5NVK

Crystal structure of the human 4EHP-GIGYF1 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003743	molecular_function	translation initiation factor activity
A	0005737	cellular_component	cytoplasm
A	0006413	biological_process	translational initiation
C	0003723	molecular_function	RNA binding
C	0003743	molecular_function	translation initiation factor activity
C	0005737	cellular_component	cytoplasm
C	0006413	biological_process	translational initiation
E	0003723	molecular_function	RNA binding
E	0003743	molecular_function	translation initiation factor activity
E	0005737	cellular_component	cytoplasm
E	0006413	biological_process	translational initiation
G	0003723	molecular_function	RNA binding
G	0003743	molecular_function	translation initiation factor activity
G	0005737	cellular_component	cytoplasm
G	0006413	biological_process	translational initiation

Functional Information from PROSITE/UniProt

site_id	PS00813
Number of Residues	24
Details	IF4E Eukaryotic initiation factor 4E signature. DFhlFKegIkPmWEDdanknGGKW

Chain	Residue	Details
A	ASP112-TRP135

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P06730

Chain	Residue	Details
A	TYR78
A	LYS222
C	TYR78
C	LYS222
E	TYR78
E	LYS222
G	TYR78
G	LYS222

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site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:17368478

Chain	Residue	Details
A	HIS110
G	HIS110
G	TRP124
G	ARG174
A	TRP124
A	ARG174
C	HIS110
C	TRP124
C	ARG174
E	HIS110
E	TRP124
E	ARG174

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS134
C	LYS134
E	LYS134
G	LYS134

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site_id	SWS_FT_FI4
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15); alternate => ECO:0000269|PubMed:17289916

Chain	Residue	Details
A	LYS134
C	LYS134
E	LYS134
G	LYS134

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site_id	SWS_FT_FI5
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15) => ECO:0000269|PubMed:17289916

Chain	Residue	Details
A	LYS222
C	LYS222
E	LYS222
G	LYS222

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