Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5MZQ

X-ray structure of the M205W mutant of GLIC in complex with bromoform

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ACT A 401

Chain	Residue
A	ARG77
A	ILE131
A	GLU181
E	PHE42
E	ARG105

site_id	AC2
Number of Residues	7
Details	binding site for residue PC8 A 402

Chain	Residue
A	ASN307
A	PHE315
A	D12404
A	ARG118
A	PHE121
A	TYR194
A	TYR254

site_id	AC3
Number of Residues	3
Details	binding site for residue 2IL A 403

Chain	Residue
A	PHE210
A	TRP217
B	TYR278

site_id	AC4
Number of Residues	1
Details	binding site for residue D12 A 404

Chain	Residue
A	PC8402

site_id	AC5
Number of Residues	3
Details	binding site for residue CL A 405

Chain	Residue
A	PHE78
A	ARG85
A	HOH539

site_id	AC6
Number of Residues	3
Details	binding site for residue CL A 406

Chain	Residue
A	ASN139
A	LEU180
D	ALA175

site_id	AC7
Number of Residues	3
Details	binding site for residue CL A 407

Chain	Residue
A	ALA175
D	ASN139
D	LEU180

site_id	AC8
Number of Residues	3
Details	binding site for residue NA A 408

Chain	Residue
A	PRO68
A	ILE71
A	ILE73

site_id	AC9
Number of Residues	5
Details	binding site for residue ACT A 409

Chain	Residue
A	ILE73
A	PRO74
A	ILE76
A	ARG85
A	TYR102

site_id	AD1
Number of Residues	2
Details	binding site for residue MBR A 411

Chain	Residue
A	THR255
A	HOH580

site_id	AD2
Number of Residues	5
Details	binding site for residue ACT B 401

Chain	Residue
A	PHE42
A	ARG105
B	ARG77
B	ILE131
B	GLU181

site_id	AD3
Number of Residues	7
Details	binding site for residue PC8 B 402

Chain	Residue
B	ARG118
B	PHE121
B	TYR194
B	TYR254
B	ASN307
B	PHE315
B	D12404

site_id	AD4
Number of Residues	4
Details	binding site for residue 2IL B 403

Chain	Residue
B	PHE210
B	TRP217
C	PHE267
C	TYR278

site_id	AD5
Number of Residues	1
Details	binding site for residue D12 B 404

Chain	Residue
B	PC8402

site_id	AD6
Number of Residues	2
Details	binding site for residue CL B 405

Chain	Residue
B	PHE78
B	ARG85

site_id	AD7
Number of Residues	2
Details	binding site for residue NA B 406

Chain	Residue
B	ILE71
B	ILE73

site_id	AD8
Number of Residues	5
Details	binding site for residue ACT B 407

Chain	Residue
B	ILE73
B	PRO74
B	ILE76
B	ARG85
B	TYR102

site_id	AD9
Number of Residues	1
Details	binding site for residue D12 B 408

Chain	Residue
B	ALA237

site_id	AE1
Number of Residues	1
Details	binding site for residue MBR B 409

Chain	Residue
B	HOH585

site_id	AE2
Number of Residues	1
Details	binding site for residue D12 C 401

Chain	Residue
C	D12409

site_id	AE3
Number of Residues	5
Details	binding site for residue ACT C 402

Chain	Residue
B	PHE42
B	ARG105
C	ARG77
C	ILE131
C	GLU181

site_id	AE4
Number of Residues	7
Details	binding site for residue PC8 C 403

Chain	Residue
C	ARG118
C	PHE121
C	TYR194
C	TYR254
C	ASN307
C	PHE315
C	D12405

site_id	AE5
Number of Residues	3
Details	binding site for residue 2IL C 404

Chain	Residue
C	PHE210
C	TRP217
D	TYR278

site_id	AE6
Number of Residues	1
Details	binding site for residue D12 C 405

Chain	Residue
C	PC8403

site_id	AE7
Number of Residues	3
Details	binding site for residue CL C 406

Chain	Residue
C	PHE78
C	ARG85
C	HOH527

site_id	AE8
Number of Residues	2
Details	binding site for residue NA C 407

Chain	Residue
C	PRO68
C	ILE71

site_id	AE9
Number of Residues	6
Details	binding site for residue ACT C 408

Chain	Residue
C	LEU45
C	ILE73
C	PRO74
C	ILE76
C	ARG85
C	TYR102

site_id	AF1
Number of Residues	1
Details	binding site for residue D12 C 409

Chain	Residue
C	D12401

site_id	AF2
Number of Residues	4
Details	binding site for residue MBR C 410

Chain	Residue
C	ILE202
C	THR255
C	ILE258
C	HOH576

site_id	AF3
Number of Residues	5
Details	binding site for residue ACT D 402

Chain	Residue
D	ILE131
D	GLU181
C	PHE42
C	ARG105
D	ARG77

site_id	AF4
Number of Residues	3
Details	binding site for residue 2IL D 404

Chain	Residue
D	PHE210
D	TRP217
E	TYR278

site_id	AF5
Number of Residues	1
Details	binding site for residue D12 D 405

Chain	Residue
D	PC8403

site_id	AF6
Number of Residues	2
Details	binding site for residue CL D 406

Chain	Residue
D	PHE78
D	ARG85

site_id	AF7
Number of Residues	2
Details	binding site for residue NA D 407

Chain	Residue
D	ILE71
D	ILE73

site_id	AF8
Number of Residues	5
Details	binding site for residue ACT D 408

Chain	Residue
D	ILE73
D	PRO74
D	ILE76
D	ARG85
D	TYR102

site_id	AF9
Number of Residues	1
Details	binding site for residue D12 D 409

Chain	Residue
D	ALA237

site_id	AG1
Number of Residues	3
Details	binding site for residue MBR D 410

Chain	Residue
D	ILE202
D	PC8403
D	HOH580

site_id	AG2
Number of Residues	5
Details	binding site for residue ACT E 401

Chain	Residue
D	PHE42
D	ARG105
E	ARG77
E	ILE131
E	GLU181

site_id	AG3
Number of Residues	7
Details	binding site for residue PC8 E 402

Chain	Residue
E	ARG118
E	PHE121
E	ILE202
E	TYR254
E	ASN307
E	PHE315
E	D12404

site_id	AG4
Number of Residues	3
Details	binding site for residue 2IL E 403

Chain	Residue
A	TYR278
E	PHE210
E	TRP217

site_id	AG5
Number of Residues	1
Details	binding site for residue D12 E 404

Chain	Residue
E	PC8402

site_id	AG6
Number of Residues	2
Details	binding site for residue CL E 405

Chain	Residue
E	PHE78
E	ARG85

site_id	AG7
Number of Residues	2
Details	binding site for residue NA E 406

Chain	Residue
E	PRO68
E	ILE71

site_id	AG8
Number of Residues	4
Details	binding site for residue ACT E 407

Chain	Residue
E	PRO74
E	ILE76
E	ARG85
E	TYR102

site_id	AG9
Number of Residues	2
Details	binding site for residue D12 E 408

Chain	Residue
D	ALA237
E	ILE240

site_id	AH1
Number of Residues	4
Details	binding site for residue MBR E 409

Chain	Residue
E	ILE201
E	ILE202
E	THR255
E	HOH566

site_id	AH2
Number of Residues	12
Details	binding site for Di-peptide PC8 D 403 and PHE D 315

Chain	Residue
D	ARG118
D	PHE121
D	ILE198
D	TYR254
D	ILE258
D	ASN307
D	ALA311
D	PHE312
D	LEU313
D	PHE314
D	D12405
D	MBR410

site_id	AH3
Number of Residues	12
Details	binding site for Di-peptide PC8 D 403 and PHE D 315

Chain	Residue
D	ARG118
D	PHE121
D	ILE198
D	TYR254
D	ILE258
D	ASN307
D	ALA311
D	PHE312
D	LEU313
D	PHE314
D	D12405
D	MBR410

site_id	AH4
Number of Residues	12
Details	binding site for Di-peptide PC8 D 403 and PHE D 315

Chain	Residue
D	ARG118
D	PHE121
D	ILE198
D	TYR254
D	ILE258
D	ASN307
D	ALA311
D	PHE312
D	LEU313
D	PHE314
D	D12405
D	MBR410

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	370
Details	Transmembrane: {"description":"Helical"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	20
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	35
Details	Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)