5NT2

Complex of influenza A NS1 with TRIM25 coiled coil domain

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
C	0030430	cellular_component	host cell cytoplasm
C	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
C	0039524	biological_process	symbiont-mediated suppression of host mRNA processing
C	0039540	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity
C	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
C	0039657	biological_process	symbiont-mediated suppression of host gene expression
C	0042025	cellular_component	host cell nucleus
C	0042802	molecular_function	identical protein binding
C	0052031	biological_process	symbiont-mediated perturbation of host defense response
C	0052170	biological_process	symbiont-mediated suppression of host innate immune response
D	0003723	molecular_function	RNA binding
D	0005515	molecular_function	protein binding
D	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
D	0030430	cellular_component	host cell cytoplasm
D	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
D	0039524	biological_process	symbiont-mediated suppression of host mRNA processing
D	0039540	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity
D	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
D	0039657	biological_process	symbiont-mediated suppression of host gene expression
D	0042025	cellular_component	host cell nucleus
D	0042802	molecular_function	identical protein binding
D	0052031	biological_process	symbiont-mediated perturbation of host defense response
D	0052170	biological_process	symbiont-mediated suppression of host innate immune response
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
E	0030430	cellular_component	host cell cytoplasm
E	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
E	0039524	biological_process	symbiont-mediated suppression of host mRNA processing
E	0039540	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity
E	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
E	0039657	biological_process	symbiont-mediated suppression of host gene expression
E	0042025	cellular_component	host cell nucleus
E	0042802	molecular_function	identical protein binding
E	0052031	biological_process	symbiont-mediated perturbation of host defense response
E	0052170	biological_process	symbiont-mediated suppression of host innate immune response
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
F	0030430	cellular_component	host cell cytoplasm
F	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
F	0039524	biological_process	symbiont-mediated suppression of host mRNA processing
F	0039540	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity
F	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
F	0039657	biological_process	symbiont-mediated suppression of host gene expression
F	0042025	cellular_component	host cell nucleus
F	0042802	molecular_function	identical protein binding
F	0052031	biological_process	symbiont-mediated perturbation of host defense response
F	0052170	biological_process	symbiont-mediated suppression of host innate immune response

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Motif: {"description":"Nuclear export signal","evidences":[{"source":"HAMAP-Rule","id":"MF_04066","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	16
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15); in band II form; by host","evidences":[{"source":"PubMed","id":"20385878","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	8
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"source":"HAMAP-Rule","id":"MF_04066","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15); in band I form; by host","evidences":[{"source":"PubMed","id":"20385878","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	360
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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