5NAN

Crystal Structure of human IL-17AF in complex with human IL-17RA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002225	biological_process	positive regulation of antimicrobial peptide production
A	0002250	biological_process	adaptive immune response
A	0005125	molecular_function	cytokine activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006915	biological_process	apoptotic process
A	0006954	biological_process	inflammatory response
A	0006955	biological_process	immune response
A	0007219	biological_process	Notch signaling pathway
A	0007267	biological_process	cell-cell signaling
A	0008219	biological_process	cell death
A	0009611	biological_process	response to wounding
A	0009897	cellular_component	external side of plasma membrane
A	0010467	biological_process	gene expression
A	0030216	biological_process	keratinocyte differentiation
A	0032731	biological_process	positive regulation of interleukin-1 beta production
A	0032735	biological_process	positive regulation of interleukin-12 production
A	0032739	biological_process	positive regulation of interleukin-16 production
A	0032747	biological_process	positive regulation of interleukin-23 production
A	0032755	biological_process	positive regulation of interleukin-6 production
A	0032760	biological_process	positive regulation of tumor necrosis factor production
A	0038173	biological_process	interleukin-17A-mediated signaling pathway
A	0042803	molecular_function	protein homodimerization activity
A	0043616	biological_process	keratinocyte proliferation
A	0045087	biological_process	innate immune response
A	0045672	biological_process	positive regulation of osteoclast differentiation
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046982	molecular_function	protein heterodimerization activity
A	0050829	biological_process	defense response to Gram-negative bacterium
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0050832	biological_process	defense response to fungus
A	0060729	biological_process	intestinal epithelial structure maintenance
A	0071347	biological_process	cellular response to interleukin-1
A	0072537	biological_process	fibroblast activation
A	0097400	biological_process	interleukin-17-mediated signaling pathway
A	0097530	biological_process	granulocyte migration
A	0106015	biological_process	negative regulation of inflammatory response to wounding
A	1900017	biological_process	positive regulation of cytokine production involved in inflammatory response
A	1903348	biological_process	positive regulation of bicellular tight junction assembly
A	2000340	biological_process	positive regulation of chemokine (C-X-C motif) ligand 1 production
B	0030368	molecular_function	interleukin-17 receptor activity
C	0030368	molecular_function	interleukin-17 receptor activity
D	0002225	biological_process	positive regulation of antimicrobial peptide production
D	0002250	biological_process	adaptive immune response
D	0005125	molecular_function	cytokine activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006915	biological_process	apoptotic process
D	0006954	biological_process	inflammatory response
D	0006955	biological_process	immune response
D	0007219	biological_process	Notch signaling pathway
D	0007267	biological_process	cell-cell signaling
D	0008219	biological_process	cell death
D	0009611	biological_process	response to wounding
D	0009897	cellular_component	external side of plasma membrane
D	0010467	biological_process	gene expression
D	0030216	biological_process	keratinocyte differentiation
D	0032731	biological_process	positive regulation of interleukin-1 beta production
D	0032735	biological_process	positive regulation of interleukin-12 production
D	0032739	biological_process	positive regulation of interleukin-16 production
D	0032747	biological_process	positive regulation of interleukin-23 production
D	0032755	biological_process	positive regulation of interleukin-6 production
D	0032760	biological_process	positive regulation of tumor necrosis factor production
D	0038173	biological_process	interleukin-17A-mediated signaling pathway
D	0042803	molecular_function	protein homodimerization activity
D	0043616	biological_process	keratinocyte proliferation
D	0045087	biological_process	innate immune response
D	0045672	biological_process	positive regulation of osteoclast differentiation
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0046982	molecular_function	protein heterodimerization activity
D	0050829	biological_process	defense response to Gram-negative bacterium
D	0050830	biological_process	defense response to Gram-positive bacterium
D	0050832	biological_process	defense response to fungus
D	0060729	biological_process	intestinal epithelial structure maintenance
D	0071347	biological_process	cellular response to interleukin-1
D	0072537	biological_process	fibroblast activation
D	0097400	biological_process	interleukin-17-mediated signaling pathway
D	0097530	biological_process	granulocyte migration
D	0106015	biological_process	negative regulation of inflammatory response to wounding
D	1900017	biological_process	positive regulation of cytokine production involved in inflammatory response
D	1903348	biological_process	positive regulation of bicellular tight junction assembly
D	2000340	biological_process	positive regulation of chemokine (C-X-C motif) ligand 1 production
E	0001819	biological_process	positive regulation of cytokine production
E	0002225	biological_process	positive regulation of antimicrobial peptide production
E	0002250	biological_process	adaptive immune response
E	0005125	molecular_function	cytokine activity
E	0005126	molecular_function	cytokine receptor binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0006954	biological_process	inflammatory response
E	0016525	biological_process	negative regulation of angiogenesis
E	0017015	biological_process	regulation of transforming growth factor beta receptor signaling pathway
E	0019955	molecular_function	cytokine binding
E	0032645	biological_process	regulation of granulocyte macrophage colony-stimulating factor production
E	0032663	biological_process	regulation of interleukin-2 production
E	0032675	biological_process	regulation of interleukin-6 production
E	0032677	biological_process	regulation of interleukin-8 production
E	0032755	biological_process	positive regulation of interleukin-6 production
E	0032761	biological_process	positive regulation of lymphotoxin A production
E	0042803	molecular_function	protein homodimerization activity
E	0045087	biological_process	innate immune response
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0046982	molecular_function	protein heterodimerization activity
E	0050829	biological_process	defense response to Gram-negative bacterium
E	0050830	biological_process	defense response to Gram-positive bacterium
E	0051216	biological_process	cartilage development
E	0097400	biological_process	interleukin-17-mediated signaling pathway
E	1900017	biological_process	positive regulation of cytokine production involved in inflammatory response
E	2000340	biological_process	positive regulation of chemokine (C-X-C motif) ligand 1 production
F	0001819	biological_process	positive regulation of cytokine production
F	0002225	biological_process	positive regulation of antimicrobial peptide production
F	0002250	biological_process	adaptive immune response
F	0005125	molecular_function	cytokine activity
F	0005126	molecular_function	cytokine receptor binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0006954	biological_process	inflammatory response
F	0016525	biological_process	negative regulation of angiogenesis
F	0017015	biological_process	regulation of transforming growth factor beta receptor signaling pathway
F	0019955	molecular_function	cytokine binding
F	0032645	biological_process	regulation of granulocyte macrophage colony-stimulating factor production
F	0032663	biological_process	regulation of interleukin-2 production
F	0032675	biological_process	regulation of interleukin-6 production
F	0032677	biological_process	regulation of interleukin-8 production
F	0032755	biological_process	positive regulation of interleukin-6 production
F	0032761	biological_process	positive regulation of lymphotoxin A production
F	0042803	molecular_function	protein homodimerization activity
F	0045087	biological_process	innate immune response
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0046982	molecular_function	protein heterodimerization activity
F	0050829	biological_process	defense response to Gram-negative bacterium
F	0050830	biological_process	defense response to Gram-positive bacterium
F	0051216	biological_process	cartilage development
F	0097400	biological_process	interleukin-17-mediated signaling pathway
F	1900017	biological_process	positive regulation of cytokine production involved in inflammatory response
F	2000340	biological_process	positive regulation of chemokine (C-X-C motif) ligand 1 production

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19838198

Chain	Residue	Details
E	ASN83
F	ASN83

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site_id	SWS_FT_FI2
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19838198, ECO:0000269|PubMed:23695682

Chain	Residue	Details
B	ASN49
B	ASN54
B	ASN225
C	ASN49
C	ASN54
C	ASN225

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site_id	SWS_FT_FI3
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19838198

Chain	Residue	Details
B	ASN67
B	ASN265
C	ASN67
C	ASN265

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site_id	SWS_FT_FI4
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
B	ASN206
B	ASN242
C	ASN206
C	ASN242

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