5MPA

26S proteasome in presence of ATP (s2)

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0004175	molecular_function	endopeptidase activity
1	0004298	molecular_function	threonine-type endopeptidase activity
1	0005515	molecular_function	protein binding
1	0005634	cellular_component	nucleus
1	0005737	cellular_component	cytoplasm
1	0005829	cellular_component	cytosol
1	0005839	cellular_component	proteasome core complex
1	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
1	0019774	cellular_component	proteasome core complex, beta-subunit complex
1	0030163	biological_process	protein catabolic process
1	0034515	cellular_component	proteasome storage granule
1	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
2	0004175	molecular_function	endopeptidase activity
2	0004298	molecular_function	threonine-type endopeptidase activity
2	0005515	molecular_function	protein binding
2	0005634	cellular_component	nucleus
2	0005737	cellular_component	cytoplasm
2	0005829	cellular_component	cytosol
2	0005839	cellular_component	proteasome core complex
2	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
2	0019774	cellular_component	proteasome core complex, beta-subunit complex
2	0030163	biological_process	protein catabolic process
2	0034515	cellular_component	proteasome storage granule
2	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
3	0005515	molecular_function	protein binding
3	0005634	cellular_component	nucleus
3	0005737	cellular_component	cytoplasm
3	0005829	cellular_component	cytosol
3	0005839	cellular_component	proteasome core complex
3	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
3	0019774	cellular_component	proteasome core complex, beta-subunit complex
3	0030163	biological_process	protein catabolic process
3	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
3	0061133	molecular_function	endopeptidase activator activity
4	0005515	molecular_function	protein binding
4	0005634	cellular_component	nucleus
4	0005737	cellular_component	cytoplasm
4	0005789	cellular_component	endoplasmic reticulum membrane
4	0005829	cellular_component	cytosol
4	0005839	cellular_component	proteasome core complex
4	0010498	biological_process	proteasomal protein catabolic process
4	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
4	0019774	cellular_component	proteasome core complex, beta-subunit complex
4	0030163	biological_process	protein catabolic process
4	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
4	0061133	molecular_function	endopeptidase activator activity
5	0004175	molecular_function	endopeptidase activity
5	0004298	molecular_function	threonine-type endopeptidase activity
5	0005515	molecular_function	protein binding
5	0005634	cellular_component	nucleus
5	0005737	cellular_component	cytoplasm
5	0005777	cellular_component	peroxisome
5	0005829	cellular_component	cytosol
5	0005839	cellular_component	proteasome core complex
5	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
5	0019774	cellular_component	proteasome core complex, beta-subunit complex
5	0030163	biological_process	protein catabolic process
5	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
5	0080129	biological_process	proteasome core complex assembly
6	0003674	molecular_function	molecular_function
6	0005515	molecular_function	protein binding
6	0005634	cellular_component	nucleus
6	0005737	cellular_component	cytoplasm
6	0005829	cellular_component	cytosol
6	0005839	cellular_component	proteasome core complex
6	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
6	0019774	cellular_component	proteasome core complex, beta-subunit complex
6	0030163	biological_process	protein catabolic process
6	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
7	0003674	molecular_function	molecular_function
7	0005515	molecular_function	protein binding
7	0005634	cellular_component	nucleus
7	0005737	cellular_component	cytoplasm
7	0005829	cellular_component	cytosol
7	0005839	cellular_component	proteasome core complex
7	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
7	0019774	cellular_component	proteasome core complex, beta-subunit complex
7	0030163	biological_process	protein catabolic process
7	0034515	cellular_component	proteasome storage granule
7	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
7	0043248	biological_process	proteasome assembly
a	0003674	molecular_function	molecular_function
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005737	cellular_component	cytoplasm
a	0005739	cellular_component	mitochondrion
a	0005839	cellular_component	proteasome core complex
a	0006511	biological_process	ubiquitin-dependent protein catabolic process
a	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
a	0019773	cellular_component	proteasome core complex, alpha-subunit complex
a	0030163	biological_process	protein catabolic process
a	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0003674	molecular_function	molecular_function
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005839	cellular_component	proteasome core complex
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0030163	biological_process	protein catabolic process
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
b	0003674	molecular_function	molecular_function
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005737	cellular_component	cytoplasm
b	0005839	cellular_component	proteasome core complex
b	0006511	biological_process	ubiquitin-dependent protein catabolic process
b	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
b	0019773	cellular_component	proteasome core complex, alpha-subunit complex
b	0030163	biological_process	protein catabolic process
b	0034515	cellular_component	proteasome storage granule
b	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0003674	molecular_function	molecular_function
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005839	cellular_component	proteasome core complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0030163	biological_process	protein catabolic process
B	0034515	cellular_component	proteasome storage granule
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
c	0003674	molecular_function	molecular_function
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005737	cellular_component	cytoplasm
c	0005829	cellular_component	cytosol
c	0005839	cellular_component	proteasome core complex
c	0006511	biological_process	ubiquitin-dependent protein catabolic process
c	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
c	0019773	cellular_component	proteasome core complex, alpha-subunit complex
c	0030163	biological_process	protein catabolic process
c	0034515	cellular_component	proteasome storage granule
c	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
c	0080129	biological_process	proteasome core complex assembly
C	0003674	molecular_function	molecular_function
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005839	cellular_component	proteasome core complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0030163	biological_process	protein catabolic process
C	0034515	cellular_component	proteasome storage granule
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0080129	biological_process	proteasome core complex assembly
d	0003674	molecular_function	molecular_function
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005737	cellular_component	cytoplasm
d	0005739	cellular_component	mitochondrion
d	0005839	cellular_component	proteasome core complex
d	0006511	biological_process	ubiquitin-dependent protein catabolic process
d	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
d	0019773	cellular_component	proteasome core complex, alpha-subunit complex
d	0030163	biological_process	protein catabolic process
d	0034515	cellular_component	proteasome storage granule
d	0042175	cellular_component	nuclear outer membrane-endoplasmic reticulum membrane network
d	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0003674	molecular_function	molecular_function
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005839	cellular_component	proteasome core complex
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0030163	biological_process	protein catabolic process
D	0034515	cellular_component	proteasome storage granule
D	0042175	cellular_component	nuclear outer membrane-endoplasmic reticulum membrane network
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
e	0003674	molecular_function	molecular_function
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005737	cellular_component	cytoplasm
e	0005839	cellular_component	proteasome core complex
e	0006511	biological_process	ubiquitin-dependent protein catabolic process
e	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
e	0019773	cellular_component	proteasome core complex, alpha-subunit complex
e	0030163	biological_process	protein catabolic process
e	0034515	cellular_component	proteasome storage granule
e	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0003674	molecular_function	molecular_function
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0030163	biological_process	protein catabolic process
E	0034515	cellular_component	proteasome storage granule
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
f	0003674	molecular_function	molecular_function
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005737	cellular_component	cytoplasm
f	0005839	cellular_component	proteasome core complex
f	0006511	biological_process	ubiquitin-dependent protein catabolic process
f	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
f	0019773	cellular_component	proteasome core complex, alpha-subunit complex
f	0030163	biological_process	protein catabolic process
f	0034515	cellular_component	proteasome storage granule
f	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0003674	molecular_function	molecular_function
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005839	cellular_component	proteasome core complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0030163	biological_process	protein catabolic process
F	0034515	cellular_component	proteasome storage granule
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
g	0003729	molecular_function	mRNA binding
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005737	cellular_component	cytoplasm
g	0005839	cellular_component	proteasome core complex
g	0006511	biological_process	ubiquitin-dependent protein catabolic process
g	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
g	0019773	cellular_component	proteasome core complex, alpha-subunit complex
g	0030163	biological_process	protein catabolic process
g	0034515	cellular_component	proteasome storage granule
g	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0003729	molecular_function	mRNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005839	cellular_component	proteasome core complex
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0030163	biological_process	protein catabolic process
G	0034515	cellular_component	proteasome storage granule
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
h	0004175	molecular_function	endopeptidase activity
h	0004298	molecular_function	threonine-type endopeptidase activity
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005737	cellular_component	cytoplasm
h	0005829	cellular_component	cytosol
h	0005839	cellular_component	proteasome core complex
h	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
h	0019774	cellular_component	proteasome core complex, beta-subunit complex
h	0030163	biological_process	protein catabolic process
h	0034515	cellular_component	proteasome storage granule
h	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0008540	cellular_component	proteasome regulatory particle, base subcomplex
H	0010498	biological_process	proteasomal protein catabolic process
H	0016887	molecular_function	ATP hydrolysis activity
H	0031625	molecular_function	ubiquitin protein ligase binding
H	0036402	molecular_function	proteasome-activating activity
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0045732	biological_process	positive regulation of protein catabolic process
H	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
H	0070682	biological_process	proteasome regulatory particle assembly
i	0004175	molecular_function	endopeptidase activity
i	0004298	molecular_function	threonine-type endopeptidase activity
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005737	cellular_component	cytoplasm
i	0005829	cellular_component	cytosol
i	0005839	cellular_component	proteasome core complex
i	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
i	0019774	cellular_component	proteasome core complex, beta-subunit complex
i	0030163	biological_process	protein catabolic process
i	0034515	cellular_component	proteasome storage granule
i	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0006511	biological_process	ubiquitin-dependent protein catabolic process
I	0008540	cellular_component	proteasome regulatory particle, base subcomplex
I	0010498	biological_process	proteasomal protein catabolic process
I	0016887	molecular_function	ATP hydrolysis activity
I	0031503	biological_process	protein-containing complex localization
I	0036402	molecular_function	proteasome-activating activity
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0043171	biological_process	peptide catabolic process
I	0045732	biological_process	positive regulation of protein catabolic process
I	0070651	biological_process	nonfunctional rRNA decay
I	0070682	biological_process	proteasome regulatory particle assembly
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005737	cellular_component	cytoplasm
j	0005829	cellular_component	cytosol
j	0005839	cellular_component	proteasome core complex
j	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
j	0019774	cellular_component	proteasome core complex, beta-subunit complex
j	0030163	biological_process	protein catabolic process
j	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
j	0061133	molecular_function	endopeptidase activator activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0006289	biological_process	nucleotide-excision repair
J	0006338	biological_process	chromatin remodeling
J	0008540	cellular_component	proteasome regulatory particle, base subcomplex
J	0010498	biological_process	proteasomal protein catabolic process
J	0016887	molecular_function	ATP hydrolysis activity
J	0019904	molecular_function	protein domain specific binding
J	0031625	molecular_function	ubiquitin protein ligase binding
J	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
J	0034515	cellular_component	proteasome storage granule
J	0036402	molecular_function	proteasome-activating activity
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
J	0070651	biological_process	nonfunctional rRNA decay
J	0070682	biological_process	proteasome regulatory particle assembly
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005737	cellular_component	cytoplasm
k	0005789	cellular_component	endoplasmic reticulum membrane
k	0005829	cellular_component	cytosol
k	0005839	cellular_component	proteasome core complex
k	0010498	biological_process	proteasomal protein catabolic process
k	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
k	0019774	cellular_component	proteasome core complex, beta-subunit complex
k	0030163	biological_process	protein catabolic process
k	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
k	0061133	molecular_function	endopeptidase activator activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0006511	biological_process	ubiquitin-dependent protein catabolic process
K	0008540	cellular_component	proteasome regulatory particle, base subcomplex
K	0010498	biological_process	proteasomal protein catabolic process
K	0016887	molecular_function	ATP hydrolysis activity
K	0036402	molecular_function	proteasome-activating activity
K	0042802	molecular_function	identical protein binding
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
K	0070682	biological_process	proteasome regulatory particle assembly
l	0004175	molecular_function	endopeptidase activity
l	0004298	molecular_function	threonine-type endopeptidase activity
l	0005515	molecular_function	protein binding
l	0005634	cellular_component	nucleus
l	0005737	cellular_component	cytoplasm
l	0005777	cellular_component	peroxisome
l	0005829	cellular_component	cytosol
l	0005839	cellular_component	proteasome core complex
l	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
l	0019774	cellular_component	proteasome core complex, beta-subunit complex
l	0030163	biological_process	protein catabolic process
l	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
l	0080129	biological_process	proteasome core complex assembly
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005634	cellular_component	nucleus
L	0006289	biological_process	nucleotide-excision repair
L	0008540	cellular_component	proteasome regulatory particle, base subcomplex
L	0010498	biological_process	proteasomal protein catabolic process
L	0016887	molecular_function	ATP hydrolysis activity
L	0019904	molecular_function	protein domain specific binding
L	0031625	molecular_function	ubiquitin protein ligase binding
L	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
L	0036402	molecular_function	proteasome-activating activity
L	0036503	biological_process	ERAD pathway
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
L	0070682	biological_process	proteasome regulatory particle assembly
m	0003674	molecular_function	molecular_function
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005737	cellular_component	cytoplasm
m	0005829	cellular_component	cytosol
m	0005839	cellular_component	proteasome core complex
m	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
m	0019774	cellular_component	proteasome core complex, beta-subunit complex
m	0030163	biological_process	protein catabolic process
m	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0006511	biological_process	ubiquitin-dependent protein catabolic process
M	0008540	cellular_component	proteasome regulatory particle, base subcomplex
M	0010498	biological_process	proteasomal protein catabolic process
M	0016887	molecular_function	ATP hydrolysis activity
M	0036402	molecular_function	proteasome-activating activity
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
M	0070682	biological_process	proteasome regulatory particle assembly
n	0003674	molecular_function	molecular_function
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0005737	cellular_component	cytoplasm
n	0005829	cellular_component	cytosol
n	0005839	cellular_component	proteasome core complex
n	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
n	0019774	cellular_component	proteasome core complex, beta-subunit complex
n	0030163	biological_process	protein catabolic process
n	0034515	cellular_component	proteasome storage granule
n	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
n	0043248	biological_process	proteasome assembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue MG H 501

Chain	Residue
H	THR257
H	ATP502

---

site_id	AC2
Number of Residues	14
Details	binding site for residue ATP H 502

Chain	Residue
H	ASN356
H	ALA417
H	ARG420
H	MG501
I	LYS214
I	ARG340
I	ARG343
H	GLY212
H	GLY253
H	THR254
H	GLY255
H	LYS256
H	THR257
H	LEU258

---

site_id	AC3
Number of Residues	14
Details	binding site for residue ATP I 501

Chain	Residue
I	ILE184
I	GLY185
I	GLY186
I	PRO225
I	GLY226
I	THR227
I	GLY228
I	LYS229
I	THR230
I	LEU231
I	ILE361
I	GLY389
I	MG502
J	ARG306

---

site_id	AC4
Number of Residues	2
Details	binding site for residue MG I 502

Chain	Residue
I	THR230
I	ATP501

---

site_id	AC5
Number of Residues	19
Details	binding site for residue ATP K 501

Chain	Residue
K	ASP173
K	GLY175
K	GLY176
K	PRO215
K	GLY216
K	THR217
K	GLY218
K	LYS219
K	THR220
K	MET221
K	GLU273
K	ASN319
K	ILE352
K	THR355
K	GLY380
K	ALA381
K	ALA384
K	MG502
L	ARG342

---

site_id	AC6
Number of Residues	2
Details	binding site for residue MG K 502

Chain	Residue
K	THR220
K	ATP501

---

site_id	AC7
Number of Residues	18
Details	binding site for residue ATP L 501

Chain	Residue
L	GLY182
L	ILE183
L	GLY225
L	THR226
L	GLY227
L	LYS228
L	THR229
L	LEU230
L	GLU282
L	ASN328
L	ILE360
L	HIS364
L	GLY388
L	ALA389
L	MG502
M	ARG213
M	ARG339
M	ARG342

---

site_id	AC8
Number of Residues	2
Details	binding site for residue MG L 502

Chain	Residue
L	THR229
L	ATP501

---

site_id	AC9
Number of Residues	12
Details	binding site for residue ATP M 501

Chain	Residue
H	ARG367
H	ARG370
M	GLY184
M	PRO224
M	GLY225
M	THR226
M	GLY227
M	LYS228
M	THR229
M	LEU230
M	HIS364
M	MG502

---

site_id	AD1
Number of Residues	2
Details	binding site for residue MG M 502

Chain	Residue
M	THR229
M	ATP501

---

site_id	AD2
Number of Residues	14
Details	binding site for residue ADP J 501

Chain	Residue
J	LYS359
J	MG502
J	MET149
J	VAL150
J	PRO191
J	GLY192
J	THR193
J	GLY194
J	LYS195
J	THR196
J	LEU197
J	ILE327
J	GLY355
J	ALA356

---

site_id	AD3
Number of Residues	2
Details	binding site for residue MG J 502

Chain	Residue
J	THR196
J	ADP501

---

Functional Information from PROSITE/UniProt

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdsrtTiFSPeGRlyQVEYAleS

Chain	Residue	Details
c	TYR5-SER27
g	TYR4-ALA26
e	TYR0-ALA22
f	TYR5-ALA27
d	TYR2-ALA24
b	TYR5-ALA27
a	TYR3-ALA25

---

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. VkVLaATNrvdvLDpALl.R

Chain	Residue	Details
M	VAL321-ARG339
H	ILE349-ARG367
J	ILE288-ARG306
L	THR321-ARG339
I	VAL322-ARG340
K	VAL312-ARG330

---

site_id	PS00854
Number of Residues	47
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VAMtGkdCVAIACDlrlgsqslgvsnkfe.Kifhyghvflgit.GlaTD

Chain	Residue	Details
j	VAL12-ASP58
h	MET4-ASP51
l	LEU4-ASP51
k	LEU5-ASP52
c	ILE35-ASP82
i	VAL4-ASP51
d	VAL32-ASP79
7	ILE12-ASP59
6	LEU13-ASP60

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	30
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"9087403","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	9
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	35
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	8
Details	M-CSA 177

Chain	Residue	Details
I	LYS30	covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor
I	LEU46	activator, steric locator
I	ASN48	activator
I	MET62	activator, electrostatic stabiliser
I	VAL76	electrostatic stabiliser
I	GLY158	activator, electrostatic stabiliser
I	LYS195	activator, steric locator
I	VAL198	activator, electrostatic stabiliser

---

site_id	MCSA2
Number of Residues	8
Details	M-CSA 177

Chain

Residue

Details

---