involved in heart process
A0090023biological_processpositive regulation of neutrophil chemotaxis
A0090103biological_processcochlea morphogenesis
A0097178biological_processruffle assembly
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0101003cellular_componentficolin-1-rich granule membrane
A0150052biological_processregulation of postsynapse assembly
A1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
A1900029biological_processpositive regulation of ruffle assembly
A1900242biological_processregulation of synaptic vesicle endocytosis
A1902622biological_processregulation of neutrophil migration
A1903348biological_processpositive regulation of bicellular tight junction assembly
A1904395biological_processpositive regulation of skeletal muscle acetylcholine-gated channel clustering
A1904936biological_processinterneuron migration
A1904948biological_processmidbrain dopaminergic neuron differentiation
A2000386biological_processpositive regulation of ovarian follicle development
A2001222biological_processregulation of neuron migration
B0005085molecular_functionguanyl-nucleotide exchange factor activity
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue EDO A 201
ChainResidue
ALYS153
ATYR154
AHOH301
AHOH370
AHOH377

site_idAC2
Number of Residues5
Detailsbinding site for residue EDO A 202
ChainResidue
BTRP1317
AASP121
AHOH331
AHOH354
BTHR1316

site_idAC3
Number of Residues18
Detailsbinding site for residue GDP A 203
ChainResidue
AASP11
AALA13
AVAL14
AGLY15
ALYS16
ATHR17
ACYS18
AILE33
ALYS116
AASP118
ALEU119
ASER158
AALA159
ALEU160
AHOH307
AHOH363
AHOH368
AHOH371

site_idAC4
Number of Residues4
Detailsbinding site for residue EDO B 1501
ChainResidue
BARG1232
BPHE1236
BALA1239
BGLN1243

site_idAC5
Number of Residues6
Detailsbinding site for residue EDO B 1502
ChainResidue
AVAL36
AASP38
BGLN1368
BARG1369
BHOH1609
BHOH1643

site_idAC6
Number of Residues5
Detailsbinding site for residue EDO B 1503
ChainResidue
ATHR138
AHOH328
BGLU1299
BHOH1669
BHOH1688

site_idAC7
Number of Residues2
Detailsbinding site for residue EDO B 1504
ChainResidue
BARG1232
BLYS1233

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:38332367, ECO:0007744|PDB:8Q0N
ChainResidueDetails
AGLY12
AALA59
ALEU119

site_idSWS_FT_FI2
Number of Residues7
DetailsBINDING: BINDING => ECO:0000269|PubMed:11090627, ECO:0000269|PubMed:38332367, ECO:0000269|PubMed:38355798, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR, ECO:0007744|PDB:8Q0N, ECO:0007744|PDB:8WEJ
ChainResidueDetails
AALA13
ALYS16
ATHR17
ACYS18
ATHR35
AALA159
ALEU160

site_idSWS_FT_FI3
Number of Residues7
DetailsBINDING: BINDING => ECO:0000269|PubMed:11090627, ECO:0000269|PubMed:38332367, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR, ECO:0007744|PDB:8Q0N
ChainResidueDetails
AVAL14
AGLY15
AGLU31
ATYR32
APRO34
ALYS116
AASP118

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:11090627, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR
ChainResidueDetails
AGLY60

site_idSWS_FT_FI5
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:38355798, ECO:0007744|PDB:8WEJ
ChainResidueDetails
ASER158

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538
ChainResidueDetails
ATYR32

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103
ChainResidueDetails
ATHR35

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:10617634
ChainResidueDetails
ASER71

site_idSWS_FT_FI9
Number of Residues1
DetailsCARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704
ChainResidueDetails
ATYR32

site_idSWS_FT_FI10
Number of Residues1
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB, and by P.sordellii toxin TcsL; alternate => ECO:0000269|PubMed:19744486, ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059
ChainResidueDetails
ATHR35

site_idSWS_FT_FI11
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:18093184, ECO:0000269|PubMed:38332367
ChainResidueDetails
ALYS147

site_idSWS_FT_FI12
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23512198
ChainResidueDetails
ALYS166

237423

PDB entries from 2025-06-11

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