5NAG
Pseudomonas fluorescens kynurenine 3-monooxygenase (KMO) in complex with 3-{5-chloro-6-[(1R)-1-(pyridin-2-yl)ethoxy]-1,2-benzoxazol-3-yl}propanoic acid
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004497 | molecular_function | monooxygenase activity |
A | 0004502 | molecular_function | kynurenine 3-monooxygenase activity |
A | 0006569 | biological_process | tryptophan catabolic process |
A | 0009435 | biological_process | NAD biosynthetic process |
A | 0016174 | molecular_function | NAD(P)H oxidase H2O2-forming activity |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
A | 0019674 | biological_process | NAD metabolic process |
A | 0019805 | biological_process | quinolinate biosynthetic process |
A | 0034354 | biological_process | 'de novo' NAD biosynthetic process from tryptophan |
A | 0043420 | biological_process | anthranilate metabolic process |
A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
A | 0070189 | biological_process | kynurenine metabolic process |
A | 0071949 | molecular_function | FAD binding |
B | 0003824 | molecular_function | catalytic activity |
B | 0004497 | molecular_function | monooxygenase activity |
B | 0004502 | molecular_function | kynurenine 3-monooxygenase activity |
B | 0006569 | biological_process | tryptophan catabolic process |
B | 0009435 | biological_process | NAD biosynthetic process |
B | 0016174 | molecular_function | NAD(P)H oxidase H2O2-forming activity |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
B | 0019674 | biological_process | NAD metabolic process |
B | 0019805 | biological_process | quinolinate biosynthetic process |
B | 0034354 | biological_process | 'de novo' NAD biosynthetic process from tryptophan |
B | 0043420 | biological_process | anthranilate metabolic process |
B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
B | 0070189 | biological_process | kynurenine metabolic process |
B | 0071949 | molecular_function | FAD binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 38 |
Details | binding site for residue FAD A 501 |
Chain | Residue |
A | ILE13 |
A | LEU55 |
A | ALA56 |
A | ARG111 |
A | GLY134 |
A | LEU135 |
A | ALA165 |
A | ASP166 |
A | GLY167 |
A | ALA171 |
A | TYR193 |
A | GLY14 |
A | GLU195 |
A | GLY310 |
A | ASP311 |
A | GLY321 |
A | GLN322 |
A | GLY323 |
A | MET324 |
A | ASN325 |
A | ALA327 |
A | 8R5502 |
A | GLY16 |
A | HOH636 |
A | HOH662 |
A | HOH737 |
A | HOH743 |
A | HOH754 |
A | HOH777 |
A | HOH781 |
A | HOH782 |
A | HOH862 |
A | LEU17 |
A | ALA18 |
A | GLU37 |
A | ARG38 |
A | ARG39 |
A | ILE53 |
site_id | AC2 |
Number of Residues | 12 |
Details | binding site for residue 8R5 A 502 |
Chain | Residue |
A | ALA56 |
A | ARG84 |
A | TYR98 |
A | ILE224 |
A | PHE238 |
A | PRO318 |
A | PHE319 |
A | GLY321 |
A | ASN369 |
A | FAD501 |
A | HOH706 |
A | HOH801 |
site_id | AC3 |
Number of Residues | 38 |
Details | binding site for residue FAD B 501 |
Chain | Residue |
B | ILE13 |
B | GLY14 |
B | GLY16 |
B | LEU17 |
B | ALA18 |
B | GLU37 |
B | ARG38 |
B | ARG39 |
B | LEU55 |
B | ALA56 |
B | ARG111 |
B | GLY134 |
B | LEU135 |
B | ALA165 |
B | ASP166 |
B | GLY167 |
B | ALA171 |
B | GLU195 |
B | GLY310 |
B | ASP311 |
B | GLY321 |
B | GLN322 |
B | GLY323 |
B | MET324 |
B | ASN325 |
B | ALA327 |
B | 8R5502 |
B | HOH601 |
B | HOH606 |
B | HOH616 |
B | HOH645 |
B | HOH661 |
B | HOH737 |
B | HOH803 |
B | HOH814 |
B | HOH841 |
B | HOH857 |
B | HOH909 |
site_id | AC4 |
Number of Residues | 18 |
Details | binding site for residue 8R5 B 502 |
Chain | Residue |
B | TYR404 |
B | FAD501 |
B | HOH601 |
B | HOH604 |
B | HOH622 |
B | HOH739 |
B | HOH836 |
B | ALA56 |
B | ARG84 |
B | LEU213 |
B | ILE215 |
B | ILE224 |
B | PHE238 |
B | PRO318 |
B | PHE319 |
B | GLY321 |
B | ASN369 |
B | MET373 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 14 |
Details | BINDING: BINDING => ECO:0000269|PubMed:28336141, ECO:0000269|PubMed:28398044, ECO:0000269|PubMed:28604669, ECO:0000269|PubMed:29208702, ECO:0000269|PubMed:29429898, ECO:0007744|PDB:5FN0, ECO:0007744|PDB:5MZC, ECO:0007744|PDB:5MZI, ECO:0007744|PDB:5MZK, ECO:0007744|PDB:5N7T, ECO:0007744|PDB:5NA5, ECO:0007744|PDB:5NAB, ECO:0007744|PDB:5NAE, ECO:0007744|PDB:5NAG, ECO:0007744|PDB:5NAH, ECO:0007744|PDB:5NAK, ECO:0007744|PDB:5X6P, ECO:0007744|PDB:5X6Q, ECO:0007744|PDB:5Y66, ECO:0007744|PDB:5Y77, ECO:0007744|PDB:5Y7A |
Chain | Residue | Details |
A | LEU17 | |
B | ALA56 | |
B | ARG111 | |
B | LEU135 | |
B | ASP311 | |
B | MET324 | |
A | GLU37 | |
A | ALA56 | |
A | ARG111 | |
A | LEU135 | |
A | ASP311 | |
A | MET324 | |
B | LEU17 | |
B | GLU37 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:29208702, ECO:0007744|PDB:5Y66, ECO:0007744|PDB:5Y77 |
Chain | Residue | Details |
A | ARG84 | |
B | ARG84 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:29208702, ECO:0007744|PDB:5Y77 |
Chain | Residue | Details |
A | TYR98 | |
B | TYR98 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:29208702, ECO:0007744|PDB:5Y66, ECO:0007744|PDB:5Y77, ECO:0007744|PDB:5Y7A |
Chain | Residue | Details |
A | ASN369 | |
A | TYR404 | |
B | ASN369 | |
B | TYR404 |