5NT2

Complex of influenza A NS1 with TRIM25 coiled coil domain

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
C	0030430	cellular_component	host cell cytoplasm
C	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
C	0039524	biological_process	symbiont-mediated suppression of host mRNA processing
C	0039540	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity
C	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
C	0039657	biological_process	symbiont-mediated suppression of host gene expression
C	0042025	cellular_component	host cell nucleus
C	0042802	molecular_function	identical protein binding
C	0052170	biological_process	symbiont-mediated suppression of host innate immune response
D	0003723	molecular_function	RNA binding
D	0005515	molecular_function	protein binding
D	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
D	0030430	cellular_component	host cell cytoplasm
D	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
D	0039524	biological_process	symbiont-mediated suppression of host mRNA processing
D	0039540	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity
D	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
D	0039657	biological_process	symbiont-mediated suppression of host gene expression
D	0042025	cellular_component	host cell nucleus
D	0042802	molecular_function	identical protein binding
D	0052170	biological_process	symbiont-mediated suppression of host innate immune response
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
E	0030430	cellular_component	host cell cytoplasm
E	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
E	0039524	biological_process	symbiont-mediated suppression of host mRNA processing
E	0039540	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity
E	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
E	0039657	biological_process	symbiont-mediated suppression of host gene expression
E	0042025	cellular_component	host cell nucleus
E	0042802	molecular_function	identical protein binding
E	0052170	biological_process	symbiont-mediated suppression of host innate immune response
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
F	0030430	cellular_component	host cell cytoplasm
F	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
F	0039524	biological_process	symbiont-mediated suppression of host mRNA processing
F	0039540	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity
F	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
F	0039657	biological_process	symbiont-mediated suppression of host gene expression
F	0042025	cellular_component	host cell nucleus
F	0042802	molecular_function	identical protein binding
F	0052170	biological_process	symbiont-mediated suppression of host innate immune response

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
I	LYS273
C	LYS219
D	LYS20
D	ALA41
D	LYS217
D	LYS219
E	LYS20
E	ALA41
E	LYS217
A	LYS273
E	LYS219
V	LYS273
N	LYS273
F	LYS219
C	LYS20
C	ALA41
C	LYS217

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site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
I	TYR278
E	LYS108
E	LYS110
E	LYS126
A	TYR278
V	TYR278
N	TYR278
C	LYS110
C	LYS126
D	LYS108
D	LYS110
D	LYS126

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