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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5MFS

The crystal structure of E. coli Aminopeptidase N in complex with 7-amino-4-phenyl-5,7,8,9-tetrahydrobenzocyclohepten-6-one

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004177	molecular_function	aminopeptidase activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1001

Chain	Residue
A	HIS297
A	HIS301
A	GLU320
A	7ML1002

site_id	AC2
Number of Residues	13
Details	binding site for residue 7ML A 1002

Chain	Residue
A	HIS297
A	GLU298
A	HIS301
A	LYS319
A	GLU320
A	TYR381
A	ZN1001
A	MLI1012
A	GLU121
A	MET260
A	ALA262
A	GLU264
A	ARG293

site_id	AC3
Number of Residues	6
Details	binding site for residue NA A 1003

Chain	Residue
A	SER332
A	ASP333
A	GLY335
A	HOH1927
A	HOH2214
A	HOH2302

site_id	AC4
Number of Residues	6
Details	binding site for residue NA A 1004

Chain	Residue
A	HIS771
A	PHE774
A	HOH1322
A	HOH1559
A	HOH2247
A	HOH2291

site_id	AC5
Number of Residues	6
Details	binding site for residue NA A 1005

Chain	Residue
A	SER508
A	HOH1882
A	HOH2060
A	HOH2145
A	HOH2340
A	HOH2806

site_id	AC6
Number of Residues	7
Details	binding site for residue NA A 1006

Chain	Residue
A	GLU123
A	GLU371
A	HOH1145
A	HOH1497
A	HOH1675
A	HOH1872
A	HOH2314

site_id	AC7
Number of Residues	6
Details	binding site for residue NA A 1007

Chain	Residue
A	ASP452
A	TYR544
A	HOH1555
A	HOH2295
A	HOH2330
A	HOH2508

site_id	AC8
Number of Residues	6
Details	binding site for residue NA A 1008

Chain	Residue
A	GLU371
A	HOH1154
A	HOH1327
A	HOH1605
A	HOH2314
A	HOH2481

site_id	AC9
Number of Residues	6
Details	binding site for residue NA A 1009

Chain	Residue
A	ASN67
A	THR91
A	HOH2262
A	HOH2378
A	HOH2400
A	HOH2449

site_id	AD1
Number of Residues	6
Details	binding site for residue NA A 1010

Chain	Residue
A	ASN511
A	THR513
A	GLN517
A	HOH1607
A	HOH2249
A	HOH2586

site_id	AD2
Number of Residues	6
Details	binding site for residue NA A 1011

Chain	Residue
A	ASP452
A	HOH1293
A	HOH1843
A	HOH2225
A	HOH2265
A	HOH2783

site_id	AD3
Number of Residues	9
Details	binding site for residue MLI A 1012

Chain	Residue
A	TYR376
A	THR377
A	LEU378
A	TYR381
A	GLU382
A	ARG825
A	7ML1002
A	GOL1038
A	HOH1160

site_id	AD4
Number of Residues	8
Details	binding site for residue MLI A 1013

Chain	Residue
A	SER205
A	LYS577
A	LEU628
A	PHE629
A	ASP630
A	HOH1103
A	HOH1396
A	HOH2492

site_id	AD5
Number of Residues	9
Details	binding site for residue MLI A 1014

Chain	Residue
A	ALA531
A	LEU532
A	TRP546
A	LEU551
A	ASP566
A	ALA567
A	SER570
A	HOH1133
A	HOH1175

site_id	AD6
Number of Residues	11
Details	binding site for residue MLI A 1015

Chain	Residue
A	GLU397
A	GLU398
A	HOH1169
A	HOH1171
A	HOH1223
A	HOH1432
A	HOH1437
A	HOH1946
A	HOH1952
A	HOH2539
A	GLY396

site_id	AD7
Number of Residues	10
Details	binding site for residue MLI A 1016

Chain	Residue
A	GLU123
A	TRP313
A	PHE314
A	VAL369
A	MET372
A	HOH1145
A	HOH1189
A	HOH1239
A	HOH1261
A	HOH1719

site_id	AD8
Number of Residues	4
Details	binding site for residue DMS A 1017

Chain	Residue
A	THR393
A	GLU535
A	HOH1214
A	HOH2077

site_id	AD9
Number of Residues	5
Details	binding site for residue DMS A 1018

Chain	Residue
A	GLU627
A	PHE629
A	ASP630
A	ARG835
A	HOH1119

site_id	AE1
Number of Residues	6
Details	binding site for residue DMS A 1019

Chain	Residue
A	THR393
A	LEU394
A	LEU395
A	GLY396
A	ASN507
A	HOH1796

site_id	AE2
Number of Residues	5
Details	binding site for residue DMS A 1020

Chain	Residue
A	ASP28
A	LEU29
A	ASP30
A	LYS33
A	ARG171

site_id	AE3
Number of Residues	6
Details	binding site for residue DMS A 1021

Chain	Residue
A	ARG14
A	ALA15
A	PRO16
A	ASP17
A	HOH2601
A	HOH2779

site_id	AE4
Number of Residues	4
Details	binding site for residue CL A 1022

Chain	Residue
A	ASP216
A	ALA254
A	SER273
A	HOH1749

site_id	AE5
Number of Residues	5
Details	binding site for residue CL A 1023

Chain	Residue
A	LEU617
A	LEU619
A	HOH1578
A	HOH1730
A	HOH1840

site_id	AE6
Number of Residues	4
Details	binding site for residue CL A 1024

Chain	Residue
A	GLU800
A	ASP801
A	HOH1870
A	HOH2464

site_id	AE7
Number of Residues	4
Details	binding site for residue CL A 1025

Chain	Residue
A	ALA31
A	GLN32
A	HOH1426
A	HOH2004

site_id	AE8
Number of Residues	5
Details	binding site for residue GOL A 1026

Chain	Residue
A	GLU292
A	VAL670
A	HIS672
A	HOH1167
A	HOH1784

site_id	AE9
Number of Residues	8
Details	binding site for residue GOL A 1027

Chain	Residue
A	ARG681
A	GLN703
A	ALA707
A	ASN708
A	ASN709
A	ASP712
A	HOH1333
A	HOH1909

site_id	AF1
Number of Residues	7
Details	binding site for residue GOL A 1028

Chain	Residue
A	PHE704
A	LYS738
A	TRP739
A	HOH1141
A	HOH1307
A	HOH1667
A	HOH2123

site_id	AF2
Number of Residues	6
Details	binding site for residue GOL A 1029

Chain	Residue
A	TRP74
A	LYS75
A	HOH1130
A	HOH1397
A	HOH1585
A	HOH1876

site_id	AF3
Number of Residues	8
Details	binding site for residue GOL A 1030

Chain	Residue
A	LEU61
A	VAL62
A	TRP74
A	ARG669
A	GLU671
A	HOH1155
A	HOH1397
A	HOH1973

site_id	AF4
Number of Residues	6
Details	binding site for residue GOL A 1031

Chain	Residue
A	ASP58
A	LEU59
A	ILE98
A	HOH1274
A	HOH1704
A	HOH1992

site_id	AF5
Number of Residues	5
Details	binding site for residue GOL A 1032

Chain	Residue
A	ASP68
A	GLU69
A	ARG279
A	ASP281
A	HOH1157

site_id	AF6
Number of Residues	8
Details	binding site for residue GOL A 1033

Chain	Residue
A	SER112
A	ALA115
A	PHE194
A	ASP216
A	ALA254
A	VAL255
A	ASP256
A	HOH1158

site_id	AF7
Number of Residues	10
Details	binding site for residue GOL A 1034

Chain	Residue
A	MET368
A	PRO473
A	ASP474
A	ALA476
A	HOH1122
A	HOH1328
A	HOH1359
A	HOH1888
A	HOH1919
A	HOH2018

site_id	AF8
Number of Residues	13
Details	binding site for residue GOL A 1035

Chain	Residue
A	HIS11
A	ASP12
A	ARG468
A	THR469
A	LYS478
A	GLN479
A	HOH1312
A	HOH1590
A	HOH1779
A	HOH1788
A	HOH1846
A	HOH2158
A	HOH2312

site_id	AF9
Number of Residues	14
Details	binding site for residue GOL A 1036

Chain	Residue
A	ARG293
A	VAL324
A	ASP327
A	GLN328
A	ASN344
A	GLU382
A	GOL1038
A	HOH1128
A	HOH1160
A	HOH1217
A	HOH1269
A	HOH1734
A	HOH1823
A	HOH1880

site_id	AG1
Number of Residues	5
Details	binding site for residue GOL A 1037

Chain	Residue
A	ASN623
A	GLY791
A	HOH1129
A	HOH1257
A	HOH1634

site_id	AG2
Number of Residues	6
Details	binding site for residue GOL A 1038

Chain	Residue
A	TYR275
A	ARG293
A	MLI1012
A	GOL1036
A	HOH1114
A	HOH1160

site_id	AG3
Number of Residues	10
Details	binding site for residue GOL A 1039

Chain	Residue
A	VAL622
A	ALA638
A	THR755
A	SER792
A	ASN793
A	HOH1179
A	HOH1488
A	HOH1606
A	HOH1966
A	HOH2033

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VIGHEYFHNW

Chain	Residue	Details
A	VAL294-TRP303

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000305\|PubMed:16885166, ECO:0000305\|PubMed:18416562, ECO:0000305\|PubMed:19622865

Chain	Residue	Details
A	GLU298

site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING:

Chain	Residue	Details
A	GLU121
A	GLY261
A	HIS297
A	HIS301
A	GLU320

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Transition state stabilizer => ECO:0000305

Chain	Residue	Details
A	TYR381

222415

PDB entries from 2024-07-10

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