Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5M73

Structure of the human SRP S domain with SRP72 RNA-binding domain

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0006614	biological_process	SRP-dependent cotranslational protein targeting to membrane
B	0008312	molecular_function	7S RNA binding
B	0048500	cellular_component	signal recognition particle
C	0003723	molecular_function	RNA binding
C	0005047	molecular_function	signal recognition particle binding
C	0005786	cellular_component	signal recognition particle, endoplasmic reticulum targeting
C	0006614	biological_process	SRP-dependent cotranslational protein targeting to membrane
C	0008312	molecular_function	7S RNA binding
C	0030942	molecular_function	endoplasmic reticulum signal peptide binding
D	0006614	biological_process	SRP-dependent cotranslational protein targeting to membrane
D	0008312	molecular_function	7S RNA binding
D	0048500	cellular_component	signal recognition particle
F	0006614	biological_process	SRP-dependent cotranslational protein targeting to membrane
F	0008312	molecular_function	7S RNA binding
F	0048500	cellular_component	signal recognition particle
G	0003723	molecular_function	RNA binding
G	0005047	molecular_function	signal recognition particle binding
G	0005786	cellular_component	signal recognition particle, endoplasmic reticulum targeting
G	0006614	biological_process	SRP-dependent cotranslational protein targeting to membrane
G	0008312	molecular_function	7S RNA binding
G	0030942	molecular_function	endoplasmic reticulum signal peptide binding
H	0006614	biological_process	SRP-dependent cotranslational protein targeting to membrane
H	0008312	molecular_function	7S RNA binding
H	0048500	cellular_component	signal recognition particle

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MG A 301

Chain	Residue
A	G194
A	U195
A	G204
A	K328

site_id	AC2
Number of Residues	2
Details	binding site for residue MG A 302

Chain	Residue
A	U132
A	G164

site_id	AC3
Number of Residues	2
Details	binding site for residue MG A 303

Chain	Residue
A	G238
A	G239

site_id	AC4
Number of Residues	1
Details	binding site for residue MG A 304

Chain	Residue
A	U241

site_id	AC5
Number of Residues	2
Details	binding site for residue MG A 305

Chain	Residue
A	G177
A	G178

site_id	AC6
Number of Residues	2
Details	binding site for residue MG A 309

Chain	Residue
A	C196
A	G198

site_id	AC7
Number of Residues	1
Details	binding site for residue MG A 310

Chain	Residue
A	G198

site_id	AC8
Number of Residues	1
Details	binding site for residue MG A 311

Chain	Residue
A	G175

site_id	AC9
Number of Residues	1
Details	binding site for residue MG A 312

Chain	Residue
A	G152

site_id	AD1
Number of Residues	2
Details	binding site for residue MG A 314

Chain	Residue
A	G168
C	SER157

site_id	AD2
Number of Residues	1
Details	binding site for residue MG A 315

Chain	Residue
A	G238

site_id	AD3
Number of Residues	2
Details	binding site for residue MG A 316

Chain	Residue
A	C129
A	A130

site_id	AD4
Number of Residues	2
Details	binding site for residue MG A 317

Chain	Residue
A	G237
A	G238

site_id	AD5
Number of Residues	3
Details	binding site for residue MG A 318

Chain	Residue
A	G209
A	G210
A	K332

site_id	AD6
Number of Residues	1
Details	binding site for residue MG A 319

Chain	Residue
A	C220

site_id	AD7
Number of Residues	1
Details	binding site for residue MG A 320

Chain	Residue
A	A184

site_id	AD8
Number of Residues	1
Details	binding site for residue MG A 321

Chain	Residue
A	C111

site_id	AD9
Number of Residues	1
Details	binding site for residue MG A 322

Chain	Residue
A	U132

site_id	AE1
Number of Residues	1
Details	binding site for residue MG A 324

Chain	Residue
A	GOL333

site_id	AE2
Number of Residues	1
Details	binding site for residue MG A 325

Chain	Residue
A	G210

site_id	AE3
Number of Residues	4
Details	binding site for residue K A 328

Chain	Residue
A	G193
A	G194
A	U195
A	MG301

site_id	AE4
Number of Residues	5
Details	binding site for residue K A 329

Chain	Residue
A	G109
A	U110
A	U241
A	G243
A	C244

site_id	AE5
Number of Residues	1
Details	binding site for residue K A 330

Chain	Residue
A	GOL335

site_id	AE6
Number of Residues	1
Details	binding site for residue K A 331

Chain	Residue
A	GOL336

site_id	AE7
Number of Residues	4
Details	binding site for residue K A 332

Chain	Residue
A	C185
A	G210
A	U211
A	MG318

site_id	AE8
Number of Residues	4
Details	binding site for residue GOL A 333

Chain	Residue
A	C191
A	A205
A	G206
A	MG324

site_id	AE9
Number of Residues	5
Details	binding site for residue GOL A 334

Chain	Residue
A	A127
A	U128
A	C221
A	G222
A	U223

site_id	AF1
Number of Residues	4
Details	binding site for residue GOL A 335

Chain	Residue
A	G179
A	U181
A	K330
A	GOL337

site_id	AF2
Number of Residues	3
Details	binding site for residue GOL A 336

Chain	Residue
A	C189
A	A205
A	K331

site_id	AF3
Number of Residues	6
Details	binding site for residue GOL A 337

Chain	Residue
A	G179
A	G180
A	A216
A	C217
A	U218
A	GOL335

site_id	AF4
Number of Residues	2
Details	binding site for residue GOL B 201

Chain	Residue
B	ASN59
B	GLN88

site_id	AF5
Number of Residues	3
Details	binding site for residue MG C 302

Chain	Residue
C	GLN70
C	ARG236
C	GLU239

site_id	AF6
Number of Residues	1
Details	binding site for residue MG C 303

Chain	Residue
A	U167

site_id	AF7
Number of Residues	2
Details	binding site for residue MG E 301

Chain	Residue
E	U132
E	G164

site_id	AF8
Number of Residues	1
Details	binding site for residue MG E 302

Chain	Residue
E	G235

site_id	AF9
Number of Residues	1
Details	binding site for residue MG E 303

Chain	Residue
E	U211

site_id	AG1
Number of Residues	1
Details	binding site for residue MG E 304

Chain	Residue
E	G146

site_id	AG2
Number of Residues	2
Details	binding site for residue MG E 305

Chain	Residue
E	G135
E	G136

site_id	AG3
Number of Residues	3
Details	binding site for residue MG E 307

Chain	Residue
E	C185
E	A208
E	G209

site_id	AG4
Number of Residues	1
Details	binding site for residue MG E 308

Chain	Residue
E	G206

site_id	AG5
Number of Residues	2
Details	binding site for residue MG E 309

Chain	Residue
E	G238
E	G239

site_id	AG6
Number of Residues	2
Details	binding site for residue MG E 310

Chain	Residue
E	U236
E	G237

site_id	AG7
Number of Residues	1
Details	binding site for residue MG E 311

Chain	Residue
E	G198

site_id	AG8
Number of Residues	1
Details	binding site for residue MG E 312

Chain	Residue
E	G198

site_id	AG9
Number of Residues	4
Details	binding site for residue K E 315

Chain	Residue
E	G194
E	U195
E	G204
E	GOL321

site_id	AH1
Number of Residues	2
Details	binding site for residue K E 316

Chain	Residue
E	U181
E	GOL320

site_id	AH2
Number of Residues	1
Details	binding site for residue K E 317

Chain	Residue
E	U223

site_id	AH3
Number of Residues	3
Details	binding site for residue K E 318

Chain	Residue
E	C217
E	U218
E	GOL322

site_id	AH4
Number of Residues	4
Details	binding site for residue K E 319

Chain	Residue
E	G109
E	U110
E	U241
E	G243

site_id	AH5
Number of Residues	5
Details	binding site for residue GOL E 320

Chain	Residue
E	G179
E	G180
E	U181
E	K316
E	GOL322

site_id	AH6
Number of Residues	5
Details	binding site for residue GOL E 321

Chain	Residue
E	A192
E	G193
E	G203
E	G204
E	K315

site_id	AH7
Number of Residues	4
Details	binding site for residue GOL E 322

Chain	Residue
E	G178
E	G179
E	K318
E	GOL320

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:18691976, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
D	THR571
H	THR571

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
D	THR618
H	THR618

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
D	SER630
D	SER635
H	SER630
H	SER635

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)