5NRW

Crystal structure of the human bromodomain of CREBBP bound to the inhibitor XDM4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004402	molecular_function	histone acetyltransferase activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue 96N A 1201

Chain	Residue
A	LEU1109
A	VAL1174
A	HOH1312
A	HOH1356
A	HOH1402
A	PRO1110
A	PHE1111
A	VAL1115
A	LEU1120
A	ILE1122
A	TYR1167
A	ASN1168
A	ARG1173

---

site_id	AC2
Number of Residues	4
Details	binding site for residue EDO A 1202

Chain	Residue
A	HOH1304
A	HOH1313
A	HOH1336
A	HOH1376

---

site_id	AC3
Number of Residues	7
Details	binding site for residue EDO A 1203

Chain	Residue
A	GLU1088
A	ARG1091
A	ASP1124
A	ASP1127
A	ARG1140
A	HOH1325
A	HOH1386

---

site_id	AC4
Number of Residues	4
Details	binding site for residue EDO A 1204

Chain	Residue
A	TYR1102
A	HOH1301
A	HOH1303
A	HOH1416

---

site_id	AC5
Number of Residues	2
Details	binding site for residue EDO A 1205

Chain	Residue
A	ARG1103
A	HOH1326

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. SlpFrqpvDpqllgipDYFdiVknpMdlstIkrkldtgq..Yqepwqyvddvwl.MfnNAwlY

Chain	Residue	Details
A	SER1108-TYR1167

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	107
Details	Domain: {"description":"Bromo","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	46
Details	Region: {"description":"Interaction with histone","evidences":[{"source":"PubMed","id":"24361270","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	Region: {"description":"Interaction with ASF1A","evidences":[{"source":"PubMed","id":"24616510","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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