Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5N9J

Core Mediator of transcriptional regulation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003712	molecular_function	transcription coregulator activity
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0016592	cellular_component	mediator complex
B	0003712	molecular_function	transcription coregulator activity
B	0003713	molecular_function	transcription coactivator activity
B	0005634	cellular_component	nucleus
B	0005635	cellular_component	nuclear envelope
B	0005737	cellular_component	cytoplasm
B	0006351	biological_process	DNA-templated transcription
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0016592	cellular_component	mediator complex
B	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
C	0003712	molecular_function	transcription coregulator activity
C	0003713	molecular_function	transcription coactivator activity
C	0005634	cellular_component	nucleus
C	0006351	biological_process	DNA-templated transcription
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0006367	biological_process	transcription initiation at RNA polymerase II promoter
C	0016592	cellular_component	mediator complex
C	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
C	0070847	cellular_component	core mediator complex
D	0003712	molecular_function	transcription coregulator activity
D	0003713	molecular_function	transcription coactivator activity
D	0005634	cellular_component	nucleus
D	0006351	biological_process	DNA-templated transcription
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0016592	cellular_component	mediator complex
D	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
E	0000791	cellular_component	euchromatin
E	0003712	molecular_function	transcription coregulator activity
E	0003713	molecular_function	transcription coactivator activity
E	0005634	cellular_component	nucleus
E	0006351	biological_process	DNA-templated transcription
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0016592	cellular_component	mediator complex
E	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
E	0070847	cellular_component	core mediator complex
F	0003713	molecular_function	transcription coactivator activity
F	0005634	cellular_component	nucleus
F	0016592	cellular_component	mediator complex
F	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
G	0003712	molecular_function	transcription coregulator activity
G	0003713	molecular_function	transcription coactivator activity
G	0005634	cellular_component	nucleus
G	0006351	biological_process	DNA-templated transcription
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0016592	cellular_component	mediator complex
G	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
G	0070847	cellular_component	core mediator complex
R	0003712	molecular_function	transcription coregulator activity
R	0003713	molecular_function	transcription coactivator activity
R	0005634	cellular_component	nucleus
R	0006351	biological_process	DNA-templated transcription
R	0006355	biological_process	regulation of DNA-templated transcription
R	0006357	biological_process	regulation of transcription by RNA polymerase II
R	0016592	cellular_component	mediator complex
R	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
R	0070847	cellular_component	core mediator complex
S	0003712	molecular_function	transcription coregulator activity
S	0003713	molecular_function	transcription coactivator activity
S	0005634	cellular_component	nucleus
S	0006351	biological_process	DNA-templated transcription
S	0006357	biological_process	regulation of transcription by RNA polymerase II
S	0016592	cellular_component	mediator complex
S	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
S	0070847	cellular_component	core mediator complex
U	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
U	0003712	molecular_function	transcription coregulator activity
U	0003713	molecular_function	transcription coactivator activity
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0006351	biological_process	DNA-templated transcription
U	0006357	biological_process	regulation of transcription by RNA polymerase II
U	0006367	biological_process	transcription initiation at RNA polymerase II promoter
U	0016592	cellular_component	mediator complex
U	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
U	0070847	cellular_component	core mediator complex
V	0003712	molecular_function	transcription coregulator activity
V	0003713	molecular_function	transcription coactivator activity
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005737	cellular_component	cytoplasm
V	0006357	biological_process	regulation of transcription by RNA polymerase II
V	0016592	cellular_component	mediator complex
V	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
W	0003712	molecular_function	transcription coregulator activity
W	0003713	molecular_function	transcription coactivator activity
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0006351	biological_process	DNA-templated transcription
W	0006357	biological_process	regulation of transcription by RNA polymerase II
W	0006367	biological_process	transcription initiation at RNA polymerase II promoter
W	0016592	cellular_component	mediator complex
W	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
W	0070847	cellular_component	core mediator complex
X	0003712	molecular_function	transcription coregulator activity
X	0003713	molecular_function	transcription coactivator activity
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0006351	biological_process	DNA-templated transcription
X	0006357	biological_process	regulation of transcription by RNA polymerase II
X	0016592	cellular_component	mediator complex
X	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
X	0070847	cellular_component	core mediator complex
Y	0003712	molecular_function	transcription coregulator activity
Y	0003713	molecular_function	transcription coactivator activity
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0006357	biological_process	regulation of transcription by RNA polymerase II
Y	0016592	cellular_component	mediator complex
Y	0032991	cellular_component	protein-containing complex
Y	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
Z	0003712	molecular_function	transcription coregulator activity
Z	0003713	molecular_function	transcription coactivator activity
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0006351	biological_process	DNA-templated transcription
Z	0006357	biological_process	regulation of transcription by RNA polymerase II
Z	0006367	biological_process	transcription initiation at RNA polymerase II promoter
Z	0016592	cellular_component	mediator complex
Z	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DENKNQSIEnaDY

Chain	Residue	Details
S	ASP177-TYR189

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	41
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	25
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	10
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18257517","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	20
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)