5MCP
Structure of IMP dehydrogenase from Ashbya gossypii bound to ATP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003938 | molecular_function | IMP dehydrogenase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006177 | biological_process | GMP biosynthetic process |
| A | 0006183 | biological_process | GTP biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0003938 | molecular_function | IMP dehydrogenase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0006177 | biological_process | GMP biosynthetic process |
| B | 0006183 | biological_process | GTP biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0003938 | molecular_function | IMP dehydrogenase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006164 | biological_process | purine nucleotide biosynthetic process |
| C | 0006177 | biological_process | GMP biosynthetic process |
| C | 0006183 | biological_process | GTP biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0003938 | molecular_function | IMP dehydrogenase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006164 | biological_process | purine nucleotide biosynthetic process |
| D | 0006177 | biological_process | GMP biosynthetic process |
| D | 0006183 | biological_process | GTP biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0003938 | molecular_function | IMP dehydrogenase activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006164 | biological_process | purine nucleotide biosynthetic process |
| E | 0006177 | biological_process | GMP biosynthetic process |
| E | 0006183 | biological_process | GTP biosynthetic process |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0000166 | molecular_function | nucleotide binding |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0003938 | molecular_function | IMP dehydrogenase activity |
| F | 0005524 | molecular_function | ATP binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006164 | biological_process | purine nucleotide biosynthetic process |
| F | 0006177 | biological_process | GMP biosynthetic process |
| F | 0006183 | biological_process | GTP biosynthetic process |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0046872 | molecular_function | metal ion binding |
| G | 0000166 | molecular_function | nucleotide binding |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0003938 | molecular_function | IMP dehydrogenase activity |
| G | 0005524 | molecular_function | ATP binding |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0006164 | biological_process | purine nucleotide biosynthetic process |
| G | 0006177 | biological_process | GMP biosynthetic process |
| G | 0006183 | biological_process | GTP biosynthetic process |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0000166 | molecular_function | nucleotide binding |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0003938 | molecular_function | IMP dehydrogenase activity |
| H | 0005524 | molecular_function | ATP binding |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0006164 | biological_process | purine nucleotide biosynthetic process |
| H | 0006177 | biological_process | GMP biosynthetic process |
| H | 0006183 | biological_process | GTP biosynthetic process |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue ATP A 601 |
| Chain | Residue |
| A | THR165 |
| A | GLY209 |
| A | LYS210 |
| A | ATP602 |
| A | HOH724 |
| E | GLN170 |
| E | MG604 |
| E | HOH703 |
| A | SER166 |
| A | ARG167 |
| A | ASP168 |
| A | THR184 |
| A | ASP186 |
| A | VAL187 |
| A | ILE188 |
| A | LYS208 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue ATP A 602 |
| Chain | Residue |
| A | ILE121 |
| A | VAL125 |
| A | PHE145 |
| A | ALA146 |
| A | GLY147 |
| A | SER166 |
| A | LYS210 |
| A | MET223 |
| A | SER225 |
| A | THR227 |
| A | ASP228 |
| A | ATP601 |
| E | MG604 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for residue ATP A 603 |
| Chain | Residue |
| A | THR255 |
| A | ILE256 |
| A | ASP257 |
| A | SER278 |
| A | SER279 |
| A | PHE285 |
| A | HOH703 |
| A | HOH731 |
| A | HOH752 |
| A | HOH754 |
| A | HOH835 |
| A | HOH840 |
| B | GLN476 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | binding site for residue ATP B 601 |
| Chain | Residue |
| B | ILE163 |
| B | THR165 |
| B | SER166 |
| B | ARG167 |
| B | ASP168 |
| B | THR184 |
| B | ASP186 |
| B | ILE188 |
| B | LYS208 |
| B | GLY209 |
| B | LYS210 |
| B | ATP602 |
| B | ATP605 |
| B | HOH708 |
| B | HOH727 |
| F | GLN170 |
| F | MG602 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | binding site for residue ATP B 602 |
| Chain | Residue |
| B | ILE121 |
| B | PRO124 |
| B | VAL125 |
| B | PHE145 |
| B | ALA146 |
| B | GLY147 |
| B | SER166 |
| B | LYS210 |
| B | MET223 |
| B | SER225 |
| B | THR227 |
| B | ASP228 |
| B | ATP601 |
| B | HOH774 |
| F | MG602 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue ATP B 603 |
| Chain | Residue |
| B | THR255 |
| B | ASP257 |
| B | SER278 |
| B | SER279 |
| B | PHE285 |
| B | HOH714 |
| B | HOH787 |
| B | HOH827 |
| C | GLN476 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue MG B 604 |
| Chain | Residue |
| B | GLN170 |
| B | ATP605 |
| B | ATP606 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | binding site for residue ATP B 605 |
| Chain | Residue |
| B | GLN170 |
| B | ATP601 |
| B | MG604 |
| B | ATP606 |
| F | THR165 |
| F | SER166 |
| F | ARG167 |
| F | ASP168 |
| F | VAL187 |
| F | ILE188 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue ATP B 606 |
| Chain | Residue |
| F | PHE145 |
| F | GLY147 |
| F | SER166 |
| B | MG604 |
| B | ATP605 |
| F | VAL125 |
| site_id | AD1 |
| Number of Residues | 17 |
| Details | binding site for residue ATP C 601 |
| Chain | Residue |
| C | ILE163 |
| C | THR165 |
| C | SER166 |
| C | ARG167 |
| C | ASP168 |
| C | THR184 |
| C | ILE188 |
| C | LYS208 |
| C | GLY209 |
| C | LYS210 |
| C | PRO212 |
| C | ATP602 |
| C | MG604 |
| C | HOH708 |
| C | HOH798 |
| H | GLN170 |
| H | HOH701 |
| site_id | AD2 |
| Number of Residues | 18 |
| Details | binding site for residue ATP C 602 |
| Chain | Residue |
| C | ILE121 |
| C | PRO124 |
| C | VAL125 |
| C | PHE145 |
| C | ALA146 |
| C | GLY147 |
| C | SER166 |
| C | LYS210 |
| C | MET223 |
| C | SER225 |
| C | THR227 |
| C | ASP228 |
| C | ATP601 |
| C | MG604 |
| C | HOH701 |
| C | HOH800 |
| C | HOH808 |
| C | HOH814 |
| site_id | AD3 |
| Number of Residues | 12 |
| Details | binding site for residue ATP C 603 |
| Chain | Residue |
| C | THR255 |
| C | ILE256 |
| C | SER278 |
| C | SER279 |
| C | PHE285 |
| C | HOH714 |
| C | HOH731 |
| C | HOH781 |
| C | HOH782 |
| C | HOH787 |
| C | HOH841 |
| D | GLN476 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue MG C 604 |
| Chain | Residue |
| C | LYS210 |
| C | ATP601 |
| C | ATP602 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue MG C 605 |
| Chain | Residue |
| H | ATP601 |
| H | ATP602 |
| site_id | AD6 |
| Number of Residues | 15 |
| Details | binding site for residue ATP D 601 |
| Chain | Residue |
| D | ILE163 |
| D | THR165 |
| D | ARG167 |
| D | ASP168 |
| D | THR184 |
| D | ASP186 |
| D | ILE188 |
| D | LYS208 |
| D | GLY209 |
| D | LYS210 |
| D | ATP602 |
| D | HOH787 |
| G | GLN170 |
| G | ATP601 |
| G | MG604 |
| site_id | AD7 |
| Number of Residues | 17 |
| Details | binding site for residue ATP D 602 |
| Chain | Residue |
| D | ILE121 |
| D | PRO124 |
| D | VAL125 |
| D | PHE145 |
| D | ALA146 |
| D | GLY147 |
| D | SER166 |
| D | LYS210 |
| D | MET223 |
| D | SER225 |
| D | THR227 |
| D | ASP228 |
| D | ATP601 |
| D | HOH751 |
| D | HOH796 |
| D | HOH838 |
| G | MG604 |
| site_id | AD8 |
| Number of Residues | 12 |
| Details | binding site for residue ATP D 603 |
| Chain | Residue |
| A | GLN476 |
| D | THR255 |
| D | ASP257 |
| D | SER278 |
| D | SER279 |
| D | PHE285 |
| D | HOH714 |
| D | HOH717 |
| D | HOH729 |
| D | HOH757 |
| D | HOH798 |
| D | HOH851 |
| site_id | AD9 |
| Number of Residues | 2 |
| Details | binding site for residue MG D 604 |
| Chain | Residue |
| G | ATP601 |
| G | ATP602 |
| site_id | AE1 |
| Number of Residues | 14 |
| Details | binding site for residue ATP E 601 |
| Chain | Residue |
| E | THR165 |
| E | SER166 |
| E | ARG167 |
| E | ASP168 |
| E | THR184 |
| E | ASP186 |
| E | VAL187 |
| E | ILE188 |
| E | LYS208 |
| E | GLY209 |
| E | LYS210 |
| E | ATP602 |
| E | MG605 |
| E | HOH725 |
| site_id | AE2 |
| Number of Residues | 8 |
| Details | binding site for residue ATP E 602 |
| Chain | Residue |
| E | PHE145 |
| E | ALA146 |
| E | PHE148 |
| E | SER166 |
| E | MET223 |
| E | THR227 |
| E | ATP601 |
| E | MG605 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue ATP E 603 |
| Chain | Residue |
| E | THR255 |
| E | SER279 |
| E | PHE285 |
| G | GLN476 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue MG E 604 |
| Chain | Residue |
| A | LYS210 |
| A | ATP601 |
| A | ATP602 |
| E | GLN170 |
| site_id | AE5 |
| Number of Residues | 2 |
| Details | binding site for residue MG E 605 |
| Chain | Residue |
| E | ATP601 |
| E | ATP602 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue ATP F 601 |
| Chain | Residue |
| F | THR255 |
| F | ILE256 |
| F | SER279 |
| F | PHE285 |
| site_id | AE7 |
| Number of Residues | 3 |
| Details | binding site for residue MG F 602 |
| Chain | Residue |
| B | LYS210 |
| B | ATP601 |
| B | ATP602 |
| site_id | AE8 |
| Number of Residues | 13 |
| Details | binding site for residue ATP G 601 |
| Chain | Residue |
| D | GLN170 |
| D | ATP601 |
| D | MG604 |
| G | THR165 |
| G | SER166 |
| G | ARG167 |
| G | ASP168 |
| G | THR184 |
| G | VAL187 |
| G | ILE188 |
| G | GLY209 |
| G | LYS210 |
| G | ATP602 |
| site_id | AE9 |
| Number of Residues | 6 |
| Details | binding site for residue ATP G 602 |
| Chain | Residue |
| D | MG604 |
| G | PHE145 |
| G | ALA146 |
| G | GLY147 |
| G | SER166 |
| G | ATP601 |
| site_id | AF1 |
| Number of Residues | 2 |
| Details | binding site for residue ATP G 603 |
| Chain | Residue |
| G | SER278 |
| G | SER279 |
| site_id | AF2 |
| Number of Residues | 3 |
| Details | binding site for residue MG G 604 |
| Chain | Residue |
| D | LYS210 |
| D | ATP601 |
| D | ATP602 |
| site_id | AF3 |
| Number of Residues | 11 |
| Details | binding site for residue ATP H 601 |
| Chain | Residue |
| C | GLN170 |
| C | MG605 |
| H | THR165 |
| H | SER166 |
| H | ARG167 |
| H | ASP168 |
| H | ILE188 |
| H | GLY209 |
| H | LYS210 |
| H | ATP602 |
| H | HOH701 |
| site_id | AF4 |
| Number of Residues | 9 |
| Details | binding site for residue ATP H 602 |
| Chain | Residue |
| C | MG605 |
| H | VAL125 |
| H | PHE145 |
| H | ALA146 |
| H | GLY147 |
| H | PHE148 |
| H | SER166 |
| H | ASP228 |
| H | ATP601 |
Functional Information from PROSITE/UniProt
| site_id | PS00487 |
| Number of Residues | 13 |
| Details | IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. LRIGMGsGSICiT |
| Chain | Residue | Details |
| A | LEU324-THR336 |
