Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0031406 | molecular_function | carboxylic acid binding |
| A | 0051287 | molecular_function | NAD binding |
| A | 0070402 | molecular_function | NADPH binding |
| A | 0070404 | molecular_function | NADH binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0031406 | molecular_function | carboxylic acid binding |
| B | 0051287 | molecular_function | NAD binding |
| B | 0070402 | molecular_function | NADPH binding |
| B | 0070404 | molecular_function | NADH binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 401 |
| Chain | Residue |
| A | HOH563 |
| A | HOH590 |
| A | HOH647 |
| B | GLU211 |
| B | HOH548 |
| B | HOH562 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 402 |
| Chain | Residue |
| B | HOH565 |
| B | HOH619 |
| B | HOH679 |
| A | GLU211 |
| A | HOH529 |
| A | HOH545 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 403 |
| Chain | Residue |
| A | ASP265 |
| A | HOH532 |
| A | HOH608 |
| A | HOH624 |
| B | HIS120 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 404 |
| Chain | Residue |
| A | HOH520 |
| A | HOH526 |
| A | HOH541 |
| A | HOH559 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 405 |
| Chain | Residue |
| A | THR132 |
| A | ALA134 |
| A | HOH556 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 406 |
| Chain | Residue |
| A | SER26 |
| A | VAL30 |
| A | PRO31 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 407 |
| Chain | Residue |
| A | PRO73 |
| A | VAL74 |
| A | GLY75 |
| A | VAL76 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 408 |
| Chain | Residue |
| A | ALA188 |
| A | THR214 |
| A | HOH537 |
| A | HOH569 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 409 |
| Chain | Residue |
| A | ASP152 |
| A | ALA156 |
| A | ASN173 |
| A | HOH557 |
| B | ALA156 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for residue 7N5 A 410 |
| Chain | Residue |
| A | ALA15 |
| A | ARG66 |
| A | ALA67 |
| A | GLY68 |
| A | HIS91 |
| A | ARG226 |
| A | HIS274 |
| A | TYR282 |
| A | NDP411 |
| site_id | AD2 |
| Number of Residues | 34 |
| Details | binding site for residue NDP A 411 |
| Chain | Residue |
| A | ALA67 |
| A | GLY68 |
| A | THR88 |
| A | LEU143 |
| A | GLY144 |
| A | THR145 |
| A | LEU146 |
| A | ARG165 |
| A | ARG166 |
| A | SER167 |
| A | PRO180 |
| A | ALA196 |
| A | THR197 |
| A | PRO198 |
| A | THR203 |
| A | VAL224 |
| A | ALA225 |
| A | ARG226 |
| A | ASP250 |
| A | HIS274 |
| A | SER276 |
| A | 7N5410 |
| A | HOH501 |
| A | HOH513 |
| A | HOH521 |
| A | HOH527 |
| A | HOH536 |
| A | HOH547 |
| A | HOH576 |
| A | HOH577 |
| A | HOH582 |
| A | HOH614 |
| A | HOH639 |
| A | HOH660 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 412 |
| Chain | Residue |
| A | ARG148 |
| A | ARG165 |
| A | HOH555 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 401 |
| Chain | Residue |
| B | PHE212 |
| B | GLU213 |
| B | MET215 |
| B | ASP243 |
| B | HOH699 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 402 |
| Chain | Residue |
| B | EDO403 |
| B | HOH513 |
| B | HOH540 |
| B | HOH547 |
| B | HOH617 |
| B | HOH706 |
| site_id | AD6 |
| Number of Residues | 10 |
| Details | binding site for residue EDO B 403 |
| Chain | Residue |
| B | GLU267 |
| B | MG402 |
| B | HOH513 |
| B | HOH540 |
| B | HOH547 |
| B | HOH556 |
| B | HOH617 |
| B | HOH627 |
| B | ARG109 |
| B | ALA112 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 404 |
| Chain | Residue |
| B | ILE90 |
| B | ASP285 |
| B | HOH560 |
| B | HOH571 |
| B | HOH629 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 405 |
| Chain | Residue |
| B | ALA245 |
| B | ASP268 |
| B | HOH625 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 406 |
| Chain | Residue |
| B | THR93 |
| B | ARG148 |
| B | GLY149 |
| B | ASP152 |
| B | ARG153 |
| B | HOH526 |
| site_id | AE1 |
| Number of Residues | 8 |
| Details | binding site for residue 7N5 B 407 |
| Chain | Residue |
| B | ARG66 |
| B | ALA67 |
| B | GLY68 |
| B | HIS91 |
| B | ARG226 |
| B | HIS274 |
| B | 7N6408 |
| B | NDP409 |
| site_id | AE2 |
| Number of Residues | 9 |
| Details | binding site for residue 7N6 B 408 |
| Chain | Residue |
| B | PHE50 |
| B | ARG66 |
| B | ALA67 |
| B | GLY68 |
| B | HIS91 |
| B | ARG226 |
| B | TYR282 |
| B | 7N5407 |
| B | NDP409 |
| site_id | AE3 |
| Number of Residues | 33 |
| Details | binding site for residue NDP B 409 |
| Chain | Residue |
| B | GLY68 |
| B | THR88 |
| B | LEU143 |
| B | GLY144 |
| B | THR145 |
| B | LEU146 |
| B | ARG165 |
| B | ARG166 |
| B | SER167 |
| B | PRO180 |
| B | ALA196 |
| B | THR197 |
| B | PRO198 |
| B | THR203 |
| B | VAL224 |
| B | ALA225 |
| B | ARG226 |
| B | ASP250 |
| B | HIS274 |
| B | SER276 |
| B | 7N5407 |
| B | 7N6408 |
| B | HOH508 |
| B | HOH528 |
| B | HOH554 |
| B | HOH573 |
| B | HOH577 |
| B | HOH582 |
| B | HOH600 |
| B | HOH639 |
| B | HOH671 |
| B | HOH673 |
| B | HOH676 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG226 | |
| A | GLU255 | |
| B | ARG226 | |
| B | GLU255 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000250 |
| Chain | Residue | Details |
| A | HIS274 | |
| B | HIS274 | |
| Chain | Residue | Details |
| A | ASP250 | |
| A | HIS274 | |
| B | THR145 | |
| B | VAL224 | |
| B | ASP250 | |
| B | HIS274 | |
| A | THR145 | |
| A | VAL224 | |
