5N7T

Pseudomonas fluorescens kynurenine 3-monooxygenase (KMO) in complex with 3-(5,6-dichloro-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid

Summary for 5N7T

• Entry DOI: 10.2210/pdb5n7t/pdb
• Descriptor: Kynurenine 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, CHLORIDE ION, ... (6 entities in total)
• Functional Keywords: kmo, kynurenine 3-monooxygenase, oxidoreductase
• Biological source: Pseudomonas fluorescens
• Total number of polymer chains: 2
• Total formula weight: 104409.94

Authors

Rowland, P. (deposition date: 2017-02-21, release date: 2017-06-14, Last modification date: 2024-05-08)

• Primary citation: Liddle, J.,Beaufils, B.,Binnie, M.,Bouillot, A.,Denis, A.A.,Hann, M.M.,Haslam, C.P.,Holmes, D.S.,Hutchinson, J.P.,Kranz, M.,McBride, A.,Mirguet, O.,Mole, D.J.,Mowat, C.G.,Pal, S.,Rowland, P.,Trottet, L.,Uings, I.J.,Walker, A.L.,Webster, S.P.; The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis.; Bioorg. Med. Chem. Lett., 27:2023-2028, 2017; PubMed: 28336141; DOI: 10.1016/j.bmcl.2017.02.078

Experimental method

X-RAY DIFFRACTION (1.81 Å)