5N4E
Prolyl oligopeptidase B from Galerina marginata bound to 35mer hydrolysis and macrocyclization substrate - H698A mutant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0070012 | molecular_function | oligopeptidase activity |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0070012 | molecular_function | oligopeptidase activity |
| C | 0035821 | biological_process | modulation of process of another organism |
| C | 0090729 | molecular_function | toxin activity |
| D | 0035821 | biological_process | modulation of process of another organism |
| D | 0090729 | molecular_function | toxin activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 801 |
| Chain | Residue |
| B | GLU268 |
| B | ASN315 |
| B | ILE316 |
| B | HOH1153 |
Functional Information from PROSITE/UniProt
| site_id | PS00708 |
| Number of Residues | 31 |
| Details | PRO_ENDOPEP_SER Prolyl endopeptidase family serine active site. DfiaAaqfLvknkyaapgkvainGaSnGGLL |
| Chain | Residue | Details |
| A | ASP552-LEU582 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PROSITE-ProRule","id":"PRU10084","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"29051530","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | Propeptide: {"featureId":"PRO_0000443566","evidences":[{"source":"UniProtKB","id":"A8W7M4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"(3R,4S)-4-hydroxyisoleucine; in form gamma-amanitin","evidences":[{"source":"UniProtKB","id":"P85421","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"4-hydroxyproline","evidences":[{"source":"UniProtKB","id":"P85421","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
